Objective To explore the clinical application of irradiated homograft costal cartilage (IHCC) granule transplantation for the pyriform aperture sunken and deformity in the facial contour.Methods From August 2016 to November 2017,a total of 29 female patients were received IHCC transplantation to the face contour.The standardized photos were taken before and after the operation and then survey of patient satisfaction was conducted.Results In a total of 29 patients,the postoperative 21 patients were satisfied with the IHCC transplantation.After the operation,5 cases were slightly highlighted and obvious bundles could be touched in the deep.At the early stage of operation,the cartilage particles were smoothed by means of manipulation.3 cases were not satisfied with full effect postoperatively and satisfied after secondary transplantation.Conclusions The IHCC granule transplantation for pyriform aperture sunken and deformity can increase the overall sense of facial coordination and anti-aging,and is a safe and effective treatment.