This study was attempted mainly to estimate the frequency of ichthyoses and its genetic characteristics among general population in Chonnam Province. One hundredand thirtyone subjects heing comprised of 121 with ichthyosis vulgaris, 6 with X-linked recessive ichthyosis and 4 with lamellar ichthyosis visited the department of Dermatology, Chonnam National University Hospital from 1971 through 1980. All except 7 patients had visited the hospital with chief complaints of a skin problem other than ichthyoses itself. The frequency of ichthyosis vulgaris seems to be somewhere between, 1/300 and 1/400. 86% were found to either be sporadic cases or come from families from which not enough information was obtained to define a mode of inheritance. The fact that 43% of the sibling of affected patients developed ichthyosis vulgaris points out that it is a highly penetrant autosomal dominant, disease. Skipped generation was observed in 2 families, and gonadal mosaicism in 1 family. Atopic diseaaes were found only in 12.0% of cnses of ichthyosis vulgaris. The disease appeared in 81% of cases before 1 year af age. The skin lesions of ichthyoses were developed on the lower limhs, back, upper limbs, abdomen and scalp in the order of frequency.
Abdomen ; Dermatology ; Gonads ; Humans ; Ichthyosis Vulgaris ; Ichthyosis* ; Ichthyosis, Lamellar ; Jeollanam-do ; Mosaicism ; Scalp ; Siblings ; Skin ; Upper Extremity ; Wills

A fifty-seven-year-old, faers wife, was affected a skin lesion of dark pigme raised, crusted ulerated, easy to bleed on touching the crust and indurated ur with mood consistancy, and the tumor was located over the inner is of left eye, which was alike to malignant melanoma clinically. The tumor 1-shaped and measure 1.;. m x l. 7cm in diameter, which did not make any itchy sensation. d with small papule about 8 years ago which zdually increased. in siiarate3 with ocsional ble 3ing. Her skin lesion was treateQ with curretation and electrodessication or surgical removement by loca.l practitioner, however, it recured after the each treatments. In this hospital, the peeived the skin biopsy of the tumor and the diagnosis was established as cell car.cinoma histopathologically, and the tumor was removed by ical technique applying transposition skin flap from the infra-orbitale face, and the result was satisfactory without "mcurence until upto bservation (for three years and three months). On the conclusion, ad a case of Solid pigmented basal cell carcin- oma resernbling maligna. with histopathological study and treated with plastic surgical management very satisfying result.
Biopsy ; Carcinoma, Basal Cell* ; Diagnosis ; Humans ; Melanoma* ; Sensation ; Skin ; Spouses

Following the Korean War, the presence of foreign troops in Korea and lowered. sexual morality caused an increase in the rate of prostitution and related venereal diseases. Though the health authorities made efforts to handle these problems, they didnt obtain any noticeable results, because they neglected the scientific prevention and treatment based on expert knowledge, and the sociopsychological problem, which was the basic cause of the increment in the rate of prostitution. They only took administrative action against the prostitutes. Therefore, in July, 1976, we went to a town(named Silver Town) located on the outskirts of a U.S. Air Force base, and, examined and guestioned a number of prostitutes. Each of the 288 subjects residing in the town was given a questionaire that dealt with individual living attitudes, family and social background, and sociopsychological aspects of tbeir lifestyle. Questionaires were completed anonymously. Serological tests for syphilis, the UDRL and TPHA, were also administered. The results of our atudy are as follows. 1) Most of the prostitutes had grown up in large families, in which females were predominant. Because of economic difficulties they dropped out of school a.t an early age and became prostitutes. The average age of a prostitute at the time of her first sexual experience was 19. 9 years, the expriences usually taking place with her first boyfriend. Forty six psrcent of tbe subjects had intercourse for the first time between the ages of 15 and 19. Fortynine & two tenths percent of them because prostitutes within one year of their initial sexual act, and all of them at an average interval of 2.5 years following the first sexual experience, the average age being 22. 4 years. 2) The longer the women had worked as prostitutes, the more they felt dissatisfied with their work, and the more they desired to change to an occupation which was healthier and entailed more self-respect. 3) Out of 283 subjects, 39% had a history of venereal disease, predominantly of gonorrhea. Tbe results of the STS administered to all subjects were,; VDRL 7.7% positive and TPHA 6% positive. It was also concluded that the subjects had no educational or working knowledge of venereal diseases.
Anonyms and Pseudonyms ; Female ; Gonorrhea ; Humans ; Jeollabuk-do* ; Korea ; Korean War ; Life Style ; Morals ; Occupations ; Prostitution ; Serologic Tests ; Sex Workers* ; Sexually Transmitted Diseases ; Silver ; Syphilis*

No abstract available.

The purpose of this study was to compare surface roughness and bone formation around two types of threaded commercially pure titanium implants manufactured by two different companies. The test implants were manufactured by Sumin synthesis dental materials Co. (Avana, Busan, Korea), while the controls were manufactured by Nobel Biocare (MK II, Goteborg, Sweden). To compare bone formation adjacent to newly product with Branemark MK II implant, surface roughness was measured by Accurate 1500M and histomorphometric analysis was done. The results were as follows : 1. Measurement of surface roughness showed that Avana implant had a slightly more irregular surface compared with Branemark implant. 2. In the light microscopic studies, no infiltration of inflammatory cells nor the giant cells wee observed on both groups. 3. In th light and fluorescent microscopic studies, the amount of osseointegration and the extent and the timing of bone formation were similar. 4. There were no statistically difference between two groups in the average bone to implant contacts. Branemark implant ; 67%(SC 23%), Avana implant ; 70%(SD 16%). Comparing with Branemark implant, Avana implant made of CP grade II titanium showed similar good bone healing, formation and osseointegration.
Busan ; Dental Materials ; Giant Cells ; Osseointegration ; Osteogenesis ; Titanium*

No abstract available.

OBJECTIVE: The pathogenesis of endometriosis is generally accepted that retrograde menstruation and alterations in the local pelvic immune environment. This study was performed to help elucidate what kind of role various cytokines might play in the pathogenesis of endometriosis. METHOD: Concentrations of peritoneal fluid cytokines were compared in 7 women with normal pelvic finding and 23 women with endometriosis by enzyme-linked immunosorbent assay(ELISA). The patterns of cytokine mRNA expression in 8 ovarian endometrioma and 12 superficial pelvic endometriosis lesions were investigated by reverse transcription-polymerase chain reaction(RT-PCR) amplification method. RESULT: Both IL-6 and IL-10 levels in peritoneal fluid specimens with endometriosis tended to be higher than normal. However, there were no significant differences between peritoneal fluid concentrations of IFN-gamma, TNF-alpha, IL-1beta, and IL-5 of women with and without endometriosis. The levels of IL-6 and IL-10 were significantly higher in peritoneal fluid of women with severe endometriosis compared to women with mild endometriosis. IL-1beta mRNA was expressed in all of 8 deep and 12 superficial endometriosis lesions. IL-5 and IL-6 mRNA were expressed in only two black lesions respectively, however, both were not expressed in the all deep lesions. Expressions of IL-10 mRNA occurred in one red and one black lesion while this was expressed in only one of the deep lesions. TNF-alpha mRNA was expressed in one red and one black lesion of 12 superficial lesions compared with four of the deep lesions. There was the difference between kinds of increased cytokines in the peritoneal fluid and those of expressed cytokines in the endometriotic lesions of patients with endometriosis. CONCLUSION: This study supports the concept that local immunologic factors may be important in the pathogenesis and pathophysiology of endometriosis. The pattern of cytokine mRNA expression of endometriotic lesions would seem to indicate that proinflammatory cytokines such as IL-1beta and TNF-alpha are responsible for the development or progression of endometriosis.
Ascitic Fluid ; Cytokines ; Endometriosis* ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunologic Factors ; Interleukin-10 ; Interleukin-5 ; Interleukin-6 ; Menstruation Disturbances ; RNA, Messenger* ; Tumor Necrosis Factor-alpha

Loss of heterozygosity (LOH) at polymorphic loci on the short arm of chromosome 3 which has multiple recurrence genes was investigated in histopathologically proven 35 sporadic renal cell carcinoma (RCC) at Dong-A University. The allelic frequencies and the rate of LOH applying a polymerase chain reaction (PCR) at five loci, D3S2 (MSPI), THRB (EcoRI), THRB (BamHI), THRB (MSPI) and D3F15S2 (Hind III) were investigated. The allelic frequencies were quite different between normal subjects and patients with RCC in Koreans. The rate of LOH was shown lower at all loci than those of Caucasians. The clear distinction in the incidence of LOH was shown between clear cell and granular cell type. LOH was not observed at THRB locus in clear cell type whereas in granular cell type, LOH could not be observed at D3Fl5S2 locus. The following conclusion was derived. The author found that one allelic gene was changed in patients with RCC because the allelic frequencies were different between normal subjects and patients with RCC. Also, the genetic characteristics in Koreans were different from Caucasians, and the detection of genetic loci specific for Koreans is important in oncogenetic studies. Lastly, Allelic analysis was compared with the histopathological findings of genetic alterations so to correlate the relationship between oncogenesis and genetic alterations. Therefore, this study suggested that different genes are involved in oncogenesis according to histopathological types.
Arm* ; Carcinogenesis ; Carcinoma, Renal Cell* ; Chromosomes, Human, Pair 3* ; Genetic Loci ; Humans ; Incidence ; Loss of Heterozygosity* ; Polymerase Chain Reaction ; Recurrence

I examined the sphericity and the congruity of the femoral head and the acetabulum in 172 Korean fetuses and in 655 Korean adults. I found that Korean fetal acetabuli and femoral heads are spherical and that the proportion of the head contained in the acetabulum remains constant and congruous throughout the fetal life. Adult actabuli and femoral heads are also spherical in both gender and are there are no visible changes in the shape of the acetabuli and the femoral heads with respect to age. No evidence was found that the congruity of the hip joint is a cause of osteoarthritis of the hip joint. Clinical Relevance: Stable hip joints at the time of birth provide an explantation for the low incidence of congenital dislocation of the hip joint in Koreans. The spherical femoral head and acetabulum (congruous hip joint) seem to be a contributing factor to the low incidence of primary osteoarthritis of the hip in Koreans.
Acetabulum/*anatomy and histology/embryology ; Adult ; Female ; Femur Head/*anatomy and histology/embryology ; Fetus/anatomy and histology ; *Hip Joint/pathology ; Human ; Incidence ; Korea/epidemiology ; Male ; Osteoarthritis, Hip/epidemiology/*etiology/pathology

I examined the sphericity and the congruity of the femoral head and the acetabulum in 172 Korean fetuses and in 655 Korean adults. I found that Korean fetal acetabuli and femoral heads are spherical and that the proportion of the head contained in the acetabulum remains constant and congruous throughout the fetal life. Adult actabuli and femoral heads are also spherical in both gender and are there are no visible changes in the shape of the acetabuli and the femoral heads with respect to age. No evidence was found that the congruity of the hip joint is a cause of osteoarthritis of the hip joint. Clinical Relevance: Stable hip joints at the time of birth provide an explantation for the low incidence of congenital dislocation of the hip joint in Koreans. The spherical femoral head and acetabulum (congruous hip joint) seem to be a contributing factor to the low incidence of primary osteoarthritis of the hip in Koreans.
Acetabulum/*anatomy and histology/embryology ; Adult ; Female ; Femur Head/*anatomy and histology/embryology ; Fetus/anatomy and histology ; *Hip Joint/pathology ; Human ; Incidence ; Korea/epidemiology ; Male ; Osteoarthritis, Hip/epidemiology/*etiology/pathology