Prurigo nodularis is a troublesome chronic dermatosis that showed unsatisfactory response to conventional therapies. Since thalidomide has been applied to the treatment of prurigo nodularis, although the action mechanism is still uncertain, many dermatologists have confirmed its effectiveness. We treated a 54-year-old male patient who had prurigo nodularis affecting the whole body for 10 years with 100 to 300mg of thalidomide daily as the sole therapy for 4 months. The skin lesions were flattened leaving postinflammatory hyperpigmentation and the pruritus also sub-sided. Two years after stopping thalidomide, no recurrence was observed.
Humans ; Hyperpigmentation ; Male ; Middle Aged ; Prurigo* ; Pruritus ; Recurrence ; Skin ; Skin Diseases ; Thalidomide*

No abstract available.
Kidney Transplantation* ; Urinary Diversion*

No abstract available.
Candidiasis* ; Chickenpox* ; Skin Manifestations* ; Skin*

We report a case of symmei.rical peripheral gangrene in a 22-day-old female associated with dissem-inated intravascular coagulation, which probably occured from septicmia of Enterobacter aerogenes. The skin lesions showed well-defined blackish gangrene surrounded by purpuric patches on the whole fingertips and toes except the loft thumb. Histopathologically, there were epidermal necrosis, diffuse extravasation of RBCs, mild petivascular inflammatory infiltrates and delated and RBC-filled vessels in the dermis. But, there was no definite evidence of vasculitis. In spit,e of aggressive antibictics therapy and other supportive measrres, she died at 39th day after birth.
Dermis ; Disseminated Intravascular Coagulation* ; Enterobacter aerogenes ; Female ; Gangrene* ; Humans ; Necrosis ; Parturition ; Skin ; Thumb ; Toes ; Vasculitis

No abstract available.
PUVA Therapy* ; Telangiectasis*

BACKGROUND: It has been well known that patients with diabetes mellitus are prone to cutaneous infections, but whether superficial mycoses are truly more prevalent in diabetic patients is still controversial. OBJECTIVE: The purpose of this study was to determine the true prevalence of superficial mycoses in diabetic patients as comparing with non-diabetic, non-immunocompromised individuals. METHODS: We examined for evidence of superficial fungal disease in 137 diabetic patients and compared it with 146 non-diabetic non-immunocompromised ones. Potassium hydroxide preparations and fungus cultures were performed from all suspected lesions. RESULTS: Superficial mycoses were more common in diabetic patients(50%) than controls(31%) (p=0.0004), especially in the age group of 4th and 5th decades9p=0.011). The duration of diabetes mallitus or blood sugar levels were not significantly correlated with the prevalence of superficial mycoses.The organism most commonly isolated was Trichophyton rubrum in both groups(53% vs 79%) and Candida albicans was more prevalent in diabetic patients(34% vs 7%). More than 2 kinds of superficial mycoses were mose common in diabetic patients than controls(38% vs 16%). CONCLUSION: This study shows that the prevalence rate of superficial mycoses in diabetic patients is higher than that in controls and the in controls and the duration of diabetes mellitus or blood sugar levels were not significantly correlated with it.
Blood Glucose ; Candida albicans ; Diabetes Mellitus ; Fungi ; Humans ; Mycoses* ; Potassium ; Prevalence ; Trichophyton

BACKGROUND: Dermatophytoses show marked differences in their incidences, distributions, and causative organisms by age, sex, occupations, environmental conditions and geographic distributions. OBJECTIVE: We evaluated the recent distributions of dermatophytes and compared them with the previous reports in Seoul. METHODS: We evaluated the incidences of dermatophytes according to the patient's age and sex, isolated month, and the infection sites with 387 strains of dermatophytes isolated from the various forms of dermatophytoses during the period from August 1985 to July 1991 in Seoul. RESULTS: T. rubrum was the most prevalent dermatophyte in all age groups except the first decade. The incidence of M. canis was high in age groups below 20 years old relatively high incidences of T. mentagrophytes and T. interdigitale in age groups over 30 years old. Dermatophytes were frequently isolated in summer season, but the incidence of M. canis was relatively high in October and December. T. rubrum was the most prevalent dermatophyte from all forms of dermatophytoses except tinea capitis, but the incidence of T. rubrum was relatively low in tinea corporis. The incidence of T. mentagrophytes was relatively high in tinea unguium and tinea manus, and M. canis was isolated only in tinea corporis and tinea capitis. From the cases showing more than two forms of dermatophytoses. T. rubrum was isolated for the most part. CONCLUSION: This study suggested that there was a rise in the cases of t. rubrum infections in Seoul and in recent years the prevalence of M. canis infections has markedly increased but those of E. floccosum and t. mentagrophytes have decreased.
Adult ; Arthrodermataceae ; Humans ; Incidence ; Occupations ; Onychomycosis ; Prevalence ; Seasons ; Seoul* ; Tinea Capitis ; Tinea* ; Young Adult

Barts syndrome was desrribed by Bart(Bart et al, 1966) with hereditary congenital localized absence of skin from the lovrer legs associated with blistering of the sun and mouth and nail abnormalities. A newborn girl presented with a congenital localized absence of skn over both shins & dorsa of both feet which were covered with the thin, translucent, brown red glistening membranes. A number of blisters were seen on the back, thighs upper extremities, and both 2rd toe nails were absent. Electron microscopic examination of defected skin revealed dermo-epidermal . paration with focal disruption of basal lamina.
Basement Membrane ; Blister ; Female ; Foot ; Humans ; Infant, Newborn ; Leg ; Membranes ; Mouth ; Nails, Malformed ; Skin ; Solar System ; Thigh ; Toes ; Upper Extremity

Pressure alopecia can occur after prolonged pressure on the scalp with the head fixed in one position. We have repor ted 5 cases of pressure alopecia, occurring over the contralateral temporoparietal 1 area after tympanomastoidectomy due to chronic ot.itis media. Total times of operations were from 4 hours to 7 hours. Four of the 5 patients experienced scalp pain during the early postoperative period and one of them showed large bulla formation. Loss of hairs followed between the 14th and 36th postoperative day, and new hairs began to grow 2 or 3 months after the operation.
Alopecia* ; Hair ; Head ; Humans ; Postoperative Period ; Scalp

The immunosuppression significantly increases the risk for acquiring opportunistic infections due to bacteria, viruses, fungi, and protozoa. These opportunistic infections are the major source of morbidity and mortality in transplanted patients. Cytomegalovirus and Aspergillus are important infectious agents in renal transplant recipients. The onset of these diseases follows the period of maximal immunosuppression for the prevention and treatment of acute rejection. Cytomegalovirus infection can suppressed immunity in renal transplant recipient and associated with other opportunistic infections. We experienced a case of Aspergillus and Cytomegalovirus pneumonia after renal transplantation. This 45-year-old woman had undergone renal transplantation. About 1 months later, she presented with dry cough and mild fever. Chest radiographs revealed multifocal patchy and conglomerated consolidation on both lung field, especially lower lung field. The invasive aspergillosis and cytomegalovirus pneumonia was diagnosed by open lung biopsy. Her condition was progressively aggravated despite amphotericin B and ganciclovir therapy and expired 53 days after renal transplantation.
Amphotericin B ; Aspergillosis ; Aspergillus ; Bacteria ; Biopsy ; Cough ; Cytomegalovirus Infections ; Cytomegalovirus* ; Female ; Fever ; Fungi ; Ganciclovir ; Humans ; Immunosuppression ; Kidney Transplantation* ; Lung ; Middle Aged ; Mortality ; Opportunistic Infections ; Pneumonia* ; Radiography, Thoracic ; Transplantation