1.Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis.
Xiaoyu LIANG ; Huiyang LI ; Xuanling LI ; Xinxin TIAN ; Aiai ZHANG ; Qingzhi LUO ; Jianwei DUAN ; Youlu CHEN ; Liyun PANG ; Chen LI ; Xing-Jie LIANG ; Yong ZENG ; Jing YANG
Acta Pharmaceutica Sinica B 2023;13(1):372-389
In atherosclerosis, chronic inflammatory processes in local diseased areas may lead to the accumulation of reactive oxygen species (ROS). In this study, we devised a highly sensitive H2O2-scavenging nano-bionic system loaded with probucol (RPP-PU), to treat atherosclerosis more effectively. The RPP material had high sensitivity to H2O2, and the response sensitivity could be reduced from 40 to 10 μmol/L which was close to the lowest concentration of H2O2 levels of the pathological environment. RPP-PU delayed the release and prolonged the duration of PU in vivo. In Apolipoprotein E deficient (ApoE‒/‒) mice, RPP-PU effectively eliminated pathological ROS, reduced the level of lipids and related metabolic enzymes, and significantly decreased the area of vascular plaques and fibers. Our study demonstrated that the H2O2-scavenging nano-bionic system could scavenge the abundant ROS in the atherosclerosis lesion, thereby reducing the oxidative stress for treating atherosclerosis and thus achieve the therapeutic goals with atherosclerosis more desirably.
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