1.Trichoadenoma: Report of a case.
Youn Soo LEE ; Mi Kyung LEE ; Seok Jin GANG ; Byoung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1993;27(1):75-77
The clinical and pathological features of trichoadenoma are presented. Trichoadenoma is very rare, and as far as we know, no report on the trichoadenoma has been published in korea literature. We experienced a case of trichoadenoma occured in a 29 year-old male, who had a 0.9x0.7x0.4cm sized and slowly growing mass in the right buttock. The histopathological findings and histogenesis of trichoadenoma were discussed and a brief review of the literature was made.
2.Total Knee Arthroplasty in Charcot's Joints
Dae Kyung BAE ; Myung Chul YOO ; Dong Kee AHB ; Youn Jae CHO
The Journal of the Korean Orthopaedic Association 1990;25(2):467-476
Four total knee arthroplasties were performed in 3 patients with the diagnosis of classical Charcot's joints associated with syphilis during past 4 years from 1985 to 1988. All patients had positive reaction in serology test(VDRL, TPHA). We corrected the bone loss and severe joint instability with allograft or autogenous bone grafting and ligament balancing. The knee score was increased from preoperative 37 points to postoperative 87.3 points. We expect that total knee arthroplasty may be the alternative treatment to the conservative treatment or knee arthrodesis in Charcots joints.
Allografts
;
Arthrodesis
;
Arthropathy, Neurogenic
;
Arthroplasty
;
Arthroplasty, Replacement, Knee
;
Bone Transplantation
;
Diagnosis
;
Humans
;
Joint Instability
;
Knee
;
Ligaments
;
Syphilis
3.Multiple Kaposi's Sarcoma in the Renal Transplant Patient: A case report .
Jae Kyung KOH ; Eun Sun JUNG ; Youn Soo LEE ; Seok Jin KANG ; Byung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1999;33(11):1097-1101
The Kaposi's sarcoma, which was found in an immunosuppressed patient of renal transplantation, may have been developed by long term use of immunosuppressant agent after the renal transplantation. The case was a 29-year-old woman who was diagnosed as chronic renal failure in 1988, and since then, she had been on CAPD until May, 1997. After the renal transplantation in May 1997, the patient has been prescribed cyclosporin and prednisone as immunosuppressant agent. In June 1997, she showed clinical symptom of Kaposi's sarcoma with multiple papules and nodules in the skin and viscera, such as ureter, urinary bladder, stomach, duodenum and subcutaneous tissue of the chest. Multiple excisional biopsies were carried out in the skin, ureter, urinary bladder, stomach and duodenum. All of excisional biopses indicated nodular stages with extensive proliferation of spindle shaped, somewhat pleomorphic cells which have slit-like vascular spaces, proliferation of small vessels, and extravasation of erythrocytes. These lesions nearly diminished after sytemic chemotherpy, excision and discontinuity of immunosuppressive agents.
Adult
;
Biopsy
;
Cyclosporine
;
Duodenum
;
Erythrocytes
;
Female
;
Humans
;
Immunosuppressive Agents
;
Kidney Failure, Chronic
;
Kidney Transplantation
;
Peritoneal Dialysis, Continuous Ambulatory
;
Prednisone
;
Sarcoma, Kaposi*
;
Skin
;
Stomach
;
Subcutaneous Tissue
;
Thorax
;
Ureter
;
Urinary Bladder
;
Viscera
4.Multiple Kaposi's Sarcoma in the Renal Transplant Patient: A case report .
Jae Kyung KOH ; Eun Sun JUNG ; Youn Soo LEE ; Seok Jin KANG ; Byung Kee KIM ; Sun Moo KIM
Korean Journal of Pathology 1999;33(11):1097-1101
The Kaposi's sarcoma, which was found in an immunosuppressed patient of renal transplantation, may have been developed by long term use of immunosuppressant agent after the renal transplantation. The case was a 29-year-old woman who was diagnosed as chronic renal failure in 1988, and since then, she had been on CAPD until May, 1997. After the renal transplantation in May 1997, the patient has been prescribed cyclosporin and prednisone as immunosuppressant agent. In June 1997, she showed clinical symptom of Kaposi's sarcoma with multiple papules and nodules in the skin and viscera, such as ureter, urinary bladder, stomach, duodenum and subcutaneous tissue of the chest. Multiple excisional biopsies were carried out in the skin, ureter, urinary bladder, stomach and duodenum. All of excisional biopses indicated nodular stages with extensive proliferation of spindle shaped, somewhat pleomorphic cells which have slit-like vascular spaces, proliferation of small vessels, and extravasation of erythrocytes. These lesions nearly diminished after sytemic chemotherpy, excision and discontinuity of immunosuppressive agents.
Adult
;
Biopsy
;
Cyclosporine
;
Duodenum
;
Erythrocytes
;
Female
;
Humans
;
Immunosuppressive Agents
;
Kidney Failure, Chronic
;
Kidney Transplantation
;
Peritoneal Dialysis, Continuous Ambulatory
;
Prednisone
;
Sarcoma, Kaposi*
;
Skin
;
Stomach
;
Subcutaneous Tissue
;
Thorax
;
Ureter
;
Urinary Bladder
;
Viscera
5.Recent Updates on Diabetic Nephropathy.
Youn Kyung KEE ; Seung Hyeok HAN
Journal of Korean Diabetes 2017;18(4):214-228
Diabetic nephropathy is a common complication of diabetes mellitus and is the leading cause of chronic kidney disease. Glycemic and blood pressure control constitute the main strategies of diabetic nephropathy prevention and treatment. However, despite current therapies, nephropathy progresses to renal failure and end-stage renal disease in many patients. Therefore, new therapeutic strategies targeting different pathophysiological mechanisms are needed. This review article briefly summarizes the standard therapy for diabetic nephropathy and also describes recent advances in potential renoprotective agents that could be used to prevent the development or progression of diabetic nephropathy.
Blood Pressure
;
Diabetes Mellitus
;
Diabetic Nephropathies*
;
Humans
;
Kidney Failure, Chronic
;
Renal Insufficiency
;
Renal Insufficiency, Chronic
6.Bilateral Contributions of the Cerebellum to the Complex Motor Tasks on EPI fMRI.
Eun Chul CHUNG ; Eun Kyung YOUN ; Young Rae LEE ; Yoo Kyung KIM ; Kee Duk PARK
Journal of the Korean Radiological Society 1999;40(1):1-6
PURPOSE: To demonstrate activation signals within the cerebellar cortex and to determine the side of thecerebellar cortex eliciting activation signals in response to complex motor tasks, as seen on EPI fMRI MATERIALS AND METHODS: Seven right-handed subjects (M:F=3:4;mean age, 30.3 years) underwent repetitive finger appositionwith the dominant right hand. Using a 1.5T MRI scanner, EPI fMR images were obtained. MR parameters used for EPIfMRI were TR/TE/Flip angle : 0.96 msec/64 msec/90 degree, FOV 22cm, 128 X 128 matrix, 10 slices, 10mm thickness whilethose for SE T1 weighted localized images were TR/TE : 450/16, FOV 23cm, 256 X 256 matrix. The paradigm was threesets of alternate resting and moving fingers for six cycles, resulting in times of 360 seconds (10 slices X 15 EPIX 6 cycles = 900 images). Image processing involoved the use of a 200mHz Dual Pentium PC with homemade software.T-testing (p<0.005) and time series analysis were performed, and to verify the locations of activated regions,resulting images were analyzed in a color-coded overlay to reference T1-weighted spin echo coronal images.percentage change in signal intensity (PCSI) was calculated from the processed data. RESULTS: All normal subjectsshowed significant activation signals in both the contralateral (left) primary motor cortex (PCSI=3.12%+/-0.96) andipsilateral (right) cerebellar cortex (PCSI=3.09%+/-1.14). Signal activation was detected in the contralateralsupplemental motor area (2.91%+/-0.82), and motor activation in the anterior upper half of the contralateralcerebellum (PCSI=2.91%+/-0.69). The difference in activation signals between both sides of the cerebellar cortexwas not statistically significant. All data were matched with time-series analysis. CONCLUSION: Bilateralcerebellar activation is associated with unilateral complex finger movements, as seen on fMRI. This result maysupport the recent neurological observation that the cerebellum may exert bilateral effects on motor performance.
Cerebellar Cortex
;
Cerebellum*
;
Fingers
;
Hand
;
Magnetic Resonance Imaging*
;
Motor Cortex
7.Development and Validation of the Korean Rome III Questionnaire for Diagnosis of Functional Gastrointestinal Disorders.
Kyung Ho SONG ; Hye Kyung JUNG ; Byung Hoon MIN ; Young Hoon YOUN ; Kee Don CHOI ; Bo Ra KEUM ; Kyu Chan HUH
Journal of Neurogastroenterology and Motility 2013;19(4):509-515
BACKGROUND/AIMS: A self-report questionnaire is frequently used to measure symptoms reliably and to distinguish patients with functional gastrointestinal disorders (FGIDs) from those with other conditions. We produced and validated a cross-cultural adaptation of the Rome III questionnaire for diagnosis of FGIDs in Korea. METHODS: The Korean version of the Rome III (Rome III-K) questionnaire was developed through structural translational processes. Subsequently, reliability was measured by a test-retest procedure. Convergent validity was evaluated by comparing self-reported questionnaire data with the subsequent completion of the questionnaire by the physician based on an interview and with the clinical diagnosis. Concurrent validation using the validated Korean version of the Short Form-36 Health Survey (SF-36) was adopted to demonstrate discriminant validity. RESULTS: A total of 306 subjects were studied. Test-retest reliability was good, with a median Cronbach's alpha value of 0.83 (range, 0.71-0.97). The degree of agreement between patient-administered and physician-administered questionnaires to diagnose FGIDs was excellent; the kappa index was 0.949 for irritable bowel syndrome, 0.883 for functional dyspepsia and 0.927 for functional heartburn. The physician's clinical diagnosis of functional dyspepsia showed the most marked discrepancy with that based on the self-administered questionnaire. Almost all SF-36 domains were impaired in participants diagnosed with one of these FGIDs according to the Rome III-K. CONCLUSIONS: We developed the Rome III-K questionnaire though structural translational processes, and it revealed good test-retest reliability and satisfactory construct validity. These results suggest that this instrument will be useful for clinical and research assessments in the Korean population.
Dyspepsia
;
Gastrointestinal Diseases*
;
Health Surveys
;
Heartburn
;
Humans
;
Irritable Bowel Syndrome
;
Surveys and Questionnaires*
8.The sustaining effect of three polymers on the release of chlorhexidine from a controlled release drug device for root canal disinfection.
Young Bin BOK ; Doug Youn LEE ; Chang Young LEE ; Kyung Nam KIM ; Kee Yeon KUM
Journal of Korean Academy of Conservative Dentistry 2004;29(6):548-554
The aim of this in vitro study was to evaluate the suitability of using chitosan, poly (lactide-co-glycolide) (PLGA), and polymethyl methacrylate (PMMA) to control the release of chlorhexidine digluconate (CHX) from a prototype of controlled release drug device (CRD) for root canal disinfection. Four different prototypes with different formulations were prepared. Group A (n = 12); The device (absorbent paper point) was loaded with CHX as control. Group B (n = 12); same as group A, but the device was coated with chitosan. In Groups C and D, the device was treated in the same way as group A and then coated three times with 5% PMMA (Group C, n = 12), or coated three times with 3% PLGA (Group D, n = 12). The devices were randomly allocated to experimental groups of 12 each. All CRD prototypes were soaked in 3 mL distilled water. The concentrations of CHX were determined using a UV spectrophotometer. The surface characteristics of each prototype were observed using a scanning electron microscope. The result showed that release rate of CHX was the greatest in the non-coated group, followed by the chitosan-coated group, the PLGA-coated group, and the PMMA-coated group (P < 0.05). Pores were observed on the surface of the prototypes that were coated with PLGA and PMMA. When the pore size was smaller, the release rate was lower. This data indicate that polymer coating can control the release rate of CHX from the CRD prototypes.
Chitosan
;
Chlorhexidine*
;
Dental Pulp Cavity*
;
Disinfection*
;
Polymers*
;
Polymethyl Methacrylate
;
Water
9.Technical Improvement of Functional MRI for Clinical Application.
Kyung Min LEE ; Soo Hwa LEE ; Chai Youn KIM ; Na Young KIM ; Jae Kyu ROH ; Kee Hyun CHANG
Journal of the Korean Neurological Association 1999;17(2):222-227
BACKGROUND: Functional MRI is a new neuroimaging method that detects focal blood flow change associated with neural activation. This study aimed at improving it for use as a clinical test. METHODS: We separated image reconstruction from scan acquisition as an off-line process, systematized post-processing stages, and employed SPM96 package for statistical analysis. Tasks easy enough for most neurological patients were designed for activation of motor, somatosensory, visual, and language areas. From twenty consecutive patients admitted to neurology wards, frequency of expected activation and inactivation among defined regions of interest was obtained as a measure of sensitivity and quasi-specificity. RESULTS: It took about 4 minutes for data acquisition per task condition. Thus within half an hour all four tasks were tested in cooperative patients. Post-processing took about an hour per task condition, using PC-based analysis packages. Sensitivity and quasi-specificity were about 70% and 90%, respectively. CONCLUSIONS: Our newly developed method shortened the time for fMRI acquisition and systematized post-scan analysis. Data obtained from patients showed acceptable reliability for clinical use, but further research and improvement should be necessary.
Humans
;
Image Processing, Computer-Assisted
;
Magnetic Resonance Imaging*
;
Neuroimaging
;
Neurology
10.A Case of Renovascular Hypertension Controlled by Renal Autotransplantation.
Eunyoung LEE ; Youn Kyung KEE ; Jungyoen LEE ; In Mee HAN ; Jae Il SHIN ; Myoung Soo KIM ; Sungha PARK
Journal of the Korean Society of Hypertension 2013;19(2):63-69
Renovascular hypertension caused by renal artery stenosis is an uncommon but curative cause of hypertension in children. We report a case of recurrent severe hypertension caused by renovascular hypertension. After recurrence of hypertension after redo percutaneous transluminal renal angioplasty, the blood pressure was finally controlled by renal autotransplantation. This case demonstrates the importance of considering renovascular hypertension as a cause of severe hypertension in children. Also, renal autotransplantation should be considered as a viable treatment option for treatment of renovascular hypertension that is recurrent after renal angioplasty.
Angioplasty
;
Blood Pressure
;
Child
;
Humans
;
Hypertension
;
Hypertension, Renovascular*
;
Recurrence
;
Renal Artery
;
Renal Artery Obstruction
;
Transplantation*