We evaluated the effects of self­care with indirect moxibustion (moxibustion group : MG) on hiesho (cold disorder) in mature females in a prospective multicenter randomized controlled trial using leg warmers (leg warmers group : LG) as a control. Subjects were 49 women aged 18 to 39 years who were judged to suffer from hiesho as measured by the hiesho sensation scale (Kusumi and Emori). Subjects were sorted by age and block-­randomized at each of the four facilities. Before going to bed, subjects in the MG (N = 25) performed two moxibustions on both sides of kI 1, SP 6, and ST 36. Subjects in the LG (N = 24) wore leg warmers while sleeping. Each intervention lasted for one month. The primary endpoint was the degree of hiesho by visual analogue scale (VAS) ; secondary endpoints were mainly suffering scores for comorbid symptoms and body temperature difference between forehead and peripheries. Two subjects in the LG dropped out due to preg­nancy and skin pruritus, respectively. The change in VAS and suffering scores was larger in the MG, showing small ES in VAS and medium ES in suffering scores. Body temperature difference between the forehead and LI 4 on both sides was reduced in the MG, and medium ES was observed. It was suggested that self-care of indirect moxibustion for hiesho in mature females could reduce the degree of hiesho and comorbid symptoms, and could suppress the expansion of body temperature difference between forehead and peripheries compared to wearing leg warmers.