1.Genetic Polymorphism of a Platelet Glycoprotein IIIa as anInherited Risk Factor for Coronary Artery Disease in Koreans.
Geon Young KIM ; Dong Soo KIM ; Hyuck Moon KWON ; Hyun Seung KIM
Korean Circulation Journal 1997;27(11):1082-1086
BACKGROUND: Platelet aggregation and thrombus formation within the coronary artery are major factors in acute coronary syndrome. The platelet glycoproteinIIb/IIIa receptor is a pivotal mediator of platelet aggregation. Recently there have been reports that the genetic polymorphism of GPIIIa is an inherited risk factor for coronary artery thrombosis. This study investigated the relation between the Pl(A) polymorphism and coronary artery disease in Korean patients. METHODS: One hundred patients with acute myocardial infarction and unstable angina were enrolled. Coronary angiogram was performed in eighty-one cases. Genomic DNA from peripheral blood was amplified by polymerase chain reaction. Allele-specific restriction digestion was used to determine the Pl(A) genotype. RESULTS AND CONCLUSIONS: The prevalence of Pl(A2) genotype was zero percent in our study group. All patients had the Pl(A1/A1) genotype. These results suggest that Pl(A) genetic polymorphism of GPIIIa is not an inherited risk factor for coronary artery diseases in Koreans.
Acute Coronary Syndrome
;
Angina, Unstable
;
Blood Platelets*
;
Coronary Artery Disease*
;
Coronary Vessels*
;
Digestion
;
DNA
;
Genotype
;
Humans
;
Integrin beta3*
;
Myocardial Infarction
;
Platelet Aggregation
;
Polymerase Chain Reaction
;
Polymorphism, Genetic*
;
Prevalence
;
Risk Factors*
;
Thrombosis
2.Merkel Cell Carcinoma Coexistent with Epidermal Cyst in an Immunosuppressed Man.
Young In JEONG ; Joon Won HUH ; Geon KIM ; Eun Jung KIM ; Hyang Joon PARK ; Mihn Sook JUE
Korean Journal of Dermatology 2014;52(5):368-370
No abstract available.
Carcinoma, Merkel Cell*
;
Epidermal Cyst*
;
Immunosuppression
3.A Case of Adult Colloid Milium on the Scalp.
Joon Won HUH ; Young In JEONG ; Geon KIM ; Mihn Sook JUE ; Hyangjoon PARK ; Eun Jung KIM
Korean Journal of Dermatology 2015;53(9):740-741
4.Photodynamic Therapy with Methyl Aminolevulinate for Disseminated Superficial Porokeratosis.
Joon Won HUH ; Young In JEONG ; Geon KIM ; Mihn Sook JUE ; Eun Jung KIM ; Hyangjoon PARK
Korean Journal of Dermatology 2014;52(10):757-758
No abstract available.
Photochemotherapy*
;
Porokeratosis*
5.Pilomatricoma on the Ear Helix.
Young In JEONG ; Joon Won HUH ; Geon KIM ; Mihn Sook JUE ; Hyang Joon PARK ; Eun Jung KIM
Korean Journal of Dermatology 2015;53(3):261-262
No abstract available.
Ear*
;
Pilomatrixoma*
7.Effects of Inhalational Anesthetics on Contractile Responses and Nitric Oxide Synthase Activity in Endotoxemic Rats.
Jin Woong PARK ; Dong Geon LIM ; Sung Sik PARK ; Byung Young CHOI ; In Kyeom KIM
Korean Journal of Anesthesiology 1997;33(2):204-214
BACKGROUND: Recent studies revealed that inhalational anesthetics (IA) attenuate NO production. But the hemodynamic changes produced by IA in septic syndrome patient are still sufficient to threaten patient, surgeon and anesthesiologist. So we examined which IA is proper to maintain vascular contractile force and evaluated the effects of NOS inhibitors on contractile force of septic rat aorta under IA. METHODS: Aortic ring preparation was obtained from LPS-treated (1.5 mg/kg, i.p. for 18h) rats. The development of sepsis was confirmed by iNOS activity and iNOS expression using RT-PCR. Contractile responses of aorta to phenylephrine admministation in the presence or absence of halothane, enflurane and isoflurane were evaluated. We also evaluated the effects of NOS inhibitors, one is NG-nitro-L-arginine methyl ester (L-NAME) and the other is aminoguanidine. Statistical significances (p<0.05) were analyzed according to data characteristics by unpaired t-test and paired t-test. RESULTS: The contractile responses to phenylephrine admministration were attenuated in LPS-treated rings. Isoflurane, even at the dose of 2 MAC, didn't affect the contractile response while both halothane and enflurane decreased the contractile response even at the dose of 1 MAC. The potentiation of contractile responses by NOS inhibitors were not affected during administeration of IA. CONCLUSIONS: From these results, it is suggested that isoflurane is the safest inhalational anesthetic and NOS inhibitors, especially L-NAME, may be very useful in the therapy of septic shock patients during general anesthesia.
Anesthesia, General
;
Anesthetics*
;
Animals
;
Aorta
;
Enflurane
;
Halothane
;
Hemodynamics
;
Humans
;
Isoflurane
;
NG-Nitroarginine Methyl Ester
;
Nitric Oxide Synthase*
;
Nitric Oxide*
;
Phenylephrine
;
Rats*
;
Sepsis
;
Shock, Septic
8.Accessory jaw bone: report of a case.
Sun Youl RYU ; Hee Kyun OH ; Geon Jung KIM ; Young Soo YUN
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1992;18(4):130-136
No abstract available.
Jaw*
9.Computerized management of radiology department: Installation and use of local area network(LAN) by personal computers.
Young Joon LEE ; Kook Sang HAN ; Do Ig GEON ; Chang Hyo SOL ; Byung Soo KIM
Journal of the Korean Radiological Society 1993;29(5):1100-1106
There is increasing need for network connecting personal computers(PC) together. Thus Local Area Network(LAN) emerged, which was designed to allow multiple computers to access and share multiple files and programs and expensive peripheral devices and to communicate with each user. We built PC-LAN in our department that consisted of 1) hardware-9 sets of personal computers(IBM compatible 80386 DX, 1 set:80286 AT, 8sets) and cables and network interface cards (Ethernet compatible, 16bits) that connected PC and peripheral devices 2) software - network operating system and database management system. We managed this network for 6 months. The benefits of PC-LAN were 1) multiuser (share multiple files and programs, peripheral devices) 2) real time data processing 3) excellent expandibility and flexibility, compatibility, easy connectivity 4) single cable for networking ) rapid data transmission 6) simple and easy installation and management 7) using conventional PC's software running under DOS(Disk Operating System) without transformation 8) low networking cost. In conclusion, PC-LAN provides an easier and more effective way to manage multiuser database system needed at hospital departments instead of more expensive and complex network of minicomputer or mainframe.
Database Management Systems
;
Hospital Departments
;
Humans
;
Microcomputers*
;
Minicomputers
;
Pliability
;
Running
10.Four cases of neonatal group B streptococcal sepsis/meningitis.
Jae Geon SIM ; Soon Wha KIM ; Young Jin HONG ; Don Hee AHN ; Keun Chan SOHN
Journal of the Korean Pediatric Society 1992;35(2):275-281
No abstract available.
Meningitis