Failure of a glaucoma filtering surgery mainly results from scarring at thefiltering wound. Postoperative proliferation of fibroblasts plays an imrortant role in scar tissue formation. Colchicine is a cytoplasmic microtubule inhibitor capable of inhibiting fibroblast proliferation. The effect of colchicine on fibroblast proliferation at the filtering wound after filtering surgery was investigated. Posterior lip sclerectomies were performed in each eye of albino rabbits.Intraocular pressures, conjunctival fibrosis, histologic findings and drug tox-icities were examined postoperatively under the topical or oral administration of colchicine. Reductions of intraocular Pressure and conjunctival fibrosis in colchicinetreated groups after filtering surgory were statistically significant (p< 0.05), and changes in the topical administration group were more significant than in the oral administration group (pl 0.05). Histologicallyr reductions of active fibroblasts and collagen fibers at the filtering wound and the subconjunctival area were seen in colchicine treated eyes.Histologic changes were more prominent in the topical administration group. Signs of orular and systemic toxicity were absent. The above results suggest that administration of colchicine, especially topicaladministration, can increase the success rate of filtering surgery.
Administration, Topical ; Animals ; Colchicine/*pharmacology ; Fibroblasts/*drug effects ; Glaucoma/*surgery ; Rabbits

The Taylor's approach is a special paramedian approach to enter the L5-S1 interspace. The L5-S1 interspace is the largest in vertebral column. This approach is particularly useful when the interspace has been narrowed by pathologic bone destruction such as rheumatoid arthritis or osteoarthritis. Surgery in geriatric patients is associated with a markedly higher incidence of perioperative complication or mortality rate. Optimal anesthetic management of geriatric patients depends on understanding of the normal anatomy and physiologic changes in response to drug in aging. We studied of 3-geriatric patients with Taylor's approach. These patients had problems with respiratory dysfunction and anatomic constraints, which make other approaches unfeasible.
Aging ; Arthritis, Rheumatoid ; Humans ; Incidence ; Mortality ; Osteoarthritis ; Spine

The Korean 30 glaucoma patients, 38 eyes were examined. The intraocular pressure was measured by Goldmann applanation tonometer. It was estimated that the intraocular pressure drop rate by instillation of 0.5% timolol eye drops was average 27.7% compared to the intraocular pressure of pre-treatment. There were no significant correlation between intraocular pressure drop rate by instillation of 0.5% timolol eye drops and the height of intraocular pressure of pre-treatment. It was considered that there will be needed some other glaucoma medication added to 0.5% timolol eye drops when pre-treatment intraocular pressure is over the 40mmHg. No any significant side-effects of drug was observed.
Glaucoma ; Humans ; Intraocular Pressure ; Ophthalmic Solutions ; Timolol*

No abstract available.
Meconium* ; Peritonitis*

Purpose: The electronic frailty index (eFI), which is derived from electronic health records, has been recommended as screening tool for frailty due to its accessibility and ease of use. The objective of this systematic review was to identify the prevalence of frailty assessed by the eFI and its influence on health outcomes in older adults with chronic diseases. Methods: We searched PubMed, Embase, Web of Science, CINAHL, SCOPUS, Cochrane, Google search, and nursing journals in Korean from January 2016 to December 2022. Results: Twelve studies were analyzed. The eFI score, based on routine clinical data, was associated with adverse health outcomes. The most frequent outcome studied was mortality, and the eFI was associated with increased mortality in nine studies. Other outcomes studied included hospitalization, length of stay, readmission, and institutionalization in relation to hospital care usage, and cardiovascular events, stroke, GI bleeding, falls, and instrumental activities of daily life as health conditions. Conclusion Early identification of frailty in older adults with chronic diseases can decrease the burden of disease and adverse health outcomes. The eFI has a good discriminative capacity to identify frail older adults with chronic diseases.

PURPOSE: To correlate SOhographic and pathologic findings of gallbladder adenoma, and to evaluate the clinical significance of sonographic findings. MATERIALS AND METHODS: Ultrasound findings of twenty gallbladder adenomas were retrospectively reviewed to evaluate the size, shape and echogenicity of the adenoma, and was correlated with the pathological finding. RESULTS: Among 14 patients, 11 patients had single lesion and 3 patients had multiple lesions. Three patients showed 2, 3 and 4 adenomas, respectively. Nine of 20 lesions showed focal dysplasia pathologically. Among the nine adenomas with dysplasia, two adenomas showed focal cancerous change. The nine adenomas showing focal dysplasia measured 25.6mm (14-35mm) in mean diameter, while the mean diameter of adenomas without dysplasia was 8.7 mm (3-13mm). The echogenicity of adenoma with focal dysplasia were hyperechoic in 8, isoechoic in 1. The echogenicity of adenomas without dysplasia were hyperechoic in 7, isoechoic in 4. Sessile(7/9) and papillary shape(6/9) were predominant in adenoma with dysplasia, but smooth shape(8/11) and stalked type(9/11) were predominant in adenoma without dysplasia. Two adenomas with focal cancerous change showed histological transition from cancer to dysplasia and to adenomatous tissue. In adenoma with dysplasia, the diameter more than 14 mm on sonography was statistically significant (p<0. 005). Also age of patient was significantly different between the two groups (p<0.01), while echogenicity and associated stone were not statistically significant. CONCLUSION: As gallbladder adenoma more than 14ram in diameter on US is suggestive of dysplasia on pathology, so, close follow up US or surgery is recommended.
Adenoma* ; Follow-Up Studies ; Gallbladder* ; Humans ; Pathology ; Retrospective Studies ; Ultrasonography

>The authors performed cycloplegic refractions in 180 eyes of 99 premature infants at the age of 6 months to evaluate the incidence and the degree of myopia according to the development and disease course of retinopathy of prematurity (ROP) and to investigate the effect of cryotherapy on the refractive error. The incidences of myopia were not different between premature infants without ROP and premature infants with spontaneously and totally regressed ROP (36.3%, 25.5%),and the degrees of myopia were low in both groups (-1.76 D, -2.25 D). In premature infants with totally regressed ROP after cryotherapy, the incidence of myopia was high (75.5%) but the degree of myopia was low (-3.03 D). In premature infants with cicatricial ROP, cryotreated or not, both the incidence and the degree of myopia were high (93.9%, -5.50 D). It is suggested that cryotherapyincreases the incidence of myopia but the degree of myopia induced by cryotherap y is low.
Cryosurgery ; Humans ; Incidence ; Infant ; Infant, Newborn ; *Infant, Premature ; Korea/epidemiology ; Myopia/*epidemiology ; Refraction, Ocular ; Retinopathy of Prematurity/epidemiology/surgery

The intraocular pressure and the anteroposterior length of the eye are of great clinical importance for the diagnosis and management, before and after surgery, of congenital glaucoma. It is well-known that the normal intraocular pressure in children is different from the normal levels in adults. We performed the measurements of the intraocular pressure and axial length in 141 children, who had been admitted for eye problem other than glaucoma. The intraocular pressures were measured with the Perkins hand-held applanation tonometer at the beginning of general anesthesia. Simultaneously, A-scan ultrasound measurements of the axial lengths of the eyes were made. In ten children under the age of 2 years, the intraocular pressure was 11.85 +/- 1.35mmHg. In seventy-nine children from 2 to 7 years, the intraocular pressure was 12.80 +/- 1.73mmHg. In fifty-two children from 7 to 15 years, the intraocular pressure was 13.31 +/- 1.79mmHg. The axial lengths of the eyes in children under the age of 2 years, from 2 to 7 years, from 7 to 15 years, were 21.31 +/- 0.97mm, 22.04 +/- 0.92mm, 23.22 +/- 1.00mm respectively. These results would be considered to be the guidelines of the measurement of the intraocular pressure and axial length in children with a suspicion of congenital glaucoma. The difference of the intraocular pressure from other authors would be due to the early measurement of the intraocular pressure at the beginn ing of general anesthesia.
Adult ; Anesthesia, General ; Child* ; Diagnosis ; Glaucoma ; Humans ; Intraocular Pressure* ; Ultrasonography

The intraocular pressure and the anteroposterior length of the eye are of great clinical importance for the diagnosis and management, before and after surgery, of congenital glaucoma. It is well-known that normal intraocular pressure in children is different from the normal levels in adults. We performed measurements of intraocular pressure and axial length in 141 children who had been admitted for eye problems other than glaucoma. The intraocular pressures were measured with the Perkins hand-held applanation tonometer at the beginning of general anesthesia. Simultaneously, A-scan ultra-sound measurements of the axial lengths of the eyes were made. In 10 children under the age of two years, the intraocular pressure was 11.85 +/- 1.35 mmHg. In 79 children from two to seven years, the intraocular pressure was 12.80 +/- 1.73 mmHg. In 52 children from seven to 15 years, the intraocular pressure was 13.31 +/- 1.79 mmHg. The axial lengths of the eyes in children under the age of two years, from two to seven years, and from seven to 15 years, were 21.31 +/- 0.97 mm, 22.04 +/- 0.92 mm, and 23.22 +/- 1.00 mm, respectively. These results were considered to be guidelines for measuring intraocular pressure and axial length in children suspected of having congenital glaucoma. The differences of intraocular pressures stated by other authors are due to early measurement of the intraocular pressure at the beginning of general anesthesia.
Adolescent ; Child ; Child, Preschool ; Eye/*anatomy & histology ; Female ; Humans ; Infant ; Infant, Newborn ; *Intraocular Pressure ; Male ; Reference Values ; Tonometry, Ocular

PURPOSE:We investigated the production of oxygen hydroxyl radicals in the striatum of neonatal rat brain after intrastriatal injection of dopamine (DA) and the effect of growth hormone (GH) on the apoptosis of striatal neurons injured by hypoxia-ischemia. METHODS:The extracellular striatal levels of 2,3-dihydroxybenzoic acid (DHBA) and 2,5-DHBA as indicators of hydroxyl radical(OH-) production were measured by in vivo microdialysis in the striatums of 7 day-old newborn rats (n=10) after direct intrastriatal infusion of dopamine hydrochloride (1.0 micromol/microL). The samples of perfused artificial cerebrospinal fluid (CSF) were collected every 10 minutes interval. The levels of DA, 2,3-DHBA and 2,5-DHBA of CSF were analysed by HPLC (high performance liquid chromatography). Also, the brains were removed at 24 hour after hypoxic-ischemic injury by Rice-Vannucci method. The coronal sections (12 micrometer) of paraffin-fixed brains were stained by TUNEL (terminal transferase-mediated dUTP nick-end-labelling) technique, and the neuronal cells undergoing apoptosis in the striatum were observed by fluorescent microscopy and compared between GH-treated (50 mg/kg, Dong-Ah Pharmacy Co.) and saline-treated rats. RESULTS:The extracellualr striatal levels of 2,3-DHBA and 2,5-DHBA increased abruptly in the first 10 minutes samples after intrastriatal injection of DA. After then, the levels declined slowely. The levels of striatal extracelluar 2.3-DHBA increased up to 621.8+/-508.7% of basal levels (P<0.05), and the levels of 2.5-DHBA increased up to 262.8+/-198.1% of basal levels (P<0.05). GH reduced markedly the number of apoptotic neuronal cells in the striatum after hypoxic-ischemic brain injury. CONCLUSION: The level of hydroxyl radicals increased abruptly after intrastriatal injection of DA and GH reduced markedly the number of apoptotic neuronal cells in the striatum after hypoxic-ischemic brain injury.
Animals ; Apoptosis* ; Brain Injuries ; Brain* ; Cerebrospinal Fluid ; Chromatography, High Pressure Liquid ; Dopamine* ; Growth Hormone* ; Humans ; Hydroxyl Radical* ; In Situ Nick-End Labeling ; Infant, Newborn* ; Microdialysis ; Microscopy ; Neurons* ; Oxygen ; Pharmacy ; Rats*