No abstract available.

No abstract available.
Embryonic Development* ; Embryonic Structures* ; Female ; Ovulation* ; Pregnancy

Solitary circumscribed neuroma is a benign nerve sheath tumor of unknown etiology. Clinically, it appears as a long-standing, solitary, asymptomatic, skin-colored papule or papulonodule. It has been found predominantly on the face in both sexes, mostly in middle age. A 53-year-old female patient visited our department because of a nodule on the side of the distal interphalangeal joint of the left second finger. A biopsy specimen showed a well-circumscribed, partially encapsulated tumor composed of interlacing fascicles of spindle cells. Neither pleomorphism nor mitosis was found. Immunohistochemical stainings for vimentin, neuron specific enolase (NSE) and epithelial membrane antigen (EMA) were positive, but negative for S-100 protein and smooth muscle actin (SMA). We herein report an uncommon case of solitary circumscribed neuroma.
Actins ; Biopsy ; Female ; Fingers ; Humans ; Joints ; Middle Aged ; Mitosis ; Mucin-1 ; Muscle, Smooth ; Neuroma* ; Phosphopyruvate Hydratase ; S100 Proteins ; Vimentin

No abstract available.
Adenoma, Pleomorphic*

Vascular tissue presumed to be the most sensitive target tissue of the immune and toxic reactions. Most of the vasculitides can be directly or indirectly associated with immunopathogenic rnechanisms. In this regards, the purpose of the study is to understand imrnunopathogenic mechanism of various cutaneous vasculitides by comparing their immunopathologic patterns. Imrnunopathologic studies were carried out on the blood vessel of various skin diseases by means of the direct immunofluorescent technique using FITC conjugated rabbit antihurnan IgG, IgA, IgM, C3 C1q, C4 and fibrinogen)(F). The results obtained were as follows : 16 patients with leukocytoclastic vasculitis out of 19 showed deposition of irnmune complex in the small upper dermal vessels and had positive reaction for F, 8 for IgA, 5 for C3 and 2 for IgM. Of the 6 patients with chronic pigmented purpura studied, 2 had IgM, 3 had Ca and all of these had F in small upper or middle dermal vessels. Immunopathologic patterns of livedo vasculitis were similar to those of chronic pigmented purpurs, except mainly affected in upper dermis. Nodular vasculitis and Behqets syndrome had deposits of F, C and IgM in medium or large vessels of the middle or lower dermis. Simultaneously, Cs in 2 patients with nodular vnsculitis and IgM in one patient with Behqets syndrorne were also noted along the basement mernbrane zone. In a patient with pityriasis lichenoides et varioliformis acuta, IgM and F were noted on the samll upper dermal vessels. With these results, the immune complex mechanism could be closly related the pathogenesis of most of cutaneous vasculitis. And various clinical manifestations or expression of vasculitis appear to be dependent upon 1) type of imrnune reaction, 2) size of blood vessels, 3) location and depth of blood vessels, 4) extend of affected areas and 5) involvement of other organs.
Antigen-Antibody Complex ; Blood Vessels ; Dermis ; Fluorescein-5-isothiocyanate ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Pityriasis Lichenoides ; Purpura ; Skin Diseases ; Vasculitis*

We present a case of lymphangioma circumscriptum in a 17 year-old girl according to tihe clinical and histopathological findings. This case is unusual in that lesions developed on the vulva and thigh without preceding lymphedema. Our patient had a plaque of grouped vesicle-like papules resembling frog's apawn on The both labia majora of vulva and several scattered, skin tag like soft papules on the right upper thigh of theree years duration. Histopathologic findings showed variable sized, dilatated lymphatic channels lined by single layer of normal endothelial cells confined to the only upper dermis.
Adolescent ; Dermis ; Endothelial Cells ; Female ; Humans ; Lymphangioma* ; Lymphedema ; Skin ; Thigh ; Vulva*

Epdemiological studies were done on 721 patients detected and confirmed as leprosy patients at the Department of Dermatology at Chonnam University Hospitai in the ten years period from l969 to 1978. Statistically, 491 cases were male and 230 cases were female, comprising 2. 1% of the total number of outpatients (34, 631) and showing a decreasing yearly tendency, The percentage of each group, or type; tuberculoid, borderline, lepromatous and indeterminate, was 53.8%, 9.6%, 31.2%, and 5.4%, respectively. The most common age at discovery for males was 30 39 and for female 20~29 with the largest group being adults aged 20~49, 482 cases (66.9%). The sex ratio was 2.1: l, male to female. However, for the tuberculoid types the ratio was 2.5: 1 which was higher than that of the lepromatous type, I. 7: 1, By disease type the most common age group was 20 29 for tubercekid type, 30 39 for lepromatous and borderline group and 10~19 for the indeterminated group. Geographically, 652 cases(90. 4%) were from Chonnam Province and 61 cases (8.5%) from Chonbuk Province. We also observed some significant sequential changes of the type of disease descovered even though 10 years is a relatively short period. There was a tendency towards decreased detection of the tuberculoid type and increased detection of the borderline an.d indeterminate group.
Adult ; Dermatology ; Female ; Humans ; Jeollabuk-do ; Jeollanam-do ; Leprosy* ; Leprosy, Paucibacillary ; Male ; Outpatients ; Sex Ratio

During a 10-year period from Jan, 1970 to Dec. 1979, 33 cases of systemic lupus erythematosys were observed clinically at the Department of Dematology, Chonnam University Hospital. Statistieally, 13 cases were male and 20 chses firnale for a sex ratio of 1: l. 5. The most common age group at eatimated onset was 10-19 and the mean age was 27, 3. There were 5 cases under the age of 15 comprising 15. 2, of all cases. There was no seasonal variation at the onset of disease. Facial lesions were the most common initial sign or symptom and chief cornplaint. During the course of the illness, varions manifeatations were obaerved: artbralgia, 87. 9%; weakness and fatigue, 84. 8%; fever, 75. 8%; cutaneous lesions, 100. 0% gastrointestinal symptoms, 54. 5%; pulmonary symptoms, 42. 4%; cardiae abnomalities, 36. 4%; enlargement of reticuloendothelial systems, 30.3%; and neuropsychiatric symptom., 30. 3%. Upon laboratory analysis we found 14 cases of lupoid hepatitis and 8 cases of lupus nephritis. There were various associated diseases such as retinopathy, congestive heart failure, pulmonary tuberculosis, diabetes mellitus, etc.
Cardia ; Diabetes Mellitus ; Fatigue ; Fever ; Heart Failure ; Hepatitis ; Humans ; Jeollanam-do ; Lupus Erythematosus, Systemic* ; Lupus Nephritis ; Male ; Mononuclear Phagocyte System ; Seasons ; Sex Ratio ; Tuberculosis, Pulmonary

No abstract available.
Animals ; Lipid Peroxides ; Mice* ; Skin*

The epithelioid angiosarcoma is recently described ns a variant of ang-osarcoma based on its pathological feature, which is characterized by the epithelioid or histiocytoid morphology af the malignant tumor cells. The existence of vascular endothelial tumor with an epithelioid feature has been accepted for many years, most notablyn the forms of epithelioid hemangioma and epithelioid hemangioendo thelioma. In recent years, cutaneous angiosarcoma with epitheloid morphology have been reported as a cutaneos epithelioid angiosarcoma in the literatures. A 60-year-old man presente with a mild tender erythematous 2 x 2 x 2.5cm sized soft fluctuating single nodule with dark hemorrhagic crust on the left forehead for 3 months. He had had an abrasion wound on the lesion site of the forehead by an accidental trauma 5 month before the lesion appeared. Histopathological findings revealed that the tumor mass was chiefly composed of solid sheets of poorly differentiated malignant cells with an epithelioid feature. The characteristics of classical angiosarcoma such as primitive vascular spaces and clefts with malignat cells, and proliferating vessels were also found in some areas. The immunohistochemical stain wi.h the factor VIII related antigen ivas focally reactive in the tumor cells. Unfortunately he refused further treatment and expired 7 months after discharge at home without knowing the direct cause of his health. We report herein an interesting and rare case of the cutaneous epitheioid angiosarcoma which had typical clinical and histopathological findings and suggested as a case with a very aggressive course.
Forehead ; Hemangioma ; Hemangiosarcoma* ; Humans ; Middle Aged ; von Willebrand Factor ; Wounds and Injuries