Objective To investigate the factors that affect the survival of patient with spinal metastases.Methods The clinical,imaging and pathologic data of 56 patients with pathologically confirmed spinal metastases were analyzed retrospectively with Cox regression.Results The type of primary tumor(P=0.001) and age(P=0.034) significantly affect the survival.Conclusion The type of primary tumor is of most significant factor affecting survival.

Objecfive To identify what factors contribute to the occurrence of avascular necrosis (AVN) of the femoral head after pediatric femoral neck fractures. Methods A series of 33 pediatric femoral neck fractures who had been admitted to our institution between June 1994 and April 2006 were retrospectively reviewed. There were 1 case of type Ⅰ,15 type Ⅱ,14 type Ⅲ and 2 type IV according to Delbet classification. The mean age at injury was 10.7(3.7 to 14.1) years, and the mean follow-up was 3.4(1 to 12.2)years. All patients were followed up until union was achieved. AVN occurred in 16 cases, including 8 cases of Ratliff type Ⅰ,3 of Ratliff type Ⅱ,4 of Ratliff type Ⅲ and 1 unclassified. Age at injury, fracture type, degree of displacement, quality of reduction and type of fixation were calculated and analyzed with respect to AVN. Results AVN occurred in 4 cases (36.4%)under 10 years old and in 12 cases (54.5%)10 years old or more. Eight cases (53.3%)of AVN occurred in Delbet type Ⅱ and 6 cases (42.9%) of AVN occurred in type Ⅲ.One case (25.0%)of AVN occurred in non-displaced group and 14 cases(53.8%)in displaced group. Ten cases(50.O%)of AVN occurred in the group whose reduction quality was satisfactory and 6 cases(66.7%)in unsatisfactory reduction group. Thirteen cases (48.1%)of AVN occurred in the unstable fixation group and 2 cases (50.0%)in the stable fixation group. Conclusion Fracture type, degree of displacement, quality of reduction and age at injury can affect the occurrence of AVN of the femoral head after pediatric femoral neck fractures.

OBJECTIVETo determine whether cancellous bone allograft is the best biological material for filling a cavity bone defect.

METHODSBetween 1992 and 1998, deep frozen cancellous bone allograft was used in the treatment of bone defect in 57 patients following tumor resection. The age of the patients varied from 6 to 56 years (mean 17.4 years).

RESULTSBone unions were achieved in 56 patients, and the average time for union was 4.5 months; One patient had the graft removed for infection. The time for union was different according to the volume of graft. The longer time for union was always accompanied with the larger volume of graft. To compare the union time of admixture of cancellous autograft and allograft with that of cancellous allograft alone, the time for union was same in both group. No immune response and infection was observed in this group. And infection happened in 1 of the 57 patients. The local recurrence rate of tumor was 7%.

CONCLUSIONSThe feasibility and security of this packing method are better than other. Compared with cancellous autograft, no significant difference was found in the time for union and complication rate except local tumor recurrence.

Adolescent ; Adult ; Bone Neoplasms ; surgery ; Bone Transplantation ; adverse effects ; methods ; Child ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Transplantation, Homologous

Objective This study is to understand the effects of RGD\|peptide(224), Echistatin and 17 ? estrodiol on bone resorption. Methods RGD\|polypeptide (224) (RGD), Echistatin(Ech) and 17 ? estrodiol (E\-2) were added into osteoclast like cells (OLC) and ivory bone slices co\|cultured system. Results It has been found that 10 -7 mol/L RGD, Ech and E\-2 decreased the number of resorption lacunae, resorption area and resorption cave on bone slices in various degrees.Conclusion RGD, Ech and E\-2 inhibits the bone resorption activities in various degrees. [