OBJECTIVE:To observe the efficacy and safety of mesalazine combined with bifidobacterium tetravaccine(live)in the treatment of ulcerative colitis(UC). METHODS:83 UC patients were tandomly divided into control group(42 cases)and test group (41 cases). Control group was orally given 1.0 g Mesalazine enteric-coated tablet,4 times a day;test group was additionally given 1.5 g Bifidobacterium tetravaccine tablet(live),3 times a day. The treatment course fr both group was 6 weeks. The clinical efficacy,and serum high sensitivity C-reactive protein(hs-CRP),interleukin(IL)-4,IL-8 levels before and after treatment and the incidence of ad-verse reactions in 2 groups were observed. RESULTS:After treatment,serum hs-CRP and IL-8 in 2 groups were significantly lower than before,and test group was lower than control group;serum IL-4 level was significantly higher than before,and test group was higher than control group,the differences were statistically significant(P<0.05 or P<0.01). Total effective rate in test group was sig-nificantly higher than control group,the difference was statistically significant(P<0.05). And there was no significant difference in the incidence of adverse reactions (P>0.05). CONCLUSIONS:Mesalazine combined with bifidobacterium tetravaccine (live) is more effective than mesalazine alone UC,with similar safety.

Objective:To summarize the experience in surgical treatment for ulcerative colitis(UC).Methods:The clinical data of 36 patients with UC who underwent surgery in Renji Hospital,Shanghai Jiao Tong University School of Medicine from Jan 2008 to Jan 2013 were retrospectively analyzed.The surgical methods and prognosis were evaluated.Results:There were 23 ca-ses of selective operation which was total colectomy with ileal pouch-anal anastomosis(IPAA)in the first stage.Among the 23 cases,4 cases complicated with toxic megacolon were treated with intestinal obstruction catheter by endoscopy,and then under-went selective IPAA.There were 13 cases of emergency operation which was total colectomy with ileostomy in the first stage and IPAA in the second stage.Open surgery was done in 1 patient with perforation of digestive tract,1 patient with toxic mega-colon and 1 patient with history of abdominal operation,and laparoscopic surgery was done in the other 33 patients.None of the 36 cases had any severe perioperative complications.Conclusions:Indication of UC operation should be strictly controlled while safe operation method should be reasonably chosen.IPAA is a safe and effective method for selective operation and emergency surgery of UC.