Child ; Histiocytosis, Sinus ; diagnosis ; drug therapy ; Humans ; Lymphatic Diseases ; diagnosis ; drug therapy ; Male

To investigate the animals infection situation of novel bunyavirus in Xinyang City ,Henan Province ,China , animal serum samples such as cattle ,dog ,swine ,mice were collected in Shangcheng County and Guangshan County in Xinyang City .All the serum samples were detected by novel bunyavirus ELISA and real time RT-PCR method .A total of 292 animal serum samples were collected including 5 kinds of animals .The result of all the animal serum samples were negative by using real time RT-PCR ,and the positive rate was 45 .19% (141/312) by ELISA method .Of the 5 animal serum samples including mice ,cattle ,goats ,swine and dogs ,the positive rate were detected to be 1 .06% ,100 .00% ,76 .27% ,3 .57% ,and 75 .00%respectively .There was significant difference in results among 5 kind of animal serum antibodies .Animals such as cattle and dog may be the host of novel bunyavirus which were detected novel bunyavirus antibodies in cattle and dog in Xinyang City , Henan Province ,China .

To explore the relationship between meteorological factors and incidences of fever, thrombocytopenia and leukopenia syndrome (FTLS), incidence data of FTLS in Xinyang City were collected and described. The relationship between FTLS and monthly meteorological factors such as average atmospheric pressure, average temperature, average relative humidity, average wind speed and precipitation was analyzed with simple correlation and multi-stepwise linear regression. The results showed that there was a significant negative correlation between incidence of FTLS and monthly average atmospheric pressure (P<0.01), and there were significant positive correlations between monthly average temperature, monthly average relative humidity, monthly precipitation and incidence of FTLS (P<0.05). The multi-stepwise regression showed that the regression equation was Y (monthly cases) =-12.70 + 0.28X2 (monthly average temperature), and the coefficient of determination was 0.76. The incidences of FTLS are correlated with temperature.

Objective To investigate the diagnosis and the microsurgical treatment of intramedullary hemangioblastoma in cervical spinal cord.Methods The signs of MRI,and the results of operations were analysed in 26 patients with the tumors.Rusults The tumors can be classified into two types:Solid type (14 cases)and cystic type(12 eases).All the tumors underwent total removal and were all hemangioblastoma confirmed by histopathologic examinations.Postoperatively,neurological status were improved in 17 patients, remained in 7 cases and worse in 2 cases.Conclusion For intrameduUary hemangioblastoma of cervical spinal cord MRI is of significant importance in the diagnosis of localization and the nature of the tumors which is conductive to selecting appropriate operative methods.There is high risk in operating at cervical section,but microsurgical total resection is the optimal method to stop the development of the clinical presentation.Opera- tive methods varied with the different typer of the tumor.It is the most important principal that dissection is performed along the correct interface and the tumor should be removed en bloc after it is devascularized.

Objective: To analyze the high risk factors and prognosis of patients with ventilator associated pneumonia(VAP) treated with mechanical ventilation(MV) in Intensive Care Unit(ICU), and to provide theoretical evidence for effective treatment and prevention. Methods: From January 2015 to January 2017, 156 MV patients treated in ICU of Shaoxing Municipal Hospital were enrolled retrospectively.According to the occurrence of VAP, the patients were divided into VAP group(76 cases) and non-VAP group(80 cases). The data including sex, age, ICU time, MV time, cases of withdrawing machine failure, prognosis, serum albumin, blood glucose levels, APACHE Ⅱ score, types of antibiotics and days of continuous applying were recorded.Single factor χ² test and multiple factor logistic regression analysis were used to analyze the high-risk factors and prognosis related to occurrence of VAP. Results: Univariate analysis showed that the age, mortality, serum albumin and blood glucose levels, MV time, weaning failure rate, APACHE Ⅱ score, antibiotic combination type and days of continuous use, application of H₂ receptor antagonists time between, the VAP group and non-VAP group had statistically significant differences (χ²=6.568, 16.558, 5.132, 5.896, 27.043, 15.018, 48.863, 46.752, 27.431, 3.981, P=0.010, 0.000, 0.023, 0.015, 0.000, 0.000, 0.000, 0.000, 0.000, 0.046). After age adjustment, logistic regression analysis showed that serum albumin <30g/L, blood glucose ≥7.8mmol/L, MV time >5 days, APACHE Ⅱ score>15 points, antibiotics continuous use>3 days, and antibiotic combination type>2 were independent risk factors for VAP(χ²=5.115, 5.984, 21.252, 18.043, 9.008, 14.545, P=0.030, 0.026, 0.000, 0.000, 0.007, 0.001). Compared with surviving patients with VAP, death patients lived longer in ICU and MV, and APACHE Ⅱ scores were higher(t=4.136, 6.382, 7.312, P=0.000, 0.000, 0.000). Conclusion There are multiple high-risk factors of VAP in patients treated with MV in ICU.The death demonstrated longer ICU time, MV time and higher APACHE Ⅱ score, need to be strengthened monitoring, early prevention and treatment.

Objective To investigate the safety and feasibility of thoracoscopic radical resection of lung carcer in patients with severe coronary stenosis at 2 weeks after stent implantation.Methods Clinical materials of 13 patients with thoracoscopic radical resection of lung cancer at 2 weeks after stent implantation for coronary heart disease were analyzed retrospectively,and were compared with the clinical materials of 127 patients without severe coronary artery stenosis by thoracoscopic radical resection for lung cancer.Results Totally 13 patients in PCI group were implanted with 25 stents.Among them,12 stents were smoothly implanted in left anterior descending branch,6 stents in left circumflex branch and 7 stents in right coronary artery.The degree of coronary artery stenosis decreased from more than 75％ to less than 10％.The patients in two groups were smoothly performed thoracoscopic radical resection of lung cancer under general anesthesia,and postoperative pathology was confirmed as malignant tumor.Blood coagulation time (TT) in PCI group was significantly longer than that in the control group (P ＜ 0.05),platelet count (PLT) decreased significantly when compared with the control group (P ＜ 0.05),and the prothrombin time (PT) and activated partial thromboplastin time (APTT) showed no significant differences between two groups (P ＞ 0.05).The operating time and the bleeding volume in two groups showed no significant differences (P ＞ 0.05),while the postoperative pleural drainage in PCI group significantly increased (P ＜ 0.05),extubation time and postoperative hospitalization time were significantly longer than those in the control group (P ＜ 0.05),but in PCI group,there was no massive bleeding during and after operation,and no major cardiovascular accident occurred.Conclusion It is safe and feasible to use thoracoscopic radical surgery of lung cancer at 2 weeks after coronary artery stent implantation on the premise of standardized anticoagulant drugs and good perioperative jobs.

Objective To investigate the safety and feasibility of thoracoscopic radical resection of lung carcer in patients with severe coronary stenosis at 2 weeks after stent implantation.Methods Clinical materials of 13 patients with thoracoscopic radical resection of lung cancer at 2 weeks after stent implantation for coronary heart disease were analyzed retrospectively,and were compared with the clinical materials of 127 patients without severe coronary artery stenosis by thoracoscopic radical resection for lung cancer.Results Totally 13 patients in PCI group were implanted with 25 stents.Among them,12 stents were smoothly implanted in left anterior descending branch,6 stents in left circumflex branch and 7 stents in right coronary artery.The degree of coronary artery stenosis decreased from more than 75％ to less than 10％.The patients in two groups were smoothly performed thoracoscopic radical resection of lung cancer under general anesthesia,and postoperative pathology was confirmed as malignant tumor.Blood coagulation time (TT) in PCI group was significantly longer than that in the control group (P ＜ 0.05),platelet count (PLT) decreased significantly when compared with the control group (P ＜ 0.05),and the prothrombin time (PT) and activated partial thromboplastin time (APTT) showed no significant differences between two groups (P ＞ 0.05).The operating time and the bleeding volume in two groups showed no significant differences (P ＞ 0.05),while the postoperative pleural drainage in PCI group significantly increased (P ＜ 0.05),extubation time and postoperative hospitalization time were significantly longer than those in the control group (P ＜ 0.05),but in PCI group,there was no massive bleeding during and after operation,and no major cardiovascular accident occurred.Conclusion It is safe and feasible to use thoracoscopic radical surgery of lung cancer at 2 weeks after coronary artery stent implantation on the premise of standardized anticoagulant drugs and good perioperative jobs.

OBJECTIVETo observe the clinical effect of Guilu Erxian Glue Cataplasm (GEGC) on carcinoma of the large intestine patients with myelosuppression after chemotherapy, and further to confirm its efficiency and safety.

METHODSTotally 60 patients with carcinoma of the large intestine were randomly assigned to two groups. Meanwhile, they all accepted FOLFIRI chemotherapy. Patients in the treatment group were additionally applied at Shenque (RN8), exchanging once per every other day, for 14 successive days. Patients in the control group took placebos with the same dose and dosage as the treatment group. The blood cell counts (WBC, NE, and PLT) were detected before chemotherapy, at day 7, 10, and 14. The TCM symptoms integrals, Karnofsky performance score (KPS), liver and kidney functions were observed before chemotherapy, at day 7 and day 14. Adverse skin reactions were observed each day. And the usage of hematopoietic growth factors was recorded.

RESULTS(1) The KPS score at day 7 was more stable in the treatment group than in the control group; the WBC and NE counts in the peripheral blood at day 14 were higher in the treatment group than in the control group; and TCM symptoms integrals at day 14 was lower in the treatment group than in the control group, all with statistical difference (P < 0.05). (2) Compared with the control group, the PLT count was higher in the treatment group than in the control group, the usage of rhG-CSF and antibiotics was less in the treatment group than in the control group, all with no statistical difference (P > 0.05). (3) No obvious adverse reactions such as liver injury, renal injury, or skin allergy were observed.

CONCLUSIONSAdjuvant treatment of GEGC could improve carcinoma of the large intestine patients with myelosuppression to some extent. No relevant adverse reactions were found.

Adjuvants, Immunologic ; therapeutic use ; Adult ; Aged ; Bone Marrow Diseases ; chemically induced ; drug therapy ; Colorectal Neoplasms ; drug therapy ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Male ; Middle Aged

Adolescent ; Adult ; Child ; Child, Preschool ; DNA, Viral ; analysis ; Female ; Fluoroimmunoassay ; methods ; Hepatitis B Antibodies ; analysis ; Hepatitis B Surface Antigens ; analysis ; Hepatitis B e Antigens ; analysis ; Humans ; Male ; Middle Aged

OBJECTIVETo explore the clinical, pathological, and imaging features of autoimmune pancreatitis (AlP).

METHODSThe clinical data of 10 patients (all men; aged 47-80 years, mean 61.3 years) with AlP in our hospital between March 2000 and August 2007 were retrospectively analyzed. gamma-globulin, immunoglobulin C (IgG), rheumatoid factors, and autoantibodies were examined for all cases. The imaging findings were reviewed, which included helical computed tomography (CT), endoscopic ultrasonography (EUS), and B-mode ultrasound in all patients, magnetic resonance cholangiopancreatography (MRCP) in 9 patients, and endoscopic retrograde cholangiopancreatography (ERCP) in 7 patients. Follow-up imaging results were available in 5 patients.

RESULTSClinically, the most common early symptoms included obstructive jaundice (9/10) and non-specific abdominal pain (1/10), accompanied by the elevated levels of serum gamma-globulin, IgG or the presence of autoantibodies. Diabetes mellitus was detected at presentation in 2 patients. imaging findings included: CT showed diffuse (n=9) and focal (n=1) enlargement of pancreas. Minimal peripancreatic stranding was found in 7 patients, with no pancreatic pseudocyst and calcification. Six patients had enlarged peripancreatic lymph nodes. After contrast injection for 4 patients, delayed enhancement of the pancreatic parenchyma was observed, along with low-density capsule-like rim surrounding the pancreas. Magnetic resonance imaging showed diffuse enlargement of pancreas in 9 patients. MRCP showed diffuse (n=6) and segmental (n=3) irregular narrowing of the main pancreatic duct. B-mode ultrasound showed diffuse (n=9) and focal (n=1) enlargement of the pancreas. EUS showed diffuse (n=9) and focal (n=1) enlargement with hypoecho. ERCP showed stricture of distal common bile duct and irregular dilation of proximal bile ducts in 7 patients, diffuse stricture in main pancreatic duct in 4 patients, and segmental stricture in 3 patients. During the follow-up, abnormalities of imaging and serum markers were resolved after steroid therapy in 5 patients.

CONCLUSIONAIP is a distinctive type of chronic pancreatitis that shows specific imaging features.

Aged ; Aged, 80 and over ; Autoantibodies ; blood ; Autoimmune Diseases ; diagnosis ; diagnostic imaging ; immunology ; Endosonography ; Female ; Humans ; Male ; Middle Aged ; Pancreatitis ; diagnosis ; diagnostic imaging ; immunology ; Retrospective Studies ; Tomography, X-Ray Computed