Objective To observe the therapeutic effect of the integration of Longji-Huoluo pill and mild manipulations Tuina therapy for the teenagers with lumbar intervertebral disc protrusion. Methods Eligible teenager patients with lumber intervertebral disc protrusion were randomly classified into two groups according to the single blind method and the treating sequence, 69 patients in the treatment group and 58 patients in the control group. The Longji-Huoluo pill and mild Tuina manipulations were adopted on the basis of the convertional treatment in the treatment group. While ibuprofen sustained release capsules and mecobalamin were given to the control group beside the convertional treatment. Both groups were treated for 4 weeks. The CT examinations were applied before and after the treatments to observe the absorption of the prolapsed lumber intervertebral disc. The Visual Analogue Scale (VAS) was used to test the pain degree and to estimate the clinical effect. Results The VAS scores in the treatment group (4.03 ± 1.67 vs. 5.41 ± 1.55, t=10.121) and the control group (3.61 ± 1.34 vs. 5.96 ± 1.71, t=11.086) after treatment were significantly lower than those before treatment (P<0.05). The sagittal diameters of the prominence in the treatment group (2.12 ± 1.89 mm vs. 4.62 ± 0.34 mm, t=2.281) after treatmentwas significantly lower than that before treatment (P<0.05). The total effective rate of the treatment group was 87.0%(60/69), and the control group was 72.4%(42/58). Statistical significance was detected on the difference of the two groups (U=1.913, P=0.043). Conclusions The integration of manipulations can effectively relieve the pain and can return the prominent disc. The therapeutic effect is considered equivalent to western medicine.

Objective To explore the role of deep brain stimulation of subthalamic nucleus (STN-DBS) in treatment of Parkinson's disease (PD) related neuroleptic malignant syndrome (NMS).Methods The medical history,clinical features,STN-DBS programmed treatment process and treatment results of two patients admitted to our hospital in December 2014 and November 2018 were retrospectively analyzed.Results Two patients with post-operative STN-DBS were evoked by dose-reduced treatment of anti-parkinsonian drugs,and presented with high fever,disorder of consciousness,aggravation of the original parkinsonism,and increase of creatine phosphokinase,which were not correlated with outcomes of infection.After admission,anti-parkinsonian drugs and other supportive therapies were supplemented;STN-DBS modulation were given to improve the symptoms;the final parameters of patient one were the left (C+,2-,1-),pulse width 110 μs,frequency 200 Hz,and strength 3.8 V;the right side (C+,6-,5-),pulse width 110 μs,frequency 200 Hz,strength 4.4 V;and those of patient two were the left (C+,3-),pulse width 60 μs,frequency 130 Hz,strength 2.0 V;right side (C+,6-),pulse width 80 μs,frequency 160 Hz,and strength 2.8 V.Both patients were cured,but their motor function and self-care ability were severely impaired.Conclusion STN-DBS may play an important role in the treatment of PD related NMS.