1.Selectivity Index of Proteinuria in Childhood Minimal Change Nephrotic Syndrome.
Cheol Ho LEE ; Young Seo PARK ; Kwang Wook KO
Journal of the Korean Pediatric Society 1989;32(10):1384-1390
No abstract available.
Nephrosis, Lipoid*
;
Proteinuria*
2.Afferent loop syndrome: role of sonography and CT.
Dong Ho LEE ; Jae Hoon LIM ; Young Tae KO
Journal of the Korean Radiological Society 1992;28(2):215-221
Afferent loop syndrome(ALS) is caused by obstruction of the afferent loop after subtotal gastrectomy with Billroth II gastrojejunostomy. Prompt diagnosis of ALS is important as perforation of the loop occurs. The aim of this study is to ascertain the value of sonography and CT to diagnose ALS. We describe the radiologic findings in ten patients with ALS. The causes of ALS, established at surgery, included cancer recurrence (n=4), internal hernia(n=4), marginal ulcer (n=1), and development of cancer at the anastomosis site(n=1). Abdominal X-ray and sonography were performed in all cases, upper GI series in five cases and computed tomography in two cases. The dilated afferent loop was detected in only two cases out of ten patients in retrospective review of abdominal X-ray. ALS with recurrence of cancer was diagnosed in three cases by upper GI series. Of the cases that had sonography, the afferent loop was seen in the upper abdomen crossing transversely over the midline in all ten patients. The causes of ALS were predicted on the basis of the sonograms in three of the five cancer patients. In two cases of computed tomography, the dilated afferent loop and recurrent cancer at the remnant stomach were seen. Our experience suggests that the diagnosis of afferent loop syndrome can be made on the basis of the typical anatomic location and shape of the dilated bowel loop in both sonography and computed tomography.
Abdomen
;
Afferent Loop Syndrome*
;
Diagnosis
;
Gastrectomy
;
Gastric Bypass
;
Gastric Stump
;
Gastroenterostomy
;
Humans
;
Peptic Ulcer
;
Recurrence
;
Retrospective Studies
3.Biliary tract obstruction due to tuberculous lymphadenopathy.
ho Sool JEONG ; Young Gwan KO ; Sung Wha HONG
Journal of the Korean Surgical Society 1993;44(5):772-776
No abstract available.
Biliary Tract*
;
Lymphatic Diseases*
5.A Case of Infantile Polycystic Kidney.
Il Young KO ; Chang Ho JUNG ; Jin Berm SONG ; Kyung Young SEO ; Jae Sik SHIM
Korean Journal of Obstetrics and Gynecology 1999;42(9):2115-2117
The infantile polycystic kidney disease is rare fetal urinary tract anomaly. It is inherited with an autosomal recessive pattern and recurrence rate is 25%. The gene locus is on chromosome 6p. The pathogenesis of infantile polycystic kidney is the primary defect of the collecting ducts. The ultrasonographic finding of infantile polycystic kidney is oligohydramnios, bilaterally symmetrical enlarged kidneys with maintenance of their reinform shape. The differential diagnosis with adult polycystic kidney disease is important. The massive enlargement of the kidneys is rarely seen in adult polycystic kidney disease and the examination of the parents and other members of the family is helpful to confirm the adult polycystic kidney disease. If there is severe renal involvements, stillbirth or neonatal death secondary to pulmonary hypoplasia would be developed. If it were diagnosed before viability, termination of pregnancy is recommended. In a fetus at risk, diagnosed after viability, pregnancy termination is also recommended since this condition is uniformly fatal. We present a case of infantile polycystic kidney.
Diagnosis, Differential
;
Female
;
Fetus
;
Humans
;
Kidney
;
Oligohydramnios
;
Parents
;
Polycystic Kidney Diseases*
;
Polycystic Kidney, Autosomal Dominant
;
Pregnancy
;
Recurrence
;
Stillbirth
;
Urinary Tract
6.Correlation between p53 Immunohistochemical Expression, DNA Ploidy and Ki-67 Expression in Gastric Carcinoma.
Young Lyun OH ; Joung Ho HAN ; Young Hyeh KO ; Cheol Keun PARK ; Hwoe J REE
Korean Journal of Pathology 1997;31(12):1264-1271
We examined the p53 protein overexpression and evaluated its correlation with pathobiological variables, including: (1) patient age, sex, tumor size, histological type and grade, invasion depth, vascular invasion, perineural invasion and lymph node status; (2) the Ki-67 labeling index in 100 gastric carcinomas; and (3) the DNA ploidy pattern, S phase fraction (SPF), and the proliferation index (PI) in 84 cases using flow cytometry. The positive rate of p53 staining was 48% and the p53 immunoreactivity was independent of variable clinicopathologic factors. No correlation was made between the Ki-67 labeling index with p53 immunostaining and DNA ploidy parameters. Aneuploidy rate was slightly higher in the p53 positive group (55.6%) than the p53 negative group (44.4%)(p=0.097). The mean values of SPF and PI were significantly higher in the p53 protein positive group. Aneuploidy was more often observed in the intestinal type (p=0.038), advanced gastric carcinoma (p=0.015) and lymph node positive group(p=0.039). The above results suggest that although the p53 protein overexpression has no significant correlation with pathological factors and the Ki-67 labeling index, it may play an important role in tumor cell proliferation. Since p53 protein overexpression was slightly higher in the aneuploidy group showing significant correlation with poor prognostic parameters, it is thought that re-evaluation of the p53 mutation by molecular biological study is needed.
Aneuploidy
;
Cell Proliferation
;
DNA*
;
Flow Cytometry
;
Humans
;
Lymph Nodes
;
Ploidies*
;
S Phase
7.Spiral CT of Hepatic Masses: Usefulness of Additional Findings Except Enhancement Patterns.
Keun Young KONG ; Dong Ho LEE ; Young Tae KO ; Ju Won LIM ; Joung Il LEE ; Byung Ho KIM
The Korean Journal of Hepatology 1998;4(1):23-32
BACKGROUND/AIMS: We compared the accuracy in the diagnosis of hepatic masses such as hepatocellular carcinoma (HCC), metastasis and hemangioma using enhancing pattern alone with using additional findings, and determined whether the additional findings could improve the diagnostic accuracy. METHODS/MATERIALS: Triphasic spiral CT images were retrospectively analyzed in 83 cases of hepatic lesions,' 40 HCC, 21 metastases, and 22 hemangiomas. Three observers made the diagnosis first by the enhancement pattern of the mass alone, and then, by the whole information. The diagnosis of a lesion was considered correct if the lesion was correctly categorized by at least two observers. Diagnostic accuracies of two sessions were compared with McNemar test. RESULTS: Using enhancing patterns alone, 31/40 HCC (78%), 8/21 metastases (38%), 21/22 hemangiomas (95%) were correctly diagnosed. The frequency of correct diagnosis was significantly improved when all images with additional findings were used: 36/40 (90%) HCC, 20/21 (95%) metastases, 22/22 (100%) hemangiomas (P=0.00006). Metastasis showed most prominent and statistically significant improvement in the diagnostic accuracy (P=0.0004). The number of correct diagnoses for HCC increased without statistical significance (P=0.17). However, the images with additional findings did not significantly contribute to the diagnosis of hemangiomas. The additional finidngs those led to correct diagnosis of metastases were multiple mass (7 cases), coexistence of primary malignancy (6 cases), and metastasis to other organ (1 case). The findings of liver cirrhosis were helpful to diagnose HCC correctly in 5 cases. CONCLUSION: The enhancing pattems of tumors were important in the diagnosis of hepatic masses in spiral CT. However, the additional finidngs were also helpful for the diagnosis of hepatic masses especially for the masses with atypical enhancement pattern. In metastases, the additional findings such as multiple masses or detection of primary malignant focus were useful to diagnose correctly.
Carcinoma, Hepatocellular
;
Diagnosis
;
Hemangioma
;
Liver Cirrhosis
;
Liver Neoplasms
;
Neoplasm Metastasis
;
Retrospective Studies
;
Tomography, Spiral Computed*
8.Comparative evaluation of excretory urogram and sonogram in renal tuberculosis.
Ju In HAN ; Dong Ho LEE ; Dal Mo YANG ; Young Tae KO ; Jae Hoon LIM
Journal of the Korean Radiological Society 1991;27(6):856-860
No abstract available.
Tuberculosis, Renal*
9.CT findings in recurrent pyogenic cholangitis.
Seung Hye JUNG ; Jae Hoon LIM ; Young Tae KO ; Dong Ho LEE
Journal of the Korean Radiological Society 1991;27(4):555-558
No abstract available.
Cholangitis*
10.Effect of Human Seminal Plasma on Cytokine Prodection and Induction of Active Systemic Anaphylaxis in Mice.
Tai You HA ; Jae Seung PARK ; Yoo Seung KO ; Yong Ho LEE ; Young Kyung PARK
Korean Journal of Immunology 1999;21(3):209-219
Human seminal plasrna (HSP) is mixture of secretion derived from various glands associated with male reproductive tract which comprises approximately 80-90% of the volume of normal ejaculate. The present study was undertaken in an effort to explore the effect of HSP pretreatment on the production of IL-1B, TNF-a and IL-12, in mice, and to investigate if HSP may cause to induce active systemic anaphylaxis (ASA) in mice. In addition, effects of HSP pretreatment on contact hypersensitivity to trinitrochlorobenzene (TNCB), antibody response to polyvinylpyrroridone (PVP), a thymus-independent antigen and on ASA induced by egg albumin (OVA) were also studied in this study. For the experiments of contact hypersensitivity, antibody response and cytokine production, mice were pretreated i.p. daily with 0.3ml of HSP or sterile saline alone (control) for 3 consecutive days before antigen sensitization or lipopolysaccharide injection for the cytokine induction. For the experiments of OVA- induced anaphylaxis, mice were pretreated by a single s.c. injection of HSP 0.3ml per mouse before sensitization. For induction of ASA in mice by HSP, a group of mice were sensitized i.p. 2 consecutive days with 0.3ml of HSP and one day with 0.3 ml of HSP plus 2x10(9) B. pertussis and 1.0 mg of alum (schedule A) or another group of mice were sensitized i.p. with a single i.p. injection of 0.3 ml of HSP with 2x10' B. pertussis and 1.0 mg of alum (schedule B). All sensitized and unsensitized control mice were challenged i.v. with 0.2ml of HSP 14 days after HSP sensitization, and mortality were observed. It was found that HSP pretreatment inhibited the production of IL-lB, TNF-a and IL-12, and also inhibited OVA-induced ASA, contact hypersensitivity to TNCB and anti-PVP antibody production. Interestingly, ASA was induced by HSP irrespective of the applied sensitization schedule. Taken together, this study may provide the direct evidences that HSP may inhibit the production of IL-1B, TNF-a and IL-12 and this may be the first to show the induction of ASA by HSP in mice.
Anaphylaxis*
;
Animals
;
Antibody Formation
;
Appointments and Schedules
;
Dermatitis, Contact
;
Humans*
;
Interleukin-12
;
Male
;
Mice*
;
Mortality
;
Ovum
;
Picryl Chloride
;
Semen*
;
Whooping Cough