Little objective information is avilable on the influence of occlusive dressings on the healing of cutaneous partial skin defect wounds. Our purpose was to examine the effects of occlusive dressing by using the synthetic dressing mateial, PolyMem in the management of 2nd degree burn wounds and donor sites of split thicknes skin graft and partial-thickness wounds in rabbits. New Zealand white rabbits, 12 to 14 weeks of age, were divided into 2 groups. Two partial thickness skin wounds measuring approximately 40x30 mm were induced using a scalpel on the back of each anesthetized animal. They were designated as group I (dressing with conventional method, n=15), group II (dressing with PolyMen, n=15). Each treated wound was individually covered with the assigned dressing immediately after wounding. Wound were examined and measured at 10 days to determine the extent of healing. By day 10, the PolyMem dressed wounds were approximately 67% healed, while all vaseline gauze dressed wounds were about 50% healed. Standardized 20 mm full-thickness biopsy wounds were treated for 10 days. Section of PolyMem group at POD 10 days showed complete epidermal regeneration above fibrotic dermis (H&E, x40). Section of conventional group at POD 10 days showed marginal epidermal regeneration (H&E, x40). 72 patients (44 patients with 2nd degree burn and 28 patients with skin graft donor sites) were divided into four groups. They were designated as group I (Burn patients with PolyMem, n=24), group II (Burn patients with conventional methods, n=24), group III (S.T.S.G. patients with PolyMem, n=14), group IV (S.T.S.G. patients with conventional methods, n=14). We investigated wound site pain, healing time, comfort and numbers of dressing change. As compared with the control group, the PolyMem dressed group had less pain, more rapid healing time, more comfort, less frequent dressing changes. From these results, we concluded that the occlusive dressing with PolyMem was an effective alternative to the conventional gauze dressig on the wound healing. Our results suggest tat PolyMem is one of the ideal dressing materials.
Animals ; Bandages ; Biopsy ; Burns ; Dermis ; Humans ; Occlusive Dressings ; Petrolatum ; Pheniramine ; Rabbits ; Regeneration ; Skin ; Tissue Donors ; Transplants ; Wound Healing* ; Wounds and Injuries*

The survival rate and motility recovered after cryopreservation of testicular spermatozoa in testicular sperm extraction (TESE)-ICSl program is low. The purpose of this study was to assess the availability and efficiency of mouse empty zona pellucida in cryopreserving human TESE spermatozoa. Mouse empty zonae pellucidae were obtained by extraction of cytoplasm with or without cytochalasin B treatment. Motile sperm from proven-fertile donor and two azoospermic patients after TESE were individually inserted into empty zona pellucida and cryopreserved. Two to five days after cyropreservation, the frozen sperm were thawed and the rates of recovery and motility were observed. The ooplasmic extraction rates of control (N=80) and cytochalasin B treated oocytes (N=80) were 94.0% and 96.2%, respectively (p>0.05). The post-thaw recovery rates of spermatozoa and rates of motility recovery of ejaculate (N=70) and testicular (N=70) sperm were 97.1%, 97.1% and 95.7%, 94.3%, respectively (p>0.05). The results of this study showed that the mouse zone pellucida is useful for cryostorage of single testicular spermatozoa.
Animals ; Cryopreservation* ; Cytochalasin B ; Cytoplasm ; Herpes Zoster* ; Humans ; Mice* ; Oocytes ; Sperm Injections, Intracytoplasmic* ; Spermatozoa* ; Survival Rate ; Tissue Donors ; Zona Pellucida*

BACKGROUND: In family practice residency program, education of common health problems in community primary care is the most important. This study was performed to evaluate whether the trainees of current tertiary hospital family practice residency programs could sufficiently experience common health problems in community primary care. METHODS: Each of three conveniently chosen tertiary hospital family practice centers in seoul was matched with one family practice clinic by its location. Whole patients visited the three family practice clinics on one specific day of June, 2001(primary care group) and the patients seen by the trainees of tertiary hospital family practice residency programs(tertiary care group), whose number was the same as that in matched family practice clinic, were included in this study. Demographic and clinical characteristics were obtained. RESULTS: In primary care group, the proportions of patients younger than 15-year(31.62%) or older than 65-year(21.79%) were significantly higher than those in tertiary care group. Laboratory tests(34.24%:2.99%) and referral(11.79%:0.85%) were significantly more common in tertiary care group. The most common health problem assessed by physician and chief complaint of patients in primary care group was respiratory illness, while digestive illness was the most common in tertiary care group. CONCLUSION: Age distribution, performance rate of laboratory tests and referral, chief complaints, and the health problems in primary care group were significantly different from those in tertiary care group. Trainees in family practice residency program needs to be provided more chances experiencing common health problems in community primary care.
Age Distribution ; Ambulatory Care* ; Education ; Family Practice* ; Humans ; Internship and Residency* ; Primary Health Care ; Referral and Consultation ; Seoul ; Tertiary Care Centers* ; Tertiary Healthcare

BACKGROUND: The management of risk factors of coronary heart disease is highly needed because the prevalence of ischemic heart disease is increasing in Korea. This study was aimed to evaluate the effects of periodic health examination on risk factors of coronary heart disease using Framingham Point Scores. METHODS: The medical records of 343 clients who underwent periodic health examination five times from January 1996 to December 2001 at one medical center in Seoul were reviewed. The five risk factor scores (age, total cholesterol, smoking, HDL-cholesterol, systolic blood pressure), total risk scores, absolute risk and the proportion of the high risk group and the obesity group were analyzed for all the periodic health examinations. RESULTS: For the five periodic health examinations, age risk factor score increased in men and women. Scores of risk factors such as smoking, total cholesterol, HDL-cholesterol and systolic blood pressure decreased in men only (P<0.0001). The total risk score (P<0.0001) and the absolute risk (P=0.0002) increased in men. The total risk score (P<0.0001) and the absolute risk (P=0.3238) increased in women with no changes of other risk factors except increased age score and decreased HDL-cholesterol score. The proportion of the high risk group (P=0.5406) and the obesity group (P=0.0762) were very small and not changed. CONCLUSION: The risk of coronary heart disease as not reduced with the five periodic health examinations. Therefore, the total risk score and the absolute risk did not decrease. Continuous risk factors management must be emphasized after periodic health examination for absolute risk reduction.
Blood Pressure ; Cholesterol ; Coronary Disease* ; Female ; Humans ; Korea ; Male ; Medical Records ; Myocardial Ischemia ; Numbers Needed To Treat ; Obesity ; Prevalence ; Risk Factors* ; Seoul ; Smoke ; Smoking

BACKGROUND: Smoking is well known as an important preventable risk factor contributing to mortality and morbidity. Telephone counseling might be one of adjunctive interventions for smoking cessation. We evaluated whether telephone counseling performed by a nurse could improve smoking cessation rate. METHODS: Study subjects were 152 male smokers who visited family practice in one tertiary hospital between November 2001 and January 2002 and agreed to participate in this study. After completing a self- administered questionnaire, the subjects received self-help materials and were randomly assigned into either an intervention or control group. A well-trained nurse provided telephone counseling only to experimental group at 8th and 17th week of follow-up. The 25-week smoking cessation rates were checked in both groups by telephone call. RESULTS: There were no significant differences in socio- demographic and smoking-related characteristics between intervention, control, and non-participants groups. Intention-to-treat smoking cessation rate at 25th-week of follow- up was 21.1% in control, 25.0% in intervention group and was not statistically different from each other. Smoking cessation rate according to the baseline stage of change toward quit smoking was not statistically different from each other. CONCLUSION: The telephone counseling performed by a nurse was not significantly effective for improving smoking cessation rate in this study.
Counseling ; Family Practice ; Follow-Up Studies ; Humans ; Male ; Mortality ; Risk Factors ; Smoke* ; Smoking Cessation ; Smoking* ; Telephone* ; Tertiary Care Centers ; Surveys and Questionnaires

PURPOSE: To evaluate the usefulness of CT for determining the causes of intestinal obstruction followingsurgery for abdominal cancer. MATERIALS AND METHODS: CT scans were performed in 54 patients with benign (n = 25)or malignant (n = 29) bowel obstruction after surgery for abdominal malignancies ; the causes of obstruction wereconfirmed pathologically (n = 34) or clinically (n = 20). Three radiologists interpreted the CT scans andevaluated their accuracy, sensitivity, and specificity. Through analysis of CT findings, malignant and benignobstruction was compared with regard to the presence of mass or lymphadenopathy, bowel change, mesenteric change,ascites, and other ancillary findings. RESULTS: In distinguishing malignant from benign obstruction, thediagnostic accuracy achieved by three radiologists was 67%, 74%, and 78%. When there was a mass at the obstructedor prior surgical site, lymphadenopathy, an abrupt transitional zone, or irregular wall thickening at anobstructed site, malignant obstruction was suspected (P < .05) ; in the absence of a mass, CT findings ofmesenteric vascular engorgement, extensive ascites, a smooth transition zone and normal or smooth wall thickeningat the obstructed site suggested benign obstruction (P < .05). The presence of omental infiltration, mesentericinfiltration and metastatic lesions at other sites did not always indicate malignant obstruction. In addition,bowel wall thckness, luminal diameter and the interval between surgery and bowel obstruction were notstatistically significant. CONCLUSION: CT is useful for determining the causes of obstruction following surgeryfor abdominal cancer, though particularly when definite peritoneal mass is not demonstrated this usefulness inlimited.
Ascites ; Humans ; Intestinal Obstruction ; Lymphatic Diseases ; Phenobarbital ; Sensitivity and Specificity ; Tomography, X-Ray Computed

BACKGROUND: While woman, old age, insufficent fiber and water supplement are well known risk factors of constipation, the relationships between constipation and stress, irregular diet and other lifestyle factors have not been well documented. We examined the relationship between constipation and those lifestyle factors in working women. METHODS: The study design was a cross-sectional study. The study subjects were 911 women who underwent health examination between May 30th, 2002 and June 30th, 2002 and completed the questionnaires relating to bowel movement. The information on bowel movement, demographic and lifestyle factors acquired through self-administered questionnaires were used for analysis. Chi-square test, t-test, and multiple logistic regression analysis were used. RESULTS: The prevalence rate of constipation defined by Rome II criteria among study subjects was 48.6%. The most frequent abnormal symptom occurring in more than 25% of abnormal bowel movement was straining (50.0%). Fewer than three bowel movements per week was observed only in 16.1% of the subjects. Among the subjects with self-reported constipation, only 66% had constipation defined by Rome II criteria. High degree of stress was the strongest independent risk factor (odds ratio[OR]:3.02, 95% confidence interval[CI]:1.68-5.41). Low intake of fiber and dieting were significantly related with increased risk of constipation and the OR was 2.08 (95%CI: 1.13-3.81), 1.92 (95%CI: 1.12-3.27), respectively. CONCLUSION: The significant relationship between constipation and stress, fiber intake, and dieting suggest that they are the risk factors of constipation. The possibility of disagreement between self-reported and objective constipation should be considered during medical consultation of patient with abnormal bowel habit.
Constipation* ; Cross-Sectional Studies ; Diet ; Female ; Humans ; Life Style* ; Logistic Models ; Prevalence ; Risk Factors ; Women, Working* ; Surveys and Questionnaires

BACKGROUND: Olmesartan medoxomil is an angiotensin II receptor blocker commonly used in hypertension. First objective of this study was to evaluate the bioequivalence of two olmesartan formulations, Olmesartan 20 mg and 40 mg tablet (Yuhan, Pharmaceutical Corp. Seoul, Korea) as test drugs and Olmetec(R) 20 mg and 40 mg tablet (Daewoong, Pharmaceutical Corp. Seoul, Korea) as reference drugs. Second objective of this study was to evaluate the dose-proportionality of two formulations. METHODS: Two studies (20 mg, 40 mg) were conducted as a randomized, open-label, 2-period, crossover design. Each subject received one 20 mg or 40 mg tablet of the reference or test formulation of olmesartan medoxomil in each study. Blood samples were obtained during the 48-hour period after the dose in each treatment period. Wash-out period was 1 week in each study. Concentrations of olmesartan medoxomil in plasma were analyzed using a liquid chromatography system with tandem mass-spectrometric detection (LC/MS/MS). The primary pharmacokinetic parameters were Cmax (maximum concentration) and AUCt (area under the concentration-time curve from time 0 to the last sampling time). RESULTS: A total number of 40 healthy male volunteers participated in the study and 37 volunteers completed both treatment periods in 20 mg trial. All 40 participants completed both treatment periods in 40 mg trial. The 90 % CIs for the geometric mean ratios of the pharmacokinetic parameters (test:reference drug) were 0.93 ~ 1.04 for AUCt and 0.97 ~ 1.08 for Cmax in 20 mg trial. The 90 CIs were 0.94 ~ 1.02 for AUCt and 1.00 ~ 1.11 for Cmax in 40 mg trial. All parameters of two studies satisfy the range of bioequivalence criterion. CONCLUSION: The obtained results indicated that pharmacokinetic exposure to Olmesartan 20 mg and 40 mg tablet was bioequivalent to that of Olmetec(R) 20 mg and 40 mg tablet, respectively.
Chromatography, Liquid ; Cross-Over Studies ; Humans ; Hypertension ; Imidazoles ; Male ; Plasma ; Receptors, Angiotensin ; Tetrazoles ; Therapeutic Equivalency