A 23 year old female patient swallowed a tooth brush about one month prior to admission. She has been felt discomfort in epigastrium and dull aching pain recently around umbilicus. Upper gastrointestinal X-Ray and gastroduodenoscopic examination disclosed that a full size, yellow tooth brush is lodged transversely in the stomach and duodenal bulb, Endoscopic remova.l was tried and failed because of impaction of the both ends into mucosa. The tooth brush was removed by gastrotomy under general anesthesia. The free end of the brush handle penetrated the duodenal bulb wall and the impaction of the tip prevented the leakage of duodenal contents before removal. Though the primary method of the gastroduodenal foreign body is endoscopic, if sharp end of the forei body seems to be impacted into the gastrointestinal wall, and if it retained same position for long duration, it should not tried to remove by force fo prevention of leakage and resulting peritonitis. Surgical removal may be safer method in these cases.
Anesthesia, General ; Female ; Foreign Bodies* ; Humans ; Mucous Membrane ; Peritonitis ; Stomach ; Tooth ; Umbilicus ; Young Adult

Heterotopic panereas is pancreactie tissue occuring outside its normal anatomical location and without any connection and normal pancreas and it is a developmental anormaly. The most commen site is stomach(esp. greater curvature of the antrum), duodenum and jejunum, In majority of cases heterotopic pancreas does not produce symptoms. When it produces complications, the symptoms depend on the site of lesion and the size of mass. Pathologically, the heterotopic pancreatic tissue is subject to all the lesions found in the normally placed pancreas. Tbe smooth broad base intramural defect with central niche ie typical radiologic fiadings of heterotoPic pancreas. Gastrofiberscopy revealed a small round, submucosal projection with a central umblication. The lesions are frequently confused with polys, lymphoma, in.tramural neoplasm and gastric uleer. Accurate diagnosis may prevent needless surgical procedures. Three cases of heterotopic pancreas of stomach were reported and the pertinent literature were reviewed briefly.
Diagnosis ; Duodenum ; Jejunum ; Lymphoma ; Pancreas* ; Stomach*

Gonadotropin releasing hormone (GnRH) is believed to be pivotal hormone in hypothalamo-pituitary gonadal axis and the hypothalamus is believed as the exclusive organ producing GnRH and pituitary is for GnRH re ceptor until recently. Some reported the exptra-hypothalamic GnRH or extra-pituitary GnRH receptors from decades ago. The aims of this study are to confirm the existence of the GnRH receptor in bladder epithelial cancer cell, HT-1197 and HT-1376, and evaluated the possible role of the GnRH on cell cycle. The GnRH and GnRH receptor were detected by immunohistochemical staining and the effect of GnRH on cell cycle change in both cell line were studied by fluorescence activated cell sorter (FACS). The control cells were cultured at media supplemented with normal serum, and experimental group were cultured at media supplemented with charcoal stripped serum (CSS) which excluding peptide hormones except exogenous GnRH with different concentration. The GnRHs and GnRH receptors were detected at both cell lines and the cell cycle analysis showed that there were little difference in proportion of cell cycle among examined 10,000 cells in both cell lines, neither control nor experimental groups. This study shows that the GnRHs and GnRH receptors exist in bladder cancer cells and GnRH did not influence on the cell cycle progression. With this study, we suppose that the bladder cancer cells produce the GnRH and GnRH receptors and the role of the GnRF produced from the bladder cancer cells might be the autocrine rather than endo-or paracrine factor.
Axis, Cervical Vertebra ; Cell Cycle* ; Cell Line ; Charcoal ; Fluorescence ; Gonadotropin-Releasing Hormone* ; Gonadotropins* ; Gonads ; Hypothalamus ; Peptide Hormones ; Receptors, LHRH ; Urinary Bladder ; Urinary Bladder Neoplasms

Recent development of oral and maxillofacial surgery has taken an interest in the regeneration of facial bone defects. For the reconstruction of bony defects, autogenousbone grafts have been widely used. However, there are some clinical problems ; the morbidity of donor sites, resorption of autogenous bone graft and the availability of the proper form and size. The purpose of this study is to find the proper filling materials for the bone defects. The present study was designed to evaluate the roles and regenerating capacity of maikture of freeze-dried domineralized allogenic bone and hydroxylapatite. Fifteen adult New Zealand white rabbits were used as the experimental animal, Four trephine defects were made by drilling on the parietal bone of each rabbit. The size of each defects was 8x8mm. In first group, the defect was filled with freeze-dried demineralized allogenic bone and hydroxylapatite. The defect in second group was filled with autogenous bone chip only. The third group was filled with autogenous bone chip and hydroxylapatite. The fourth group was filled with freeze-dried dimineralized allogenic bone only. The results were carefully examined grossly and micorsocopically from the 2 weeks to 12 weeks postoperatively. The following results were obtained ; 1. In the case of the graft with autogenous bone chip only, new bone formation was more active than any other groups. 2. In the case of the graft with combination of freeze-dried demineralized allogenic bone and hydroxylapatite, new bone formation was similar to the case of autogenous bone and hydroxylapatite mixture. 3. In the case of the graft with freeze-dried demineralized bone, new bone formation was observed, but less than the other groups. And the time of new bone appeared was later than the other groups. A combination of freeze-dried deminearalized allogenic bone and hydroxylapatite plays an effective role in forming new bone. The results of this study may suggest the possible usage of the mixture of freeze-dried allogenic bone and hydroxylapatite as an alternative to autogenous bone in maxillofacial orthopedic surgery.
Adult ; Animals ; Bone Regeneration* ; Durapatite* ; Facial Bones ; Humans ; Orthopedics ; Osteogenesis ; Parietal Bone ; Rabbits ; Regeneration ; Surgery, Oral ; Tissue Donors ; Transplants*

Congenital pseudarthrosis of the tibia is a condition most often combined with cafe-au-lait spots and neurofibromatosis. It is notoriously difficult to attain a sound bony union. Compression plating and screw fixation with massive bone graft resulted in successful union in our case.
Cafe-au-Lait Spots ; Neurofibromatoses ; Pseudarthrosis ; Tibia ; Transplants

No abstract available.
Hydronephrosis*

Results from two in vitro assays, Pharmacia CAP system(CAP) and fluoroallergosorbent test(FAST), for detecting serum specific IgE to three allergens, mugwort, Derraatophagoides pteronyssinus, and eat epithelium, were compared with skin prick test(SPT) results in 53 atopie dermatitis patients with positive SPT and 25 non-atopic controls. Using SPT results as the reference standards, CAP achieved higher sensitivity than FAST in determination of three allergens. CAP for measuring total IgE and eosinophil cationic protein(ECP) was also compared with FAST and ECP radioimmunoassay(RIA), respectively. In comparison of two assays for total serum IgE, the values obtained with CAP were significantly higher than those with FAST. In comparison of CAP and RIA for measuring ECP, the values obrained with CAP were significantly higher than those with RIA and the differences between ECP values of two assays were significant in high ECP group(>8.3 micro gram/1). These results suggest that CAP is the preferred test and seems to be more appropriate method for detection of specific IgE and ECP in patients with allergic digeases.
Allergens ; Artemisia ; Dermatitis ; Eosinophil Cationic Protein* ; Eosinophils* ; Epithelium ; Humans ; Immunoglobulin E ; Radioimmunoassay* ; Skin

BACKGROUND: Stratum corneum lipids serve as a water retainer as well as permeability barrier by forming a multi-lamellae structure in the stratum corneum. The major constituent of these lipids, ceramides, have been shown to be predominantly associated with both functions. OBJECTIVE: Exposure of human epidermis to ultraviolet(UV) irradiation leads to changes in the physiologic and biochemical features of the skin. In order to investigate the effect of UVB irradiation on the skin barrier function in hairless mice, transepidermal water loss (TEWL) and lipid composition of stratum corneum were evaluated in hairless mice. METHODS: Hairless mice were irradiated 3 times weekly for 3 weeks with suberythemal dose (0.6MED, Group I) and minimal erythemal dose(MED), Group II) of UB. The mice of Group III received high dose of UVB(3MED) on the back in a single exposure. The control was Group IV. TEWL measured by evaporimeter and lipid composition of stratum corneum appraised by high performance thin layer chromatography(HPTLC) were evaluated weekly for 3 weeks. RESULTS: 1. Each time it was measured, the values of TEWL in group I were lower than group IV, but the difference was not significant. The peak value of TEWL in group II was 8.2+/-1.56 g/cm/h on the 7th day. The increase in TEWL was markedly significant at this point(P<0.001). Although the values of TEWL on the 14th and 21th day in group E increased compared with those of the control group, the significance of the values decreased (P<0.05). 2. The peak value of TEWL in group III was 9.88+/-1.13 g/cm/h on the 2nd day, showed a markedly significant increase compared with that of the control group(P<0.001). The values of TEWL decreased to the level of the control group on the 14th day. 3. The lipid(cholesterol sulfate, ceramide and neutral lipid) and total lipid mass in group 1 were insignificantly larger than that of the group IV measured each time. On the 7th and 14th day, the amount of each three lipid and total lipid mass significantly increased (P<0.05). On the 21th day, the amount of ceramide and neutral lipid showed a significant increase(P<0.05), furthermore the total lipid mass increased pronouncedly(P<0.01) in group II. 4. The amount of the 3 kinds of lipid and total lipid mass in group III significantly increased compared with those of the control group on the 2nd day(P<0.05). After the 7th day, no significant difference of the lipid mass except neutral lipid compared with that of the control group was seen. Comparing the 2nd and 14th day, there was a significant decrease in the amount of ceramide and total lipid mass(P<0.05) CONCLUSION: These results results suggest that considerable amount of UVB irradiation given in single or repeated exposure causes the disruption of skin barrier function, but a compensatory increase of skin lipid, especially ceramide, protests it from further damage and also improves skin barrier function.
Animals ; Ceramides ; Epidermis ; Humans ; Mice ; Mice, Hairless* ; Permeability ; Skin*

Fibrofolliculoma is a benign follicular neoplasm which usually occurs in multiple and rarely solitarily. We have found only seven cases of previous reports of solitary fibrofolliculomas worldwide and only two in Korean literature. Herein we report on a 40-year-old female patient with a solitary flesh-colored bean sized mass on the scalp which histopathologically proved to be a fibrofolliculoma.
Adult ; Female ; Humans ; Scalp

We report a case of a 25-year-old woman with systematized epidermal nevi associated with alopecia universalis and onychodystrophy. The histopathologic examinations by light and electron microscopies of the epidermis of the trunk and scalp lesions showed epidermal nevus with characteristic features of epidermolytic hyperkeratosis. This is a rare case of systematized epidermal nevi associated with congenital alopecia universalis and onychodystrophy. Though there is no apparent gross skin lesion on the hair bearing area, the development of epidermal nevi can affect the hair and nail units which are derived from the common epidermal germinative cells.
Adult ; Alopecia* ; Epidermis ; Female ; Hair ; Humans ; Hyperkeratosis, Epidermolytic ; Microscopy ; Nevus* ; Scalp ; Skin