OBJECTIVETo study the prevalence of cerebral palsy (here in after referred to CP) in children aged 1 - 6 in Guangxi, China, and its epidemiologic characteristics and relevant risk factors.

METHODSInvestigations on the prevalence and etiology of CP in children at ages of 1 - 6 were conducted in Nanning, Hengxian and Qinzhou of Guangxi from June to December in 1998, with a cluster sampling.

RESULTSTotally, 150 806 children aged 1 - 6 were investigated in Nanning, Hengxian and Qinzhou of Guangxi, with 89 418 boys and 61 388 girls. Among them, 193 children were diagnosed as CP, with a prevalence rate of 1.28 per thousand, higher in boys (136 cases, 1.52 per thousand ) than in girls (57 cases, 0.93 per thousand ), with statistical significance (chi(2) = 9.536 7, P = 0.02). Logistic regression analysis showed that risk factors for CP were children who could not cry after birth (neonatal asphyxia), Apgar score less than eight, delivery at lower level of maternity hospital, number of mother's gravidity, no prenatal checks for mothers, and taking antipyretics and preserved food with salt during pregnancy.

CONCLUSIONSPrevalence of CP in children of Guangxi was at a lower level in comparison with that in other areas at home and abroad, which, maybe, was related with the lower neonatal survival and higher infant mortality.

Cerebral Palsy ; classification ; epidemiology ; etiology ; Child ; Child, Preschool ; China ; epidemiology ; Female ; Humans ; Infant ; Logistic Models ; Male ; Pregnancy ; Pregnancy Trimesters ; Prevalence ; Risk Factors

Objective To investigate the effect of adjuvant therapy of Shenfu Injection on NOD-like receptor protein 3(NLRP3)/cysteine-aspartic acid-specific protease 1(Caspase-1)mediated py-roptosis signaling pathway and inflammatory factor levels in rats with acute myocardial infarction(AMI).Methods A total of 40 rats were randomly divided into sham operation group,model group,betaloc group(0.9 mg/kg),and combination group(0.9 mg/kg betaloc combined with 6 mL/kg Shenfu Injection),with 10 rats in each group.The rats were treated by gavage continuously for 3 weeks.The levels of serum troponin Ⅰ(cTnⅠ),creatine kinase-MB(CK-MB),interleukin(IL)-6,IL-1β,and tumor necrosis factor-α(TNF-α)in rats were detected before modeling,after modeling,and at 3 weeks of treatment.Echocardiographic parameters such as left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),and myocardial infarction area were compared among groups after modeling and at 3 weeks of treatment.Real-time fluorescence quantitative polymerase chain reaction(qRT-PCR)and Western blot were used to detect the mRNA and protein expression levels of NLRP3 and Caspase-1 in the myocardium.Results Compared with the sham operation group,the levels of cTnⅠ,CK-MB,IL-6,IL-1 β,TNF-α,myocardial infarction area,and the expressions of NLRP3 mRNA and Caspase-1 mRNA in the model group were significantly increased after modeling and at 3 weeks of treatment(P＜0.05);compared with the model group,the levels of cTnⅠ,CK-MB,IL-6,IL-1β,TNF-α,myocardial infarction area,and the expressions of NLRP3 mRNA and Caspase-1 mRNA in the betaloc group and the combination group were significantly decreased at 3 weeks of treatment,and the above indicators in the combination group were significantly lower than those in the betaloc group(P＜0.05).Conclusion Adjuvant therapy of Shenfu Injection for AMI can fur-ther alleviate myocardial cell injury,shorten infarction size,and inhibit inflammatory response and pyroptosis activity.

Objective To investigate the effect of adjuvant therapy of Shenfu Injection on NOD-like receptor protein 3(NLRP3)/cysteine-aspartic acid-specific protease 1(Caspase-1)mediated py-roptosis signaling pathway and inflammatory factor levels in rats with acute myocardial infarction(AMI).Methods A total of 40 rats were randomly divided into sham operation group,model group,betaloc group(0.9 mg/kg),and combination group(0.9 mg/kg betaloc combined with 6 mL/kg Shenfu Injection),with 10 rats in each group.The rats were treated by gavage continuously for 3 weeks.The levels of serum troponin Ⅰ(cTnⅠ),creatine kinase-MB(CK-MB),interleukin(IL)-6,IL-1β,and tumor necrosis factor-α(TNF-α)in rats were detected before modeling,after modeling,and at 3 weeks of treatment.Echocardiographic parameters such as left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),and myocardial infarction area were compared among groups after modeling and at 3 weeks of treatment.Real-time fluorescence quantitative polymerase chain reaction(qRT-PCR)and Western blot were used to detect the mRNA and protein expression levels of NLRP3 and Caspase-1 in the myocardium.Results Compared with the sham operation group,the levels of cTnⅠ,CK-MB,IL-6,IL-1 β,TNF-α,myocardial infarction area,and the expressions of NLRP3 mRNA and Caspase-1 mRNA in the model group were significantly increased after modeling and at 3 weeks of treatment(P＜0.05);compared with the model group,the levels of cTnⅠ,CK-MB,IL-6,IL-1β,TNF-α,myocardial infarction area,and the expressions of NLRP3 mRNA and Caspase-1 mRNA in the betaloc group and the combination group were significantly decreased at 3 weeks of treatment,and the above indicators in the combination group were significantly lower than those in the betaloc group(P＜0.05).Conclusion Adjuvant therapy of Shenfu Injection for AMI can fur-ther alleviate myocardial cell injury,shorten infarction size,and inhibit inflammatory response and pyroptosis activity.