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Measurement of the serum CA 125 level as a tumor marker in patients with epithelial ovarian cancer has been widely used to monitor disease status and predict survival of patient. While a number of benign gynecologic as well as benign or malignant non-gynecologic conditions are associated with elevations of serum CA 125 levels, the established normal range describes a healthy population of women. Because the metabolism and clearance of CA 125 is not well understood and mild or moderate degrees of renal impairment frequently occurs in ovarian cancer patients during treatment or course of disease, it is valuable to investigate the effect of impaired renal function on serum level of CA 125. Eighty-nine women on hemodialysis who had no other definite cause to elevate serum CA 125 level were selected at random. The age of the patients ranged from 19 to 83 and renal disease was secondary in most cases to diabetes mellitus, hypertension or glomeru-lonephritis. The creatinine clearance was less than 10cc/min for all patients. (continue)
Creatinine ; Diabetes Mellitus ; Female ; Humans ; Hypertension ; Metabolism ; Ovarian Neoplasms ; Reference Values ; Renal Dialysis

1.Early Diagnosis of Ovarian Cancer.

2.Flow cytometric analysis of DNA patterns in carcinoma of the uterine cervix.

3.Flow cytometric analysis of DNA patterns in benign and malignant ovarian tumors.

4.Comparison of blood velocity waveforms of the fetal umbilical artery and the fetal aorta between normal and hypertensive pregnancies.

5.A case of Goldenhar's syndrome.

6.Two cases of squamous cell carcinoma arising from benign teratomaas of ovary.

7.Doppler blood flow velocity waveforms of the fetal descending thoracic aorta in normal pregnancies.

8.A Short-Term In-Vitro Chemosensitivity Test for Ovarian Cancer: Nuclear Damage Assay.

9.Analysis of doppler blood flow velocity waveforms of the fetal umbilical artery in normal pregnancies.

10.Serum CA 125 Levels in Patients with Impaired Renal Function.

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