No abstract available.
Leukemia*

The purpose of this study was to investigate children's nutrient intakes by school lunch. Evaluation of nutrient intakes by school lunch for three days was conducted with 86 children in urban and 64 children in rural of Jeonbuk area. The results of this study were as follows. 1) With respect to amounts of provided nutrients in school lunch, CPF (carbohydrate : protein : fat) energy ratio was 48.6 : 19.7 : 31.6 in urban and was 46.7 : 20.5 : 32.7 in rural. Compared to 1/3 RDA (RDA) of children for 10-12 years, folic acid and zinc were provided below 50 % of RDA. Protein, fat, phosphorus, vitamin B1, vitamin B2, niacin, vitamin C and vitamin E were provided above 125 % of RDA. There were no differences in amounts of provided nutrients-except calcium, vitamin A, vitamin B6, folic acid and zinc-between urban and rural. 2) With respect to amounts of nutrient intakes, CPF energy ratio was 51.1 : 17.4 : 31.5 in urban and 47.5 : 19.7 : 32.7 in rural. Compared to RDA, folic and zinc were below 50 % of RDA. Iron and vitamin B6 were below 75 % of RDA. Protein, fat, phosphorus and vitamin E were above 125 % of RDA. There were significant differences in nutrient intakes between urban and rural. The children in rural showed higher levels of nutrient intakes-energy, carbohydrate, protein, fat, calcium, phosphorus, iron, zinc, vitamins and folic acid-compared to those of children in urban. These results suggest that programs are needed for providing adequate nutrient intakes for children in school lunch and for improving nutrient intakes of children in urban.
Ascorbic Acid ; Calcium ; Child ; Folic Acid ; Humans ; Iron ; Jeollabuk-do* ; Lunch* ; Niacin ; Phosphorus ; Riboflavin ; Thiamine ; Vitamin A ; Vitamin B 6 ; Vitamin E ; Vitamins ; Zinc

BACKGROUND/OBJECTIVES: This study explores the parental characteristics that affect the eating behaviors of preschool children. The nutrition quotient for preschool children (NQ-P) tool was applied to measure the eating behaviors of preschool children, and the relationship between parents’ health beliefs and children’s eating behaviors was investigated by applying the health belief model.MATERIALS/METHODS: In August 2018, a self-administered online survey was conducted on a sample of parents of children aged 3 to 5 years living in the Seoul and Gyeonggi area. A total of 248 respondents were analyzed via descriptive statistics, one-way ANOVA, Tukey’s multiple comparison test, Pearson correlation analysis, and multiple regression analysis. RESULTS: The eating behaviors of preschool children significantly differed based on parents’ education level and monthly income (P < 0.01). Among the factors of the health belief model, “perceived benefit” had the highest score at 4.37 points. The multiple regression analysis confirmed that parents’ “self-efficacy” raised the NQ-P scores (β = 0.175, P< 0.05), balance scores (β = 0.204, P < 0.01), and environment scores of preschool children (β = 0.149,P < 0.05). The study results showed that if parents are educated on healthy eating habits and their level of self-efficacy for healthy eating practices increases, the formation of correct eating behaviors for preschool children is more likely. CONCLUSION This study provides preliminary data to develop an education program for parents to understand proper eating behaviors for their children and may help form healthy eating habits and encourage the healthy growth of preschool children.

We present a case of erosive adenomatosis of the nipple in a 22-year-old woman. The clinical features of erosive adenomatosis of the nipple are similar to Paget's disease in that it has erythematous erosions with oozing and fissured crusts on one nipple. However, histologic findings are characteristic, consisting of dilated tubular structures that are lined by a peripheral layer of cuboidal cells and a luminal layer of columnar cells showing secretary properties into the lumen. The clinical course is benign, so simple mastectomy is enough for treatment.
Female ; Humans ; Mastectomy, Simple ; Nipples* ; Phenobarbital ; Young Adult

BACKGROUND/OBJECTIVES: Oxidative stress is caused by an imbalance between harmful free radicals and antioxidants. Long-term oxidative stress can lead to an “exhausted” status of antioxidant defense system triggering development of metabolic syndrome and chronic inflammation. Green perilla (Perilla frutescens) is commonly used in Asian cuisines and traditional medicine in southeast Asia. Green perilla possesses numerous beneficial effects including anti-inflammatory and antioxidant functions. To investigate the potentials of green perilla leaf extract (PE) on oxidative stress, we induced oxidative stress by high-fat diet (HFD) in aging mice.MATERIALS/METHODS: C57BL/6J male mice were fed HFD continuously for 53 weeks.Then, mice were divided into three groups for 12 weeks: a normal diet fed reference group (NDcon), high-fat diet fed group (HDcon), and high-fat diet PE treated group (HDPE, 400 mg/kg of body weight). Biochemical analyses of serum and liver tissues were performed to assess metabolic and inflammatory damage and oxidative status. Hepatic gene expression of oxidative stress and inflammation related enzymes were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: PE improved hepatopathology. PE also improved the lipid profiles and antioxidant enzymes, including hepatic glutathione peroxidase (GPx) and superoxide dismutase (SOD) and catalase (CAT) in serum and liver. Hepatic gene expressions of antioxidant and antiinflammatory related enzymes, such as SOD-1, CAT, interleukin 4 (IL-4) and nuclear factor erythroid 2-related factor (Nrf2) were significantly enhanced by PE. PE also reduced the levels of hydrogen peroxide (H 2 O 2 ) and malondialdehyde (MDA) in the serum and liver;moreover, PE suppressed hepatic gene expression involved in pro-inflammatory response;Cyclooxygenase-2 (COX-2), nitric oxide synthase (NOS), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6). CONCLUSIONS This research opens opportunities for further investigations of PE as a functional food and possible anti-aging agent due to its attenuative effects against oxidative stress, resulting from HFD and aging in the future.

PURPOSE: To analysis the chronological changes of surgical strategy for early gastric cancer (EGC) in our hospital over a 10-year period. METHODS: From November 1993 to August 2003, we experienced 201 patients with EGC at Ewha Womans University Mokdong Hospital. The medical and pathologic records of these patients were reviewed retrospectively. The patients were categorized into three groups in chronological order: P1 (1993~1996), P2 (1997~2000), and P3 (2001~2003). The clinicopathological characteristics and treatment modalities among these three groups were compared. RESULTS: Of the 683 gastric cancer patients, 201 patients (29.7%) were pathologically confirmed to have EGC. The proportion of EGC gradually increased in chronological order: 19.2% in P1, 33.2% in P2 and 32.9% in P3. There were no significant differences in clinicopathological characteristics among three groups, including age, sex, location, size, gross type, histology, depth of invasion, and lymph node metastasis. Open surgery was performed in 134 patients, laparoscopic surgery in 52 and endoscopic mucosal resection (EMR) in 15. The proportion of minimally invasive surgery such as EMR, laparoscopic wedge resection, laparoscopy- assisted distal gastrectomy (LADG), and hand-assisted laparoscopic surgery (HALS) increased in chronological order: 0% in P1, 22.4% in P2 and 58.5% in P3. The postoperative mortality was 1.49% (3/201): 2 cases after open surgery, and 1 case after laparoscopic wedge resection. One case after open conventional surgery recurred. There were no significant difference in postoperative complication, postoperative mortality and survival rate among the three groups. Overall 5-year survival rate was 95.4%. CONCLUSION: The proportion of minimally invasive surgery increased during a 10-year period in our hospital. However, there were no significant differences in postoperative complication, postoperative mortality, recurrence rate, and survival rate among three chronological groups.
Female ; Gastrectomy ; Hand-Assisted Laparoscopy ; Humans ; Laparoscopy ; Lymph Nodes ; Mortality ; Neoplasm Metastasis ; Postoperative Complications ; Recurrence ; Retrospective Studies ; Stomach Neoplasms* ; Surgical Procedures, Minimally Invasive ; Survival Rate

PURPOSE: Systemic lupus erythematosus(SLE) is a disease of immunologic origin, affecting multiple organs including joints, skin, kidneys, nervous system, heart and blood, with rare involvement of gut and liver. The incidence of renal disease in children with SLE was approximately 70 percent and tended to be more severe than in adults. Accordingly we have retrospectively studied on the prognostic indicators. METHODS: We investigated clinical manifestations, laboratory findings and renal biopsy findings of 14 cases of childhood lupus nephritis. RESULTS: A review of the clinical and pathological findings revealed as follows : male to female ratio was 1 : 6, immunologic laboratory findings showed, positive rates of anti-ds DNA antibody which was 57%, FANA 85%. The incidence of decreased C3 and C4 was 57%. The most common clinical features were fever(92%) and malar rash(21%). Renal biopsies were performed with the following results. There were 3 cases of mesangial proliferative glomerulonephritis, 1 case of focal and segmental proliferative glomerulonephritis, 9 cases of diffuse proliferative glomerulonephritis, and 1 of membranous glomerulonephritis. During the follow-up period, 3 patients with diffuse proliferative glomerulonephritis expired due to renal failure and pulmonary edema. CONCLUSION: When lupus nephritis is suspected, renal biopsy, tests for antinuclear antibody (ANA) and anti-ds-DNA, and complement profile should be performed. Early diagnosis and proper treatment can prevent rapid deterioration of renal function and improve long-term survival. Renal biopsy in lupus nephritis is of considerable value to both choice of therapy and predicting prognosis.
Adult ; Antibodies, Antinuclear ; Biopsy ; Child ; Complement System Proteins ; DNA ; Early Diagnosis ; Female ; Follow-Up Studies ; Glomerulonephritis ; Glomerulonephritis, Membranous ; Heart ; Humans ; Incidence ; Joints ; Kidney ; Liver ; Lupus Nephritis* ; Male ; Nervous System ; Prognosis ; Pulmonary Edema ; Renal Insufficiency ; Retrospective Studies ; Skin

BACKGROUND/OBJECTIVES: Different fatty acids exert different health benefits. This study investigated the potential protective effects of perilla, olive, and safflower oils on high-fat diet-induced obesity and colon inflammation.MATERIALS/METHODS: Five-week old, C57BL/6J mice were assigned to 5 groups: low-fat diet (LFD), high-fat diet (HFD) and high-fat diet supplemented with-perilla oil (HPO), olive oil (HOO), and safflower oil (HSO). After 16 weeks of the experimental period, the mice were sacrificed, and blood and tissues were collected. The serum was analyzed for obesity- and inflammation-related biomarkers. Gene expression of the biomarkers in the liver, adipose tissue, and colon tissue was analyzed. Micro-computed tomography (CT) analysis was performed one week before sacrifice. RESULTS: Treatment with all the three oils significantly improved obesity-induced increases in body weight, liver weight, and epididymal fat weight as well as serum triglyceride and leptin levels. Treatment with perilla oil (PO) and safflower oil (SO) increased adiponectin levels. The micro-CT analysis revealed that PO and SO reduced abdominal fat volume considerably. The mRNA expression of lipogenic genes was reduced in all the three oilsupplemented groups and PO upregulated lipid oxidation in the liver. Supplementation of oils improved macroscopic score, increased colon length, and decreased serum endotoxin and proinflammatory cytokine levels in the colon. The abundance of Bifidobacteria was increased and that of Enterobacteriaceae was reduced in the PO-supplemented group. All three oils reduced proinflammatory cytokine levels, as indicated by the mRNA expression. In addition, PO increased the expression of tight junction proteins. CONCLUSIONS Taken together, our data indicate that the three oils exert similar anti-obesity effects. Interestingly, compared with olive oil and SO, PO provides better protection against high-fat diet-induced colon inflammation, suggesting that PO consumption helps manage inflammation-related diseases and provides omega-3 fatty acids needed by the body.

This study was conducted to evaluate changes in plasma concentration and urinary excretion of carnitine, as well as plasma lipid level and fatty acid composition, caused by short term supplementation of carnitine in humans. Ten healthy male subjects (21.2 +/- 0.5 years old) received oral carnitine supplementation (4 g/day) as tablets for two weeks. Fasting blood and random urine samples were collected from each subject both prior to and at the end of carnitine supplemention program. Following the 2 weeks of carnitine supplementation, plasma total carnitine (TCNE) concentration increased 20% (85.1 +/- 7.4 vs 67.3 +/- 9.1 micro mol/1, p>0.05), while urinary excretion of total carnitine increased ten times compared to the value measured prior to the supplementation (3051 +/- 692 vs 278 +/- 90.1 micro mol/g creatinine, p<0.01). Non-esterified carnitine (NEC) comprised from 71 to 88% of TCNE in plasma, and from 32 to 40% of TCNE excreted in the urine. Two weeks of carnitine supplementation in healthy adults significantly elevated plasma level of acid soluble acylcarnitine (ASAC) which is esterified mostly with short chain fatty acids (21.6 +/- 1.6 micro mol/l) compared to the value measured prior to the supplementation (6.4 +/- 0.8 micro mol/l) (p<0.05). Carnitine supplementation significantly increased plasma HDL-cholesterol level (p<0.05), and decreased the atherogenic index (p<0.05), but failed to cause any significant change in plasma levels of total cholesterol, triglyceride, and free fatty acids. Plasma triglyceride and phospholipid fatty acid compositions were not significaly affected as well by the oral supplementation of carnitine in subjects with normal range of blood lipid levels.
Adult* ; Carnitine* ; Cholesterol ; Creatinine ; Fasting ; Fatty Acids ; Fatty Acids, Nonesterified ; Humans ; Male* ; Plasma* ; Reference Values ; Tablets ; Triglycerides

BACKGROUND/OBJECTIVES: The steamed ginger has been shown to have antioxidative effects and a protective effect against obesity. In the present study, we investigated the effects of ethanolic extract of steamed ginger (SGE) on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity (DIO) mouse model.MATERIALS/METHODS: The protective effects of SGE on adipogenesis were examined in 3T3-L1 adipocytes by measuring lipid accumulations and genes involved in adipogenesis.Male C57BL/6J mice were fed a normal diet (ND, 10% fat w/w), a high-fat diet (HFD, 60% fat w/w), and HFD supplemented with either 40 mg/kg or 80 mg/kg of SGE for 12 weeks.Serum chemistry was measured, and the expression of genes involved in lipid metabolism was determined in the adipose tissue. Histological analysis and micro-computed tomography were performed to identify lipid accumulations in epididymal fat pads. RESULTS: In 3T3-L1 cells, SGE significantly decreased lipid accumulation, with concomitant decreases in the expression of adipogenesis-related genes. SGE significantly attenuated the increase in body, liver, and epididymal adipose tissue weights by HFD. Serum total cholesterol and triglyceride levels were significantly lower in SGE fed groups compared to HFD. In adipose tissue, SGE significantly decreased adipocyte size than that of HFD and altered adipogenesis-related genes. CONCLUSIONS In conclusion, steamed ginger exerted anti-obesity effects by regulating genes involved in adipogenesis and lipogenesis in 3T3-L1 cell and epididymal adipose tissue of DIO mice.