Objective To investigate the influence of different doses of flurbiprofen axetil on neurological behavior in CCI rats.Methods All SD rats were randomly assigned to 3 groups:control group(C group),operation but without CCI,n=5;CCI group,without injection,n=5;flurbiprofen axetil (FA) group,different doses of flurbiprofen axetil were intraperitoneally administered every 12 hours for 7 days beginning on postoperative 6 hours in CCI rats (FA1 group:2mg/kg,FA2 group:4mg/kg,FA3 group:8mg/kg,FA4 group:16mg/kg),5 rats in each subgroup.The thermal withdrawal latency(TWL) and mechanical withdrawal threshold(MWT) were tested on preoperative 1,3,5 and 7 days and postoperative 1,3,5 and 7 days.Results Firstly,compared with C group[TWL:(12.396±1.144)s;MWT:(12.801±0.494)g],the TWL and MWT of CCI and FA groups[TWL:(5.645±1.144)s,(5.901±0.914)s,(6.300±0.835)s,(7.631±0.597)s,(7.894±0.526)s;MWT:(5.14±0.71)g,(5.28±0.60)g,(6.74±0.50)g,(6.74±0.25)g,(6.70±0.42)g]were significantly declined after surgery (tTWL=26.973,31.047,31.176,30.373,30.772;tMWT=44.192,48.132,51.136,54.326,46.937,all P<0.05),and the TWL and MWT of FA groups significantly improved with the doses from 2mg/kg to 16mg/kg of flurbiprofen axetil[TWL:the minimum (5.030±0.240)s,the maximum (8.300±0.430)s;MWT:the minimum (4.56±0.14)g,the maximum (7.11±0.20)g].Secondly,there were no statistically significant differences in TWL and MWT between CCI group and FA1 group(all P>0.05).However,the TWL and MWT of FA2 group,FA3 group and FA4 group[TWL:(6.300±0.835)s,(7.631±0.597)s,(7.894±0.526)s;MWT:(6.74±0.50)g,(6.74±0.25)g,(6.70±0.42)g] increased significantly compared with CCI group(tTWL=-3.768,-11.569,-13.867,tMWT=-3.898,-15.233,-14.801,all P<0.05).Thirdly,there were no statistically significant differences in TWL and MWT between FA3 group and FA4 group (all P>0.05).Conclusion Over 4mg/kg of flurbiprofen axetil can significantly reduce the thermal hyperalgesia and mechanical allodynia in CCI rats,however,there is a ceiling effect of flurbiprofen axetil,and the dosage of 8mg/kg can provide a maximum analgesic effect.

Mesenchymal stem cells (MSCs) are a group of stem cells derived from mesodermal mesenchyme.They can be recovered from a variety of tissues,including bone marrow,umbilical cord tissue,umbilical cord blood,peripheral blood,and adipose tissue.Under given conditions,MSCs can differentiate into bone,fat,nerve cells,bepatocytes,and many other cells.Thus,MSCs can be used as a new treatment to substitute for organ transplantation.In recent years,the incidence of end-stage liver disease has been increasing and liver disease has become one of the major diseases affecting human health.Donor scarcity and immunological rejection limit the clinical application of liver transplantation.Numerous studies have confirmed the therapeutic effects of MSCs on hepatic fibrosis,cirrhosis,and other liver diseases,which may be related to the differentiation of MSCs into functional hepatocytes.This paper reviews the capacity,regulation,and molecular mechanism of MSC differentiation,and it discusses the therapeutic effects of different sources of stem cells for liver fibrosis.

With the development of magnetic resonance (MR) technology, the concern is focused on molecular and physiological imaging besides structural information. Ultra high field MR scanner shows great superiority. 3. 0-T MR scanners provide almost two-fold signal-to-noise ratio (SNR) compared with a standard 1. 5-T MR scanner. The higher baseline SNR can be converted into a variety of alternative benefits. There are still some other changes brought about by 3. 0-T, such as higher sensitivity to motion, susceptibility effect, more difference in resonant frequency among different metabolites, and so on. These features may be a double-edged sword in structural and functional imaging. But with the ceaseless progress of the technology and gains in experience, 3. 0-T systems will provide more information and show more advantages.
Animals ; Humans ; Image Enhancement ; methods ; Magnetic Resonance Imaging ; instrumentation ; methods ; Magnetic Resonance Spectroscopy ; instrumentation ; Sensitivity and Specificity

Environmental Health ; Occupational Health ; Social Responsibility

Chronic Periodontitis ; diagnosis ; diagnostic imaging ; therapy ; Dental Scaling ; Follow-Up Studies ; Furcation Defects ; diagnosis ; diagnostic imaging ; therapy ; Gingival Hyperplasia ; diagnosis ; diagnostic imaging ; therapy ; Humans ; Male ; Middle Aged ; Periodontal Index ; Radiography, Panoramic ; Root Canal Therapy ; Tooth Loss ; diagnosis ; diagnostic imaging ; therapy ; Tooth, Artificial

Objective To study the clinical features of cardiac arrest patients and the influence factors of effective resuscitation. Methods The clinical data of 76 patients in our hospital who underwent cardiac arrest and resuscitation were analyzed retrospectively. Results The effective resuscitation were observed in forty-seven patients (47/76, 61.8%), 28 patients completely survived(28/76,36.8%), and the total death rate was 63.2%. The successful rate of resuscitation was positive relation to the starting time of resuscitation, the way of cardiac arrest, and the structure and function of heart, but was negative relation to the times of cardioversion. The successful rate of resuscitation had indefinite relation with the patients age and gender. Conclusion The immediate cardioversion was the key factor of successful resuscitation.The successful resuscitation was dependent on the continuous and effective cardio-press. Basical cardio-disease was the major factor affecting prognosis.

Environmental Pollution ; prevention & control ; Metals, Heavy

Nursing work environment impacts patient outcomes. This article summarized the concept and connotation of nursing work environment, related theories of how nursing work environment impacts patient safety outcomes and related researches conducted by foreign scholars. The effort of this review article aims to put forward new research direction.

Objective With the increasing of the CT examination, the dose of x-ray has been brought to public attention. For the sake of making the MDCT technology better applied, available optimal technology has to be used to reduce the x-ray dose to the patients. Methods Many optimal technologies were involved in, such as ECG modulation, cardiac bowtie, 3D dose modulation, compact geometry design, electron collector and speed 4D CARE dose. Results The result of the research showed that the dose of scanning x-ray of CT could be decreased sharply by using optimal technologies. The Q2 values was the standard which could well evaluate the quality of the CT′s images and the dose of x-ray. Conclusion The quality of images and the dose of x-ray can′t be separated, which must be quoted together.

Objective To evaluate the clinical application of the auto trigger technique with dual-source CT in cerebral and cervical vessel. Methods 35 patients were randomly divided into three groups, taking triggered threshold as 20HU,50HU and 70HU respectively, CT-values in segments of left middle cerebral artery, superior sagittal sinus, left common carotid artery adjacent to the fourth cervical vertebrate and internal jugular vein by injection at antecubital vein were all measured. Results The discrepancy of peak in artery among groups was not statistically different. It was statistically different in the same segments of vein. Conclusion CTA of cerebral and carotid arteries with the dual-source CT triggered technique can be clearly showed with 20HU as triggered threshold.