1.A study on the mutual interactions of atherosclerotic risk factors:results from employee pediatric health examinations.
Mi Na NHA ; Hee Cheol OH ; You Lan PYEON ; Jeong Jin CHO
Journal of the Korean Academy of Family Medicine 1992;13(2):140-151
No abstract available.
2.Relationship between first-twitch depression and train-of-four ratio during sugammadex reversal of rocuronium-induced neuromuscular blockade.
Kyo Sang KIM ; You Na OH ; Tae Yeon KIM ; Song Yee OH ; Yeong Hun SIN
Korean Journal of Anesthesiology 2016;69(3):239-243
BACKGROUND: The primary outcome of sugammadex reversal for rocuronium-induced neuromuscular block (NMB) is a train-of-four ratio (TOFR) of 0.9, not first twitch (T1) height. We investigated whether the recovery of TOFR or T1 differs based on the reversal of NMB with neostigmine or sugammadex. METHODS: The acceleromyographic responses from 0.6 mg/kg of rocuronium were monitored supramaximally in 80 patients after induction of anesthesia. The TOFR and T1 height were recorded, and saved in a personal computer using TOF-Watch SX Monitor software in all patients. Patients were randomly assigned to 2 groups to receive either neostigmine 50 µg/kg with glycopyrrolate 10 µg/kg (neostigmine group, n = 40) or sugammadex 2.0 mg/kg (sugammadex group, n = 40). The primary objective was to determine the difference of recovery time between TOFR to 0.9 and T1 to 0.9 after sugammadex or neostigmine administration during moderate rocuronium-induced NMB. RESULTS: The recovery pattern of the TOFR 2 min after sugammadex administration was 1.0 or more, but that of T1 was less than 90% (T1 / control value) up to 6 min after drug was injected. The recovery pattern of TOFR and T1 was similar during the 20 min after reversal with neostigmine. CONCLUSIONS: If you have not performed the T1 monitoring, both TOFR and T1 should be considered to confirm suitable recovery during the 6 min after reversal with sugammadex during rocuronium-induced moderate NMB.
Anesthesia
;
Depression*
;
Glycopyrrolate
;
Humans
;
Microcomputers
;
Neostigmine
;
Neuromuscular Blockade*
;
Neuromuscular Monitoring
3.Accidental ingestion of a fixed partial denture during general anesthesia: A case report.
Kyu Nam KIM ; Kyo Sang KIM ; Hee Jong LEE ; You Na OH
Anesthesia and Pain Medicine 2015;10(2):138-140
Swallowing a foreign body of dental origin is a rare occurrence; but, it can be dangerous if the foreign body is large, sharp, and pointed. We report a case in which a large fixed partial denture became dislodged and was ingested while the patient was undergoing general anesthesia, and was removed postoperatively with endoscopy. Anesthesiologists should understand the dangers and recognize this complication when it occurs, and prepare a suitable treatment plan.
Anesthesia, General*
;
Deglutition
;
Denture, Partial
;
Denture, Partial, Fixed*
;
Eating*
;
Endoscopy
;
Foreign Bodies
;
Humans
4.Extracorporeal Membrane Oxygenation Support in Adult Patients with Hematologic Malignancies and Severe Acute Respiratory Failure.
Tai Sun PARK ; You Na OH ; Sang Bum HONG ; Chae Man LIM ; Younsuck KOH ; Je Hwan LEE ; Jung Hee LEE ; Kyoo Hyung LEE ; Jin Won HUH
Korean Journal of Critical Care Medicine 2016;31(3):243-250
BACKGROUND: Administering extracorporeal membrane oxygenation (ECMO) to critically ill patients with acute respiratory distress syndrome has substantially increased over the last decade, however administering ECMO to patients with hematologic malignancies may carry a particularly high risk. Here, we report the clinical outcomes of patients with hematologic malignancies and severe acute respiratory failure who were treated with ECMO. METHODS: We performed a retrospective review of the medical records of patients with hematologic malignancies and severe acute respiratory failure who were treated with ECMO at the medical intensive care unit of a tertiary referral hospital between March 2010 and April 2015. RESULTS: A total of 15 patients (9 men; median age 45 years) with hematologic malignancies and severe acute respiratory failure received ECMO therapy during the study period. The median values of the Acute Physiology and Chronic Health Evaluation II score, Murray Lung Injury Score, and Respiratory Extracorporeal Membrane Oxygenation Survival Prediction Score were 29, 3.3, and -2, respectively. Seven patients received venovenous ECMO, whereas 8 patients received venoarterial ECMO. The median ECMO duration was 2 days. Successful weaning of ECMO was achieved in 3 patients. Hemorrhage complications developed in 4 patients (1 pulmonary hemorrhage, 1 intracranial hemorrhage, and 2 cases of gastrointestinal bleeding). The longest period of patient survival was 59 days after ECMO initiation. No significant differences in survival were noted between venovenous and venoarterial ECMO groups (10.0 vs. 10.5 days; p = 0.56). CONCLUSIONS: Patients with hematologic malignancies and severe acute respiratory failure demonstrate poor outcomes after ECMO treatment. Careful and appropriate selection of candidates for ECMO in these patients is necessary.
Adult*
;
APACHE
;
Critical Illness
;
Extracorporeal Membrane Oxygenation*
;
Hematologic Neoplasms*
;
Hemorrhage
;
Humans
;
Intensive Care Units
;
Intracranial Hemorrhages
;
Lung Injury
;
Male
;
Medical Records
;
Respiratory Distress Syndrome, Adult
;
Respiratory Insufficiency*
;
Retrospective Studies
;
Tertiary Care Centers
;
Weaning
5.Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells.
You Na OH ; Soojung JIN ; Hyun Jin PARK ; Hyun Ju KWON ; Byung Woo KIM
Journal of Cancer Prevention 2016;21(4):249-256
BACKGROUND: Sorbus rufopilosa, a tsema rowan, is a species of the small ornamental trees in the genus Sorbus and the family Rosaceae found in East Asia. The bioactivities of S. rufopilosa have not yet been fully determined. The objective of this study is to evaluate the antioxidant and anticancer effects of ethanol extract of S. rufopilosa (EESR) and to determine the molecular mechanism of its anticancer activity in human colon carcinoma HT29 cells. METHODS: To examine the antioxidant activity of EESR, 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity assay was performed. Inhibitory effect of EESR on cancer cell growth and proliferation was determined by water-soluble tetrazolium salt assay. To investigate the mechanism of EESR-mediated cytotoxicity, HT29 cells were treated with various concentrations of EESR and the induction of cell cycle arrest and apoptosis was analyzed by flow cytometry, 4,6-diamidino-2-phenylindole staining, and Western blot analysis. RESULTS: EESR showed significant antioxidant activity and inhibitory effect on HT29 cell growth in a dose-dependent manner. EESR induced cell cycle arrest at G2/M phase in a dose-dependent manner by modulating cyclin B, cyclin-dependent kinase 1 (CDK1), and CDK inhibitor p21 expression. EESR-induced apoptosis was associated with the upregulation of p53, a death receptor Fas, and a pro-apoptotic protein Bax and the activation of caspase 3, 8, and 9, resulting in the degradation of PARP. CONCLUSIONS: EESR possessing antioxidant activity efficiently inhibits proliferation of HT29 cells by inducing both cell cycle arrest and apoptosis. EESR may be a possible candidate for the anticancer drug development.
Adenocarcinoma*
;
Apoptosis*
;
Blotting, Western
;
Caspase 3
;
CDC2 Protein Kinase
;
Cell Cycle Checkpoints*
;
Cell Cycle*
;
Colon*
;
Cyclin B
;
Ethanol
;
Far East
;
Flow Cytometry
;
HT29 Cells*
;
Humans*
;
Rosacea
;
Rosaceae
;
Sorbus*
;
Trees
;
Up-Regulation
6.Influence of acute normovolemic hemodilution on the potency and time course of action of rocuronium in rabbits.
Jeoung Hyuk LEE ; Kyo Sang KIM ; Tae Yeon KIM ; You na OH ; Wonho LEE
Anesthesia and Pain Medicine 2016;11(3):273-279
BACKGROUND: We performed this study to evaluate the potency and time course of rocuronium-induced neuromuscular block following moderate or severe acute normovolemic hemodilution (ANH) in rabbits. METHODS: Forty five rabbits were randomly assigned to the control (C) group, the moderate ANH (M) group, or the severe ANH (S) group. After stabilization of sevoflurane anesthesia, ANH was achieved by drainage of arterial blood and an intravenous infusion of 6% hydroxyethyl starch, during which hematocrit (Hct) decreased to 26.2 ± 2.5% in the M group and 17.6 ± 2.2% in the S group. We determined dose-response relationships of rocuronium in the three groups and created a time course of the action of 0.6 mg/kg rocuronium. RESULTS: The 50% effective dose (ED50) for rocuronium was 45% and 50% lower in the M and S groups, respectively, than in the C group (50.9 ± 6.3 µg/kg) (P < 0.001). The onset time after 0.6 mg/kg rocuronium was faster in the ANH groups compared with the C group (P < 0.001). The duration of neuromuscular block was prolonged by 38% and 43% in the M and S groups, respectively, compared with the C group (49.1 ± 6.9 min) (P < 0.001). CONCLUSIONS: ANH resulted in high potency, rapid onset, and prolonged duration of rocuronium. However, the severity of ANH did not alter the potency and duration of action of rocuronium.
Anesthesia
;
Drainage
;
Hematocrit
;
Hemodilution*
;
Infusions, Intravenous
;
Neuromuscular Blockade
;
Rabbits*
;
Starch
8.Cedrol, a Sesquiterpene Isolated from Juniperus chinensis, Inhibits Human Colorectal Tumor Growth associated through Downregulation of Minichromosome Maintenance Proteins
Soojung JIN ; Jung-ha PARK ; Hee Jung YUN ; You Na OH ; Seunghye OH ; Yung Hyun CHOI ; Byung Woo KIM ; Hyun Ju KWON
Journal of Cancer Prevention 2022;27(4):221-228
Cedrol, a sesquiterpene alcohol, isolated from Juniperus chinensis has been reported to inhibit minichromosome maintenance (MCM) proteins as cancer biomarkers in human lung cancer in vitro. In the present study, we investigated the anti-cancer activity of cedrol in vitro and in vivo using human colorectal cancer HT29 cells and a human colorectal tumor xenograft model. Cedrol inhibited MCM protein expression and cell growth in HT29 cells, which are associated with G1 arrest and the induction of apoptosis. We demonstrated that cedrol effectively reduced HT29 tumor growth without apparent weight loss in a human tumor xenograft model.Compared with vehicle- and adriamycin-treated tumor tissues, cedrol induced changes in the tumor tissue structure, resulting in a reduced cell density within the tumor parenchyma and reduced vascularization. Moreover, the expression of MCM7, an important subunit of MCM helicase, was significantly suppressed by cedrol in tumor tissue. Collectively, these results suggest that cedrol may act as a potential anti-cancer agent for colorectal cancer by inhibiting MCM protein expression and tumor growth.
9.Cedrol, a Sesquiterpene Isolated from Juniperus chinensis, Inhibits Human Colorectal Tumor Growth associated through Downregulation of Minichromosome Maintenance Proteins
Soojung JIN ; Jung-ha PARK ; Hee Jung YUN ; You Na OH ; Seunghye OH ; Yung Hyun CHOI ; Byung Woo KIM ; Hyun Ju KWON
Journal of Cancer Prevention 2023;28(2):75-75
10.Effect of palmitoylethanolamide on inflammatory and neuropathic pain in rats.
Tai Kyung SEOL ; Wonho LEE ; Sunah PARK ; Kyu Nam KIM ; Tae Yeon KIM ; You Na OH ; Jong Hun JUN
Korean Journal of Anesthesiology 2017;70(5):561-566
BACKGROUND: A growing body of evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of mast cells and glial cells, and production of inflammatory mediators in the peripheral and central nervous systems, plays an important role in the induction and maintenance of chronic pain. Palmitoylethanolamide (PEA), which is a type of N-acylethanolamide and a lipid, has an anti-inflammatory effect. Relative to the anti-inflammatory effect, little is known about its analgesic effect in chronic pain. This study aimed to determine whether PEA relieves chronic inflammatory and neuropathic pain. METHODS: Male Sprague-Dawley rats were injured by transection of the left L5 and L6 spinal nerves to induce neuropathic pain or were injected with monoiodoacetic acid into the synovial cavity of knee joints to induce inflammatory pain. To assess the degree of pain, two kinds of stimuli - pressing von Frey filaments and wetting with acetone - were applied to the plantar surface of the rat to measure mechanical and cold sensitivity, respectively. Pain was measured by assessing behavioral responses, including paw withdrawal response threshold and paw withdrawal frequency upon stimulation. RESULTS: Neuropathic pain caused by spinal nerve transection (SNT) decreased the mechanical threshold and increased the frequency of response to acetone application. But, cold allodynia caused by SNT did not decrease the withdrawal frequency. Mechanical hyperalgesia caused by chronic inflammation was significantly reduced by both intraperitoneal and intra-articular injections of PEA. CONCLUSIONS: These outcomes revealed that PEA might be effective in relieving inflammatory and neuropathic pain, especially pain induced by mechanical hyperalgesia, but not cold allodynia.
Acetone
;
Animals
;
Central Nervous System
;
Chronic Pain
;
Humans
;
Hyperalgesia
;
Inflammation
;
Injections, Intra-Articular
;
Iodoacetic Acid
;
Knee Joint
;
Male
;
Mast Cells
;
Neuralgia*
;
Neuroglia
;
Peas
;
Rats*
;
Rats, Sprague-Dawley
;
Spinal Nerves