1.Measurement of Colloid Osmotic Pressure in Pregnancy Induced Hypertensive Patients.
Korean Journal of Anesthesiology 1998;34(1):108-113
BACKGROUND: Pregnancy induced hypertension (PIH) is a common cause of maternal morbidity and death in late pregnancy. Pulmonary edema, although infrequently encountered, may cause death in severe cases of PIH. However, the mechanisms that account for pulmonary edema have not been clarified. Mobilization of peripheral edema, excess fluid intake, myocardial dysfunction, and reduced plasma protein concentration are factors that have been postulated as contributing to the development of pulmonary edema in this syndrome. Colloid osmotic pressure is a principal regulator of capillary fluid exchange. METHODS: In a study of 50 normotensive and severe PIH patients who underwent cesarean section, peripartum plasma colloid osmotic pressure, serum albumin, and total serum protein were compared. RESULTS: Both groups exhibited significantly lower plasma colloid osmotic pressure in the postpartum period than that measured antepartum (p<0.05). The mean antepartum plasma colloid osmotic pressure in severe PIH patients was significantly lower than in normotensive subjects (p<0.05). CONCLUSIONS: We believe that serial COP measurments may be helpful to guide optimal fluid management in severe PIH patients.
Capillaries
;
Cesarean Section
;
Colloids*
;
Edema
;
Female
;
Humans
;
Hypertension, Pregnancy-Induced
;
Osmotic Pressure*
;
Peripartum Period
;
Plasma
;
Postpartum Period
;
Pregnancy*
;
Pulmonary Edema
;
Serum Albumin
2.Induction of Anesthesia with Low-Dose Midazolam and Thiopental.
Young Du NA ; Young Ho JANG ; Jung Kil CHUNG
Korean Journal of Anesthesiology 1997;32(5):745-749
BACKGROUND: This study was undertaken to evaluate the hemodynamic response of midazolam-thiopental coinduction technique compared with thiopental or midazolam induction after tracheal intubation. METHODS: 60 patients were divided into 3 groups. Group I thiopental 5 mg/kg induction groups: Group II, midazolam 0.2 mg/kg induction group: Group III 2 mg/kg of thiopental was injected intravenously to each patient 2min after 0.02 mg/kg of midazolam injected. After tracheal intubation, blood pressure and heart rate were measured for 5 minutes at 1 minute interval. Results: There were not significant differences in systolic, diastotic, mean arterial pressure and heart rate in 3 groups. CONCLUSIONS: Low dose midazolam-thiopental coinduction can be a useful method for induction because of same hemodynamic changes as to thiopental or midazolam alone.
Anesthesia*
;
Anesthetics
;
Arterial Pressure
;
Blood Pressure
;
Heart Rate
;
Hemodynamics
;
Humans
;
Intubation
;
Midazolam*
;
Thiopental*
3.The effect of bracket width on frictional force between bracket and arch wire during sliding tooth movement.
Won Cheul CHOI ; Tae Woo KIM ; Joo Young PARK ; Jae Hyuk KWAK ; Hyo Jeong NA ; Du Nam PARK
Korean Journal of Orthodontics 2004;34(3):253-260
Frictional force between the orthodontic bracket and arch wire during sliding tooth movement is related to many factors, such as the size, shape and material of both the bracket and wire, ligation method and the angle formed between the bracket and wire. There have been clear conclusions drawn in regard to most of these factors, but as to the effect of bracket width on frictional force there are only conflicting studies. This study was designed to investigate the effect of bracket width on the amount of frictional forces generated during clinically simulated tooth movement. Three different widths of brackets (0.018x0.025"standard), narrow (2.40mm), medium (3.00mm) and wide (4.25mm) were used in tandem with 0.016x0.022" stainless steel wire. Three bracket-arch wire combinations were drawn on for 4 minutes on a testing apparatus with a head speed of 0.5mm/min and tested 7 times each. To reproduce biological conditions, dentoalveolar models were designed with indirect technique using a material with similar elastic properties as periodontal ligament (PDL). In addition, to minimize the effect of ligation force, elastomer was used with added resin, which was attached to the bracket to make up for the discrepancies of bracket width. The results were as follows: 1. Maximum frictional force for each bracket-arch wire combination was: Narrow (2.40mm) : 68.09+/-4.69 gmf Medium (3.00mm) : 72.75+/-4.98 gmf Wide (4.25mm) : 72.59+/-4.54 gmf 2. Frictional force was increased with more displacement of wire through the bracket slot. 3. The ANOVA post-hoc test showed that the bracket width had no significant effect on frictional force when tested under clinically simulated conditions (P>0.05)
Elastomers
;
Friction*
;
Glia Maturation Factor
;
Head
;
Ligation
;
Orthodontic Brackets
;
Periodontal Ligament
;
Stainless Steel
;
Tooth Movement*
;
Tooth*
4.Rhus verniciflua Stokes attenuates cholestatic liver cirrhosis-induced interstitial fibrosis via Smad3 down-regulation and Smad7 up-regulation.
Mi Na GIL ; Du Ri CHOI ; Kwang Sik YU ; Ji Heun JEONG ; Dong Ho BAK ; Do Kyung KIM ; Nam Seob LEE ; Je Hun LEE ; Young Gil JEONG ; Chun Soo NA ; Dae Seung NA ; Ki Hyun RYU ; Seung Yun HAN
Anatomy & Cell Biology 2016;49(3):189-198
Cholestatic liver cirrhosis (CLC) eventually proceeds to end-stage liver failure by mediating overwhelming deposition of collagen, which is produced by activated interstitial myofibroblasts. Although the beneficial effects of Rhus verniciflua Stokes (RVS) on various diseases are well-known, its therapeutic effect and possible underlying mechanism on interstitial fibrosis associated with CLC are not elucidated. This study was designed to assess the protective effects of RVS and its possible underlying mechanisms in rat models of CLC established by bile duct ligation (BDL). We demonstrated that BDL markedly elevated the serological parameters such as aspartate aminotransferase, alanine transaminase, total bilirubin, and direct bilirubin, all of which were significantly attenuated by the daily uptake of RVS (2 mg/kg/day) for 28 days (14 days before and after operation) via intragastric route. We observed that BDL drastically induced the deterioration of liver histoarchitecture and excessive deposition of extracellular matrix (ECM), both of which were significantly attenuated by RVS. In addition, we revealed that RVS inhibited BDL-induced proliferation and activation of interstitial myofibroblasts, a highly suggestive cell type for ECM production, as shown by immunohistochemical and semi-quantitative detection of α-smooth muscle actin and vimentin. Finally, we demonstrated that the anti-fibrotic effect of RVS was associated with the inactivation of Smad3, the key downstream target of a major fibrogenic cytokine, i.e., transforming growth factor β (TGF-β). Simultaneously, we also found that RVS reciprocally increased the expression of Smad7, a negative regulatory protein of the TGF-β/Smad3 pathway. Taken together, these results suggested that RVS has a therapeutic effect on CLC, and these effects are, at least partly, due to the inhibition of liver fibrosis by the downregulation of Smad3 and upregulation of Smad7.
Actins
;
Alanine Transaminase
;
Aspartate Aminotransferases
;
Bile Ducts
;
Bilirubin
;
Collagen
;
Down-Regulation*
;
Extracellular Matrix
;
Fibrosis*
;
Ligation
;
Liver Cirrhosis
;
Liver Failure
;
Liver*
;
Models, Animal
;
Myofibroblasts
;
Negotiating
;
Rhus*
;
Transforming Growth Factors
;
Up-Regulation*
;
Vimentin
5.Efficacy of Slimming Cream Containing 3.5% Water-Soluble Caffeine and Xanthenes for the Treatment of Cellulite: Clinical Study and Literature Review.
Sang Young BYUN ; Soon Hyo KWON ; Su Hak HEO ; Jae Seong SHIM ; Mi Hee DU ; Jung Im NA
Annals of Dermatology 2015;27(3):243-249
BACKGROUND: Cellulite is a 'cottage cheese-like' cutaneous change caused by subcutaneous fat bulging into the dermis that usually leads to cosmetic problems. Slimming cream containing 3.5% water-soluble caffeine and xanthenes exhibits a lipolytic effect with penetration into the dermis. OBJECTIVE: To evaluate the efficacy and safety of slimming cream for the treatment of cellulite. METHODS: Fifteen subjects with cellulite applied slimming cream to the thighs and inner side of the upper arms twice daily for 6 weeks. Efficacy was assessed using a standard visual scale, changes in the circumferences of the thighs and upper arms, and patient satisfaction by a questionnaire at baseline, week 3, and week 6. Safety was assessed by inquiring about adverse events through questionnaires. RESULTS: The standard visual scale score improved significantly by 0.49 points (19.8%) at week 6. Thigh and upper-arm circumferences decreased by 0.7 cm (1.7%) and 0.8 cm (2.3%), respectively, at week 6. Slight itching and transient flushing were commonly reported, but no serious adverse event occurred. CONCLUSION: The slimming cream tested appears to be effective for the treatment of cellulitis without serious adverse effects. However, additional large clinical trials are required to confirm the efficacy and safety of slimming cream for the treatment of cellulitis.
Arm
;
Caffeine*
;
Cellulitis
;
Dermis
;
Flushing
;
Patient Satisfaction
;
Pruritus
;
Subcutaneous Fat
;
Thigh
;
Xanthenes*
;
Surveys and Questionnaires
6.Two Granular Cell Tumors of the Colon with the Endosonographic Features.
Du San BAIK ; Jeong Eun SHIN ; Sang Soo LIM ; Se Young YUN ; Suk Bae KIM ; Hong Ja KIM ; Il Han SONG ; Na Hye MYONG
Korean Journal of Gastrointestinal Endoscopy 2010;40(4):280-284
Granular cell tumor is relatively uncommon, it is usually benign and it can be located anywhere throughout the body. It is uncommon in the digestive tract, and especially in the colon and rectum. The endosonographic features of granular cell tumor are usually a relatively hypoechoic, heterogenous lesion in the submucosa, but this tumor has rarely been reported in the colon. We report here on two cases of granular cell tumors of the colon that were observed by using endoscopic ultrasonograpy for making the differential diagnosis of a submucosal tumor and these tumors were confirmed by microscopic examinations after endoscopic mucosal resection.
Colon
;
Diagnosis, Differential
;
Gastrointestinal Tract
;
Granular Cell Tumor
;
Rectum
7.Acute Displaced Fracture of Lateral Acromion after Reverse Shoulder Arthroplasty: A Case Report and Surgical Technique
Chul Hyun CHO ; Jae Won JUNG ; Young Jae LIM ; Sang Soo NA ; Du Han KIM
Clinics in Shoulder and Elbow 2019;22(2):106-109
Acromial fractures are well-documented complications subsequent to reverse shoulder arthroplasty (RSA), and most appear as stress fractures with no history of single trauma. To date, no study has reported the occurrence of acute displaced acromial fracture due to sudden strong deltoid contraction during heavy work. Displacement of the fracture results in a challenging surgery since it is difficult to obtain adequate fixation in thin and osteoporotic bones. We report a rare case of acute displaced acromial fracture after successful RSA treatment, using a novel technique of open reduction and internal fixation, applying two 4.5 mm cannulated screws and lateral clavicle precontoured plate.
8.Acute Displaced Fracture of Lateral Acromion after Reverse Shoulder Arthroplasty: A Case Report and Surgical Technique
Chul Hyun CHO ; Jae Won JUNG ; Young Jae LIM ; Sang Soo NA ; Du Han KIM
Journal of the Korean Shoulder and Elbow Society 2019;22(2):106-109
Acromial fractures are well-documented complications subsequent to reverse shoulder arthroplasty (RSA), and most appear as stress fractures with no history of single trauma. To date, no study has reported the occurrence of acute displaced acromial fracture due to sudden strong deltoid contraction during heavy work. Displacement of the fracture results in a challenging surgery since it is difficult to obtain adequate fixation in thin and osteoporotic bones. We report a rare case of acute displaced acromial fracture after successful RSA treatment, using a novel technique of open reduction and internal fixation, applying two 4.5 mm cannulated screws and lateral clavicle precontoured plate.
Acromion
;
Arthroplasty
;
Clavicle
;
Fractures, Stress
;
Scapula
;
Shoulder
9.Estimation of Cell Concentration by Light Transmitter During the Culture of Methylotrophic Yeast Pichia pastoris.
Du Bok CHOI ; Enoch Y S PARK ; Yong Bo LEE ; Young Hee NA ; Chae Kyu LIM
Mycobiology 2003;31(4):226-228
The multiple correlation coefficient between the values determined by dry weight and those determined by fluorometer was observed with r = 0.96 and the standard error of calibration was 0.034. Using the best calibration data, in order to reconfirm the reliability of the fluorometer results in comparison with those obtained by dry weight on the cell concentration, fedbatch cultures were carried out. The results obtained by fluorometer measurements were in good agreement with those obtained by dry weight. The on-line monitoring of cell concentration by the fermentor system linked to a computer equipped with fluorometer was successfully carried out.
Bioreactors
;
Calibration
;
Pichia*
;
Yeasts*
10.An Experience of Living Related Liver Transplantation Showed Hepatic Artery Stenosis Postoperatively.
Young Hoon KIM ; Hyung Ho KIM ; Hong Jo CHOI ; Ghap Joong JUNG ; Sang Soon KIM ; Su Il LEE ; Young Jun JIN ; Han Sug PARK ; Bong Sik GU ; Young Ho LEE ; Hyung Du LEE ; Seo Hee NA ; Young Yeon LEE ; Tung Tae KIM
Journal of the Korean Surgical Society 1997;53(4):611-616
Liver transplantation is an accepted and successful mode of treatment for pediatric end-stage liver disease. A living related liver transplatation(LRLT) in a child has certain potential advantages, such as short cold ischemic time, accurate graft size, and vessel diameter match based on elective preoperative preparations. Recently, microvasular surgery techniques have been introduced in hepatic artery reconstruction but still the possibility of hepatic artery thrombosis remains. Herein, We report an LRLT case, which showed hepatic artery stenosis postoperatively, successfully dilated by balloon angioplasty technique.
Angioplasty, Balloon
;
Child
;
Cold Ischemia
;
Constriction, Pathologic*
;
Hepatic Artery*
;
Humans
;
Liver Diseases
;
Liver Transplantation*
;
Liver*
;
Thrombosis
;
Transplants