Kawasaki disease, an acute febrile illness which primarily affects in children under the age of six, was first described by Tomisaku Kawasaki in 1967. It has been reported that Kawasaki disease is probable driven by abnormalities of the immune system after an infectious insult, but this has not been confirmed. It mainly affects small and medium-sized arteries, particularly the coronary arteries. Deaths may occur at any time with cardiovascular complications. The early recognition and treatment with follow-up evaluation for the coronary arterial lesion is very important in a case of Kawasaki disease.
Arteries ; Child ; Coronary Vessels ; Humans ; Immune System ; Mucocutaneous Lymph Node Syndrome* ; Prognosis

Since Dr. Angell introduced cryopreservation method for tissue preservation in 1980s, it became a preferred method for cardiovascular tissues. Cryopreservation has been proven to provide better cell viavility and clinical result than any other preservation method. The quality of cryopreserved cardiovascular tissue is a very critical point of patients' survival when transplanted. To obtain high quality cryopreserved tissue, each processing methods from harvesting to delivery should be standardized. Various factors, such as range of possible tissues, acceptable ischemic time, temperature during transportation, facility for processing, method of freezing, use of cryoprotectant, method of storage, condition of delivery, and method of thawing for cardiovascular tissues should be standardized. Different standards should be established and applied to different tissues. Various kinds of tissues can be harvested from each living or cadaveric donor. Therefore, it is reasonable to harvest and handle all tissues in one laboratory by one tissue bank. In U.S.A, tissue banks are operated under standardized condition. The American Association of Tissue Banks affords the certification of specialist and tissue banks on very strict conditions, and provides the Food and Drug Administration with consultation in making regulations regarding tissue transplantation. In Korea, tissues have been simply stored in refrigerator since mid 1990s, and cryopreservation method is getting popular. Tissue banking has been started recently and now six major hospitals treat the cardiovascular tissues and are equipped with good facilities. Korean Association of Tissue Banks was established last year and now setting up regulations and standards. In Conclusion, I suggest that the cardiovascular tissue bank should belong to a university hospital till regulations and standards are completed. And then commercial tissue bank will be able to take it over to manage more tissues. The financial state of tissue banking is also an important point to be considered to balance between quality control and easy access to the public. Also the cost of cryopreserved allograft should be covered by medical insurance.
Allografts ; Cadaver ; Certification ; Cryopreservation* ; Freezing ; Humans ; Insurance ; Korea ; Methods ; Quality Control ; Social Control, Formal ; Specialization ; Tissue Banks ; Tissue Donors ; Tissue Preservation ; Tissue Transplantation ; Transplants ; Transportation ; United States Food and Drug Administration

The patient was a sixty-year-old obese woman with the long history of hypertension, amenorrhea and occasional psychic disturbances. She had eigbt, thumb to adult-fist sized, slightly movable, relatively soft, and painful subcutaneous nodules with tenderness and paresthcsia, of which overlying skin appeared to be normal except senile changes, on the abdomen and both upper extremities for 10 years. There was no evidence of inheritance in her family. Laboratory data revealed no abnormalities in lipid metabolism or in a variety of endocrinological functions. Microscopically, an excised mass from the forearm showed thin connective tissue capsule encircling numerous lobules cornposed entirely of the mature fat. cells vith minimal focal capillary proliferatios.
Abdomen ; Adiposis Dolorosa* ; Amenorrhea ; Capillaries ; Connective Tissue ; Female ; Forearm ; Humans ; Hypertension ; Lipid Metabolism ; Skin ; Thumb ; Upper Extremity ; Wills

No abstract available.
Carcinoma, Papillary* ; Thyroid Gland*

The effect of retinoic acid. on hyperkeratotic diseases and. Acne as being published. To confirm the effect of topical retinoic acid, vre subjected 50 patients with mild to severe Acne vulgaris of the face, The patients chosen were not previously treated. with any remedy at least for the past 2 weeks. Eudyna' cream or gel were applied. once or twice a day to the face keeping some distance from the mucous membrane. We checked the number of closed comedones, open comedones, papules, pustules and scara before the treatment and every week for 14 wks during the treatment, The result were as follows: l. 42 patients began to improve in 2 to 8 wks and markedly improved in 6 to 8 wks. 3 patients dropped out because of severe side effects. Very good: 13 patients(26%) Good: 14 patinets(28%) Satisfactory: 15 patients(80%) None: 5 patients(10%) 2. The side effects: Most of patients suffered from mild to severe erythema, scaling and buming sensation in 2 to 3 days after the initiation of application. In severe cases developed severe erythema, vesicles, pustules, edema and exudation within a week.
Acne Vulgaris* ; Edema ; Erythema ; Humans ; Mucous Membrane ; Sensation ; Tretinoin

Gout is not very rare disorder in high economic countries and it is seldom observed in our country and is hard to find its report in Korean dermatologic literature. Gout is a disease of inbom metabolic and/or acquired form of the disease chara-cterized by hyperuricemia, tophaceous deposits of sodium urate and recurrent attacks of arthrit.is which dramatically responds to Colchine. A case of tophaceous gout in a 56 year old Korean male is reported. The patient showed pea to waInut size, yellowish tender subcutaneous masses on right great toe and both solee of 15 year duration which are adherented to the overIying skin. The hiatology of the lesion revealed variously sized, sharply demarcated aggregates of needle shaped urate crystals in bund.his and sheaves which are surrounded by fibrous connective tissue which are in tum surrounded by granulomatous infiltrate containing small round cells and foreign body glant cells. The urate crystals have a brownish color and are doubly refractile on polariscopic examination. The use of colchine, in a initial dose of 1mg foIIowed by 0. 5mg every hour for 6 hours. The patient failed to attend the clinic regularly and was lost for folIow up.
Connective Tissue ; Foreign Bodies ; Gout* ; Humans ; Hyperuricemia ; Male ; Middle Aged ; Needles ; Peas ; Skin ; Toes ; Uric Acid

OBJECTIVE: This study was performed to evaluate the clinical efficacy of high-risk HPV DNA test using Hybrid Capture System in the detection of high-grade cervical intraepithelial neo- plasia(CIN II, III) from patients with atypical squamous cells of undetermined significance(ASCUS) or a low-grade squamous intraepithelial lesion(LGSIL) on referral Papanicolaou smear. STUDY DESIGN: Fifty-four patients referred to our hospital with a Papanicolaou smear report of atypical squamous cells of undetermined significance or a low-grade squamous intraepithelial lesion underwent repeat Papanicolaou smear, cervical colposcopy and directed cervical biopsy. In addition, high-risk human papillomavirus(HPV) test by Hybrid Capture System was done. A comparison of detection rate of the high-grade CIN between positive and negative results of HPV test according to repeat Papanicolaou smear report was done. Biopsy result according to HPV test result in total patients was also compared. RESULTS: HPV of high-risk type was detected in 22 of 54 women(40.7%) by Hybrid Capture System. Prevalence rate of high-risk HPV in no CIN, CIN I, and CIN II, III was 13.6%, 18.2% and 68.2% respectively. As expected, high-risk HPV was detected with greater frequency in relation to increasing severity of CIN. In 18 women, the repeat smear obtained in our clinic was reported as negative. High-risk HPV types were found in 16.7% of theses women. In the HPV-negative women, 40% had CIN II or III confirmed on cervical biopsy. In comparison, 66.7% of those with a positive result of the HPV test had CIN II or III on biopsy(P<0.05). Among the women with ASCUS or LGSIL on repeat smear, there was no significant difference in the frequency of biopsy-proved CIN II or III between positive and negative results of high-risk HPV test. In total patients, the group that had positive results for high-risk HPV showed higher incidence of CIN II or III than group with negative results(P<0.05). CONCLUSION: From these results testing women with Papanicolaou smears showing ASCUS or LGSIL for infection with high-risk HPV types would identify the patients who are at risk for HGSIL or invasive carcinoma and who require aggressive intervention. High-risk HPV DNA test using Hybrid Capture System may be a usefule method in supplement the pitfalls of cervical cytology. This test might also have prgnostic value in the management of patients with cervical intraepithelial lesions.
Biopsy ; Colposcopy ; Female ; Human Papillomavirus DNA Tests ; Humans* ; Incidence ; Papanicolaou Test ; Papilloma* ; Prevalence ; Referral and Consultation

No abstract available.
Multiple Endocrine Neoplasia*

No abstract available.

No abstract available.
Calcium* ; Diet* ; Hypercalciuria* ; Osteocalcin*