Cystadenoma of the liver is a rare neoplasm. Although many cystadenomas are asymptomatic, symptoms can include abdominal pain, postprandial epigastric discomfort, and nausea. Dramatic changes in hepatic imaging techniques have been helpful for diagnosing cystic lesions of the liver, such as simple cyst, hydatid cyst, cystadenoma, cystadenocarcinoma, and metastatic neuroendocrine tumors. However, it remains difficult to differentiate cystadenoma from cystadenocarcinoma for multiseptated cystic hepatic lesions with papillary projection on computed tomography (CT) and magnetic resonance imaging (MRI). Here we report the case of a 47-year-old woman with several months of postprandial discomfort and abdominal fullness. CT and MRI revealed multiseptated cystic lesions with papillary excrescences. A left hemihepatectomy was performed. Histology showed a benign mucinous cystic tumor with ovarian-like stroma.
Abdominal Pain ; Cystadenocarcinoma ; Cystadenoma ; Cystadenoma, Mucinous ; Cystadenoma, Papillary ; Echinococcosis ; Female ; Humans ; Liver ; Magnetic Resonance Imaging ; Middle Aged ; Mucins ; Nausea ; Neuroendocrine Tumors

No abstract available.
Gangwon-do* ; Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Liver Diseases* ; Liver* ; Prevalence*

Midazolam, rather than diazepam does provide relatively more rapid recovery and more effective amnesia when used to supplement regional anesthesia for ambulatory case. In this study, low dose sufentanil, relatively new synthetic narcotic was administered supplementarily to potentiate the other agent. In human volunteers, depression of respiratory center sensitivity to carbon dioxide from sufentanil is of shorter duration than equipotent doses of fentanyl. Sufentanil has a potency about ten times that of fentanyl, and its duration of action is about one half as long. Concomitant use of low dose of sufentanil and midazolam intravenously for the pretreatment for retrobulbar block in outpatient cataract surgery produced satisfactory analgesia, anxiolysis, sedation, anterograde amnesia and hypnotic effects while preserving the maximal hemodynamic stability with minimal respiratory suppression and rapid recovery in a serverely compromised senile patient population.
Amnesia ; Amnesia, Anterograde ; Analgesia ; Anesthesia, Conduction ; Benzodiazepines ; Carbon Dioxide ; Cataract* ; Depression ; Diazepam ; Fentanyl ; Healthy Volunteers ; Hemodynamics ; Humans ; Hypnotics and Sedatives ; Midazolam* ; Outpatients* ; Respiratory Center ; Sufentanil*

Midazolam, rather than diazepam does provide relatively more rapid recovery and more effective amnesia when used to supplement regional anesthesia for ambulatory case. In this study, low dose sufentanil, relatively new synthetic narcotic was administered supplementarily to potentiate the other agent. In human volunteers, depression of respiratory center sensitivity to carbon dioxide from sufentanil is of shorter duration than equipotent doses of fentanyl. Sufentanil has a potency about ten times that of fentanyl, and its duration of action is about one half as long. Concomitant use of low dose of sufentanil and midazolam intravenously for the pretreatment for retrobulbar block in outpatient cataract surgery produced satisfactory analgesia, anxiolysis, sedation, anterograde amnesia and hypnotic effects while preserving the maximal hemodynamic stability with minimal respiratory suppression and rapid recovery in a serverely compromised senile patient population.
Amnesia ; Amnesia, Anterograde ; Analgesia ; Anesthesia, Conduction ; Benzodiazepines ; Carbon Dioxide ; Cataract* ; Depression ; Diazepam ; Fentanyl ; Healthy Volunteers ; Hemodynamics ; Humans ; Hypnotics and Sedatives ; Midazolam* ; Outpatients* ; Respiratory Center ; Sufentanil*

No abstract available.
Female ; Pregnancy ; Pregnancy, Abdominal*

No abstract available.
Cerebrospinal Fluid* ; Immunoglobulin G* ; Meningitis, Aseptic*

Meigs' syndrome is defined as a hydrothorax with ascites and a pelvic tumor, both of which resolve on removal of the tumor. Pseudo-Meigs' syndrome is a variant not possessing the original tumor cell types described by Meigs. Both these syndromes should be considered in otherwise healthy women who present with either new or recurrent hydrothorax and ascites. Pseudo-Meigs' syndrome occurs with the clinical triad of (1)ascites, (2)pleural effusion and (3)Brenner tumors, struma ovarii, benign thecomas, extreme ovarian edema, uterine leiomyomas or other benign pelvic tumors. A case of Pseudo-Meigs' syndrome associated with Brenner tumor is presented with a brief review of literatures.
Ascites ; Brenner Tumor ; Edema ; Female ; Humans ; Hydrothorax ; Leiomyoma ; Meigs Syndrome ; Struma Ovarii ; Thecoma

BACKGROUND/AIMS: Pancreatic cancer has a very poor prognosis, and early diagnosis is a way to increase the survival rate of patients. The purpose of this study was to develop pancreatic cancer-specific peptides for imaging studies. METHODS: Three pancreatic cancer cell lines, MIA PaCa-2, UACC-462, and BxPC-3, and a control cell line, CCD841, were used. Biopannings were performed on MIA PaCa-2 using a phage display library. After this, the peptides were synthesized and labeled with fluorescein isothiocyanate (FITC). Immunocytochemistry (ICC), enzyme-linked immunosorbent assay (ELISA), and fluorescence-activated cell sorter (FACS) were performed to examine the specific binding. To examine its therapeutic applications, a photosensitizer, chlorin e6 (Ce6), was conjugated on the peptide and photodynamic therapy was performed. Cell survival was investigated using a [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay. RESULTS: After three biopannings, the phages were amplified from 1.4×104 to 3.2×105 plaque-forming units. The most strongly binding phage was selected from the ELISA and ICC results. FITC-labeled peptide, M5, in the three pancreatic cancer cell lines showed significantly higher immunofluorescence in the ICC experiments than that of CCD841. The higher binding ability to MIA PaCa-2 cells was confirmed from FACS analysis, which showed a right shift compared to CCD841. M5 bound to Ce6 showed a significantly lower cell survival rate than that of Ce6 alone in photodynamic therapy, which was observed consistently as a change in the tumor size and fluorescence intensity in MIA PaCa-2 cell-implanted animal models. CONCLUSIONS: This study showed that the noble peptide, M5, binds specifically to the pancreatic cancer cell line, MIA PaCa-2. The M5 peptide has potential use in future optical diagnostic and therapeutic purposes.
Bacteriophages ; Cell Line ; Cell Survival ; Early Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Fluorescein ; Fluorescence ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Models, Animal ; Pancreatic Neoplasms ; Peptides ; Photochemotherapy ; Prognosis ; Survival Rate

Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P＜0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up.

BACKGROUND/AIMS: Pancreatic cancer has a very poor prognosis, and early diagnosis is a way to increase the survival rate of patients. The purpose of this study was to develop pancreatic cancer-specific peptides for imaging studies.METHODS: Three pancreatic cancer cell lines, MIA PaCa-2, UACC-462, and BxPC-3, and a control cell line, CCD841, were used. Biopannings were performed on MIA PaCa-2 using a phage display library. After this, the peptides were synthesized and labeled with fluorescein isothiocyanate (FITC). Immunocytochemistry (ICC), enzyme-linked immunosorbent assay (ELISA), and fluorescence-activated cell sorter (FACS) were performed to examine the specific binding. To examine its therapeutic applications, a photosensitizer, chlorin e6 (Ce6), was conjugated on the peptide and photodynamic therapy was performed. Cell survival was investigated using a [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay.RESULTS: After three biopannings, the phages were amplified from 1.4×104 to 3.2×105 plaque-forming units. The most strongly binding phage was selected from the ELISA and ICC results. FITC-labeled peptide, M5, in the three pancreatic cancer cell lines showed significantly higher immunofluorescence in the ICC experiments than that of CCD841. The higher binding ability to MIA PaCa-2 cells was confirmed from FACS analysis, which showed a right shift compared to CCD841. M5 bound to Ce6 showed a significantly lower cell survival rate than that of Ce6 alone in photodynamic therapy, which was observed consistently as a change in the tumor size and fluorescence intensity in MIA PaCa-2 cell-implanted animal models.CONCLUSIONS: This study showed that the noble peptide, M5, binds specifically to the pancreatic cancer cell line, MIA PaCa-2. The M5 peptide has potential use in future optical diagnostic and therapeutic purposes.
Bacteriophages ; Cell Line ; Cell Survival ; Early Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Fluorescein ; Fluorescence ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Models, Animal ; Pancreatic Neoplasms ; Peptides ; Photochemotherapy ; Prognosis ; Survival Rate