Objective To observe the effect of different doses of pregabalin and self-control analgesia (PCA) in early postoperative pain in orthopedic lumbar spine surgery patitens.Methods A total of 54 patients with lumbar spinal canal stenosis lumbar vertebrae decompression surgery were randomly divided into high,middle and low dose groups,each group 18 cases.High,middle and low dose groups were orally given pregabalin 300,150,75 mg at 2 h before anesthesia.The patient controlled analgesia (PCA) was used after surgery.The visual analogue score (VAS) at 2,6,12,24 h after surgery,the analgesia drug dosage within 24 h of self-control,incidence of adverse drug reactions were observed in two groups.Results The VAS at 2 h after surgery in high,middle and low dose groups were 3.72 ± 1.27,3.67 ± 1.14,4.78 ± 1.31,with significant difference between high dose and low dose groups(P ＜0.05).The VAS at 6 h after surgery in high,middle and low dose groups were 3.06 ± 0.80,3.28 ± 1.49,4.00 ± 0.69,with significant difference between high dose and low dose groups (P ＜ 0.05).The VAS at 12 h after surgery in high,middle and low dose groups were 2.28 ± 0.67,3.11 ± 1.28,3.33 ± 0.84,with significant difference (P ＜ 0.05).The VAS at 24 h after surgery in high,middle and low dose groups were 2.17 ±0.62,2.83 ± 1.10,2.83 ±0.71,with no significant difference (P ＞0.05).There were 1 case of dizziness,nausea and vomiting,1 case of somnolence,1 case of nausea and vomiting,with the incidence of 16.67％ (3/18 cases).There was 1 case of nausea and vomiting respectively in middle dose and low dose group,with the incidence of 5.56％ (1/18 cases).There was no significant difference in the incidence among three groups (P ＞ 0.05).Conclusion Lyrica drugs prior to application in orthopedic surgery,early postoperative analgesic effect is good,with low incidence of adverse reactions,300 mg of drug delivery in advance can be a good solution.

Objective To investigate the metabolic effects of glucose dependent insulinotropic peptide receptor antagomst pro3 (GIP) in induced diabetes mice about blood glucose,triglyceride,cholesterol,leptin and fatty issue.Methods 27 C57 mice were randomly divided into normal group and diabetes mice group,and the mice in diabetes group were fed with high fat food and intraperitoneal injected streptozocin.Then 1 mouse that random blood giucose lower than 16.9 mmol/L was deleted in diabetes group.The rest mice in diabetes group were divided into two groups,diabetes control group,pro3 (GIP) group.Pro3 (GIP) group was given drug pro3 (GIP).The bloodglucose and glucose tolerance were measured.After treatment for 6 weeks,all mice were sacrificed and fatty tissues were collected.Results After 6 weeks,the blood glucose of the pro3 (GIP) group was obviously lower than diabetes control group (t=8.43,P＜0.01),and insulin levers in 0,30,60 and 120 min were obviously lower than diabetes control group (t =3.90,2.60,6.88 and 3.33,P＜0.05).There was significant difference between pro3 (GIP) group and diabetes control group about inflammatory cells.Moreover,leptin in pro3 (GIP) group was obviously lower than in diabetes control group (t =5.04,P＜0.01),but triglyceride,cholesterol,and adiponectin had no significant difference between two groups.Conclusion Pro3 (GIP) can significantly reduce blood glucose,insulin level,leptin of diabetes mice,and attenuate the inflammatory cells infiltration in fatty issue.

Background Restylane, a hyaluronic acid gel, has been widely used as a dermal filler in USA and European countries. This study was designed to study the safety and efficacy of Restylane as a non-permanent dermal filler for facial augmentation therapy in China for the correction of nasolabial folds during a follow-up period of 6 months. Methods The study consisted of a screening visit, a baseline visit during which injection with Restylane was given, and follow-up visits after four weeks, three months and six months. The efficacy was subjectively assessed by comparing the treatment results between pre-treatment and post-treatment. Adverse events were analyzed by severity and duration. Results At six months post-baseline, the subjects and the investigators' independent assessment score of Wrinkle Severity Rating Scale was decreased. Global Aesthetic Improvement Scale was considered to have improved by over 90% in some cases. Adverse events related to product and injection was reported in 21.5% of the injections. A vast majority of the post-treatment reactions were mild. Conclusions The efficacy of Restylane for nasolabial fold in a Chinese population was excellent. Restylane was well tolerated and no systemic reactions or other safety concerns were raised.

Objective To compare the clinical efficacy and safety of nifedipine controlled-release tablets and felodipine sustained release tablets in the treatment of elderly isolated systolic hypertension.Methods A total of 76 elderly patients with isolated systolic hypertension were randomly divided into control group and treatment group with 38 cases per group.Control group was given felodipine sustained release tablets 5 rag,qd,oral.Treatment group was given nifedipine controlled-release tablets 30 mg,qd,oral.Two groups were treated for 6 weeks.The clinical efficacy,blood pressure and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 92.11％ (35/38 cases) and 73.68％ (28/38 cases).The systolic blood pressure in treatment and control groups were (129.28 ± 13.02),(136.35 ± 14.09) mmHg,with significant difference (P ＜ 0.05).The adverse drug reactions in treatment group were dizziness and edema,which in control group were dizziness,edema and rash.The incidences of adverse drug reactions in treatment and control groups were 5.26％ and 7.89％,without significant difference (P ＞ 0.05).Conclusion Nifedipine controlled-release tablets had a definitive clinical efficacy in the treatment of isolated systolic hypertension in the elderly,which are better than felodipine sustained release tablets,without increasing the incidence of adverse drug reactions.

Background Roux-en-Y gastric bypass (GBP) is the main surgical procedure used in type 2 diabetes.The objective of this study was to evaluate the different types of GBP in treatment of type 2 diabetes.Methods Patients with type 2 diabetes were randomly divided into two groups:those who underwent gastrojejunal loop anastomosis bypass and those who underwent gastrojejunal Roux-en-Y bypass.Blood glucose alterations,operation time,and operation complicatiors were observed.Results Gastrojejunal loop anastomosis bypass and gastrojejunal Roux-en-Y bypass were both effective in the treatment of selected patients with type 2 diabetes.Compared with gastrojejunal Roux-en-Y bypass,gastrojejunal loop anastomosis bypass had the advantages of easier implementation,shorter operation time,and fewer operation complications.Conclusions Gastrojejunal loop anastomosis is effective in treatment of type 2 diabetes.It is safe,easy to implement,and worthy of clinical popularization.

Objective To evaluate the safety and efficiency of the dobutamine stress echocardiography in patients with hypertrophic cardiomyopathy and estimate the difference between provokable obstruction and resting obstruction in these patients.nethods Echocardiogarphy was performed in 22 patients with HCM(LVOTPG<50 mm Hg at rest, 1 mm Hg=0.133 kPa)at rest and at the end point of dobutamine stress.Dobutamine was administered via an infusion pump, starting at a dose of 5 μg·min-1·kg-1 and increasing every 5 minutes by 5μg·min-1·kg-1 till the maximum dose of 20μg·min-1·kg-1.Fifty-seven patients with HCM(LVOTPG>50 mm Hg at rest)were also studied at rest.Results In these 22 patients, the mean maximum velocity of LVOT was 5.39±1.60 m/s, the mean maximum LVOTPG was 125.7±62.4 mm Hg at the end point of dobutamine stress and the mean dose of dobutamine Was 13.90 ±6.85 μg·min-1·kg-1.Sixteen patients evidenced positive stress results at the end point of dobutamine stress.The main difference between the provokable obstruction and resting obstruction was that in provokable obstruction patients, the SAM positive patients were fewer and the proportion of Maron Ⅱ patients was higher(50%).Conclusions Dobutamine stress echocardiography Was a safe and sensitive way for detecting patients with hypertrophic cardiomyopathy.Provokable obstruction patients had fewer SAM and higher proportion of Maron Ⅱ.