No abstract available.

No abstract available.

Hypoparathyoidism is rarely reported during pregnancy or the puerperium. Since hypocalcemia during pregnancy increases the mortality and morbidity of fetus, neonate, and mother, the early diagnosis and treatment of hypocalcemia, especially hypocalcemic crisis, might be very important to reduce severe complications. We experienced a case of hypocalcemic crisis induced by hypoparathyroidism developed after Cesarean section. This case represents symptoms and signs of hypocalcemia such as dyspnea, tingling sensation of upper and lower limbs, chest pain during hypocalcemic crisis. Physicians should be aware of the symptoms and signs, and treatment of hypocalcemic crisis.
Cesarean Section* ; Chest Pain ; Dyspnea ; Early Diagnosis ; Female ; Fetus ; Humans ; Hypocalcemia ; Hypoparathyroidism ; Infant, Newborn ; Lower Extremity ; Mortality ; Mothers ; Postpartum Period ; Pregnancy ; Sensation

OBJECTIVES: Obesity and osteoporosis have been increasing for decades but their relationship to bone mineral density (BMD) and fat mass has not been defined. The aim of this study was to investigate how changes in body composition affect BMD after a weight reduction. MATERIALS AND METHODS: We reviewed 48 middle-aged obese women who had participated in our diet program and succeeded in reducing their weight. Body composition was measured by the dual-energy X-ray absorptiometry method, and metabolic syndrome was defined as described in the ATP-III guidelines. All differences between baseline and 12 weeks later were expressed as [{12th week data-baseline data}/baseline datax100]. RESULTS: The mean age of the participants was 38.29+/-10.89 years, and the mean follow-up time was 85 days. The mean body mass index was 31.50+/-5.19 kg/m2. Basal BMD decreased with age and increased with weight and appendicular lean mass. In a regression analysis, appendicular lean mass was positively correlated with leg BMD (R2=0.235, B=0.015, P<0.001) and age (B=-0.002, P=0.046), and appendicular lean mass (B=0.019, P=0.049) was the main determinant of total BMD (R2=0.272). After weight reduction, the total body BMD change ratio (R2=0.281) was negatively related to the change of fat mass, trunk fat mass (B=-0.042, P=0.087) and waist circumference (B=-0.108, P=0.014). CONCLUSIONS: Our findings suggest that BMD is determined by muscle mass, and that changes in central obesity may also affect BMD.
Absorptiometry, Photon ; Body Composition ; Body Mass Index ; Bone Density ; Diet ; Female ; Follow-Up Studies ; Humans ; Leg ; Muscles ; Obesity ; Obesity, Abdominal ; Osteoporosis ; Waist Circumference ; Weight Loss

A 49-year-old man with liver cirrhosis and hypertension was found to have hyperkalemia out of a degree of renal insufficiency and metabolic acidosis with low to normal anion gap, aggravated by volume contraction with diarrhea and medications (captopril, spironolactone and atenolol) interfering with potassium homeostasis. Plasma renin activity and serum aldosterone levels of this patient on a regular diet after discontinuation of medications were very low compared to those of five other cirrhotic patients with normokalemia as controls. Also, the renin-aldosterone stimulation testing on this patient performed by sodium restricted diet and furosemide, upright position and by angiotensin converting enzyme inhibition (captopril, 50 mg) showed the blunted renin and aldosterone responses to each of these stimuli, almost no changes from baseline renin and aldosterone levels, it was concluded that the underlying defect responsible for hyperkalemia in this case was hyporeninemic hypoaldosteronism and this was aggravated by other factors or drugs affecting potassium homeostasis.
Aldosterone/blood ; Captopril/pharmacology ; Furosemide/pharmacology ; Humans ; Hyperkalemia/*etiology ; Hypertension/*complications ; Hypoaldosteronism/*complications ; Liver Cirrhosis/*complications ; Male ; Middle Aged ; Renin/blood

A 32 year-old-man was admitted because of paraparesis. Hypertension and hypokalemia was noted with increased aldosterone level in his serum. Computerized tomography of abdomen showed well-defined an ovoid mass of low density in the right adrenal gland. Right adrenalectomy was done and pathologic findings showed a golden yellow color adenoma with large clear cells. Postoperatively there was reversal of hypertension and hypokalemia. We present a case of periodic paralysis due to aldosterone producing adrenal cortical adenoma with brief review of literature.
Abdomen ; Adenoma ; Adrenal Glands ; Adrenalectomy ; Adrenocortical Adenoma* ; Aldosterone* ; Hypertension ; Hypokalemia ; Paralysis* ; Paraparesis

OBJECTIVES: Psychiatric patients are known to use alternative medicine more frequently than medical patients. However, the factors increasing the frequency of use are not clearly understood. In an attempt to find predictive factors for the use of alternative medicine, we conducted a questionnaire survey on outpatients in psychiatric and endocrinology units of a university hospital. METHODS: A total of 'first come, first served' consecutive sample of 95 psychiatric outpatients and 100 medical outpatients as a control group were surveyed. The questionnaire contained sociodemographic information, use of alternative medicine, clinical information, and depressiv symptoms. RESULTS: As a result, 62.1% of psychiatric and 23.0% of medical patients reported to have used at least one type of alternative medicine during the past 12 months. Logistic regression analysis revealed predictive factors for alternative medicine user as being psychiatric patients (odds ratio=4.09, 95% confidence interval 2.11-7.95, pc<0.001) and those who didn't finish high school (OR=30.23, 95% CI 3.68-248.18, p=0.002). CONCLUSION: The finding of low education as a predictive factor is contrary to Western findings, which suggested higher education as a predictive factor for use of alternative medicine. This finding needs to be replicated and investigated for culturally different illness concept and behavior. These finding suggest that asking the patient's use of alternative medicine should be a part of routine psychiatric history taking.
Complementary Therapies* ; Education ; Endocrinology ; Fibrinogen ; Humans ; Logistic Models ; Outpatients* ; Surveys and Questionnaires ; Risk Factors

Chronic stable diabetic patients (n = 6) were compared with healthy control subjects (n = 5) after acute oral intake of 50 mEq of potassium chloride (KCl) to investigate for possible derangements of homeostatic responses for acute term (3 hrs) to acute potassium load. Plasma renin activity (PRA), plasma aldosterone (PA), and transtubular potassium concentration gradient (TTKG) known as a useful semiquantative index of distal nephron potassium secretion were measured. All the baseline parameters were comparable between diabetic and non-diabetic subjects except for significantly reduced creatinine clearance in diabetics (mean +/- SEM, 105 +/- 4 vs. 85 +/- 5 ml/min, p < 0.05). Following acute oral KCl load, the peak increases of serum potassium changes from basal levels were noted at 2 hours in both groups, but were higher in diabetic subjects (mean +/- SEM, 0.42 +/- 0.06 vs. 0.62 +/- 0.09 mEq/L). Also, 4 out of 6 diabetic subjects but none of the control subjects at 2 hours after oral KCl load became hyperkalemic ( > 5.0 mEq/L). PRA did not show any significant changes, whereas PA was increased simultaneously with increments in serum potassium in both groups, with blunted increases in the diabetics. However, TTKG was increased prominently in control subjects (8.18 from 4.98), but only slightly in diabetic subjects (4.55 from 4.18), with statistical difference between the two groups (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Adult ; Aged ; Aldosterone/blood ; Diabetes Mellitus, Type 2/*metabolism ; *Homeostasis ; Humans ; Kidney Tubules/metabolism ; Male ; Middle Aged ; Potassium/*metabolism ; Renin/blood

PURPOSE: After the RS (respiratory syncytial) virus, the influenza virus is the most common cause of childhood lower respiratory tract infection. We assessed the radiologic findings of childhood lower respiratory tract infection by the influenza virus. MATERIALS AND METHODS: A total of 105 pediatric patients (76 males and 29 females; mean age, 2.4 years) with symptoms of respiratory tract infection were examined between March 1997 and April 2000. Nasopharyngeal aspirates were obtained and influenza virus infection was confirmed by direct or indirect immunofluorescent assays. Peribronchial infiltration, hyperinflation, atelectasis, pulmonary consolidation, and hilar lymphadenopathy were evaluated retrospectively at simple chest radiography. RESULTS: Bilateral perihilar peribronchial infiltration was noted in 78.1% of patients (n=82), hyperinflation in 63.8% (n=67), atelectasis in 3.8% (n=4; segmental 50%, lobar 50%), and pulmonary consolidation in 16.2% [n=17; segmental 70.6% (n=12), lobar 29.4% (n=5)]. Hilar lymphadenopathy was noted in one patient in whom there was no pleural effusion, and subglottic airway narrowing in 12 of 14 in whom the croup symptom complex was present. CONCLUSION: The major radiologic findings of influenza virus infection were bilateral perihilar peribronchial infiltration and hyperinflation. In some patients, upper respiratory tract infection was combined with subgolttic airway narrowing. Atelectasis or pleural effusion was rare.
Croup ; Female ; Humans ; Influenza, Human* ; Lymphatic Diseases ; Male ; Orthomyxoviridae* ; Pleural Effusion ; Pulmonary Atelectasis ; Radiography ; Respiratory System* ; Respiratory Tract Infections* ; Retrospective Studies ; Thorax

BACKGROUND: GH3 cells are a well characterized and widely used model used for the in vitro study of growth hormone (GH) secretion. Thyrotropin releasing hormone (TRH) binds to receptors belonging to the family of G protein-coupled receptors, and secrets both GH & prolactin. Phospholipase D (PLD) is an enzyme that hydrolyses phosphatidylcholine to yield phosphatidic acid and choline, and plays important roles in cellular proliferation and hormonal secretion. To elucidate the pathway of the action of TRH in GH3 cells, we investigated the activities of PLC and PLD in GH3 cells treated with TRH or phorbor 12-myristate 13-acetate (PMA). METHODS: GH3 cells were labeled with [3H] myristate, followed by incubation of with 0.3% ethanol, prior to before the addition of the agonists. The total lipids were extracted from the harvested cells following treatment with the agonists. The PLD activity was assessed by measuring [3H] phosphatidylethanol from the [3H] phospholipid using thin layer chromatography. RESULTS: TRH (1 muM) stimulated the PLC activity by 44-fold over that of the control values. TRH (1 microM), mastoparan (5 muM), and PMA (500 muM) for 30 minutes increased PLD activity by 1.9, 1.5 and 2.2 fold, respectively, in comparison to the controls. The PLD activities after 15, 30, 60, 120 and 240 min treatments of TRH (1 microM) were 142%, 170%, 172%, 160% and 115%, respectively. CONCLUSION: These results suggest that TRH stimulates not only the PLC activity, but also the PLD activity in GH3 cells.
Cell Proliferation ; Choline ; Chromatography, Thin Layer ; Ethanol ; Growth Hormone ; Humans ; Myristic Acid ; Phosphatidic Acids ; Phosphatidylcholines ; Phospholipase D* ; Phospholipases* ; Prolactin ; Thyrotropin-Releasing Hormone