No abstract available.
Anticonvulsants* ; Drug Therapy* ; Polypharmacy*

No abstract available.
Humans

No abstract available.
Child* ; Crowding* ; Humans

No abstract available.
Facial Asymmetry*

No abstract available.

No abstract available.
Animals ; Fetus* ; Rats*

The high incidence of intestinal parasites among the Korean people almost same as 40 years ago might be partly interpreted by the fact that they are all fond of raw vegetables cultivated on the farms fertilized with non-treated night soil. The cabbages, onions and radishes were collected from the five areas of Seoul vicinity and the number of parasites attached to those vegetables were investigated to compare with the results obtained 10 years ago by the same methods of sampling and examination as the present survey. The resultant findings were summarized as follows: The eggs of Ascaris, hookworm, Trichostrongylus and whipworm, rhabditoid larvae and filariform larvae of hookworms were detected from those vegetables. Additionally, a number of larvae of free living nematodes and morphologically undetermined eggs were also observed. The maximum number of parasites found from one vegetable were as follows: 16 Ascaris eggs on a cabbage, 27 hookworm eggs on an onion, 8 whipworm eggs on a cabbage, 68 filariform larvae of hookworm on an onion. The onions were highly contaminated by the number of parasites as much as 177.6 including the larvae of free living nematodes, the next being the cabbages with 25.3 and the radishes with 4.1 in average. No notable relationship was observed between the size of vegetables and the number of parasites attached to them. Ascaris eggs were found from 56 percent of all cabbages, 28 percent of the onions and 40 percent of the radishes; whipworm eggs were detected on 40 percent of radishes and the filariform larvae of hookworms were observed from 40 percent of onions examined. It may be concluded that there is no notable change in the number of parasites attached to the vegetables collected from the Seoul vicinity compared to the results investigated by the same method 10 years ago.
parasitology-helminth-nematoda-Ascaris ; hookworm ; Trichuris trichiura ; epidemiology ; vegetable

Pyuria, pain and hematuria are the predominant symptoms in urologic diseases. Among them hematuria is the most important complaint referable to the urinary tract in both children and adults Accordingly, hematuria should never be ignored, and no matter how trivial the bleeding a complete urologic investigation into itscause is mandatory. A statistical survey was made on hematuria of the in-patientsin the Department of Urology at ST. Mary's Hospital, during the two years from August 1966 to July 1968 and the following results were obtained. 1. During that period. out of 437 cases who were hospitalized, 246 cases(179 males and 67 females) had hematuria, giving a rate of 5t percent (gross: 24 percent, micro-hematuria: 30 percent) 2. More than 70 percent of all the cases of hematuria processed were found to be calculus, tumor and tuberculosis of the genitourinary tract. 3. Most frequent incidences of hematuria 'were shown to be trauma in children, while calculus, tuberculosis and tumor in young and middle aged group, and tumor in old aged group as well. 4. Among 141 cases of micro-hematuria, grade I showed 78 cases(55 percent) 5. The location of bleeding in 1O5 cases of gross hematuria was in the kidney by 40 percent, bladder, ureter and urethra in that order of frequency.
Adult ; Calculi ; Child ; Hematuria* ; Hemorrhage ; Humans ; Incidence ; Kidney ; Male ; Middle Aged ; Pyuria ; Tuberculosis ; Ureter ; Urethra ; Urinary Bladder ; Urinary Tract ; Urolithiasis ; Urologic Diseases* ; Urology

PURPOSE: Platinum coordination complex (cisplatin) has been currently used as one of the most effective compound in the treatment of various solid tumors. However, its use has been limited by severe side effects such as renal toxicity. Our platinum-based drug discovery program has been aimed at developing drugs capable of diminishing toxicity and selective cytotoxicity. MATERIALS AND METHODS: A new series of highly water soluble platinum (II) complexes Pt (II) [1,3-Bis (phenylthio) propane) (trans-l-1,2-diaminocyclohexane) (PC-1) and Pt (II) [1,3-Bis-(phenylthio) (propane)]-1,2-diaminocyclohexane (PC-2) were synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (.IR), ""C-nuclear magnetic resonance (NMR)]. In vitro antitumor activity and nephrotoxi -cities of new Pt (II) complexes were tested against MKN-45 human gastric cancer cell- lines and normal kidney cells using colorimetric MTT[3-(4,5-dimethyl thiazol-2-yl)-2,5- diphenyl tetrazolium bromide] assay for cell survival and proliferation. RESULTS: PC-1 showed activity against MKN-45/P and MKN-45/CDDP human gastric adenocarcinoma cells, and the antitumor activity of this compound was comparable or superior to that of PC-2 and cisplatin. The nephrotoxicity of PC-1 and PC-2 were found quite less than that of cisplatin using MTT, [H] thymidine uptake and glucose consumption tests in rabbit proximal tubule cells, human kidney cortical cells and human renal cortical tissues. CONCLUSION: Based on these results, this novel platinum (II) complex compound (PC-1) represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.
Adenocarcinoma ; Cell Survival ; Cisplatin ; Drug Discovery ; Glucose ; Humans* ; Kidney* ; Platinum ; Stomach Neoplasms* ; Thymidine

No abstract available.
Parkinsonian Disorders*