No abstract available.
Antibodies* ; Arthritis, Rheumatoid* ; Diagnosis ; Prognosis

No abstract available.
Atrophy* ; Brain*

PURPOSE: Both headache and obesity are prevalent and chronic conditions among children. A well-known pathophysiology of migraine is that calcitonin gene-related peptide (CGRP) is an important postsynaptic mediator of trigemino-vascular inflammation. Plasma CGRP levels have been shown to increase in obese individuals during the headache phase of migraines. The purpose of this study was to assess the relationship between headache and plasma CGRP levels in obese children. METHODS: We prospectively studied plasma CGRP levels in 33 patients (20 overweight and obese subjects without headache, 13 overweight and obese subjects with headache) who visited Chosun University Hospital from March 2009 to September 2009. Blood samples were collected from cubital veins and plasma levels of CGRP were measured by radioimmunoassay. RESULTS: The mean age was 12.3+/-2.3 (range 6-15 years) and mean CGRP level was 19.1+/-2.5 pg/ml in the overweight and obese with headache group and 17.4+/-5.1 pg/mL in the overweight and obese without headache group. In the group CGRP levels lower than 19 pg/mL, mean headache frequency per month, mean severity, and mean disability were 17.0+/-18.4, 4.0+/-2.8 and 2.0+/-0.0, respectively. In the group with CGRP levels of 19 or greater pg/ml, levels were 11.0+/-9.8, 5.6+/-1.0, and 23.1+/-8.2, respectively. CONCLUSION: The mean CGRP level in overweight and obese children with headache was not significantly higher than in those without headache (P =0.202). Further, there was no significant correlation between CGRP level and frequency, severity of headache, and disability due to headache (P > 0.05). Further studies are needed to access the relationship of CGRP and pediatric headache in obese subjects.
Calcitonin ; Calcitonin Gene-Related Peptide ; Child ; Headache ; Humans ; Inflammation ; Migraine Disorders ; Obesity ; Overweight ; Plasma ; Prospective Studies ; Veins

Takayasu's arteritis is briefly as an inflammatory process of unknown etiology occuring dominantly in young female most commonly involving the great vessels arising from the aortic arch. The disease process results in stenosis and obliteration of involved vessels. Syncope in Takayasu's arteritis is known to result from decreased blood flow to brain because of stenosing blood vessels. We herein describe a case of paroxysmal atrioventricular block in a 40-year old man with Takayasu's arteritis. The patient presented with spontaneous recurrent syncope associated with paroxysmal AV block. Carotid sinus pressure repeatedly induced paroxysmal AV block and syncope. Carotid sinus pressure after pretreatment of atropine failed to induce AV block or syncope. Coronary angiogram was normal. We concluded that syncope in this patients was attributed to carotid hypersensitivity rather than decreased blood flow to the brain due to vessel stenosis.
Adult ; Aorta, Thoracic ; Atrioventricular Block* ; Atropine ; Blood Vessels ; Brain ; Carotid Sinus ; Constriction, Pathologic ; Female ; Humans ; Hypersensitivity ; Syncope ; Takayasu Arteritis*

2 patients of forearm deformities with ulnar defect and radial head dislocation were treated with the Ilizarov apparatus at Chungnam University Hospital. One patient had a severe hypoplastic remnant-like ulnar fragment and a anterolaterally dislocated radial head due to complicated osteomyelitis of ulnar. We applied an Ilizarov apparatus to transport the radial head distally, and fixed to remaining proximal ulnar fragment. The other had a large bony defect at the ulnar shaft and a dislocated radial head due to complicated osteomyelitis of ulna. We performed internal transport of ulna to decreased the ulnar defect and to descend the dislocated radial head. The clinical-radiological features and functional results of those 2 forearm deformities were described with brief review of the articles about the Ilizarov method for correction of forearm defor- mities.
Chungcheongnam-do ; Congenital Abnormalities ; Dislocations ; Forearm ; Head ; Humans ; Ilizarov Technique ; Osteomyelitis ; Ulna

No abstract available.
Pregnancy* ; Uric Acid*

No abstract available.

The purpose of this study was to assess the expression of ICAM-1, VCAM-1 and PECAM-1 in allergic and chemical conjunctivitis. The allergic and chemical conjunctivitis were induced in C57BL/6 mouse by compound 48/80(C48/80) and 2% characterized clinically by blepharospasm 100%, chemosis 80%, injection AgNO3, respectively. The allergic conjunctivitis was characterized clinically by blepharospasm 100%, chemosis 80%, injection, 40%, mucous discharge 20%, but the chemical conjunctivitis by blepharospasm 80%, chemosis 60%, infection 40% and no mucous discharge at 30 minute after topical application. On the endothelial cells, ICAM-1 was expressed from 1 to 48 hours, VCAM-1 from 6 to 72 hours and PECAM-1 from 1 to 72 hours in allergic conjunctivitis. In chemical conjuctivitis, the expression of ICAM-1 was observed from 6 to 72 hours. The expression of VCAM-1 was observed from 24 and 72 hours. The expression of PECAM-1 was demonstrated from 6 to 72 hours. The expression of cell adhesion molecules, particulary VCAM-1 and PECAM-1, was slighter in chemical conjunctivitis compared to allergic conjunctivitis. In conclusion, experimental allergic and chemical conjunctivitis demonstrate that cell adhesion molecules play a role in part in ocular inflammation and that there are differences between the adhesion molecule expression of two types of confunctivitis.
Animals ; Antigens, CD31 ; Blepharospasm ; Cell Adhesion Molecules ; Conjunctivitis* ; Conjunctivitis, Allergic ; Endothelial Cells ; Inflammation ; Intercellular Adhesion Molecule-1 ; Mice ; Vascular Cell Adhesion Molecule-1

This is a report of 2-cases of mandibular prognathism corrected by Intraoral oblique splitting osteotomy of mandibular rami. The Intraoral oblique splitting osteotomy is a modification of sagittal split osteotomy of ramus and it is documented by Yoshida, on 1985. By this method, authors obtained the following results. 1. The patients' esthetic, psychological and functional problems were dissolved by setback of mandibular prognathism. 2. The postoperative infection splitted bone segments fracture, paresthesia of the face and T.M.J. dysfunction were not appeared. 3. Postoperative intermaxillary fixation was maintained for 8 weeks. The patients could open their mouths in normal range after a week of intermaxillary fixation removal. 4. The soft tissue changes of lower lip and chin were about 1:1 to the hard tissue changes. 5. During intermaxillary fixation period and postoperative orthodontic treatment, slight relapse was observed. Now, the patients are under postoperative orthodontic treatment.
Chin ; Humans ; Lip ; Methods ; Mouth ; Osteotomy* ; Paresthesia ; Prognathism* ; Recurrence ; Reference Values

PURPOSE: We investigated the impact of treatment on electroencephalogram (EEG) findings, and determined treatment efficacy according to EEG findings and antiepileptic drugs in children and adolescents with recurrent headaches. METHODS: We retrospectively analyzed the medical records of 131 patients, aged 5–18 years, with recurrent primary headaches and performed EEG study who visited the Chosun University Hospital Department of Pediatrics from January 2014 to December 2016. Headaches were classified according to the International Classification of Headache Disorders-III (ICHD-III, beta version), and EEGs were analyzed for changes after treatment for primary headache. RESULTS: Among 131 patients, we successfully collected completed all the data on 30 patients (18 boys, 12 girls). The frequency of abnormal EEG findings before treatment was not significantly different according to the type of primary headache (P= 0.390). The mean frequency (P=0.001), duration (P=0.002), and intensity of headaches (P < 0.001), and disability due to headache (P=0.003) were significantly decreased after treatment in patients with epileptiform discharges on EEG. The mean frequency and intensity of headaches and disability due to headache (P < 0.005) was also significantly decreased in the patients with both slow and normal EEG findings. The mean frequency (P=0.007), duration (P=0.01), and intensity (P < 0.001) of headaches, and disability due to headache (P=0.002) were significantly decreased after treatment with antiepileptic drugs in patients with epileptiform discharges. CONCLUSION: Abnormal EEG findings were no significant differences in terms of type of primary headaches. Our results suggest that antiepileptic drugs may alleviate headaches in patients with epileptiform discharges on EEG.
Adolescent* ; Anticonvulsants ; Child* ; Classification ; Electroencephalography* ; Headache* ; Hospital Departments ; Humans ; Medical Records ; Pediatrics ; Retrospective Studies ; Treatment Outcome