No abstract available.
Precursor Cell Lymphoblastic Leukemia-Lymphoma*

Drowning is a leading cause of accidental deaths worldwide, but its pathological diagnosis remains a challenge for forensic pathologists owing to a lack of pathognomonic findings in drowning deaths and inconclusive autopsy findings caused by postmortem changes. The aim of the present study was to investigate the pathway taken by inhaled drowning medium through the airway after death in a variety of experimental conditions, including underwater pressurization. We used methylene blue dye to monitor the spread of drowning medium to the lungs. Results of theses experiments demonstrated that it is possible for a significant amount of downing medium to enter the airway during immersion after death. Our results suggest that autopsies of immersed bodies and interpretation of these findings should be performed with special care.
Animal Experimentation* ; Animals* ; Autopsy ; Diagnosis ; Drowning* ; Immersion ; Inhalation* ; Lung ; Methylene Blue* ; Postmortem Changes

No abstract available.
Facial Paralysis* ; Fascia Lata* ; Fascia*

No abstract available.
Hyperbilirubinemia, Neonatal*

Neurofibromatosis is a syndrome of multiple neurofibromas, abnormal skin pigmentation and certain bony abnormalities. Sometimes the growth of plexiform neurofibromatosis on the face or trunk is centripetal and usually involves the mediastinum and skull base. However, it is very rare that neurofibromatosis involves the trigeminal ganglion. Its encroachment around the foramina of the skull base may induce facial palsy or conductive hearing loss. The guiding principle in the treatment of generalized neurofibromatosis is a radical excision with preservation of vital structures and an immediate reconstruction of the bony skeleton and soft tissue defect. The authors experienced 4 cases of neurofibromatosis involving the trigeminal ganglion. All had trigeminal symptoms for 3 to 4 years. These were severe headache and intractable trigeminal neuralgia. Tumors in all 4 cases were spread in the centripetal type from extracranial neurofibromatosis. The facial nerve was affected in 4 cases. Malignat Schwannoma occurred in 1 case. Accurate diagnosis and assessments were necessary with CT, MRI art oomputer-aided simulation design. Intraoperative bleeding was minimal with hypotensive anesthesia. Surgical approach to the middle cranial fossa involved temporary removal of the zygomatic arch and TMJ disarticulation with downward traction of the mandible. Satisfactory results have been obtained far 3 to 7 years(mean 5 years) follow-up.
Anesthesia ; Cranial Fossa, Middle ; Diagnosis ; Disarticulation ; Facial Nerve ; Facial Paralysis ; Follow-Up Studies ; Headache ; Hearing Loss, Conductive ; Hemorrhage ; Magnetic Resonance Imaging ; Mandible ; Mediastinum ; Neurilemmoma ; Neurofibromatoses* ; Neurofibromatosis 1 ; Skeleton ; Skin Pigmentation ; Skull Base ; Temporomandibular Joint ; Traction ; Trigeminal Ganglion* ; Trigeminal Neuralgia ; Zygoma

Although the incidence is not high in the general surgical population, pulmonary aspiration of gastric contents can result in serious long-term morbidity and mortality. We report a case of early use of extracorporeal membrane oxygenation (ECMO) to correct severe hypoxemia refractory to conventional mechanical ventilation in a patient with massive aspiration of gastric contents immediately followed by acute lung injury during general anesthesia induction. A 64-year-old woman diagnosed with stomach cancer was scheduled for elective diagnostic laparoscopy. Although there was no sign of gastrointestinal tract obstruction and midnight Nil per Os (NPO) was performed before the operation, pulmonary aspiration occurred during the induction of anesthesia. Despite the endotracheal intubation with mechanical ventilation, severe hypoxemia with hypercapnea persisted. Medical team agreed with applying veno-venous (VV) ECMO, and her blood gas analysis results became stable. ECMO was weaned successfully 9 days after the first aspiration event had occurred. Based on this case, early application of extracorporeal life support can have survival benefits.
Acute Lung Injury ; Anesthesia* ; Anesthesia, General ; Anoxia ; Blood Gas Analysis ; Extracorporeal Membrane Oxygenation* ; Female ; Gastrointestinal Tract ; Humans ; Incidence ; Intubation, Intratracheal ; Laparoscopy ; Middle Aged ; Mortality ; Pneumonia, Aspiration ; Respiration, Artificial ; Stomach Neoplasms

We herein report a case of occupational contact urticaria syndrome induced by cefotiam di-hydrochloride in a nurse. She had generalized pruritic wheals accompanied by palpitations and tachypnea during the preparation of cefotiam solution. A scratch patch test with cefotiam di-hydrochloride, a major component of cefotiam ingredient showed multiple erythema and wheals within 5 minutes, accompanied by palpitations and tachypnea. No delayed type reaction was observed. Based on her clinical history and scratch test result, we diagnosed her condition as contact urticaria syndrome caused by cefotiam.
Cefotiam* ; Erythema ; Patch Tests ; Tachypnea ; Urticaria*

This study was undertaken to investigate the efficacy of 5% PABA cream using mouse ear swelling reaction(ESR). Mice were exposed to 100mJ/cm of UVB, five times a week for four weeks, on the both ventral aspect of the ear, with application of 5% PABA cream on the right ear. The results were as follows : 1. The intensity of ear swelling reaction of 5% PABA protected group was reduced greater than unproteeted group after the first 3 days of UUR. 2. The intensity of ear swelling reached at peak after 1 week of the ultraviolet radiation. Thereafter it has decreased gradually the following 4 weeks. The difference of ear swelling between the two groups was the greatest after 1 week, and the sunscreening efficacy of 5% PABA cream has remained persisted for 4 weeks. 3. The number of mice which have shown severe inflarnmatory response after ultravioiet radiation was more in unprotected group than that in 5% PABA protected group. 4. Determination of mouse ESR is considered a good method for the evaluation of longterm efficacy of sunscreen preparation.
4-Aminobenzoic Acid ; Animals ; Ear* ; Mice*

Objectives: This study aimed to investigate the relationship between oral function and activities of daily living among older adults in Korea. Specifically, it examines how changes in oral health over time impact the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scores using longitudinal data from the Korean Social Life, Health, and Aging Project (KSHAP). This study aims to identify the oral functions that significantly affect these abilities, thereby contributing to strategies for maintaining healthy aging. Methods: Data from the KSHAP Cohort K (Wave 4 in 2016 and Wave 5 in 2019) were analyzed. A total of 454 participants were included, after excluding those with incomplete data. Oral function was assessed using subjective self-reported measures of chewing and swallowing abilities, and salivary function. ADL and IADL were evaluated using Korean-specific tools (K-ADL and K-IADL, respectively), with higher scores indicating greater dependency. Statistical analyses included crosstabulations, independent t-tests, and generalized estimating equations (GEE) to assess the relationship between oral function and changes in ADL/IADL over time, with adjustments for covariates such as age, gender, socioeconomic status, and comorbidities. Results: Significant differences in ADL and IADL limitations were observed based on oral function. Participants with fewer teeth (0-10) were more likely to experience functional limitations than those with more teeth (21-32). Regression analyses using GEE revealed that difficulty in chewing (B=0.067, P=0.044) and swallowing (B=0.445, P<0.001) were associated with increased ADL dependency. For IADL, swallowing difficulty moderately affected dependency (B=0.234, P=0.003).These findings suggest that ADL limitations are more closely associated with oral function than are IADL limitations, highlighting the physiological importance of basic oral functions, such as chewing and swallowing, in daily activities. Conclusions This study demonstrates that oral health plays a critical role in maintaining activities of daily living among older adults, with ADL being more affected than IADL. A decline in oral function, particularly in chewing and swallowing, is associated with greater dependency over time. These findings underscore the need for targeted oral health management strategies to support functional independence and the overall quality of life in older populations. Future research should explore the bidirectional causality and broader demographic representations to further substantiate these results.

Objectives: This study aimed to investigate the relationship between oral function and activities of daily living among older adults in Korea. Specifically, it examines how changes in oral health over time impact the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scores using longitudinal data from the Korean Social Life, Health, and Aging Project (KSHAP). This study aims to identify the oral functions that significantly affect these abilities, thereby contributing to strategies for maintaining healthy aging. Methods: Data from the KSHAP Cohort K (Wave 4 in 2016 and Wave 5 in 2019) were analyzed. A total of 454 participants were included, after excluding those with incomplete data. Oral function was assessed using subjective self-reported measures of chewing and swallowing abilities, and salivary function. ADL and IADL were evaluated using Korean-specific tools (K-ADL and K-IADL, respectively), with higher scores indicating greater dependency. Statistical analyses included crosstabulations, independent t-tests, and generalized estimating equations (GEE) to assess the relationship between oral function and changes in ADL/IADL over time, with adjustments for covariates such as age, gender, socioeconomic status, and comorbidities. Results: Significant differences in ADL and IADL limitations were observed based on oral function. Participants with fewer teeth (0-10) were more likely to experience functional limitations than those with more teeth (21-32). Regression analyses using GEE revealed that difficulty in chewing (B=0.067, P=0.044) and swallowing (B=0.445, P<0.001) were associated with increased ADL dependency. For IADL, swallowing difficulty moderately affected dependency (B=0.234, P=0.003).These findings suggest that ADL limitations are more closely associated with oral function than are IADL limitations, highlighting the physiological importance of basic oral functions, such as chewing and swallowing, in daily activities. Conclusions This study demonstrates that oral health plays a critical role in maintaining activities of daily living among older adults, with ADL being more affected than IADL. A decline in oral function, particularly in chewing and swallowing, is associated with greater dependency over time. These findings underscore the need for targeted oral health management strategies to support functional independence and the overall quality of life in older populations. Future research should explore the bidirectional causality and broader demographic representations to further substantiate these results.