1.Effect of 1-A ( OH ) D3 on Steroid Induced Bone Loss in Frequently Relapsing Childhood Nephrotic Syndrome.
Byoung Soo CHO ; Deog Yoon KIM
Journal of the Korean Society of Pediatric Nephrology 1997;1(1):13-16
CT guided percutaneous fine-needle aspiration (FNA) of the liver for both cytologic and histologic examination has great value in diagnosing liver malignancy. From March, 1986 to April, 1990, 62 patients with the clinical impression of liver mal- ignancy underwent CT guided percutaneous FNA biopsy. Of these, 43 cases were revi- ewed for this study, 19 were reported to be liver cell carcinoma, 2 were adenocarcinoma, 11 were reported as anaplastic cell present, and the rest (11 cases) were negative (9) or necrotic (2). Among the 11 cases of the last group, 9 were diagnosed as liver cell carcinoma and 2 were necrotic histologically. Retrospective review, in order to clarify the cause of cytologic diagnostic error, of both cytologic and histologic slides of all cases showed discordance of 23% between these diagnoses and sensitivity is 93.9% and specificity is 90.9%. The reasons were as follows ; 1) the lack of awareness of tumor cells of well differentiated liver cell carcinoma (4 cases), 2) missed tumor cells due to too scanty cellularity (1 case), 3) improper smear (2 cases) and no tumor cell in the cytologic smears (3 cases). In such cases, at the initiation of FNA, a correct diagnosis of liver malignancy could only be made by a combination of cytologic and histologic examinations. However after three years' exper- ience we can conclude that cytomorphologic features of liver cell carcinoma are sufficiently distinctive from other liver malignancies to be diagnostic.
Adenocarcinoma
;
Biopsy
;
Biopsy, Fine-Needle
;
Carcinoma, Hepatocellular
;
Diagnosis
;
Diagnostic Errors
;
Humans
;
Liver
;
Nephrotic Syndrome*
;
Retrospective Studies
;
Sensitivity and Specificity
2.Present status of descrpition and application of statistics in papers in the Journal of Neuropsychiatric Association.
Journal of Korean Neuropsychiatric Association 1991;30(3):462-476
No abstract available.
3.Surface Properties of Cell Membrane in Early Stage of Transformed Cell -I. Early Detection of Transformed Cell by Concanavalin A; II. Properties of Plasma Membrane of Transformed Rat Liver Cell Induced by 3'-Me DAB.
Yonsei Medical Journal 1985;26(2):167-174
The present study was designed in order to investigate the lectin induced cytoagglutination properties of normal and transformed cells and surface alterations in the early stage of the transformed cells by characterizing the structural changes on the hepatoma surface membrane. Rat and rabbit erythrocytes and Sarcoma 180 ascites tumor cells were used for the lectin-induced cytoagglutination. Plotting % agglutination versus concanavalin A(Con A) concentration, sigmoid curves appeared in all cases. alpha-methyl-D-mannopyranoside(alphaMM) inhibited Con A induced cytoagglutination and the degrees of inhibition depended on the cell types and species. When rats were fed a diet containing 0.06% 3'-methyl-4dimethylaminoazobenzene(3'-Me DAB) for 12 weeks, almost all of the rats had solid liver tumors. Polyacrylamide gel electrophoresis of surface membrane proteins of these rat livers and of transplanted tumor cells showed three distinct protein bands, of which two were absent in normal rat livers. The molecular weights of these proteins were 73,000, 66,000, and 57,000 daltons. Antiserum against primary hepatocarcinoma surface proteins precipitated with three membrane proteins obtained from primary hepatocarcinoma cells as well as transplanted hepatocarcinoma cells, suggesting the presence of specific tumor antigens in these cells.
Animal
;
Cell Membrane/pathology*
;
Cell Transformation, Neoplastic/ultrastructure*
;
Concanavalin A/diagnostic use
;
Liver Neoplasms, Experimental/chemically induced
;
Liver Neoplasms, Experimental/ultrastructure*
;
Methyldimethylaminoazobenzene
;
Rabbits
;
Rats
;
Surface Properties
4.The effect of transforming growth factor-beta on the expression of CD8 in the CTLL-2 cell line.
Soo Young PARK ; Yoon Hae CHANG ; Young Joo CHO
Journal of Asthma, Allergy and Clinical Immunology 2000;20(1):92-98
BACKGROUND: Transforming growth factor-beta(TGF-beta) has multiple regulatory effects on cells of the immune system, and it has been suggested that differentiation of lymphoid cells is influenced by low concentra tions of this cytokine. OBJECTIVES: The aim or this study was to investigate the role of TGF-beta in regulation of T cell growth and differentiation, and to compare this effect with that of other cell signals known to be important in T cell ontogeny. METHODS: We used the CTLL-2 cell line in the presence of IL-2. Surface phenotype expression was analysed to see whether these cells could be switched to the other subtype of cells. RESULT: Treatment of CTLL-2 cells with TGF-beta resulted in dose dependent growth inhibition and morphological changes. Curing routine passage, less than 5% of cells were CD8alpha positive, whereas 38% of cells expressed CD8alpha when treated with IL-2 plus TGF-beta. However, TPA plus calcium ionophore, IFN-gamma, or TNF-alpha caused no significant changes in the proportion of CD8 cells. CONCLUSION: Our results show that this experiment can be a useful model for investigating CD8 precursor potentials in populations of CD4-CD8-(double negative) cells, and such a model may offer a way to study the molecular regulation of CD8 gene expression.
Calcium
;
Cell Line*
;
Gene Expression
;
Immune System
;
Interleukin-2
;
Lymphocytes
;
Phenotype
;
Transforming Growth Factor beta
;
Tumor Necrosis Factor-alpha
5.A Case of Tuberous Sclerosis And Review of Literatures on 25 Cases Reported in Korea.
Yoon Ja KIM ; Soo Kyung JEONG ; Nam Ji CHO
Journal of the Korean Pediatric Society 1983;26(3):290-294
No abstract available.
Korea*
;
Tuberous Sclerosis*
6.Effect of High-dose Intrevenous Immune Globulin in the Treatment of Neonatal Immune Hemolytic Jaundice Unresponsive to Phototherapy.
Sang Lak LEE ; Yoon Jung CHO ; Cheon Soo KIM
Korean Journal of Perinatology 1999;10(2):176-182
OBJECTIVE: Immune hemolytic jaundice is caused by the destruction of antibody-sensitized erythrocytes and is associated with antibody-dependent cellular cytotoxic effects mediated by Fc receptor-bearing cells of the reticuloendothelial system. Intravenous immune globulin(IVIG) may have exerted its effect through Fc receptor blockade. We studied the effect of high-dose intravenous immune globulin(HDIVIG) in neonatal hemolytic jaundice unresponsive to phototherapy. METHODS: We selected only those with Coombs test(+) immune hemolytic jaundice who had admittcd at the NICU of the Dcpartment of Pediatzics of Dongsan Medical Center, Keimyung University between January 1995 and December 1998. They were unresponsive to phototherapy. Ten newborn infants(9 ABO incomplatibilities, l minor group incompatabillity due to anti-E) received HDIVIG therapy combined with phototherapy. IVIG was given as a dose of lg/kg for 6 hours, and serial hemoglobin, reticulocyte count, and bilirubin levels were evaluated. If the serum bilirubin level went up and reached the level above 22mg/dl, we conducted exchange transfusion for the patient. RESULTS: HDIVIG induced a significant decrease of serum billirubin levels in 8(80%, group I, HDIVIG responsive poup) of 10 cases and only 2 cases(group II, HDIVIG unreponsive group) required exchange tnnsfusions. No side effect was observed after HDIVIG therapy. CONCLUSION: We suggest HDIVIG may be effective in the treatment of phototherapy-resistant hyperbilirubinemia due to blood group incompatibility. More studies are needed to confirm the optimal dosage and therapeutic indication of HDIVIG in the therapy of neonatal immune hemolytic jaundice.
Bilirubin
;
Blood Group Incompatibility
;
Erythrocytes
;
Humans
;
Hyperbilirubinemia
;
Immunoglobulins, Intravenous
;
Infant, Newborn
;
Jaundice*
;
Mononuclear Phagocyte System
;
Phototherapy*
;
Receptors, Fc
;
Reticulocyte Count
7.Pathological Fracture of The Distal Femur, Caused by Chronic Actinomycotic Osteomyelitis: A case report
Ki Hong KIM ; Yong Joo KIM ; Jang Soo KANG ; Bun Soo YOON ; Sung Soo CHO
The Journal of the Korean Orthopaedic Association 1979;14(3):461-464
Actinomycosis is a chronic suppurative and granulomatous disease characterized by peripheral spread and extension to contagious tissue, rare hematogenous spread, and the formation of multiple draining sinus tracts. In the rare case of hematogenous disseminated Actinomycosis; lesions appear in all parts of the body. Bone involvement, however, is very rare except the jaw and there has been only some reports about the ribs and vertebral columns. To our knowledge, this case represents the first report of documented distal femoral involvement.
Actinomycosis
;
Femur
;
Fractures, Spontaneous
;
Jaw
;
Osteomyelitis
;
Ribs
;
Spine
8.Improvement of titration methods for porcine rotavirus, its serum neutralizing antibody and of virus isolation from feces.
Hyock Jin KWON ; Seok Min YOON ; Rung Kong HA ; Sung Soo CHO ; Ji Byung YOON
Journal of the Korean Society of Virology 1991;21(2):113-117
No abstract available.
Antibodies, Neutralizing*
;
Feces*
;
Rotavirus*
9.A case of solar urticaria.
Moon Soo YOON ; Min Seok SONG ; Jong Hee NA ; Young Ho CHO ; Yoon Kee PARK
Korean Journal of Dermatology 1991;29(4):514-517
No abstract available.
Urticaria*
10.Three cases of atypical Kawasaki disease with coronary aneurysm.
Min Young PARK ; Kwang Sun HAN ; Sung Yoon CHO ; Byoung Soo CHO ; Sung Ho CHA
Journal of the Korean Pediatric Society 1993;36(9):1315-1319
Kawasaki disease is described by fever lasting five days or more, bilateral conjunctival injection, changes of lips and oral cavity, polymorphous exanthema, acute non-purulent cervical lymphadenopathy, and changes of extremities. Atypical Kawasaki disease is defined as fewer than 4 of 6 criteria described above including coronary artery abnormalities. Especially, atypical clinical manifestations of Kawasaki disease appear in infants younger than 6 months old of age. Thus we recommend echocardiography in early infancy who has prolonged fever in order to diagnose atypical Kawasaki disease and treat early. We have experienced three cases of atypical Kawasaki disease with coronary aneurysm who were admitted because of fever and revealed coronary aneurysm on echocardiography.
Coronary Aneurysm*
;
Coronary Vessels
;
Echocardiography
;
Exanthema
;
Extremities
;
Fever
;
Humans
;
Infant
;
Lip
;
Lymphatic Diseases
;
Mouth
;
Mucocutaneous Lymph Node Syndrome*