BACKGROUND: There were several studies for the incidence of gastroesophageal reflux associated with the laryngeal mask airway(LMA), but the results of those studies were much different from one another. The authors of this study measured the intraesophageal pH at 5cm above lower esophageal sphincter(LES) to compare the incidence of gastroesophageal reflux associated with the LMA and the endotracheal tube(ETT) in positive pressure ventilated patients during long surgical procedures. METHOD: Ninety patients scheduled for elective orthopedic surgery with a standardized general anesthetic technique were randomly allocated to receive either a LMA(n=49) or a ETT(n=41) for airway management. The esophageal manometry was carried out for the exclusion of esophageal motility disorders and a probe with a pH electrode was passed nasally into the esophagus and positioned at 5 cm above LES one day before the operation. After that, recordings of pH for the diagnosis of gastroesophageal reflux disorder and for the detection of reflux episodes during and immediate after anesthesia were performed. RESULTS: There was no significant difference in the incidence of reflux(pH< or =4) between groups; only two patients in LMA and three patients in ETT had reflux episodes in the removal or arousal phase. All of them had experiences such as a coughing or straining during those phases. There was no clinical evidence of aspiration of gastric contents in either group. CONCLUSION: In comparison with ETT, use of LMA does not appear to result in increased incidence of reflux in positive pressure ventilated patients during long surgical procedures.
Airway Management ; Anesthesia ; Arousal ; Cough ; Diagnosis ; Electrodes ; Esophageal Motility Disorders ; Esophagus ; Gastroesophageal Reflux* ; Humans ; Hydrogen-Ion Concentration ; Incidence* ; Laryngeal Masks* ; Manometry ; Orthopedics

Hydatid disease is a parasitic infestation caused by the larval form of the cestode worms Echinococcus. In humans, the most commonly affected organs are liver and lung. Most cysts remain clinically silent and are diagnosed incidentally or when complications occur. The incidence of hydatid disease is high in the Middle East, Australia, East and South Africa and Central Europe. In Korea, hydatid disease is rare and has been reported in a few cases. We experienced a case of multiple intraperitoneal cysts from ruptured hepatic hydatid cysts in a 35-year old man. His complaint was palpable abdominal mass and discomfort. Abdominal ultrasound and CT scan revealed multiple hepatic and intraperitoneal cysts. The surgical findings showed multiple cysts and daughter cysts. The pathologic finding of resected cyst was the characteristic pattern of outer thick laminated membrane and inner thin germinal layer. Albendazole was administrated for prophylatic purpose.
Adult ; Animals ; Cysts/parasitology/surgery ; Echinococcosis, Hepatic/*diagnosis/parasitology ; Echinococcus/isolation & purification ; Humans ; Liver/injuries/parasitology ; Male ; Peritoneal Cavity ; Rupture/diagnosis/surgery ; Tomography, X-Ray Computed

BACKGROUND: Exercise has almost always been intuitively considered beneficial, but although rewards greatly outweigh risks, exercise occasionally produces bad or even fatal outcomes such as acute renal failure or sudden death. Exertional rhabdomyolysis has been occasionally reported in adult patients following such strenuous activities as military basic training, weight lifting, and marathon running. The purpose of the present study was to investigate whether exertional rhabdomyolysis developed, and how exercise could influence biochemical markers of rhabdomyolysis during resting, exercise, and recovery period in long-distance runners. METHODS: Twenty-four young long-distance runners who volunteered to participate in the study, trained with running over 200km every week for 2 to 3 years were studied. Levels of serum creatine kinase(CK), lactate dehydrogenase(LDH), asparatate amino-transferase (AST), and myoglobin, and urine myoglobin were measured at 24hr(pre-exercise period) before, immediately (post-exercise period), and at 24hr(recovery period) after 10km running. Ten long-distance runners who were randomly selected at 24hr after 10km running, including one complaining of calf pain, and age-matched nine young control students were subjected to bone scan with technetiun-99m methylene diphosphonate(99mTc-MDP) RESULTS: Serum CK activities in pre-exercise period were higher than that of the upper normal range. Serum CK and LDH activities were significantly increased in post-exercise period compared with pre-exercise period(p<0.05), were not decreased to the level of post- exercise in recovery period. The level of serum myoglobin was increased and decreased significantly,(p<0.05, p<0.01, respectively) and urine myoglobin and serum AST activities were remained within nomal range in each period. The mean uptake count of 99mTc-MDP in both lower extremities of runners was significantly greater than that of the control group(p<0.001), and had good correlation with the serum CK activities of post-exercise, and recovery period(r=0.87 p<0.001, r=0.8 p<0.01, respectively). CONCLUSION: This study suggests that rhabdomyolysis in the well trained long-distance runners may be developed in low grade, but ongoing injuries during each running. For the diagnosis of rhabdomyolysis in the well trained long-distance runners, serum CK levels are thought to be the most useful marker, and the cut- off value of serum CK levels should be lowered less than usual five times of normal value. A quantitative measurements of 99mTc-MDP uptake with serum CK levels can be more helpful in making the diagnosis of rhabdomyolysis in the well trained long-distance runners.
Acute Kidney Injury ; Adult ; Biomarkers* ; Creatine ; Creatine Kinase ; Death, Sudden ; Diagnosis ; Fatal Outcome ; Humans ; L-Lactate Dehydrogenase ; Lactic Acid ; Lower Extremity ; Military Personnel ; Myoglobin ; Reference Values ; Reward ; Rhabdomyolysis* ; Running ; Technetium Tc 99m Medronate ; Weight Lifting

OBJECTIVES: This study aimed to investigate the psychosocial characteristics of functional gastrointestinal disorder (FGID) in patients with psychiatric disorders. METHODS: This study was conducted with 144 outpatients visiting the psychiatric clinic at a university hospital. FGIDs were screened according to the Rome III questionnaire-Korean version. Demographic factors were investigated, and psychosocial factors were evaluated using the Hospital Anxiety Depression Scale, Patient Health Questionnaire-15, Childhood Trauma Questionnaire-Korean, and State-Trait Anger Expression Inventory. Chi-squared test and student's t-test were used as statistical analysis methods. RESULTS: There were differences in education level between two groups divided according to FGID status (χ²=10.139, p=0.017). Comparing the psychiatric disorder by FGID group, irritable bowel syndrome (IBS) group showed significant differences (χ²=11.408, p=0.022). According to FGID status, IBS group showed significant differences for anxiety (t=−3.106, p=0.002), depressive symptom (t=−2.105, p=0.037), somatic symptom (t=−3.565, p < 0.001), trait anger (t=−3.683, p < 0.001), anger-in (t=−2.463, p=0.015), and anger-out (t=− 2.355, p=0.020). Functional dyspepsia group showed significant differences for anxiety (t=−4.893, p < 0.001), depressive symptom (t=−3.459, p < 0.001), somatic symptom (t=−7.906, p < 0.001), trait-anger (t=−4.148, p < 0.001), state-anger (t=−2.181, p=0.031), anger-in (t=−2.684, p=0.008), and anger-out (t=−3.005, p=0.003). Nonerosive reflux disease group showed significant differences for anxiety (t=−4.286, p < 0.001), depressive symptom (t=−3.402, p < 0.001), somatic symptom (t=−7.162, p < 0.001), trait anger (t=−2.994, p=0.003), state anger (t=−2.259, p=0.025), anger-in (t=−2.772, p=0.006), and anger-out (t=−2.958, p=0.004). CONCLUSIONS: Patients with psychiatric disorders had a high prevalence of FGID, and various psychosocial factors contributed to such differences. Therefore, the psychiatric approach can offer better understandings and treatments to patients with FGID.
Anger ; Anxiety ; Demography ; Depression ; Dyspepsia ; Education ; Gastrointestinal Diseases ; Humans ; Irritable Bowel Syndrome ; Outpatients ; Prevalence ; Psychology

BACKGROUND/AIMS: Lymphoid follicular proctitis (LFP) is an uncommon inflammatory condition confined to the rectum. Patients with LFP constitute a special group with clinical, endoscopic, and histological features unrelated to other types of inflammatory bowel diseases, and have been reported to be refractory to local steroid and/or oral sulfasalazine therapy. The aim of this study was to clarify whether mesalazine suppositories have a therapeutic effect in LFP. METHODS: The histologic slides of 8 cases indexed in our pathology files as "lymphoid follicular proctitis of the rectal mucosa" from January 2001 to November 2003 were reviewed retrospectively. RESULTS: The most common symptom in the patients with LFP was rectal bleeding. The endoscopic mucosal changes were discontinuous, sparing whole circumferential involvement, and were strictly confined to the rectum. Average period of medication was 12 months. All the symptomatic patients with LFP responded to mesalazine suppository therapy. In addition, these patients did not progress to other disease including ulcerative proctitis or lymphoma. CONCLUSIONS: Mesalazine suppository treatment is a useful therapeutic option for symptomatic patients with LFP.
Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage ; Female ; Humans ; Male ; Mesalamine/*administration & dosage ; Middle Aged ; Proctitis/*drug therapy/pathology ; Rectum/pathology ; Suppositories

BACKGROUND/AIMS: Lymphoid follicular proctitis (LFP) is an uncommon inflammatory condition confined to the rectum. Patients with LFP constitute a special group with clinical, endoscopic, and histological features unrelated to other types of inflammatory bowel diseases, and have been reported to be refractory to local steroid and/or oral sulfasalazine therapy. The aim of this study was to clarify whether mesalazine suppositories have a therapeutic effect in LFP. METHODS: The histologic slides of 8 cases indexed in our pathology files as "lymphoid follicular proctitis of the rectal mucosa" from January 2001 to November 2003 were reviewed retrospectively. RESULTS: The most common symptom in the patients with LFP was rectal bleeding. The endoscopic mucosal changes were discontinuous, sparing whole circumferential involvement, and were strictly confined to the rectum. Average period of medication was 12 months. All the symptomatic patients with LFP responded to mesalazine suppository therapy. In addition, these patients did not progress to other disease including ulcerative proctitis or lymphoma. CONCLUSIONS: Mesalazine suppository treatment is a useful therapeutic option for symptomatic patients with LFP.
Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage ; Female ; Humans ; Male ; Mesalamine/*administration & dosage ; Middle Aged ; Proctitis/*drug therapy/pathology ; Rectum/pathology ; Suppositories

BACKGROUND/AIMS: The aim of this study was to assess the diagnostic use of endoscopic ultrasonograpy (EUS) in detecting the cause of common bile duct (CBD) dilatation in patients in whom abdominal ultrasonography or abdominal CT scan could not identify the cause of dilatation. METHODS: Thirty-seven patients (23 men, 14 women, mean age 62.2 years) with uncertain causes of CBD dilatation on abdominal sonogram and CT scan between October 1999 and November 2003 were enrolled. All patients were evaluated by EUS and endoscopic retrograde cholangiopancreatography (ERCP). Final diagnosis were determined by ERCP, surgical exploration and clinical follow-up. RESULTS: The following diagnosis were made by EUS: choledocholithiasis in 11 patients, CBD dilatation only in 12, benign stricture of distal CBD in 8, periampullary tumor in 6. The definitive diagnosis of choledocholithiasis (n=11), benign stricture of distal CBD (n=10), ampullary tumor (n= 5) were determined by ERCP with or without sphincterotomy and surgical exploration. EUS provided the accurate explanation for CBD dilatation in 32 of the 37 patients (86%). CONCLUSIONS: When the diagnosis of biliary obstruction remains obscure on abdominal sonography or CT scan, EUS may be useful.
Cholangiopancreatography, Endoscopic Retrograde ; Choledocholithiasis ; Common Bile Duct* ; Constriction, Pathologic ; Diagnosis ; Dilatation* ; Endosonography* ; Female ; Follow-Up Studies ; Humans ; Male ; Tomography, X-Ray Computed ; Ultrasonography

In addition to inhibiting cyclooxygenase and prostaglandin, nonsteroidal anti-inflammatory drugs (NSAIDs) may cause gastroduodenal injuries due to reactive oxygen species produced by recruited inflammatory cells. DA-9601 is a novel antioxidant with anti-inflammatory and cyto-protective effects. This study was conducted to compare the efficacy and safety of DA-9601 with misoprostol for preventing NSAID-associated gastroduodenal injury. In this randomized, double-blind, multicenter, noninferiority trial we compared the extents of protection of gastric and duodenal mucosae by endoscopy after 4 weeks of treatment with DA-9601 60 mg or misoprostol 200 microg three times daily, in subjects with normal baseline endoscopic findings who received an NSAID twice daily for 4 weeks. A total of 266 subjects were randomized to treatment. At week 4, the gastric protection rates with DA-9601 and misoprostol were 85.1% and 95.2%, respectively; the difference between the groups was -10.1% (var = 0.001), which was shown to indicate noninferiority of DA-9601 compared to misoprostol. Adverse events were lower in the DA-9601 group, 56.4% (95% CI, 48.0%-64.8%) than in the misoprostol group, 69.2% (95% CI, 61.3%-77.0%) (P = 0.031). DA-9601 is not inferior to misoprostol for preventing NSAID-associated gastroduodenal injury, and superior to it with respect to treatment-related side effects.
Adolescent ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/*adverse effects ; Double-Blind Method ; Duodenal Ulcer/chemically induced/*prevention & control ; Endoscopy, Gastrointestinal ; Female ; Gastric Mucosa/drug effects ; Humans ; Male ; Middle Aged ; Misoprostol/*adverse effects ; Plant Extracts/*adverse effects ; Stomach Ulcer/chemically induced/*prevention & control

Although skin metastasis from a malignant tumor of an internal organ usually occurs at an advanced disease stage, there has been no prior report of a cutaneous acral metastasis from ampullary carcinoma to date. We report a 71-year old male patient with cutaneous metastasis from an ampullary adenocarcinoma. The patient had a history of pylorus preserving pancreaticoduodenectomy for carcinoma of the ampulla of Vater two years prior to presentation. Physical examination revealed ill-defined, painful and hard erythematous nodules at the left thumb and distal phalanx of the right middle finger. The computed tomography scan showed low density masses in the retroperitoneum; the histological examination of a nodule from the right middle finger showed a metastatic adenocarcinoma. This case illustrates that cutaneous metastasis from ampullary carcinoma has a poor prognosis.
Skin Neoplasms/*secondary ; Prognosis ; Male ; Humans ; Fatal Outcome ; Common Bile Duct Neoplasms/*pathology ; Ampulla of Vater/*pathology ; Aged ; Adenocarcinoma/*pathology

Aerophagia is a disorder caused by abnormal accumulation of air in the gastrointestinal tract as a result of repetitive and frequent inflow of air through the mouth. For the diagnosis of this condition, it is difficult to objectively measure the air swallowing. However, multichannel intraluminal impedance monitoring facilitates the differential diagnosis between normal air swallowing and pathologic aerophagia, and can aid in the determination of the frequency and amount of air swallowed. In this report, in addition to a literature review, we describe a case of 36-year-old man with abdominal distension who was diagnosed with aerophagia using esophageal impedance monitoring and was treated with clonazepam.
Adult ; Aerophagy/*diagnosis/diagnostic imaging/drug therapy ; Anticonvulsants/therapeutic use ; Clonazepam/therapeutic use ; Diagnosis, Differential ; Electric Impedance ; Humans ; Male ; Mental Disorders/complications ; Tomography, X-Ray Computed