1.Esthesioneuroblastoma with Intracranial Extension: Case Report.
Jang Son YOU ; Bong Jin PARK ; Young Joon KIM ; Maeng Ki CHO
Journal of Korean Neurosurgical Society 2003;33(2):211-213
We report a case of esthesioneuroblastoma with intracranial extension treated with surgical resection and chemotherapy. A 5-year-old child presented with visual disturbance, and was subsequently found to have a huge sized mass in the anterior skull base, suprasellar region and lateral ventricle. A bifrontal craniotomy with excision of the tumor through subfrontal and interhemispheric approach was performed. The patient received postoperative chemotherapy according to Tandem protocol. A follow-up magnetic resonance(MR) image showed that the tumor showed partial regression, however, there was no change in tumor size in lateral ventricle. Second operation with excision of remnant mass through a transcallosal approach was performed. MR image, 9 months after first operation showed the postoperative change in frontal area without enhancing mass. By employing staged operation and chemotherapy, the authors obtained good results in the treatment of esthesioneuroblastoma with intracranial extension.
Child
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Child, Preschool
;
Craniotomy
;
Drug Therapy
;
Esthesioneuroblastoma, Olfactory*
;
Follow-Up Studies
;
Humans
;
Lateral Ventricles
;
Skull Base
2.A Study on Burden and Well-being of Primary Caregivers of Patients with a Stroke.
You Jin LIM ; Bok Hee CHO ; Hyun Sook JANG ; Hyun Ju JEONG
Journal of Korean Academy of Fundamental Nursing 2009;16(3):272-281
PURPOSES: The purposes of this study were to identify factors related to burden and well-being in primary caregivers of patients who have had a stroke and examine the correlation between burden and well-being of the caregivers. METHODS: Between April 2006 to June 2007 data were collected using self-report questionnaires and interviews with 85 primary caregivers of stroke patients in C University Hospital. Data were analyzed using t-test, ANOVA, Duncan test and Pearson's correlation with SPSSWIN 15.0. RESULTS: Factors related to burden of primary caregivers were sex and activities of daily living of the patients, and age, education level and satisfaction with income of the caregivers. The factors related to well-being of primary caregivers were sex of patients, and age and education level of caregivers as well as cohabitation with the patient. A negative correlation was found between burden and well-being of the caregivers (r= -.393, p<.001). CONCLUSION: These results indicate a need to develop a nursing intervention program for caregivers and education program for other family members to reduce caregiver burden. These programs should lead to improvements in the well-being of the caregiver.
Activities of Daily Living
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Caregivers
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Humans
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Surveys and Questionnaires
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Stroke
3.The Influence of Androgen Deficiency and Osteopenia on Fracture Healing in Orchiectomized Rats.
Jang Suk CHOI ; Chang Seop LEE ; Jung Woog SHIN ; You Gwun JANG ; Sung Jin YOU ; Jong Moon CHOI
The Journal of the Korean Orthopaedic Association 2003;38(6):646-652
PURPOSE: The purpose of this study was to evaluate the effect of testosterone deficiency and osteopenia on fracture healing using orchiectomized adult rats. MATERIALS AND METHODS: Fifty-two 3 month old male rats were used. Animals were divided into 3 groups. Group 1 received sham operations and groups 2 and 3 were orchiectomized. At 4 weeks, right tibial shaft fractures were administered in all animals. Afterwards in group 3, testosterone was injected intra-peritoneally for 4 weeks. After 8 weeks of breeding, animals were sacrified for morphometrical, histopathological and biomechanical testing. RESULTS: No nonunion or delayed union was observed. Differences in tibial volumes and circumferences between the fracture site and the corresponding contralateral site were less in groups 2 and 3 than in group 1, with statistical significance. The yield strength and the trabecular area of the fractured tibiae were significantly lower in group 2, but group 3 and group 1 were similar. CONCLUSION: Even though there was no evidence of compromised fracture healing, both of the androgen deficiency and osteopenia induced by orchiectomy negatively influenced callus volume and strength. But osteopenia did not influece callus strength. The above results demonstrate the positive effect of testosterone injection on fracture healing.
Adult
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Animals
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Bone Diseases, Metabolic*
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Bony Callus
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Breeding
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Fracture Healing*
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Humans
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Infant
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Male
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Orchiectomy
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Rats*
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Testosterone
;
Tibia
4.Anti-Ma2-Associated Encephalitis Presenting as Hypersomnia.
Ji Yeong JANG ; Soon Won PARK ; You Jin CHOI ; Yoon Jung KANG ; Han Jin CHO ; Jiyoung KIM
Journal of the Korean Neurological Association 2016;34(3):228-230
Anti-Ma2-associated encephalitis is one of the paraneoplastic neurological syndromes. It has been shown to be associated with various neoplasms, mainly testicular, lung, and breast cancers. Most patients with anti-Ma2-associated encephalitis present limbic-diencephalic-brainstem dysfunctions such as seizure, mood disorder, excessive daytime sleepiness, and ophthalmoparesis. Some patients develop symptoms indicating the multifocal involvement of the limbic system, diencephalon, or brainstem. However, there are few case studies of anti-Ma2-associated encephalitis presenting as isolated hypersomnia. We report a case of anti-Ma2-associated encephalitis presenting as hypersomnia.
Brain Stem
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Breast
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Diencephalon
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Disorders of Excessive Somnolence*
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Encephalitis*
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Humans
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Limbic System
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Lung
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Mood Disorders
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Ophthalmoplegia
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Paraneoplastic Syndromes
;
Seizures
5.Sleep Pattern and Factors Causing Sleep Disturbance in Adolescents with Cancer before and after Hospital Admission.
Jin JUNG ; Eun Hye LEE ; You Jin YANG ; Bo Yoon JANG
Asian Oncology Nursing 2017;17(3):143-150
PURPOSE: This is a descriptive study conducted in order to survey sleep patterns and factors responsible for sleep disturbance among adolescent cancer patients after hospital admission. METHODS: The study group included 46 adolescent cancer patients aged 10 to 19 who received admission care in multi-bed hospital rooms from March to June 2016. Data on patterns and quality of sleep, and factors causing sleep disturbance were recorded using the Verran and Snyder-Halpern (VSH) Sleep Scale, the Pittsburgh Sleep Quality Index (PSQI), and a sleep disturbance questionnaire. RESULTS: There was no difference in patterns and quality of sleep prior to and after hospital admission in the study group. However, patients experienced sleep disturbance, as defined by PSQI > 5, both before (5.43) and after (6.30) admission. The most important physical, emotional and environmental factors causing sleep disturbance after admission were nocturnal diuresis, monotony of admission care, and crying of younger patients respectively. CONCLUSION: This study focused on sleep patterns and factors causing sleep disturbance after hospital admission for adolescent cancer patients. Future studies should aim to develop nursing interventions resulting in an environment that improves sleep quality. Additional studies should focus on developing daytime programs to determine the impact of admission care on other quality of life parameters.
Adolescent*
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Crying
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Diuresis
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Humans
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Nursing
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Quality of Life
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Sleep Wake Disorders
7.A Case of Pancreatic Arteriovenous Malformation Presenting Upper Gastrointestinal Bleeding.
Su Hee PARK ; Mi Jeong KIM ; You Sang KO ; You Jin LIM ; Seung Yong HAN ; Hyun Woo BYUN ; Min Ho CHOI ; Hyun Joo JANG ; Sea Hyub KYE ; Jin LEE
Korean Journal of Gastrointestinal Endoscopy 2007;35(5):359-363
A pancreatic arteriovenous malformation (AVM) is a very rare disease entity that is usually asymptomatic; however, it may present with a massive gastrointestinal hemorrhage. Recent advances in cross-sectional imaging and the widespread availability of angiography have contributed to the diagnosis of this condition. A patient was transferred to our clinic due to unknown origin gastrointestinal bleeding and upper abdominal pain. Double balloon enteroscopy and duodenoscopy revealed a bleeding pancreatico-cholangio-duodenal fistula. We were able to diagnose an arteriovnous malformation with a pancreatico-cholangio-duodenal fistula by the use of angiography and from the post-operative pathological findings.
Abdominal Pain
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Angiography
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Arteriovenous Malformations*
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Diagnosis
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Double-Balloon Enteroscopy
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Duodenoscopy
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Fistula
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Gastrointestinal Hemorrhage
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Hemorrhage*
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Humans
;
Pancreas
;
Rare Diseases
8.A case of vitamin D hydroxylation-deficient rickets type 1A caused by 2 novel pathogenic variants in CYP27B1 gene
You Min KIM ; Yoon Young JANG ; Ji Eun JEONG ; Hye Jin PARK ; Ja Hyun JANG ; Jin Kyung KIM
Annals of Pediatric Endocrinology & Metabolism 2019;24(2):137-141
Vitamin D hydroxylation-deficient rickets type 1A (VDDR1A, OMIM 264700) is a rare autosomal recessive inherited disorder. Pathogenic variants in the CYP27B1 gene lead to loss of 1α-hydroxylase activity. We report the case of a 22-month-old toddler who presented with growth retardation and delayed development. The patient exhibited the typical laboratory findings of VDDR1A, including hypocalcemia (calcium: 5.2 mg/dL), elevated serum level of alkaline phosphatase (2,600 U/L), elevated serum level of intact-parathyroid hormone (238 pg/mL), low 1,25(OH)₂D₃ level (11.2 pg/mL), and normal 25(OH)D₃ level (40.7 ng/mL). His height and weight were 76.5 cm and 9.5 kg, respectively (both <3rd percentile). The Bayley Scales of Infant and Toddler Development II indicated significantly delayed development (mental development index <50, psychomotor development index <50). The patient was a compound heterozygous for two novel pathogenic variants in the CYP27B1 gene: c.57_69del (p.Glu20Profs*2) and c.171dupG (p.Leu58Alafs*275), inherited from his mother and father, respectively. The patient showed remarkable improvement after treatment with calcitriol and calcium carbonate.
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
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Alkaline Phosphatase
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Calcitriol
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Calcium Carbonate
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Databases, Genetic
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Fathers
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Humans
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Hypocalcemia
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Infant
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Mothers
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Rickets
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Vitamin D
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Vitamins
;
Weights and Measures
9.Hyperkalemia from preoperative non-steroidal anti-inflammatory drugs and angiotensin II receptor blockers in patients with nephropathy.
Ho Kyung SONG ; Yeon JANG ; Jin Woo NAM ; Ju Hyun YOU
Korean Journal of Anesthesiology 2011;61(6):533-534
No abstract available.
Angiotensin II
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Angiotensin Receptor Antagonists
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Angiotensins
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Hyperkalemia
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Receptors, Angiotensin
10.Results of Surgical Treatment for Primary Gastric Adenocarcinoma: Single Institute Experience for 14 Years.
Jun Min CHO ; You Jin JANG ; Jong Han KIM ; Sung Soo PARK ; Seong Heum PARK ; Young Jae MOK
Journal of the Korean Gastric Cancer Association 2009;9(4):193-199
PURPOSE: The aim of this study was to evaluate the clinicopathologic features, treatment outcomes, and prognostic factors of gastric cancer based on 14 years' experience in a single medical center, and to compare treatment outcomes with a previous study. MATERIALS AND METHODS: We retrospectively studied 2,327 patients who were operated on for gastric cancer between 1993 and 2006 at Korea University Hospital. RESULTS: The resection rate was 92.8% and curative resection was achieved for 1,960 (90.8%) patients. The 5-year survival rate was 70.0% for all patients undergoing resection and 79.2% for patients undergoing curative resection. The 5-year survival rate was 1.5% for unresected cases. Age, tumor size, location of the tumor, gross tumor type, depth of tumor invasion, lymph node involvement, distant metastasis, tumor stage, combined resection, complications, histology, and type of operation each had prognostic significance on univariate analysis. On multivariate analysis, lymph node involvement, depth of invasion, venous invasion, and age were independent prognostic factors. CONCLUSION: The 5-year survival rate for patients who underwent curative resection was 79.2%. Depth of invasion, lymph node involvement, venous invasion, and age were independent prognostic factors. The fact that tumor stage is the most important prognostic factor after curative resection, increases the importance of early detection.
Humans
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Korea
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Lymph Nodes
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Multivariate Analysis
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Neoplasm Metastasis
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Retrospective Studies
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Stomach Neoplasms
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Survival Rate