1.Central Skull Base Osteomyelitis Causing Bilateral Hypoglossal Nerve Palsy.
Jun Sang SUNWOO ; Yoori SON ; Hye Jin MOON ; Hong Kyun PARK ; Yoon Ho HONG
Journal of the Korean Neurological Association 2010;28(4):311-314
Bilateral hypoglossal nerve palsy is a rare clinical presentation. We report a case of central skull base osteomyelitis (SBO) presenting with complete tongue paralysis in a 53-year-old man who was not diabetic or immunocompromised. Magnetic resonance imaging demonstrated characteristic features including abnormal contrast enhancement in the clivus (T1-weighted images). Blood tests revealed elevated acute-phase reactants and leukocytosis, which prompted prolonged antibiotic treatment. He responded well to the antibiotics, which together with typical clinical and imaging findings led to the diagnosis of bacterial SBO.
Acute-Phase Proteins
;
Anti-Bacterial Agents
;
Cranial Fossa, Posterior
;
Hematologic Tests
;
Humans
;
Hypoglossal Nerve
;
Hypoglossal Nerve Diseases
;
Leukocytosis
;
Magnetic Resonance Imaging
;
Middle Aged
;
Osteomyelitis
;
Paralysis
;
Skull
;
Skull Base
;
Tongue
2.Thyroid Autoantibody Positive Anti-N-Methyl-D-Aspartate Receptor Encephalitis.
Yoori JUNG ; Soonwon PARK ; Hwan Jun SON ; Dae Soo JUNG ; Eun Hi SA ; Sun Tae LEE ; Eun Soo KIM ; Na Yeon JUNG ; Eun Joo KIM
Dementia and Neurocognitive Disorders 2016;15(1):24-27
BACKGROUND: Hashimoto's encephalopathy (HE) and anti N-methyl-D-aspartate receptor (NMDAR) encephalitis have clinical overlaps. CASE REPORT: A 70-year-old woman presented with acutely developed confusion, disorientations and psychosis. HE was suspected based on goiter, markedly elevated anti-thyroglobulin and anti-thyroid peroxidase antibody. She was placed on high dose steroid and intravenous immunoglobulins administration, which did not ameliorate her symptoms. After the antibodies to the NMDAR were identified, weekly 500 mg of rituximab with 4 cycles were started. The current followed up indicated a complete recovery. CONCLUSIONS: The possible associations between NMDAR antibody and autoimmune thyroid antibodies in anti-NMDAR encephalitis with positive thyroid autoantibodies remain unclear. However, a trend toward a higher incidence of NMDAR antibody in patients with autoimmune thyroid antibodies than without has been observed. Cases of encephalitis with only NMDAR antibody (pure anti-NMDAR encephalitis) also occur. Therefore, it is important for clinicians to know the clinical and pathogenic differences between anti-NMDAR encephalitis with positive thyroid autoantibody and pure anti-NMDAR encephalitis for relevant treatment, predicting prognosis, and future follow-up.
Aged
;
Anti-N-Methyl-D-Aspartate Receptor Encephalitis*
;
Antibodies
;
Autoantibodies
;
Encephalitis
;
Female
;
Follow-Up Studies
;
Goiter
;
Humans
;
Immunoglobulins, Intravenous
;
Incidence
;
N-Methylaspartate
;
Peroxidase
;
Prognosis
;
Psychotic Disorders
;
Thyroid Gland*
;
Rituximab