A dedifferentiated liposarcoma is a uncommon neoplasm characterized by the coexistence of a well-differentiated liposarcoma and non-lipogenic sarcomas. A peculiar neural-like or meningothelial-like whorling pattern of dedifferentiation has recently been reported. We report a case of dedifferentiated liposarcoma with a peculiar whorling pattern in the scrotum of a 76-year-old man. Histologically, the tumor consisted of areas of a well differentiated liposarcoma admixed with areas of a morphologically non-lipogenic sarcoma. The whorls were scattered throughout the tumor. The cells in the whorls and dedifferentiated area showed a significant nuclear PCNA and p53 protein reactivity.
Aged ; Humans ; Liposarcoma* ; Proliferating Cell Nuclear Antigen ; Sarcoma ; Scrotum

BACKGROUND: No-reflow is a specific type of vascular damage occuring when removal of coronary occlusion dose not lead to restoration of coronary flow. There are three major explanations for the no-reflow phenomenon such as endothelial cell edema, microvascular plugging by platelets or thrombi and coronary occlusion by ischemic contracture of the myocardium. But detailed mechanisms of no-reflow phenomenon are not known. The objects of this study are to elucidate the possibility whether elevation of cytosolic Ca2+ concentration during ischemic cardioplegic period is mechanism of no-reflow phenomenon or not. METHODS: Changes in cytosolic Ca2+ concentration were measured under varying experimental condition. Free [Ca2+] in the cytosole [Ca2+]i of single rabbit coronary artery cells was measured with fluorescent Ca2+ indicator, Fura-2. RESULTS: Resting [Ca2+]i was 134.2+/-34 nM (n=43). When single cells were perfused with cardioplegic or ischemic cardioplegic solution, [Ca2+]i was significantly increased and degree of [Ca2+]i elevation was further augmented by ischemic cardioplegic solution. Pretreatment of sarcoplasmic reticulum emptying agent (20mM caffeine) had no effect on cardioplegia-induced [Ca2+]i change, but application of Ca2+ channel blocker (5x10-7M nifedipine) or an antagonist of Na+/Ca2+ exchange (5mM Ni2+ ) partially (nifedipine) or completely (nickel) inhibited the [Ca2+]i elevation. Pretreament of caffeine had no effect on ischemic cardioplegia-induced [Ca2+]i change, but application of nifedipine or nickel partially inhibited the [Ca2+]i elevation. Magnitude of ischemic cardioplegia-induced [Ca2+]i elevation was dependent on the Ca2+ concentration of perfusate from 0 to 2.5mM. When Ni2+ was added to reperfusion solution, recovery of ischemic cardioplegia-induced [Ca2+]i elevation was very rapid compared with control. CONCLUSIONS: From the above results, it may be speculated that ischemic cardioplegia-induced [Ca2+]i elevation may act as one of the mechanism of no-reflow phenomenon in rabbit coronary artery.
Caffeine ; Cardioplegic Solutions ; Coronary Occlusion ; Coronary Vessels* ; Cytosol* ; Edema ; Endothelial Cells ; Fura-2 ; Ischemic Contracture ; Muscle, Smooth* ; Myocardium ; Myocytes, Smooth Muscle* ; Nickel ; Nifedipine ; No-Reflow Phenomenon ; Reperfusion ; Sarcoplasmic Reticulum

No abstract available.
Arteriovenous Fistula* ; Humans ; Renal Dialysis*

No abstract available.
Arteriovenous Fistula* ; Humans ; Renal Dialysis*

Tubulolobular carcinoma is a tumor of the breast that shares histologic features of both tubular and lobular carcinoma of the breast. The cytologic features of this neoplasm have not been reported in Korea. We described a case of tubulolobular carcinoma diagnosed by fine needle aspiration cytology in a 46-year-old female. The tumor contained several cytologic features of both tubular and lobuar carcinoma, including tubular structures, single filing of cells, intracytoplasmic vacuoles, and low nuclear grade.
Biopsy, Fine-Needle* ; Breast* ; Carcinoma, Lobular ; Female ; Humans ; Korea ; Middle Aged ; Vacuoles

Despite the availability of second-generation antipsychotic drugs, chlorpromazine is still commonly used in Korea and many other countries due to its cost effectiveness, particularly for patients experiencing psychomotor excitement. Adverse effects of chlorpromazine include photosensitivity and phototoxic and photoallergic skin reactions. We present a case of severe photoallergic skin reactions to chlorpromazine that developed 3 days after use of the drug. The skin lesions resolved completely within one week after stopping the drug. A previous history of exposure to chlorpromazine was unknown and the patient had never previously experienced any form of drug-induced photosensitivity. This case highlights the need for awareness of the cutaneous adverse effects of chlorpromazine and the importance of educating patients.

Three-types of expandable metallic stents were constructed to evaluate the differences between the stents : one, formed in a cylindrical zigzag pattern with stainless steel wire (Gianturco stent), another, made by coating the Gianturco stent with silicone rubber(Silicone stent), the third, made by coating the Gianturco stent with 24 carat gold(God stent) for tissue acceptance. A total of 69 stents(each 23 stents of Glanturco, Silicone, and Gold stents) of 8-12 mm in diameter and 20 mm long were placed into normal abdominal aorta, inferior vena cava and iliac artery of nine adult dogs for 2 weeks to 11 months. It was more difficult to introcuce Silicone stent into an introducing sheath than Gianturco or Gold stent due to the thickness of silicone rubber, Four Gianturco stents and three Silicone stents showed migration but Gold stent did not. Luminal narrowing or occlusion was noted in 3 Silicone stents, in 2 Gianturco stents, and in 1 Gold stent. Neointimal proliferation over the stent wires was more rapid and even in God stent than Silicone or Gianturco stent. Although further study is needed, Gold stent seems to be better than Gianturco or Silicone stent as an endovascular graft material.
Adult ; Animals ; Aorta, Abdominal ; Dogs* ; Humans ; Iliac Artery ; Phenobarbital ; Silicon ; Silicone Elastomers ; Silicones ; Stainless Steel ; Stents* ; Transplants ; Vena Cava, Inferior

To make an accurate diagnosis of esophageal rupture during balloon dilatation without the help of esophagograph, an infusion pump, a pressure transducer and a radiopaque esophageal balloon were connected through a three-way connector. The pressure transducer was connected consecutively to an amplifier, a differentiator and a speaker to detect a pressure drop in the esophageal balloon. Under fluoroscopic monitoring, a radiopaque balloon catheter was inserted in the mid-thoracic esophagus of 30 rabbits and inflated with air until the esophagus was ruptured. A pressure drop in the balloon at the time of esophageal rupture was not only recorded graphically, but also was identified through a speaker. To examine esophageal rupture grossly, the rabbits were sacrificed after esophagography. We could detect the time of esophageal rupture during balloon dilatation in all rabbits accurately by observing the pressure drop on the pressure recorder and by hearing the sound made on a speaker. In 8 patients with esophageal stricture, a deflated radiopaque balloon catheter was inserted to the position inside the narrowing point and inflated by injecting air until the 'hourglass' deformity created by the stricture disappeared from the balloon contour which the pressure change in the balloon was monitored with a pressure recorder. The balloon pressures at the time of disappearance of the "hourglass" deformity from the balloon contour ranged from 200 mmHg to 2000 mmHg in 8 patients with esophageal strictures. Esophageal ruptured did not occur in these patients. In conclusion, our results indicate that this new method is not only safe but promising for patients in the future with esophageal strictures. First, it would reduce the chance of mediastinitis in patients of esophageal rupture. Second, esophageal balloon dilatation can be performed more effectively and safely. Third, it is cost-effective. Forth, radiation esposure to the patient can be reduced.
Catheters ; Congenital Abnormalities ; Constriction, Pathologic ; Diagnosis* ; Dilatation ; Esophageal Stenosis ; Esophagus ; Hearing ; Humans ; Infusion Pumps ; Mediastinitis ; Methods ; Rabbits ; Rupture* ; Transducers, Pressure

To make an accurate diagnosis of esophageal rupture during balloon dilatation without the help of esophagograph, an infusion pump, a pressure transducer and a radiopaque esophageal balloon were connected through a three-way connector. The pressure transducer was connected consecutively to an amplifier, a differentiator and a speaker to detect a pressure drop in the esophageal balloon. Under fluoroscopic monitoring, a radiopaque balloon catheter was inserted in the mid-thoracic esophagus of 30 rabbits and inflated with air until the esophagus was ruptured. A pressure drop in the balloon at the time of esophageal rupture was not only recorded graphically, but also was identified through a speaker. To examine esophageal rupture grossly, the rabbits were sacrificed after esophagography. We could detect the time of esophageal rupture during balloon dilatation in all rabbits accurately by observing the pressure drop on the pressure recorder and by hearing the sound made on a speaker. In 8 patients with esophageal stricture, a deflated radiopaque balloon catheter was inserted to the position inside the narrowing point and inflated by injecting air until the 'hourglass' deformity created by the stricture disappeared from the balloon contour which the pressure change in the balloon was monitored with a pressure recorder. The balloon pressures at the time of disappearance of the "hourglass" deformity from the balloon contour ranged from 200 mmHg to 2000 mmHg in 8 patients with esophageal strictures. Esophageal ruptured did not occur in these patients. In conclusion, our results indicate that this new method is not only safe but promising for patients in the future with esophageal strictures. First, it would reduce the chance of mediastinitis in patients of esophageal rupture. Second, esophageal balloon dilatation can be performed more effectively and safely. Third, it is cost-effective. Forth, radiation esposure to the patient can be reduced.
Catheters ; Congenital Abnormalities ; Constriction, Pathologic ; Diagnosis* ; Dilatation ; Esophageal Stenosis ; Esophagus ; Hearing ; Humans ; Infusion Pumps ; Mediastinitis ; Methods ; Rabbits ; Rupture* ; Transducers, Pressure

OBJECTIVES: The aim of this study was to examine changes in the dentinal fluid flow (DFF) during desensitizing agent application and to compare permeability after application among the agents. MATERIALS AND METHODS: A Class 5 cavity was prepared to exposure cervical dentin on an extracted human premolar which was connected to a sub-nanoliter fluid flow measuring device (NFMD) under 20 cm water pressure. DFF was measured from before application of desensitizing agent (Seal&Protect, SP; SuperSeal, SS; BisBlock, BB; Gluma desensitizer, GL; Bi-Fluoride 12, BF) through application procedure to 5 min after application. RESULTS: DFF rate after each desensitizing agent application was significantly reduced when compared to initial DFF rate before application (p < 0.05). SP showed a greater reduction in DFF rate than GL and BF did (p < 0.05). SS and BB showed a greater reduction in DFF rate than BF did (p < 0.05). CONCLUSIONS: Characteristic DFF aspect of each desensitizing agent was shown in NFMD during the application procedure.
Bicuspid ; Dentin ; Dentin Sensitivity ; Dentinal Fluid ; Glutaral ; Humans ; Methacrylates ; Oxalic Acid ; Permeability ; Water