Helicobacter pylori infection has been shown to be associated with gastric carcinoma. However, despite the frequent detection of seropositivity for H. pylori and histologic detection in biopsy specimen, histologic detection rate of H. pylori in surgical specimens has been low. In this study, we investigated the prevalence of H. pylori infection in gastrectomy specimens bearing gastric adenocarcinoma and compared it with both endoscopic biopsy and serologic results. H. pylori infection was identified by Giemsa stain in the mucosa stripped from the tumor, body, and antrum in 61 gastrectomy specimens. We evaluated the effect of H. pylori infection on gastric mucosal cell proliferation by using monoclonal antibody for Ki-67. H. pylori detection rate using Giemsa stain was higher in gastrectomy specimens (67.3%) compared to that (48.1%) of biopsy specimens (p=0.006). The detection rate was higher in body than that of antrum or tumor site in the same patients (p=0.001). The H. pylori seropositivity was 60.5% and relatively nonspecific. The mean value of Ki-67 labeling index in the H. pylori-positive group was higher than that in the H. pylori-negative group (p<0.05). The increase in gastric epithelial cell proliferation was not influenced by the location of the tumor or the site of the specimen. The results suggest that the actual prevalence of H. pylori infection in patients with gastric carcinoma is considerably higher than that evaluated on endoscopic biopsy specimens. In addition, the increased cell proliferation in the H. pylori-positive group suggests some evidence that H. pylori may be involved in gastric carcinogenesis.
Adenocarcinoma* ; Azure Stains ; Biopsy ; Carcinogenesis ; Cell Proliferation ; Epithelial Cells ; Epithelium* ; Gastrectomy ; Helicobacter pylori* ; Helicobacter* ; Humans ; Mucous Membrane ; Prevalence

No abstract available.
Animals ; Antigen-Antibody Reactions* ; Guinea Pigs* ; Guinea* ; Lung* ; Mast Cells*

No abstract available.
Subcutaneous Tissue*

PURPOSE: Septic arthritis of the knee is a relative rare complication of the arthroscopic anterior cruciate ligament reconstruction, but inadequate treatment of this complication may lead to a devastating conse- quence of a chronic infection. Moreover, no guidelines have been proposed for the treatment of patients with knee infections after the anterior cruciate ligament reconstruction. To determine the optimal diagno- sis and treatment recommendation, we performed this study. MATERIALS AND METHODS: We performed retrospective study of the knee joint infections after the arthroscopic anterior cruciate ligament reconstruction between August 1993 and August 1998, Of the 420 patients who reviewed arthroscopic ACL reconstruction during this period from one surgeon, we experi- enced 4 cases(0.95%) of postoperative deep infections of the knee. RESULTS: All 4 patients were male, and the average age was 32 years(range from 19 to 43). Two patients had acute(< 2 weeks), two patients had subacute infections(2 weeks to 2 months). The acute cases had more severe symptoms, and positive cultures from knee joint aspirates. All patients underwent immediate open(1 case), or arthroscopic irrigation and debridement. One patient underwent repeat irriga- tion and debridement. The graft was removed from all patients in acute cases. CONCLUSION: The clinical symptoms, and the infected organism were more helpful than the peripheral blood counts in the diagnosis of a deep infection of the knee. Arthroscopic lavage, and debridement com- bined with intravenous antibiotics were effective treatment options. Clinical symptoms were more severe in acute cases, and early graft removal is an adequate method of surgical treatment.
Anterior Cruciate Ligament Reconstruction* ; Anterior Cruciate Ligament* ; Anti-Bacterial Agents ; Arthritis, Infectious* ; Debridement ; Diagnosis ; Humans ; Knee Joint ; Knee* ; Male ; Retrospective Studies ; Therapeutic Irrigation ; Transplants

No abstract available.
Giant Cell Tumors* ; Giant Cells* ; Knee Joint* ; Knee*

The goals of hip arthroplasty have been to eliminate pain, decrease deformity, increase morbility and obtain stabiIity. Currently total hip replacement is the best avaliable procedure to accomplish these goals. A prospective study of total hip arthroplasty was begun at the orthopedic dept of Kyung Hee Medical College in 1974. Between May, 1974 and June, 1977. 69 total hip replacements of the Charnley type, the Trapesoidal-28 type and the Muller type were peformed by the authors. Of the 60 Patients involved in this study, 9 had bilateral operations. The Charnley type Prosthetic device was used in 56 cases, the Trapesoidal-28 type in 7 cases and the Muller type in 6 cases. Complications included wire breakage, dislocation, loosening, femur shaft perforation, nonunion of greater-trochanter, acetabular protrusion, transient femoral nerve palsy, femur shaft fracture, infection, socket lateralization, ectopic bone formation and death. In 59 patients of the 60 patients, 53 patients felt that they were definitely improved, 5 patients felt their condition was unchanged and 1 patient felt her condition was worse.
Acetabulum ; Arthroplasty ; Arthroplasty, Replacement, Hip ; Clinical Study ; Congenital Abnormalities ; Dislocations ; Femoral Nerve ; Femur ; Hip Prosthesis ; Hip ; Humans ; Orthopedics ; Osteogenesis ; Paralysis ; Prospective Studies

Persistently elevated intracranial pressure(ICP) has been associated with poor clinical outcome after intracerebral hemorrhage(ICH). Increased ICP is one of the main target of treatment in hypertensive ICH. To evaluate the efficacy of stereotactic surgery for the patients with hypertensive ICH, continuous ICP monitoring was done in these patients. This study is based on 30 patients(39-75 years of age, with a mean age of 59.4 years) between January 1996 and December 1997, who had suffered hypertensive supratentorial ICH. All patients underwent partial removal of the hematoma(mean 11.8cc in volume) through the stereotactically placed catheters and the residual hematoma was drained by urokinase irrigation for average of 3.4 days. ICP was monitored in all cases starting before the surgery and continuously until two days after the surgery. Patients were assigned into three categories(Category A; less than 20mmHg, Category B; 20-30mmHg, and Category C; above 30mmHg) according to the initial(preoperative) ICP. Ten patients(39.5cc in average volume of hematoma) were defined to category A, six(45cc) to category B, and fourteen(62.4cc) to category C. After partial removal of the hematoma, there was statistically significant difference in drop of ICP(average 8.4mmHg in category A, 16mmHg in category B, and 36.7mmHg in category C)(p<0.001) and postoperative ICP was maintained under 20mmHg in all patients by urokinase irrigation and external drainage through the stereotactically placed catheters. Cerebral perfusion pressure(CPP) was maintained more than 90mmHg after partial removal of hematoma in all patients. This study demonstrates that ICP was controlled effectively by stereotactic external drainage with intermittent mannitol infusion under the continuous ICP monitoring without large decompressive surgery under general anesthesia for patients whose ICH volume was more than 60cc. Exception to this would be those with rapid progression of neurologic deterioration.
Anesthesia, General ; Catheters ; Drainage ; Hematoma ; Humans ; Intracranial Hemorrhage, Hypertensive* ; Intracranial Pressure* ; Mannitol ; Perfusion ; Urokinase-Type Plasminogen Activator

Phamacokinetic study of the antibiotic concentrations in the cerebrospinal fluid was done with high pressure liquid chromatography of CSF samples from twelve patients who had various amount of continuous extra-ventricular drainage during antibiotic administration. Five patients with large amount(over 150cc/day) of drainage had decreased CSF antibiotic concentrations dramatically below the effective concentration within 4 hours after intraventricular antibiotic administration, but six patients with small(less than 150cc/day) drainage maintained CSF antibiotic level above effective concentration even 24 hours after administration. In conclusion, repeated intraventricular administration of antibiotic is necessary to maintain the effective drug level in the patient with CSF drainage over 150cc/day.
Cerebrospinal Fluid* ; Chromatography, Liquid ; Drainage* ; Humans ; Infusions, Intraventricular*

We evaluated one month follow-up results of the 12 adult patients who showed ventriculomegaly in the aspects of symptoms. Evans ratio, periventricular low density, grades of radio-isotope cisternography, and grades of continuous intracranial pressure monitoring that were classified on the pressure wave and basal pressure level. The grades of continuous ICP monitoring were compared to the grades of radio-isotope cisternography. History, symptoms, CT findings, and radio-isotope cisternography are often helpful to decide shunt operation but sometimes continuous intracranial pressure monitoring gives invaluable information.
Adult* ; Follow-Up Studies ; Humans ; Intracranial Pressure

Meconium peritonitis is an aseptic peritonitis caused by spill of meconium in the abdominal cavity through one or several intestinal perforations which have taken place during intrauterine life or early neonatal life. We experienced three cases of meconium peritonitis with ileal perforation in two cases 1 day-old male neonate and 2 day-old male neonate, respectively, which had the chief complaint of vomiting and abdominal distension. Literatures are reviewed, briefly.
Abdominal Cavity ; Humans ; Infant, Newborn ; Intestinal Perforation ; Male ; Meconium* ; Peritonitis* ; Vomiting