No abstract available.
Aged* ; Humans ; Hypertension* ; Motor Activity*

No abstract available.
Humans* ; Keratosis, Seborrheic* ; Oligonucleotide Array Sequence Analysis ; Polymerase Chain Reaction

No abstract available.
Cisterna Magna*

No abstract available.
Movement Disorders* ; Prevalence*

BACKGROUND: The activity of drug metabolizing enzymes and the modulation of their expression by inducers in the skin are the key factors for understanding of pharmacological and toxic effects of topically applied drugs. The role of these enzymes is of major importance, as they may contribute to determine the steady-state levels of biologically active substances. 3-Methylcholanthrene and all-trans- retinoic acid have been known to be inducers of the drug metabolizing enzymes. And all-trans- retinoic acid has many biological actions including anti-cancer effects. OBJECTIVE: The purpose of this study was to evaluate the effect of all-trans-retinoic acid on inducing the expression and modulation of genetic polymorphism of drug metabolizing enzymes as well as to estimate the role of all-trans-retinoic acid in carcinogenesis and drug interactions. METHODS: We analyzed the activities of CYP1A1(Cytochrome P450 1Al), NADPH cytochrome P450-reductase, UGT1 and GST after administration of 3-methylcholanthrene and all-trans-retinoic acid to the Sprague-Dawley male rats. We observed the inducible gene expression of CYP1A1, UGT1, GSTJt by RT-PCR and the genetic polymorphism of CYP1A1, UGT1, GSTK by PCR. RESULTS: 1. The expression of CYP1A1, NADPH cytochrome P450-reductase, UGT1 and GST was induced by 3-methylcholanthrene and all-trans-retinoic acid. That of NADPH cytochrome P450-reductase and UGT1 is pronouncedly enhanced by all-trans- retinoic acid. 2. The effects of 3-methylcholanthrene and all-trans-retinoic acid on inducing the expression of CYP1A1 and UGT1 correlated with an increase of mRNA expression levels of CYP1A1 and UGT1. The modulation of mRNA expression levels of GST was downregulated by all-trans-retinoic acid. 3. The genetic polymorphism of CYP1A1 was induced by 3-methylcholanthrene and all-trans- retinoic acid, and that of GSTM1 was not affected by the inducers. The induction of genetic polymorphism of GST was down regulated by all-trans-retinoic acid. CONCLUSION: 3-Methylcholanthrene and all-trans-retinoic acid modulate the inducible expression and genetic polymorphism of drug metabolizing enzymes differentially. All-trans-retinoic acid can modulate the metabolism of procarcinogen such as 3-methylcholanthrene by inducing drug metabolizing enzymes. Furthermore, the elucidation of the molecular mechanisms underlying the regulation of drug metabolizing enzymes by 3-methylcholanthrene, all-trans-retinoic acid and other drugs could help to understand their respective roles in drug interactions and carcinogenesis.
Animals ; Carcinogenesis ; Cytochrome P-450 CYP1A1 ; Cytochromes ; Drug Interactions ; Gene Expression* ; Humans ; Male ; Metabolism ; Methylcholanthrene ; NADP ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Rats* ; Rats, Sprague-Dawley ; RNA, Messenger ; Skin* ; Tretinoin*

No abstract available.
Oocytes* ; Pregnancy* ; Spermatozoa*

A 45-year-old woman presented with a generalized fixed drug eruption due to mefenamic acid, characterized by recurring erythematous patches with central bullae on the same sites of the whole body and leaving hyperpigmentation after each attack. Patch testing of a quiescent lesion with 50% mefenamic acid in vaselin revealed an eczematous reaction after 48 hours. The disease course was mild compared to the severe clinical manifestation. We here-in report a case of generalized fixed drug eruption due to mefenamic acid which is considered a rare occurrence.
Drug Eruptions* ; Female ; Humans ; Hyperpigmentation ; Mefenamic Acid* ; Middle Aged ; Patch Tests

No abstract available.
Caves*

No abstract available.
Organization and Administration* ; Psychotherapy*

Ionizing radiation has brought powerful aids to medical practitioners, but it has also brought new and bewildering problems. Radiation in the form of systemically administered radionuclides or external radiation may produce such abnormal reactions in the musculoskeletal system as growth disturbances, myelofibrosis, radiation osteitis, necrosis of bone, exostosis, pathologic fracture, and on rare occasion malignant tumors. The incidence of postirradiation sarcoma was quite rare and there were some histologic hypes of postirradition sarcoma. Of them, incidence of osteosarcoma and fibrosarcoma is most common, although there is some difference between each reports. The authors have experienced recently two cases of postirradiation fibrosarcoma developed in sacrum. In one case, the patient was 55 years old female and the latent period was about 12 years. In another case, the patient was 67 years old female and the latent period was about 15 years. In these cases, they received radiation therapy due to cervical cancer of uterus. They had nerve roots compression symptoms and recieved operation of nerve roots decompression. The diagnosis was confirmed by core bone biopsy. A clinical analysis of these cases is to be reported with review of references.
Biopsy ; Decompression ; Diagnosis ; Exostoses ; Female ; Fibrosarcoma ; Fractures, Spontaneous ; Humans ; Incidence ; Musculoskeletal System ; Necrosis ; Osteitis ; Osteosarcoma ; Primary Myelofibrosis ; Radiation, Ionizing ; Radioisotopes ; Sacrum ; Sarcoma ; Uterine Cervical Neoplasms ; Uterus