1.Efficacy and safety of budesonide turbuhaler in Korean asthmatic patients.
You Young KIM ; Sang Heon CHO ; Kyung Up MIN
Korean Journal of Allergy 1997;17(1):49-57
A controlled study was carried out in 50 patients with perennial bronchial asthma to assess the efficacy and safety of budesonide turbuhaler. Subjects have suffered from cough, wheezing, dyspnea and chest tightness and showed either 15% of reversibility in FEV after bronchodilator inhalation or airway hyperresponsiveness to methacholine(PC20 < or = 25mg/ml.) Patients were randomized to treatment with budesonide turbuhaler or terbutaline turbuhaler for 8 weeks after 2 weeks of run-in period. Budesonide turbuhaler was effective for cough, wheezing, dyspnea and chest tightness. It improved peak expiratory flow rate and FEV1. Budesonide turbuhaler was tolerated well and the laboratory tests showed no abnormality. It is suggested that budesonide turbuhaler is effective and safe in the management of bronchial asthma.
Asthma
;
Budesonide*
;
Cough
;
Dyspnea
;
Humans
;
Inhalation
;
Peak Expiratory Flow Rate
;
Respiratory Sounds
;
Terbutaline
;
Thorax
2.Ultrastructural study of basement membrane of choleastoma epithelium.
Kyung You PARK ; Joong Saeng CHO ; Chang Il CHA
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(4):649-658
No abstract available.
Basement Membrane*
;
Epithelium*
3.Studies on efficacy and dosage for schoolchildren of some anthelminthic drugs.
The Korean Journal of Parasitology 1974;12(2):147-156
The evaluation of the effects of anthelmintic drug dose was done by the eggs reduction and the eggs negative conversion rate. The drug dose according to the age of the patient was estimated by the formula of Augsberger, the dose according to the body weight of patient was estimated by the Rule of Six, and the dose to the body surface of the patient was estimated by the formula of Costeff. It is considered that the application of the drug dose according to the age of the patient resulted in reduction of dose in the younger patient, and resulted in the excess dose in older patient. The application of the drug dose according to the body weight also resulted in the reduction of dose in the lighter patient and the excess dose in the heavier patient. It is suggested that the application of drug dose according to the body surface is more reasonable than those by the age and the body weight. The value of this application was also proved to be medium value between those of age method and body weight method.
parasitology-helminth-nematoda-Ascaris lumbricoides
;
pyrantel pamoate
;
piperazine adipate
;
santonin-kainic acid complex
;
chemotherapy
;
drug evaluation
;
body weight
;
body surface
;
age
4.Studies on the Effects of Various Topical Phototoxic Drugs and UVA on Melanocytes of C57 BL Mice.
Yoon Kee PARK ; You Chan KIM ; Seung Kyung HANN ; Moo Yon CHO ; Sang Wahn KOO
Annals of Dermatology 1991;3(1):15-22
One hundred sixteen C57 BL mice were painted with either 8-MOP, 5-MOP or TMP solution in concentrations of 0.02%, 0.1%, and 0.5% each and UVA irradiated. Skin biopsies were performed at 1, 3, 5 and 7 weeks after LJVA irradiation. The results measuring the number, area, and perimeter of the melanocytes after topical PLJVA were higher in the TMP-painted group than in the 8-MOP or 5-MOP painted groups. In all groups, the weekly changes showed an increasing value through five weeks. In comparing the drug concentrations used, 0.1% of chemicals produced the same or higher values than 0.5%. There have been few studies on the effects of 5-MOP in photochemotherapy. In tho study 5-MOP produced a pigment-producing effect similar to 8-MOP. Therefore, if topical PIJVA with 5-MOP is used in clinical practice, we could expect a significant therapeutic effect in vitiligo.
Animals
;
Biopsy
;
Melanocytes*
;
Methoxsalen
;
Mice*
;
Paint
;
Photochemotherapy
;
Skin
;
Thymidine Monophosphate
;
Vitiligo
5.A Study of Pure Aortic Valvular Stenosis in Adult.
Yang Koo YUN ; Kyung Jong YOU ; Meyun Shick KANG ; Byung Chul CHANG ; Bum Koo CHO
Korean Circulation Journal 1995;25(6):1183-1188
BACKGROUND: There has been a change in the causes of aortic stenosis when comparence of rheumatioc aortic stenosis in recent year. Therefore, we studied the etiology factor of pure aortic stenosis. METHODS: The gross surgical pathologic features of the aortic valves were reviewed in 92 patients with pure aotic stenosis whom underwent aortic valve replacement at Yonsei University, Cardiovascular center between July 1989 and June 1994. RESULTS: The three most frequent causes were 1) calcification of congenital bicuspid valve in 30%, 2) degenerative calcification of aortic valve in 22%, 3) rheumatioc valvular change in 48%. The mean age at the time of aortic valve replacement for the entire series of patients was 54.4 years. The range of age was from 18 years to 77 years. Males predominated for degenerative disease and congenital bicuspid valves, but there were reversed rheumatic origin. One or more complications occured in 17% of patients undergoing operation. The surgical mortality was 3.3%. CONCLUSION: Our data suggest that more common cause of aortic stenosis is non-rheumatic disease rather than rheumatinc origin.
Adult*
;
Aortic Valve
;
Aortic Valve Stenosis
;
Constriction, Pathologic*
;
Humans
;
Male
;
Mitral Valve
;
Mortality
6.Comparative study of radiologic-pathologic findings of experimental clonorchiasis in rabbits.
Kyung Nam RYU ; Jae Hoon LIM ; You Jung CHO ; Moon Ho YANG
Journal of the Korean Radiological Society 1993;29(1):1-8
Radiological investigation in patients with clonorchiasis is very important as this is the only method of evaluating the severity of clonorchiasis. In order to correlate the radiologic and pathologic findings of clonorchiasis, fourteen rabbits infested with Clonorchis sinensis and five control rabbits were examined radiologically by ultrasonography, computed tomography and cholangiography and the results were correlated with pathologic findings. Dilatation of the intrahepatic small bile ducts of the liver was due to obstruction by flukes: oval or elliptical small filling defects or irregular margin of the bile ducts on cholangiogram or intraluminal echoes on sonogram represented flukes per se; periductal thickening on sonogram and periductal enhancement of bile ducts on CT were due to inflammatory cell infiltration, adenomatous hyperplasia and periductal fibrosis: band like enhancement at the periphery of the liver on CT represented proliferated bile ducts, destruction of liver cells and resultant fibrosis. The study confirmed the pathological bases for the radiological findings of clonorchiasis in liver and bile ducts and will, perhaps, serve as a basis for the future radiologic-pathological correlation of clonorchiasis and in further clinical and experimental researches in the biliary tract diseases.
Bile Ducts
;
Biliary Tract Diseases
;
Cholangiography
;
Clonorchiasis*
;
Clonorchis sinensis
;
Dilatation
;
Fibrosis
;
Humans
;
Hyperplasia
;
Liver
;
Methods
;
Rabbits*
;
Trematoda
;
Ultrasonography
7.The clinical and histopathological studies of nasal polyps.
Suk Tae KANG ; Sir Kyeu LIM ; Chin Saeng CHO ; Yin Gyo JUNG ; Kyung You PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(6):1199-1205
No abstract available.
Nasal Polyps*
8.A case of salivary gland choristoma of the middle ear.
Sir Kyeu LIM ; Chin Saeng CHO ; Yin Gyo JUNG ; Kyung You PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(5):1049-1053
No abstract available.
Choristoma*
;
Ear, Middle*
;
Salivary Glands*
9.A case of large tonsillolith.
Suk Tae KANG ; Yin Gyo JUNG ; Chin Saeng CHO ; Kyung You PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(4):827-830
No abstract available.
10.Waldenstrom's macroglobulinemia associated with eosinophilia.
Eunkyoung YOU ; Kyung Sam CHO ; Tae Sung PARK
Blood Research 2013;48(1):8-8
No abstract available.
Eosinophilia
;
Waldenstrom Macroglobulinemia