1.Inhibitory Effect of Tetrandrine on Extracellular Matrix Deposition in Rat Hepatic Fibrosis.
Won Young CHOI ; Hyo Jeong CHAE ; Sun Kyung LEE
Korean Journal of Pathology 1999;33(5):319-325
No effective therapy has yet developed for liver fibrosis/cirrhosis by directly inhibiting the accumulation of extracellular matrix. This study was undertaken to determine the effect of tetrandrine in rat model of liver fibrosis induced by carborn tetrachloride (CCl4) administration intraorally. Tetrandrine, a calcium channel blocker, is anti-inflammatory constituent of the families Menispermaceae and Ranunculaceae, which have been used as folk remedies in China. Repeated administration of CCl4 for 14 weeks to rats induced liver fibrosis with steatosis. Rats were killed after 4, 8 or 14 weeks of treatment with CCl4, CCl4 tetrandrine (30 mg/kg) or CCl4 tetrandrine (50 mg/kg). The histopathological findings of liver were observed semi-quantitatively by light microscopy and volume percentage of the collagen deposition was determined by image analyzer. Tetrandrine inhibited collagen deposition induced by CCl4 administration, as shown by less severe steatosis and fibrosis and significantly decreased volume percentage of collagen fibers in CCl4 tetrandrine treated animals compared with CCl4 only group. Thus, the administration of tetrandrine holds great promise for treating subjects with liver fibrosis/cirrhosis as a result of chronic hepatic injury.
Animals
;
Calcium Channels
;
Carbon Tetrachloride
;
China
;
Collagen
;
Extracellular Matrix*
;
Fibrosis*
;
Humans
;
Liver
;
Liver Cirrhosis
;
Medicine, Traditional
;
Menispermaceae
;
Microscopy
;
Models, Animal
;
Ranunculaceae
;
Rats*
2.A Case of Epstein's Syndrome.
Seon Young CHOI ; Hyun Chul CHAE ; Hae Young CHO ; Hong Bae KIM ; Ji Sub OH
Journal of the Korean Pediatric Society 1994;37(11):1610-1614
Epstein's syndrome is a rare disease whish is characterized by the association of thrombocytopenia, macrothrombocytopathia, nephritis and deafness. We experienced a case of Epstein's syndrome in a 12 years old male patient who was presented with a life long history of bleeding, usually as epistaxis, bilateral sensorineural deafness and hematuria with proteinuria starting in late childhood. Hematologic studies showed thrombocytopenia with giant platelets and anemia. A bone marrow aspirate revealed the megakaryocytes to be adequate in number and many giant size platelets. Platelet do not respond to addition of A and epinephrine; collagen and ristocetin induced agglutination response is decreased. It is difficult to be certain the association of thrombocytopenia with giant platelets, nephritis and deafness constitutes a new hereditary disease with a distinct pathogenesis or if it is an expansion of the well recognized Alport's syndrome of hereditary nephritis deafness. We report a case of Epstein's syndrome syndrome with brief review of related literatures.
Agglutination
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Anemia
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Blood Platelets
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Bone Marrow
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Child
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Collagen
;
Deafness
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Epinephrine
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Epistaxis
;
Genetic Diseases, Inborn
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Hematuria
;
Hemorrhage
;
Humans
;
Male
;
Megakaryocytes
;
Nephritis
;
Nephritis, Hereditary
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Proteinuria
;
Rare Diseases
;
Ristocetin
;
Thrombocytopenia
3.Endobronchial Inflammatory Pseudotumor: A case report.
Seoung Wan CHAE ; Young Hee CHOI ; Hye KYung AHN ; Young Euy PARK
Korean Journal of Pathology 1994;28(2):213-215
Inflammatory pseudotumors of the bronchus have been reported infrequently. Histologic diagnosis remains difficult because of their Polymorphic histologic characteristics and confusing terminology, which are also the problems in the diagnosis of intrapulmonary pseudotumors. We report a case of inflammatory pseudotumor in the left main bronchus which occurred in a 37-year-old man. Histologically, the main portion of the tumor was composed of pale eosinophilic spindle shaped cells covered by respiratory epithelium with squamous metaplasia. Mononuclear inflammatory cells, including plasma cells but acute inflammatory cells were also present in the superficial portion.
4.A Case Report of Strumal Carcinoid of the Ovary.
Young Hee CHOI ; Seoung Wan CHAE ; Hye Rim PARK ; Min Chul LEE ; Young Euy PARK
Korean Journal of Pathology 1994;28(3):307-312
Strumal carcinoid of the ovary is a rare turkor characterized by an intimate mixture of thyroid follicles and carcinoid. Herein is reported an ovarian strumal carcinoid in a serous cystadenoma from a 27-year-old pregnant woman. The thyroid follicular epithelial cells had immunohistochemically thyroglobulin and carcinoid tumor cells contained neuron-specific enolase, chromogranin and carcinoembryonic antigen. In addition, carcinoid cells showed neuroendocrine granules ultrastructurally. Calcitonin and amyloid were not found. This tumor may be originated from pluripotent endodermal germ cells on the basis of morphologic, immunohistochemical and ultrastructural studies.
Pregnancy
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Female
;
Humans
5.Giant Cystic Adenomatoid Tumor of the Uterus: A case report.
Young Hee CHOI ; Seoung Wan CHAE ; Hye Kyung AHN ; Min Chul LEE ; Young Euy PARK
Korean Journal of Pathology 1993;27(1):85-87
Adenomatoid tumor of the uterus is a rare benign neoplasm which has been known as mesothelial origin. Characteristically, it appears as a small nodular lesion less than 2.0cm in the myometrium of subserosal region. We describe a case of giant adenomatoid tumor of the uterus having multicystic gross appearance. A 49-year-old woman complained of vaginal bleeding. The tumor was an intramural mass with maximum diameter of 10 cm and located at posterior wall of the uterus. Histologically, the tumor was composed of multiple cystic cavities of variable size lined by flattened cells, lying among thin septa of connective tissue. Immunohistochemically, the cells are positive for low molecular weight cytokeratin(CAM 5.2) and are negative for factor VIII.
Female
;
Humans
6.Apolipoprotein E Polymorphism in Schizophrenic Patients.
Young Sook CHOI ; Chae Ki LIM ; Chul Hyoung LYOO
Journal of Korean Neuropsychiatric Association 2001;40(3):503-509
OBJECTIVES: To explore the role of apolipoprotein E in schizophrenia, we investigated apoli-poprotein E polymorphism in groups of patients with schizophrenia and normal controls. We also examined the relationship of clinical characteristics of schizophrenia to apolipoprotein E genotypes. METHODS: Samples were obtained from 101 schizophrenic patients and 96 controls in Korea and apolipoprotein E polymorphisms were analysed using polymerase chain reaction. RESULTS: The genotype and allele frequencies did not differ from those of controls. The clinical variables of schizophrenia, such as positive and negative groups by PANSS, subtypes by DSM-IV, family history were not associated with each genotypes. CONCLUSION: We could not find the association of apolipoprotein E in Korean schizophrenic patients and it could be suggested that apolipoprotein E isoforms might not play a main role in expression of schizophrenia.
Apolipoproteins*
;
Diagnostic and Statistical Manual of Mental Disorders
;
Gene Frequency
;
Genotype
;
Humans
;
Korea
;
Polymerase Chain Reaction
;
Protein Isoforms
;
Schizophrenia
7.Bleeding Gastric Ulcer - Clinical Observation of 120 Cases of Bleeding Gastric Ulcer).
Yeun Suk RA ; Young Chae JUNG ; Dae Whan KIM ; Yong Whan CHOI ; Joon Mo CHUNG
Korean Journal of Gastrointestinal Endoscopy 1983;3(1):17-21
Analyses were done on one hudred and twenty caaes of bleeding gastric ulcers diagnosed by emergency endoscopy for the past five years. The reaults are as the following: Much more cases were found in male than female and the most prevalent age group was 6th decade. The body of stomach along the lesser curvature was the most common bleeding site. No age related difference was noted in bleeding sites. Most common type of ulcer was in the round and shallow form. Five of six cases with exposed vessels showed atrophic changes in surrounding mucosa. Among the probable precipitating factors, analgesica, alcohols and certicosteroids were found in such order,
Alcohols
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Emergencies
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Endoscopy
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Female
;
Hemorrhage*
;
Humans
;
Male
;
Mucous Membrane
;
Precipitating Factors
;
Stomach
;
Stomach Ulcer*
;
Ulcer
8.Rehospitalization of Low-birth-weight Infants Who Were Discharged from NICU.
Kyung Dan CHOI ; Young Suk CHAE ; Oh Kyung LEE
Journal of the Korean Pediatric Society 1999;42(4):484-490
PURPOSE: We tried to compare normal term infants with low-birth-weight infants discharged from NICU by evaluating morbidity. So we studied rates of rehospitalization, reasons for rehospitalization and neonatal risk factors that affect rehospitalization of normal term infants and low-birth-weight infants discharged from NICU. METHODS: This study was performed on 217 low-birth-weight infants discharged from NICU and 126 normal term infants born in Presbyterian Medical Center from January 1992 to December 1994. RESULTS: Low-birth-weight infants discharged from NICU had higher rates of rehospitalization than normal term infants. Twenty-nine percent of low-birth-weight infants discharged from NICU were rehospitalized, compared with 12.7% of normal term infants(P<0.001). Rates of rehospitalization by birth weight was 45.5% in infants of 1500g or less and 31.2% in infants of 1500-1999g of birth weight. The rates of rehospitalization increased as birth weight decreased (P<0.001), but there was no significant difference between 16.4% in infants of 2000-2500g of birth weight and 12.7% of normal term infants(P=0.442). Reasons for rehospitalization of low bith weight infants were respiratory problem(63.1%), congenital/developmental problem(10.8%), surgical problem(9.2%), G-I problem(7.7%), ophthalmic problem(3.1%), and cardiac problem(1.5%). Neonatal risk factors related to rehospitalization of low birth weight infants were mechanical ventilation, duration of mechanical ventilation, bronchopulmonary dysplasia and duration of hospitalization(P<0.01). CONCLUSION: Rates of rehospitalization increased accordingly to decreasing birth weight. The most common cause of rehospitalization was respirartory problem. Neonatal risk factors related to rehospitalization were mechanical ventilation, bronchopulmonary dysplasia and duration of hospitalization. The data suggest that high risk infants of rehospitalization require close follow up.
Birth Weight
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Bronchopulmonary Dysplasia
;
Hospitalization
;
Humans
;
Infant
;
Infant, Low Birth Weight*
;
Infant, Newborn
;
Protestantism
;
Respiration, Artificial
;
Risk Factors
9.A Case of Benign Cephalic Histiocytosis.
Jun Young SEONG ; Woong Suk CHAE ; Ha Na JUNG ; Ho Seok SUH ; Yu Sung CHOI
Korean Journal of Dermatology 2014;52(8):587-588
No abstract available.
Histiocytosis*
10.An Evaluation of the Accuracy of Mini-Wright Peak Flow Meter.
Young Il KOH ; In Seon CHOI ; Hyun Ju NA ; Seok Chae PARK ; An Soo JANG
Tuberculosis and Respiratory Diseases 1997;44(2):298-308
BACKGROUND: Portable devices for measuring peak expiratory flow(PEF) are now of proved value in the diagnosis and management of asthma and many lightweight PEF meters have become available. However, it is necessary to determine whether peak expiratory flow rate(PEFR) measurements measured with peak flowmeters is accurate and reproducible for clinical application. The aim of the present study is to define accuracy, agreement, and precision of mini-Wright peak flow meter(MPFM) against standard pneumotachygraph. METHODS: The lung function tests by standard pneumotachygraph and PEFR measurement by MPFM were performed in a random order for 2 hours in 22 normal and 17 asthmatic subjects and also were performed for 3 successive days in 22 normals. RESULTS: The PEFR measured with MPFM was significantly related to the PEFR and FEV1 measured with standard pneumotachygraph in normal and asthmatics(for PEFR, r=0.92 p<0.001; for FEV1, r=0.78 ; p<0.001). The accuracy of MPFM was within 10%(limits of accuracy recommeded by NAEP) in all the subjects or 22 normal, mean difference from standard pneumotachygraph being I 6.5L/min(percentage of difference being 2.90%) or 1 0.6L/min(percentage of difference being 1.75%), respectively. According to the method proposed by Bland and Altman, the 95% limits of the distribution of differences between MPFM and standard pneumotachygraph after correction of PEFR using our regression equation were +38.2 and -71.5L/min in all the subjects or -20.49~ + 9.49L/min in 22 normal and was similar to the intraindividual agreements for 3 successive days in normal. There was no statistically significant difference of PEFR measured with MPFM and standard pneumotachygraph among three days(p>0.05) and the coefficient of variation(2.4 1.2%) of PEFR measured with MPFM was significantly lower than that( 5.2 3.5%) with standard pneurnotachygraph in normal (p<0.05). CONCLUSION: This results suggest that the MPFM was as accurate and reproducible as standard pneumotachygraph for monitoring of PEFR in the asthmatic subjects.
Asthma
;
Diagnosis
;
Flowmeters
;
Peak Expiratory Flow Rate
;
Respiratory Function Tests