No abstract available.
Licensure*

No abstract available.
Precipitating Factors* ; Vitiligo*

In order to investigate a hemodynamic complication associated with the resection of a large arteriovenous malformation, we planed the following experiment. We divided the left common caroted artery and the internal jugular vein for microsurgical anastomsis between the rostral carotid and caudal jugular vessel ends : the 2 remaining wessel stumps were ligated. This created an arteriovenous shunt with afferent flow from the contralateral caroted and the basilar artery and retrograde down to the carotid-jugular anastomosis. And then, we occluded the shunt vessels at the each stage of the first and fourth week after anteriovenous shunt. Forty adult cats weighing from 2.2 to 2.4kg were used in this study The animals were devided into 4 groups : group 1(acute occlusion-1 week after shunt, n=10), group 2(staged occlusion-1 week after shunt, n=10), group 3(acute occlusion-4 week after shunt, n=10), group 4(staged occlusion-4 week after shunt, n=10) respectively. The regional cerebral blood flow(rCBF), cardiopulmonary function were measured in each animal group and also observed the response of the cerebral blood flow on induced changes of the blood pressure and the arterial bicarbonate. The arteriovenous shunt patency was evaluated by serial angiography. The results were as follows ; 1) Considerable increases in the mean arterial blood pressure(mABP) as well as bradycardia were observed in acute occlusion groups(group 1, 3). After induced hyercarbia, the increments of mABP in acute occlusion groups were less than staged occlusion groups, considerbly. 2) Significant decreases in the mean pulse rate were observed in acute occlusion groups. the mean pulse rate were the highest decrease in group 3. 3) The values of rCBF of left frontal cortex in acute occlusion groups were more greater increase than those of staged occlusion groups considerably. 4) After induced hypercarbia, considerable increases of the rCBF were demonstrated in all groups and increases of the rCBF were lowest in group 3 compared with the other groups. After induced hypercarbia, considerable increases of the rCBF were demonstrated in all groups and reductions of the rCBF were lowest in group 3 compared with the other groups. 5) After induced hypercarbia, considerable increases of the rCBF were demonstrated in all groups. The rCBFs were the highest increase in group3 and lowest increase in group 2 compared with the other groups. After induced hypotension, considerable reductions of the rCBF were demonstrated in all groups. The rCBFs were the highest reduction in group 3 and lowest reduction in group 2 compared with the other groups. It might be infered from these results that patients with large arteriovenous malformations, particulary those with cerebral steal symptoms, are at risk to develp neurologic defictis related to perfusion breakthrough if their malformed vessels are abruptly removed, and staged or gradual occlusion of feeding arteries may prevent this potentially devastating complication.
Adult ; Angiography ; Animals ; Arteries ; Arteriovenous Malformations ; Basilar Artery ; Blood Pressure ; Bradycardia ; Cats ; Heart Rate ; Hemodynamics ; Homeostasis* ; Humans ; Hypotension ; Jugular Veins ; Perfusion

No abstract available.
Atropine* ; Hidrocystoma*

No abstract available.
Biological Clocks* ; Periodicity*

No abstract available.
Sleep Initiation and Maintenance Disorders*

No abstract available.
Extremities*

AIM:To evaluate the demographics, characteristics and visual outcomes of open globe injuries in children of amblyogenic age in Hong Kong.
METHODS: All medical records of children aged between 0 to 8y old who sustained open globe injuries between Jan. 1st, 2005 and Jan. 1st, 2015 were reviewed retrospectively. The demographics, clinical features ( laterality, etiology and zone of injury, other associated ocular injuries ) , type of primary and secondary operations performed, preoperative and postoperative best spectacle corrected visual acuity ( BSCVA ) complications were collected and analysed.
RESULTS: A total of 7 cases, 2 males and 5 females were identified. The median age of presentation was 5 years old. All suffered from penetrating injuries (100%). Four cases ( 57%) had improvement of visual acuity compared with preoperative visual acuity. Final visual acuity was hand movement in one (14%) patient, 20/200-20/50 in four ( 57%) patients, and 20/40 or better in two (29%) patients.
CONCLUSION: There is a relative low rate of open globe injuries in young children in Hong Kong. Good visual outcomes may be obtained depending on the location and severity of the open globe injury together with prompt surgical management to restore the integrity of the globe and aggressive management of amblyopia.

There are a number of approaches in developing experimental models for depression. but there is no such thing as a best model for depressive syndrome. Animal models are subject to the obvious limitations inherent in the assumption that human psychopathology can be represented accurately in lower animals. Recently, the concern increasingly is to develop a variety of experimental paradigms in animal to study selected aspects of human psychopathology, and animal models should be understood as basically experimental preparations that are developed to carry out these objects. Therefore, a battery of a variety of animal models should be applied to permit detailed pathophysiological studies and to develop new antidepressant treatments. Animal models of depression basically consider behavioral isomorphism with the human depression a plus, but not a requirement, and the model behavior should be defined operationally in order to be reproduced reliably by other researchers and be responsive to those agents possessing demonstrated clinical efficacy in human depression. In conclusion, animal models of depression have played a significant role in elucidating pathophysiology of depression and developing current treatments for depression, but there is no single comprehensive model for depression until now. Each of the proposed animal model has its advantages and limitations. In other words, certain paradigms are suitable for studying certain phenomena, whereas others are more suitable for studying other aspects. The best model for depression depends upon what the question is.
Animals ; Depression* ; Depressive Disorder ; Humans ; Models, Animal ; Models, Theoretical* ; Psychopathology

No abstract available in English.
Child ; Humans ; Legg-Calve-Perthes Disease ; Plasma ; Somatomedins