This study was aimed to clarify whether urinary calcium stones may be associated with uric acid disorders. Serum uric acid concentrations and 24-hour urinary excretion of uric acid were determined in 73 calcium stone formers and in 60 controls. The following results were obtained: 1. The mean values of serum uric acid were 4.59+/-0.84 mg/dl in male controls and 4.07+/-1.21 mg/dl in female controls, 5.36+/-1.34 mg/dl in male stone formers and 4.87+/-1.34 mg/dl in female stone formers. Serum uric acid concentrations of male stone formers were significantly higher than those of male controls. 2. The mean values of 24-hour urinary excretion of uric acid were 644.1+/-313.4 mg in male controls and 510.0+/-2256.7 mg in female controls, 808.7+/-411.7 mg in male stone formers and 701.9+/-278.4 mg in female stone formers. The 24-hour urinary excretion of uric acid of male stone formers were significantly higher than those of male controls. 3. Hyperuricemia was observed in non of male and female controls, 10.9% of male stone formers and 14.8% of female stone formers. 4. Hyperuricosuria was observed in 22.4% of male controls and 18.2% of female controls, 45.7% of male stone formers and 40.7% of female stone formers. Hyperuricosuria was more frequent in male stone formers. 5. The incidence of patients with hyperuricemia and/or hyperuricosuria was observed in 21.7% of controls and 50.7% of calcium stone formers. The result, that patients with calcium stone disease were hyperuricemic and hyperuricosuric more often than controls suggested that some urinary calcium stones may be associated with uric acid disorders.
Calcium* ; Female ; Humans ; Hyperuricemia ; Incidence ; Male ; Schools, Medical ; Uric Acid*

A clinical observation was made on 34 patients with renal tumor who had been admitted to the Department of Urology, Chonnam University Hospital during the period from Jan. 1977 to Dec. 1982. The following results were obtained: 1. During the period, the renal tumor was 1.6 percent of total urological in-patients and 7.5 percent of total genitourinary tract tumors. The mean age of patients with renal cell carcinoma was 49 years. Wilms' tumor 4 years, and transitional cell carcinoma 41 years. The male sex was favored by a ratio of 2.1 to 1 in the renal tumors. 2. The pathological classification of 34 patients with renal tumors revealed renal cell carcinoma in 16 cases (47.1%), Wilms' tumor in 9 cases (26.5%) and transitional cell carcinoma in 9 cases (26.5%). 3. The most common symptoms and signs were hematuria in 21 cases (61.7%), palpable mass in 18 cases (52.9%) and flank pain in 14 cases (46.2%) The classical triad of symptoms and signs including hematuria, flank pain and palpable mass was presented in only 5 cases (14.%). 4. Distant metastasis was found in 6 patients, of whom 3 had lung metastasis, 2 liver metastasis and 1 vertebral metastasis. 5. Treatment of renal tumors consisted of surgery and adjuvant radiation and/or chemotherapy. In 16 cases with renal cell carcinoma, 5 simple nephrectomies, 8 radical nephrectomies and 3 explorations with biopsy were done. Postoperative radiation and/or chemotherapy were performed in 2 cases. In 9 cases with Wilms' tumors, 3 simple nephrectomies, 5 radical nephrectomies and 1 exploration with biopsy were done. Postoperative radiation and/or chemotherapy were performed in 6 cases. In 9 cases with transitional cell carcinoma, 5 nephroureterectomies, 2 nephroureterectomies with partial cystectomy and 2 nephroureterectomies with total cystectomy and ileal conduit were done. Postoperative radiation and/or chemotherapy were performed in 1 cases. 6. The mean weight of resected kidneys with renal tumors was about 594 gm. The mean weight of resected kidneys with renal cell carcinoma was about 594 gm, that with transitional cell carcinoma 354 gm, and that with Wilms' tumor 440 gm. 7. The 1-year survival rate of the patients with malignant renal tumors was 71.4 percent. The 1-year survival rate of the patients with renal cell carcinoma was 63.6 percent, that with transitional cell carcinoma 83.3 percent, and that with Wilms' tumor 75 percent.
Biopsy ; Carcinoma, Renal Cell ; Carcinoma, Transitional Cell ; Classification ; Cystectomy ; Drug Therapy ; Flank Pain ; Hematuria ; Humans ; Jeollanam-do ; Kidney ; Liver ; Lung ; Male ; Neoplasm Metastasis ; Nephrectomy ; Survival Rate ; Urinary Diversion ; Urology ; Wilms Tumor

A clinical observation was made on 34 patients with renal tumor who had been admitted to the Department of Urology, Chonnam University Hospital during the period from Jan. 1977 to Dec. 1982. The following results were obtained: 1. During the period, the renal tumor was 1.6 percent of total urological in-patients and 7.5 percent of total genitourinary tract tumors. The mean age of patients with renal cell carcinoma was 49 years. Wilms' tumor 4 years, and transitional cell carcinoma 41 years. The male sex was favored by a ratio of 2.1 to 1 in the renal tumors. 2. The pathological classification of 34 patients with renal tumors revealed renal cell carcinoma in 16 cases (47.1%), Wilms' tumor in 9 cases (26.5%) and transitional cell carcinoma in 9 cases (26.5%). 3. The most common symptoms and signs were hematuria in 21 cases (61.7%), palpable mass in 18 cases (52.9%) and flank pain in 14 cases (46.2%) The classical triad of symptoms and signs including hematuria, flank pain and palpable mass was presented in only 5 cases (14.%). 4. Distant metastasis was found in 6 patients, of whom 3 had lung metastasis, 2 liver metastasis and 1 vertebral metastasis. 5. Treatment of renal tumors consisted of surgery and adjuvant radiation and/or chemotherapy. In 16 cases with renal cell carcinoma, 5 simple nephrectomies, 8 radical nephrectomies and 3 explorations with biopsy were done. Postoperative radiation and/or chemotherapy were performed in 2 cases. In 9 cases with Wilms' tumors, 3 simple nephrectomies, 5 radical nephrectomies and 1 exploration with biopsy were done. Postoperative radiation and/or chemotherapy were performed in 6 cases. In 9 cases with transitional cell carcinoma, 5 nephroureterectomies, 2 nephroureterectomies with partial cystectomy and 2 nephroureterectomies with total cystectomy and ileal conduit were done. Postoperative radiation and/or chemotherapy were performed in 1 cases. 6. The mean weight of resected kidneys with renal tumors was about 594 gm. The mean weight of resected kidneys with renal cell carcinoma was about 594 gm, that with transitional cell carcinoma 354 gm, and that with Wilms' tumor 440 gm. 7. The 1-year survival rate of the patients with malignant renal tumors was 71.4 percent. The 1-year survival rate of the patients with renal cell carcinoma was 63.6 percent, that with transitional cell carcinoma 83.3 percent, and that with Wilms' tumor 75 percent.
Biopsy ; Carcinoma, Renal Cell ; Carcinoma, Transitional Cell ; Classification ; Cystectomy ; Drug Therapy ; Flank Pain ; Hematuria ; Humans ; Jeollanam-do ; Kidney ; Liver ; Lung ; Male ; Neoplasm Metastasis ; Nephrectomy ; Survival Rate ; Urinary Diversion ; Urology ; Wilms Tumor