A 45-year-old woman presented with a generalized fixed drug eruption due to mefenamic acid, characterized by recurring erythematous patches with central bullae on the same sites of the whole body and leaving hyperpigmentation after each attack. Patch testing of a quiescent lesion with 50% mefenamic acid in vaselin revealed an eczematous reaction after 48 hours. The disease course was mild compared to the severe clinical manifestation. We here-in report a case of generalized fixed drug eruption due to mefenamic acid which is considered a rare occurrence.
Drug Eruptions* ; Female ; Humans ; Hyperpigmentation ; Mefenamic Acid* ; Middle Aged ; Patch Tests

No abstract available.
Humans ; Infant, Newborn* ; Respiration, Artificial*

BACKGROUND: Herpes zoster with generalized varicelliform eruptions occurs in 2 to 10% of patients with herpes zoster. It occurs mainly in old or debilitated persons especially those who have immunologic defects such as lymphoproliferative diseases, AIDS, or recipients of immunosuppressive therapy. The reported incidence of herpes zoster with generalized varicelliform eruptions is variable. OBJECTIVE: The purpose of this study was to elucidate the incidence and clinical features of herpes zoster with generalized varicelliform eruptions. METHODS: We reviewed the clinical data of 962 patients with herpes zoster by retrospective methods. The annual incidence, age, sex, seasonal variation, predilection sites, and associated conditions of herpes zoster with generalized varicelliform eruptions were analyzed from January 1990 to December 1996 (7 years). RESULTS: 1. Among 962 patients, 8 patients with herpes zoster revealed generalixed varicelliform eruptions (0.83%). 2. The age ranged from 20 to 85 and the majority of cases occurred in the 6th decade. There were 4 females and 4 males. 3. Past histories of malignancy were observed in 2 patients. However, there were no signs of malignancy at the time of diagnosis of herpes zoster with generalized varicelliform eruptions. 4. The most common site of initial lesion was the thoracic dermatome,followed by the lumbar and the cervical ones. CONCLUSION: From our observation, it is suggested that herpes zoster with generalized varicelliform eruptions may occur in patients without underlying malignancy or immunosuppressive disorders. Sudden incidental uprising of herpes zoster with generalized varicelliform eruptions was observed in 1996.
Clinical Study* ; Diagnosis ; Female ; Herpes Zoster* ; Humans ; Incidence ; Male ; Retrospective Studies ; Seasons

No abstract available.
Blood Platelets* ; Leukocytes* ; Plateletpheresis*

No abstract available.
Lymphadenitis*

OBJECTIVES: The prevalence of psychiatric disorders in homeless people is higher than the prevalence in a general population. With the increasing interests in homeless people after the economic crisis in Korea, psychiatrists started to investigate the prevalence of psychiatric disorders in homeless people. This study is to assess the prevalence of psychiatric disorders in homeless men living in a city shelter in Seoul and to compare these results with those of previous epiaemiological studies in Korea of homeless people and abroad. METHODS: Among 960 homeless men living in a city shelter in Seoul, 420 men were selected randomly from December 14 to December 29, 1999. Eight trained interviewer administered the Korean version of Composite International Diagnostic Interview (K-CIDI) to the subjects. The lifetime, one-year, and one-month prevalence of the psychiatric disorders in this study were compared to those of the previous studies of Korean general population and of homeless people abroad. RESULTS: The lifetime, one-year, and one-month prevalence of total psychiatric disorders were 71.7%, 49.8% and 45.0% respectively. The lifetime prevalence of nicotine dependence/withdrawal, alcohol use disorders (abuse/dependence), substance use disorders, major depressive disorder, psychotic disorders, and anxiety disorders were 31.0%, 58.6% (39.3%/19.3%), 3.1%, 11.7%, 2.4%, and 16.9% respectively. CONCLUSION: This study suggested that the prevalence of psychiatric disorders in homeless men is higher than the prevalence in general population, as the previous studies in Korea. The prevalence of alcohol use disorder was highest. The prevalence of non-alcohol substance use disorder and psychotic disorder were lower than the prevalence of these disorders in homeless people of other countries. These results suggest that there is a need to treat the psychiatric disorders, especially alcohol use disorder which is the major psychiatric problem in homeless men.
Anxiety Disorders ; Depressive Disorder, Major ; Epidemiology ; Humans ; Korea ; Male* ; Multiple Endocrine Neoplasia Type 1 ; Nicotine ; Prevalence* ; Psychiatry ; Psychotic Disorders ; Seoul ; Substance-Related Disorders

PURPOSE: Kimura's disease is an uncommon, chronic inflammatory disorder of unknown etiology which occurs predominantly in Orientals and presents with tumor-like swellings mainly in the head and neck region. Orbital and ocular adnexal cases are rare. We report a case of Kimura's disease of the eyelid. METHODS: A 52-year-old male presented with a 10-year history of intermittently recurrent swelling and a painless mass of the left upper eyelid. The mass was resected and biopsied for histological examination. RESULTS: The case was diagnosed with Kimura's disease by the clinical and histopathologic findings.
Eyelids* ; Head ; Humans ; Male ; Middle Aged ; Neck ; Orbit

Mucinous ductal ectasia(MDE) is a newly described entity of mucinous neoplasm of pancreas with characteristic endoscopic and pancreatographic findings. It is charaeterized by a patulous duodenal papilla extruding mucus and a pancreatogram showing dilatation with amorphous filling defects, communication of the mass with the pancreatic duct. MDE is intraductal lesion consisting of dilated "cystified" ducts lined by mucin-producing columnar cells. The lesion is usually located in the head or uncinate process. When the radiographic appearance of the ERCP cannot provide sufficient information for definite diagnosis, additional endoscopic visualization is desirable. With the advent of pancreatoscopy, an endoscopic procedure is now available that has proven to enhance diagnostic accuracy. The 0.8-mm ultrathin pancreatoscope allows macroscopic diagnosis under direct vision. Endoscopic sphincterotomy is not required, and insertion into the pancreatic duct is feasible in most cases with the aid of guidewires. Major indications are unclear filling defects on ERCP, strictures of uncertain origin, and duct cut-offs. A limitation of this procedure are the lack of angulation, insufficient illumination, fragility of endoscopic equipment, and nonspecific findings. In addition, biopsy while directly viewing the lesion is impossible at present. We experienced one case of MDE who presented with the symptom of weight loss. Ultrathin pancreatoscopy was useful for the direct visualization af pancreatic duct in the differential diagnosis of filling defects of main pancreatic duct.
Biopsy ; Cholangiopancreatography, Endoscopic Retrograde ; Constriction, Pathologic ; Diagnosis ; Diagnosis, Differential ; Dilatation ; Dilatation, Pathologic* ; Head ; Lighting ; Mucins* ; Mucus ; Pancreas ; Pancreatic Ducts ; Sphincterotomy, Endoscopic ; Weight Loss

OBJECTIVES: The purpose of this study was to examine whether Symptom Management Module-Korean Brief Version(SMM-B) is effective as a psychosocial treatment of the inpatients with chronic schizophrenia. We also questioned which of demographic and clinical characteristics could be predictors of differential treatment response. METHODS: The subjects were composed of 30 inpatients with chronic schizophrenia, who were trained with weekly session of SMM-B for 5 weeks. Before and after the training, the level of psychopathology, knowledge about schizophrenia were assessed as dependent variables by using Clinical Global Impression(CGI) and Scale to Assess Unawareness of Mental Disorder(SUMD). RESULTS: Overall, patients showed improvement over the treatment period on psychopathology as well as knowledge about psychosis. Total scores of SUMD were changed from 16.9+/-4.0 before training to 12.9+/-4.2 after training(p<0.01) and scores of CGI were improved from 3.7+/-0.9 to 2.8+/-0.8 (p<0.01). However age, gender, years of education, age of onset, duration of illness, duration of admission, numbers of psychiatric admission, and clinical status evaluated by CGI were not correlated with un-awareness of psychosis. CONCLUSION: These results suggest that SMM-B could be a reliable method to improve self-awareness of psychosis in patients with chronic schizophrenia and one of important elements in rehabilitation.
Age of Onset ; Education ; Humans ; Inpatients* ; Psychopathology ; Psychotic Disorders ; Rehabilitation ; Schizophrenia*

BACKGROUND: Though infections of Helicobacter pylori (H. pylori) are closely associated with activation of host angiogenesis, the underlying mechanisms, as well as the strategy for its prevention, have not been identified. Here, we investigated a causal role of H. pylori infection in angiogenesis of gastric mucosa and a potent inhibitory effect of a gastric proton pump inhibitor (PPI) on the gastropathy. MATERIALS AND METHODS: A comparative analysis of CD 34 expression in tissues obtained from 20 H. pylori-associated gastritis and 18 H. pylori-negative gastritis patients was performed. Expression of HIF-1alpha and VEGF were tested by using RT-PCR. To evaluate the direct effect of H. pylori infection on differentiation of endothelial HUVEC cells, we carried out an in vitro angiogenesis assay. RESULTS: H. pylori-associated gastritis tissues showed significantly higher density of CD34+ blood vessels than did H. pylori-negative gastritis tissues, and the levels were well correlated with expressions of HIF-1alpha. Conditioned media from H. pylori-infected gastric mucosal cells stimulated a tubular formation of HUVEC cells. We also found a significant inhibitory effect of PPI, an agent frequently used for H. pylori eradication, on H. pylori-induced angiogenesis. This drug effectively inhibited the phosphorylation of MAP kinase ERK1/2, which is a principal signal for H. pylori-induced angiogenesis. CONCLUSION: The fact that PPIs can down-regulate H. pylori-induced angiogenesis suggest that anti-angiogenic treatment using PPI may be a preventive approach for H. pylori-associated carcinogenesis.
Blood Vessels ; Carcinogenesis ; Culture Media, Conditioned ; Gastric Mucosa ; Gastritis ; Helicobacter pylori ; Helicobacter* ; Human Umbilical Vein Endothelial Cells ; Humans ; Phosphorylation ; Phosphotransferases ; Proton Pumps* ; Protons* ; Stomach Neoplasms ; Vascular Endothelial Growth Factor A