1.A Case of Chronic Pancreatitis with Pancreatic Stones in Childhood.
Young Kyoo SHIN ; Chan Wook WOO ; Kee Hyoung LEE ; Young Chang TOCKGO ; Chang Duck KIM
Journal of the Korean Pediatric Society 1995;38(7):1012-1017
No abstract available.
Pancreatitis, Chronic*
2.The Effect of ACTH on Mouse Heart.
Sang Young SEO ; Joo Won LEE ; Chang Sugn SON ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1995;38(6):804-810
No abstract available.
Adrenocorticotropic Hormone*
;
Animals
;
Heart*
;
Mice*
3.Expression of Protein Kinase C Isoform mRNAs in the Developing Rat Heart.
Sae Keun PARK ; Hyung Suk KIM ; Chang Sung SON ; Young Chang TOCKGO ; Young Hyuk JEON
Korean Circulation Journal 1998;28(8):1341-1349
BACKGROUND AND OBJECTIVES: Protein kinase C (PKC) is known to be related with development of various cells. In the heart, each isoform reacts differentially against agonists and the reaction changes during development. In this study, the roles of PKC isoforms (alpha, beta, gamma, delta, epsilon, zeta) were investigated through the localization of mRNA expression in the developing rat heart with in situ hybridization histochemistry. MATERIALS AND METHOD: The mRNA expression pattern of PKC isoforms (alpha, beta, gamma, delta, epsilon, zeta) was investigated with in situ hybridization histochemistry in developing and adult rat hearts. Whole body parasagittal sections were used for embryonal day 14 (E14), E16, E18 and heart sections were used for just born (P0), postnatal day 7 (P7), P14, P21 and adult rat. RESULTS: The expression of PKC alpha was found from E14, peaked at P7, and gradually decreased to adult level. The expression of PKC beta was observed from P14, peaked at P21, and decreased to adult level. The expression of PKC delta in the heart was observed from E14, peaked at P0, and abruptly disappeared at P14. The expression of PKC epsilon was observed from E14, peaked at P0, after that gradually decreased and disappeared at adult rat heart. The expression of PKC gamma and zeta was not found from any stage of developing rat heart. CONCLUSION: From these results, it is suspected that each PKC isoform may be differentially related with development of heart. The strong expression of PKC alpha, delta, epsilon around perinatal period, rapidly developing stage, suggests that PKC alpha, delta, epsilon may be related with rapid development of rat heart. And the late postnatal expression of PKC beta suggests that PKC beta may be related with maturation of rat heart.
Adult
;
Animals
;
Heart*
;
Humans
;
In Situ Hybridization
;
Protein Isoforms
;
Protein Kinase C*
;
Protein Kinase C-epsilon
;
Protein Kinases*
;
Rats*
;
RNA, Messenger*
4.Changein Regional Cerebral Blood Flow Velocity in Premature Infant.
Young Kyoo SHIN ; Chang Sung SON ; Joo Won LEE ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1990;33(10):1333-1340
No abstract available.
Blood Flow Velocity*
;
Humans
;
Infant, Newborn
;
Infant, Premature*
5.Plasma immunoreactive endothlin-1, creatine kinase and CK isoenzyme and its relation to neonate with asphyxia.
Kang Woo LEE ; Kee Hyoung LEE ; Chang Sung SON ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1993;36(10):1434-1440
Endotheline-1 (ET-1) is a potent vasoconstrictor peptide with 21 amino acid residues. ET-1 is thought to have a key role in vasoconstriction, and cardiac, renal, and endocrine actions of the peptide. Creatine Kinase(CK), also referred to as ATP-creatine-N-phosphotransferase, consists of either the B or M type. CK is found almost exclusively in muscle(MM), myocardium(MB), and brain(BB). It is to be an almost specific index of injury of myocardium and brain in hypoxic damage. I measured the ET-1, CK isoenzyme in neonates among asphyxia group (14 cases), as a control devide into two group. 1st group(birth weight (2500 g, n=9) and 2nd group (body weight 2500g, n=11). 1) There was no significant difference between asphyxia and control 1st, 2nd group during postnatal 24 hrs include cord blood on irET-1(p< 0.05). 2) There was significant difference between asphyxia and control 1 st, 2nd group during postnatal 24 hrs include cord blood on CK and CK and CK isoenzyme (p<0.001). 3) There was significant difference between asphyxia and control 1st, 2nd group on CK-MB and CK-BB proportion (p< 0.001). 4) There was significant difference between cord blood and postnatal 24 hrs on total CK level (P< 0.001).
Asphyxia*
;
Brain
;
Creatine Kinase*
;
Creatine*
;
Fetal Blood
;
Humans
;
Infant, Newborn*
;
Myocardium
;
Plasma*
;
Vasoconstriction
6.Pulsed doppler echocardiographic analysis of pulmonary venous flow in congenital heart diseases with left-to-right shunt.
Kye Hwan SEOL ; Chang Sung SON ; Joo Won LEE ; Soon Kyum KIM ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1991;34(7):934-939
No abstract available.
Echocardiography*
;
Echocardiography, Doppler, Pulsed
;
Heart Diseases*
;
Heart*
7.The study on extracardiac anomalies associated with congenital heart diseases.
Kye Hwan SEOL ; Kang Won LEE ; Chang Sung SON ; Joo Woo LEE ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1992;35(1):26-33
No abstract available.
Heart Diseases*
;
Heart*
8.The effect of prostaglandin E1 infusion for papillation of ductus dependent cyanotic congenital heart disease in neonates.
Ji Hee PARK ; Chang Sung SON ; Joo Won LEE ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1992;35(3):364-370
No abstract available.
Alprostadil*
;
Ductus Arteriosus
;
Heart Defects, Congenital*
;
Humans
;
Infant, Newborn*
9.A case of fetal atrial flutter with hydrops fetalis.
Seong Hang CHOI ; Kee Hyoung LEE ; Chang Sung SOHN ; Ju Won LEE ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1993;36(8):1165-1170
Fetal hydrops is often serious and associated with a high perinatal motality rate. Cardiac causes of fetal hydrops include congenital heart diseases and rhythm disturbances. An irregular fetal heart rate may indicate atrial fibrillation and atrial flutter with variable AV conduction. Fetal atrial flutter is characterized by the pressence of flutter waves which are regular sawtooth undulations in the baseline that are larger than p waves. Authors experienced a case of fetal atrial flutter with hydrops fetalis at 30 week's gestation which was confirmed by fetal M-mode echocardiogram and electrocardiography. A new born infant had shown to have atrial flutter in utero and after delivery was successfully converted to normal sinus rhythm with digoxin and quinidene.
Atrial Fibrillation
;
Atrial Flutter*
;
Digoxin
;
Edema*
;
Electrocardiography
;
Female
;
Heart Diseases
;
Heart Rate, Fetal
;
Humans
;
Hydrops Fetalis*
;
Infant
;
Pregnancy
10.Plasma Fibronectin Concentration in the Neonate.
Young YOO ; Kwang Chul LEE ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1996;39(3):319-325
PURPOSE: Plasma fibronectin is thought to have important role in the inflammatory response and host defense. We performed this study to evaluate concentration in the full-term, healthy preterm, asphyxia and respiratory distress syndrome and how that correlated with gestational age and birth weight. METHODS: We evaluate 51 neonates who were delivered at Korea University Hospital from Jan. 1992 to Jul. 1992. In order to evaluate concentration of plasma fibronectin according to gestational age and birth weight in 51 neonates, we measured plasma fibronectin in healthy premature and term infants and investigated the alteration in plasma values in infants with perinatal asphyxia and respiratory distress syndrome. RESULTS: 1) The concentration of plasma fibronectin was lower in preterm infants(123+/-30ug/dl) than in term infants(151+/-26ug/dl). 2) There was a significant correlation between the plasma fibronectin concentration and both gestational age and weight (p<0.01). 3) The infant with perinatal asphyxia and respiratory distress syndrome had lower plasma fibronectin concentration than those in age matched healthy infant. CONCLUSIONS: This results shows that the plasma fibronectin correlate with gestational age and birth weight and suggests that deficiency of plasma fibronectin correlate with reticuloendothelial system hypofunction in infants with complicated birth.
Asphyxia
;
Birth Weight
;
Fibronectins*
;
Gestational Age
;
Humans
;
Infant
;
Infant, Newborn*
;
Korea
;
Mononuclear Phagocyte System
;
Parturition
;
Plasma*