Objective: To investigate the influencing factors of colorectal cancer and precancerous lesions among cured leprosy patients, so as to provide insights into prevention of colorectal cancer among cured leprosy patients. Methods: All cured leprosy patients were recruited from each leprosy village (hospital) in Zhejiang Province from 2019 to 2020. Participants' demographic features, family and medical history of intestinal polyps, smoking, alcohol consumption, dietary behaviors and defecation during the recent three years were collected using questionnaire surveys. Colorectal cancer and precancerous lesions were diagnosed using rectal examination, electronic colonoscopy and histopathological examinations, and factors affecting the development of colorectal cancer and precancerous lesions were identified with a multivariable logistic regression model among cured leprosy patients. Results: Totally 100 cured leprosy cases were enrolled, including 72 men and 28 women, and with a mean age of (67.23±3.42) years. There were 13 cases with grade 0 leprosy disability, 16 cases with grade 1 leprosy disability and 71 cases with grade 2 leprosy disability. The detection of colorectal cancer and precancerous lesions was 5.00% and 26.00%, respectively. Multivariable logistic regression analysis showed that age of 65 years and older (OR=7.128, 95%CI: 5.019-10.123), disability (OR=4.591, 95%CI: 2.942-7.163), a medical history of intestinal polyps (OR=4.031, 95%CI: 3.052-5.325), eating moldy food frequently (OR=4.433, 95%CI: 2.920-6.729), seldom eating vegetables (OR=4.411, 95%CI: 3.204-6.071), bloody stools (OR=4.341, 95%CI: 2.771-6.799), mucous stools (OR=4.577, 95%CI: 2.771-7.559) and presence of depression (OR=3.935, 95%CI: 3.026-5.117) were statistically associated with the development of colorectal cancer and precancerous lesions among cured leprosy patients. Conclusion Advanced age, disability, history of intestinal polyps, frequent intake of moldy food, infrequent consumption of vegetables, bloody stools, mucous stools, and depression may increase the risk of colorectal cancer and precancerous lesions among cured leprosy patients.

Objective To explore the clinical efficacy of Qingpeng unguentum(QU)combined with auricular acupuncture(AA)and multi-dimensional collaborative intervention(MDCI)in the treatment of postherpetic neuralgia(PHN).Methods Patients with PHN who attended the department of dermatology at Zhejiang Provincial Dermatology Hospital from January 2022 to January 2023 were retrospectively selected.According to the intervention regimens,patients were divided into three groups:the QU group(QU external application),the AA group(QU external application combined with AA),and the MDCI group(QU external application combined with AA and MDCI).Changes in negative mood[self-rating anxiety scale(SAS)and self-rating depression scale(SDS)],pain degree(visual analogue scale,VAS score),sleep quality(Pittsburgh sleep quality index,PSQI score),quality of life(mos36-item short form health survey,SF-36 score)and inflammatory markers(IL-6,TNF-α and CRP)were compared before and after intervention using paired sample t-tests.Differences among the groups in these parameters and in nursing satisfaction were analyzed using ANOVA,rank-sum test,or chi-square test.Results A total of 110 PHN patients were included in this study,with 30 in the QU group,41 in the AA group,and 39 in the MDCI group.There were no significant differences among the three groups in negative mood,pain degree,sleep quality,quality of life,and inflammatory markers(P>0.05).After 1 month of intervention,the scores for SAS,SDS,VAS,PSQI,as well as serum levels of IL-6,TNF-α,and CRP,significantly decreased compared to pre-intervention levels(P<0.05).The level of these indicators were lower in the AA group than in the QU group(P<0.05),and the level in the MDCI group were lower than those in the AA group(P<0.05).SF-36 scores were elevated in the 3 groups compared with the pre-intervention period,and were greater in the MDCI group than in the AA group,and in the AA group than in the QU group(P<0.05).Additionally,the total response rate and total satisfaction rate were significantly higher in the AA group than in the QU group(P<0.05),and higher in the MDCI group than in the AA group(P<0.05).Conclusion QU combined with AA and MDCI significantly improves negative mood,pain degree,sleep quality,and quality of life in PHN patients,reduces levels of inflammatory markers,and enhances overall treatment efficacy.It is recommended for promotion in clinical practice.

ObjectiveTo investigate the clinical characteristics of leprosy-related neuritis with bullous pemphigoid after treatment of paucibacillary leprosy. MethodsThe treatment of leprosy reaction combined with bullous pemphigoid of a cured case of leprosy was analysed. ResultsFive years after standard treatment for leprosy， erythema and vesicles appeared in the limbs without obvious inducement， and the disease became more and more severe. With clinical diagnosis and pathological examination， pemphigoid was confirmed， and the patients were given hormone treatment for leprosy reaction and anti-immunotherapy， as well as symptomatic supportive treatment. ConclusionLeprosy reaction and pemphigoid are both related to immunity， but the occurrence of both at the same time is relatively rare， so in the clinical process we should attach great importance to early detection， early diagnosis and prompt treatment to prevent further harm to the patient.