1.Hypotensive Efficacy and Safety of Manidipine on the Patient with Essential Hypertension.
Won Sang YOO ; Young Bin JEON ; Sang Hyun PARK ; Chang Young LIM ; Suck Koo CHOI
Korean Circulation Journal 1991;21(2):350-355
Thirty patient with essential hypertension were administered Manidipine, a new calcium antagonist, 10~20mg once daily to evaluate the hypotensive efficacy and safety for 8 weeks. And the followings were the result. 1) Patients were consists of 14 male, 16 female, aged 53 in average and classified as mild in 21 and moderate in 9 patients. 2) Optimum intial dose was 10mg and 10 to 20mg were the doses recommended. 3) Blood pressure dropped after 8 weeks 24/13mmHg in average, rewarding 80% effectiveness and normalized in 87%. 4) Most frequent side reaction was facial flushing in 5 patiens followed by palpitation and dizziness, all of which did not disturb the continuation of medication. 5) Most of routine laboratory parameter were normal and unchanged between before and after the trial. 6) Overall rating of usefulness was 77%. In conclusion, Manidipine 10 to 20mg once daily regimen is well tolerated and effective in the treatment of mild to moderate essential hypertension.
Blood Pressure
;
Calcium
;
Dizziness
;
Female
;
Flushing
;
Humans
;
Hypertension*
;
Male
;
Reward
2.Effects of Tripamide(Tripamol(R)) on Serum Lipids and Hypertension.
Young Bin JEON ; Myun Ho KIM ; Suck Koo CHOI ; Won Sang YOO
Korean Circulation Journal 1985;15(3):467-471
The antihypertensive effects and serial changes of serum lipids were observed in 17 patients with essential hypertension, administered daily 30-60mg dose of Tripamide(Tripamol(R)) for 8 weeks. The results were as follows ; 1) After 8 weeks treatment, there is no change of serum total cholesterol, serum triglyceride and HDL-cholesterol were decreased by 3.2mg/dl(-1.9%) and 0.9mg/dl(-2.8%) respectively. The changes were not significant statistically. 2) After 8 weeks treatment, mean systolic and diastolic blood pressure were decreased by 11.2mmHg(-6.8%) and 7.7mmHg(-7.3%). 3) No significant side effect was observed during treatment except of 2 patients of mild headache and insomnia.
Blood Pressure
;
Cholesterol
;
Headache
;
Humans
;
Hypertension*
;
Sleep Initiation and Maintenance Disorders
;
Triglycerides
3.Reproducibility of Ambulatory Electrocardiography.
Suck Koo CHOI ; Kun Joo RHEE ; Young Bin JEON ; Won Sang YOO ; Dong Chul LEE
Korean Circulation Journal 1991;21(3):646-651
To evaluate the reproducibility of the Ambulatory Electrocardiography (AECG), we examined the consistency rates of premature beats between the baseline AECG's and the repeat AECG's in 23 patients who underwent AECG's times within 1 year. 12 patients were male and 11 patients were female. Their mean age was 48 years. (Range ; 20 years-75 years) The time interval between both AECG's was 1 month 20 days. (Range ; 1 day-9months) They did not take any antiarrhythmic druge during the observation period except 4 patients who were taking calcium channel blockers or beta receptor blockers for hypertensive heart disease or ischemic heart disease. The consistency rate of both frequency and complexity of ventricular premature beats was 52%. The consisency rate of both frequency and complexity of supraventicular premature beats was 35%. These consistency rates seemed to vary as the time interval between both AECG's differed. In the case of ventricular premature beats, the consistency rates of 1 day, 8 days and 5 months as the time interval were 100%, 38% and 14% respectively. In the case of supraventricular premature beats, the consistency rates were 50%, 25% and 29%. We concluded that the reproducility of the AECG was low and this reproducibility became lower as the time interval between both AECG's became longer and that hese facts had to be considered when the effect of the antiarrhythmic drugs was evaluated.
Anti-Arrhythmia Agents
;
Calcium Channel Blockers
;
Cardiac Complexes, Premature
;
Electrocardiography, Ambulatory*
;
Female
;
Heart Diseases
;
Humans
;
Male
;
Myocardial Ischemia
4.Multiple Sclerosing Hemangiomas of the Lung: A Case Report.
Soon Ho CHON ; Tae Yol JUNG ; Yang Bin JEON ; Won Sang CHUNG ; Young Hak KIM ; Jung Ho KANG ; Heng Ok JEE ; Eun Kyung HONG ; Seok Chul JEON
The Korean Journal of Thoracic and Cardiovascular Surgery 1999;32(4):408-412
Since sclerosing hemangioma of the lung was first described by Liebow and Hubbell in 1956, there have been several reports on cases occurring as a solitary nodule; however, sclerosing hemangiomas occurring as multiple nodules are extremely rare. The histogenesis of this tumor remains controversial and there are several hypotheses of the etiology. Three separate nodules were found in a 57-year-old housewife, one found in the right middle lobe, one in the apicoposterior segment of the left upper lobe, and one in the superior segment of the left lower lobe. The only symptom or sign presented was a dry cough. Apicoposterior segmentectomy of the left upper lobe and wedge resection of the superior segment of the left lower lobe were performed. The postoperative course was uneventful and the patient was discharged on the postoperative 15th day.
Cough
;
Hemangioma
;
Histiocytoma, Benign Fibrous*
;
Humans
;
Lung Neoplasms
;
Lung*
;
Mastectomy, Segmental
;
Middle Aged
;
Pulmonary Sclerosing Hemangioma
5.The Significance of Electroencephalography in the Hypothermic Circulatory Arrest in Human.
Yang Bin JEON ; Chang Ha LEE ; Chan Young NAH ; Jung Ho KANG
The Korean Journal of Thoracic and Cardiovascular Surgery 2001;34(6):465-471
BACKGROUND: Hypothermia protects the brain by suppressing the cerebral metabolism and it is performed well enough before the total circulatory arrest(TCA) in the operation of aortic disease. Generally, TCA has been performed depending on the rectal or nasopharyngeal temperatures; however, there is no definite range of optimal temperature for TCA or an objective indicator determining the temperature for safe TCA. In this study, we tried to determine the optimal range of temperature for safe hypothermic circulatory arrest by using the intraoperative electroencephalogram(EEG), and studied the role of EEG as an indicator of optimal hypothermia. MATERIAL AND METHOD: Between March, 1999 and August 31, 2000, 27 patients underwent graft replacement of the part of thoracic aorta using hypothermia and TCA with intraoperative EEG. The rectal and nasopharyngeal temperatures were monitored continuously from the time of anesthetic induction and the EEG was recorded with a ten-channel portable electroencephalography from the time of anesthetic induction to electrocerebral silence(ECS). RESULT: On ECS, the rectal and nasopharyngeal temperatures were not consistent but variable(rectal 11degree C -25degree C, nasopharynx 7.7degree C -23degree C). The correlation between two temperatures was not significant(p=0.171). The cooling time from the start of cardiopulmonary bypass to ECS was also variable(25-127min), but correlated with the body surface area(p=0.027). CONCLUSION: We have found that ECS appeared at various body temperatures, and thus, the use of rectal or nasopharyngeal temperature were not useful in identifying ECS. Conclusively, we can not fully assure cerebral protection during hypothermic circulatory arrest in regards to the body temperatures, and therefore, the intraoperative EEG is one of the necessary methods for determining the range of optimal hypothermia for safe circulatory arrest.
Aorta, Thoracic
;
Aortic Diseases
;
Body Temperature
;
Brain
;
Cardiopulmonary Bypass
;
Electroencephalography*
;
Humans*
;
Hypothermia
;
Metabolism
;
Nasopharynx
;
Transplants
6.The Childbirth Experience and Life Satisfaction among Women with Disabilities
Su-Bin MA ; Young-Min CHOI ; Minyoung LEE ; Boyoung JEON
Journal of the Korean Society of Maternal and Child Health 2023;27(1):32-44
Purpose:
The aim of this study was to show the association between the childbirth experience and life satisfaction among women with disabilities and estimate the moderating effect of family strengths and social support.
Methods:
The target sample included disabled married women aged 20-49 years. We used the Disability and Life Dynamics Panel 2018. The total number of participants was 220. Three groups were defined based on the childbirth experience: women who had never given birth (13.6%), those who gave birth before the onset of disability (73.2%), and those who gave birth after the onset of disability (13.2%). We identified differences in general characteristics, family strengths, social support, and life satisfaction across the 3 groups and examined the moderating effect of family strengths and social support for the childbirth experience and life satisfaction.
Results:
Women who gave birth after the onset of disability were in better health, exhibiting longer disability retention periods. The multiple regression analysis revealed that among women who gave birth after the onset of disability, life satisfaction was significantly higher than that of women without the childbirth experience because of the moderating effect of family strengths. However, social support had no significant effect on the childbirth experience and life satisfaction.
Conclusion
We empirically analyzed the status of childbirth before and after the onset of disability using representative survey data. The findings indicate a positive moderating effect of family strengths on the level of life satisfaction among women with disabilities.
7.A Compound Heterozygous Pathogenic Variant in B4GALNT1 Is Associated With Axonal Charcot-Marie-Tooth Disease
Ji-Man HONG ; Hyeonjin JEON ; Young-Chul CHOI ; Hanna CHO ; Young Bin HONG ; Hyung Jun PARK
Journal of Clinical Neurology 2021;17(4):534-540
Background:
and PurposePathogenic variants in B4GALNT1 have been reported to cause hereditary spastic paraplegia 26. This study has revealed that a novel compound heterozygous pathogenic variant in B4GALNT1 is associated with axonal Charcot-Marie-Tooth disease (CMT).
Methods:
Whole-exome sequencing (WES) was used to identify the causative factors and characterize the clinical features of a Korean family with sensorimotor polyneuropathy. Functional assessment of the mutant genes was performed using a motor neuron cell line.
Results:
The WES revealed a compound heterozygous pathogenic variant (c.128dupC and c.451G>A) in B4GALNT1 as the causative of the present patient, a 53-year-old male who presented with axonal sensorimotor polyneuropathy and cognitive impairment without spasticity. The electrodiagnostic study showed axonal sensorimotor polyneuropathy. B4GALNT1 was critical to the proliferation of motor neuron cells. The compensation assay revealed that the pathogenic variants might affect the enzymatic activity of B4GALNT1.
Conclusions
This study is the first to identify a case of autosomal recessive axonal CMT associated with a compound heterozygous pathogenic variant in B4GALNT1. This finding expands the clinical and genetic spectra of peripheral neuropathy.
8.A Compound Heterozygous Pathogenic Variant in B4GALNT1 Is Associated With Axonal Charcot-Marie-Tooth Disease
Ji-Man HONG ; Hyeonjin JEON ; Young-Chul CHOI ; Hanna CHO ; Young Bin HONG ; Hyung Jun PARK
Journal of Clinical Neurology 2021;17(4):534-540
Background:
and PurposePathogenic variants in B4GALNT1 have been reported to cause hereditary spastic paraplegia 26. This study has revealed that a novel compound heterozygous pathogenic variant in B4GALNT1 is associated with axonal Charcot-Marie-Tooth disease (CMT).
Methods:
Whole-exome sequencing (WES) was used to identify the causative factors and characterize the clinical features of a Korean family with sensorimotor polyneuropathy. Functional assessment of the mutant genes was performed using a motor neuron cell line.
Results:
The WES revealed a compound heterozygous pathogenic variant (c.128dupC and c.451G>A) in B4GALNT1 as the causative of the present patient, a 53-year-old male who presented with axonal sensorimotor polyneuropathy and cognitive impairment without spasticity. The electrodiagnostic study showed axonal sensorimotor polyneuropathy. B4GALNT1 was critical to the proliferation of motor neuron cells. The compensation assay revealed that the pathogenic variants might affect the enzymatic activity of B4GALNT1.
Conclusions
This study is the first to identify a case of autosomal recessive axonal CMT associated with a compound heterozygous pathogenic variant in B4GALNT1. This finding expands the clinical and genetic spectra of peripheral neuropathy.
9.Arginine Vasopressin Therapy of Vasodilatory Shock after Cardiopulmonary Bypass : Two cases.
Young Chan AHN ; Chul Hyun PARK ; Jae Ik LEE ; Yang Bin JEON ; Kook Yang PARK
The Korean Journal of Thoracic and Cardiovascular Surgery 2006;39(1):60-63
Vasodilatory shock has been implicated in life-threatening complications after cardiac surgery. This syndrome may result from the vasopressin deficiency following cardiopulmonary bypass (CPB), which do not respond to fluids or usual intravenous inotropes. We used arginine-vasopressin in adults with vasodilatory shock coming off cardiopulmonary bypass. Therefore, we report these cases with a review of articles.
Adult
;
Arginine Vasopressin*
;
Arginine*
;
Cardiopulmonary Bypass*
;
Diabetes Insipidus, Neurogenic
;
Humans
;
Shock*
;
Thoracic Surgery
;
Vasodilation
;
Vasopressins
10.Analysis of Weight Control Behaviors by Body Image Perception among Korean Women in Different Age Groups: Using the 2010 Korea National Health and Nutrition Examination Survey Data.
Young Suk LIM ; Na Ri PARK ; Su Bin JEON ; So Yeon JEONG ; Zuunnast TSERENDEJID ; Hae Ryun PARK
Korean Journal of Community Nutrition 2015;20(2):141-150
OBJECTIVES: Self perceived body image among women is drawing a lot of attention in Korea due to their unhealthy weight control behaviors. To determine the relationship between self-perceived body image and dietary behaviors among Korean women, the discrepancy between actual body size and body image perception, weight control behaviors were assessed based on age groups using the 2010 KNHANES data. METHODS: A total of 1,747 subjects were selected after eliminating those of likely changing their diet recently using the 2010 KNHANES data. The subjects were divided into 3 groups, self-underweight, self-normal, and self-obese according to their perception of body image. The BMI and weight control behaviors were assessed based on age groups according to the body image perception. RESULTS: The younger, the higher ratio of underweight, women perceived their body size as normal or overweight. Exercise and reduced food intakes were dominant among various weight control methods but unhealthy methods were dominant among self perceived overweight group. CONCLUSIONS: Incorrect body image perception and unhealthy weight control behaviors can cause nutritional problems. Nutritional education should emphasize the importance of healthy weight and proper body image perception for Korean women.
Body Image*
;
Body Size
;
Diet
;
Education
;
Female
;
Humans
;
Korea
;
Nutrition Surveys*
;
Overweight
;
Thinness
;
Weight Perception