At present,the standard for the diagnosis of ventilator-associated pneumonia(VAP)is imperfect.The risk factors of VAP include body position, medical staffing, invasive procedure and so on. To strengthen the education and management of medical staff, improve the standard of care and breast feeding can reduce the incidence rate of VAP.There are controversial that H2 blockers/sucralfate, selective digestive tract decontamination and topical treatment with skin barrier can reduce the incidence rate of VAP. Common pathogenic bacteria of VAP are Klebsiella pneumoniae,Escherichia coli,Pseudomonas aeruginosa,Baumanii and so on in our country.Compreh-ensive prevention and treatment measures including selection of antibiotics appropriately and generalized supportive therapy should be applied.