3.Laparoscopic Transperitoneal Adrenalectomy : Clinical Experinece with 18 Cases.
Woo Keun LEE ; Tae Gyun KWON ; Yoon Kyu PARK
Korean Journal of Urology 2000;41(12):1471-1476
No abstract available.
Adrenalectomy*
4.Sex differences in large artery atherosclerotic stroke, a Korean study
Cindy W Yoon ; Hee-Kwon Park ; Joung-Ho Rha
Neurology Asia 2016;21(4):311-316
Background & Objective: Sex differences in cerebral atherosclerosis and subsequent stroke have
not been thoroughly investigated and conflicting data exist. The aim of this study was to investigate
sex differences in the risk factors and distribution of large artery atherosclerotic stroke in a Korean
population. Methods: We included consecutive acute ischemic stroke patients with symptomatic
extracranial atherosclerosis (ECAS) or intracranial atherosclerosis (ICAS) based on brain and vascular
imaging who presented at our hospital between January 2011 and December 2015. We then compared
risk factor profiles and the proportion of symptomatic ECAS and ICAS between men and women.
Results: Eight hundred and forty four patients were enrolled during the study period. The proportion
of ECAS in men was notably higher than in women (19.4% in men vs. 9.3% in women; p < 0.001).
A multiple regression analysis showed that male gender was a factor favoring ECAS (vs. ICAS, odds
ratio [OR], 3.554; 95% confidence interval [CI], 2.175-5.808; p < 0.001). Age (OR, 1.051; 95% CI,
1.031-1.072; p = 0.001) and hyperlipidemia (OR, 2.330; 95% CI, 1.538-3.529; p < 0.001) were also
factors favoring ECAS. However, after stratification by sex, the association was only significant in men.
Conclusions: There is a sex difference in the distribution of atherosclerotic stroke. Sex may be an
effect modifier of the association between atherosclerotic risk factors and atherosclerotic distribution.
Stroke
5.Left Atrial Spontaneous Echo Contrast and Thrombus in Nonrheumatic Atrial Fibrillation.
Yeo Hak YOON ; Young Kwon KIM ; Yoon Suk CHO ; Bong Nam CHAE ; Jin Yong CHOI ; In SOHN ; Seong Hoon PARK
Korean Circulation Journal 1994;24(1):66-76
BACKGROUND: Nonrheumatic atrial fibrillation is common in elderly and associated with an increased risk for thromboembolism. Left atrial spontaneous echo contrast(SEC) and thrombus. which are easily detected by transesophageal echocardiography(TEE) in patients with rheumatic mitral valve disease and atrial fibrillation, have been known as markers of thromboembolism. However, most of the previous studies on left atrial SEC and thrombus were performed in rheumatic mitral valve disease or various conditions including rheumatic mitral valve disease. Therefore this study was underaken in order to investigatd 1) the prevalence of left atrial SEC and thrombus, and 2) clinical and echocardiographic variables related to left atrial SEC and thrombus in nonrheumatic atrial fibrillation. METHODS: In patients with estabished atrial fibrillation over 7 days, we examined the clinical gistory and performed transthoracic echocardiography(TTE) and TEE simultaneously. Enlisted patients were those without rheumatic mitral valve disease, prosthetic valves, previous thromboembolism, and recent anticoagulant therapy. RESULTS: 1) Left atrial SEC was detected in 32(62.7%) of 51 patients and left atrial thrombus in 10(19.6%). All thrombi were located in the left atrial appendage. 2) In univariate analysis, SEC positive group showed higher prevalence of congestive heart failure(CHF)(56.3% vs 0%, p<0.001), lower ejection fraction(42.2+/-14.1% vs 50.8+/-9.7%, p<0.05), lower left atrial appendage blood flow velocity(peak positive flow velocity ; 18.7+/-11.1cm/sec vs 32+/-12.4cm/sec, p<0.01, and peak negative flow velocity ; 21.4+/-12.4cm/sec vs 31.9+/-12.8cm/sec, p<0.01) than SEC negative group. Multivariate analysis identifed CHF as an independent variable related to left atrial SEC(p=0.02, Odds ratio ; 2.38, 95% CI ; 1.18-4.82). 3) In univariate analysis. left atrial thrombus positive group showed higher prevalence of CHF(70% vs 26.8%, p<0.05), larger left atrial demension(34+/-3.4mm/m2 vs 30.6+/-4.6mm/m2, p<0.05) than thrombus negative group. Multivariate analysis identifed CHF as an independent variable related to left atrial thrombus(p=0.04, Odds ratio ; 4.30, 95% CI ; 1.11-16.68). 4) Left atrial thrombus is more frequent in SEC positive group than in SEC negative group(28.1% vs 5.3%), however, there was no statistical significance(p=0.07). CONCLUSION: 1) Left atrial SEC is common in nonrheumatic atrial fibrillation and significantly related to CHF. 2) Left atrial thrombus is frequently detected in SEC positive patients, however, it is more realted to CHF than left atrial SEC itself.
Aged
;
Atrial Appendage
;
Atrial Fibrillation*
;
Echocardiography
;
Estrogens, Conjugated (USP)
;
Heart
;
Humans
;
Mitral Valve
;
Multivariate Analysis
;
Odds Ratio
;
Prevalence
;
Thromboembolism
;
Thrombosis*
6.The 24-Hour Ambulatory Blood Pressure in Normotensive Korean Adults.
Bong Nam CHAE ; Young Kwon KIM ; Yeo Hak YOON ; Yoon Sook CHO ; Jin Yong CHOI ; In SOHN ; Seong Hoon PARK
Korean Circulation Journal 1994;24(1):9-16
BACKGROUND: Twenty-four-hour ambulatory blood pressure(ABP) monitoring has become increasingly popular for diagnosing and treating hypertension. Therefore the reference value of normotensive subjects was necessary for interpretation of hypertensive subjects. Several studies were reported on reference values in normotensive subjects. The purpose of this study was to determine 24-hour ABP in normotensive Korean adults stratified for sex and five age groups. This study also assessed ABP in relation to a family history of hypertension, smoking and body mass index(BMI). METHODS: ABP monitoring was performed in 200 healthy normotensive volunteers(ranged in age from 20 to 69 years, five decades, 20 men and 20 women per each decade), over 24 hours, taking measurement at 30-min intervals. The 24-hour interval was divided into day-time(6am-10pm) and night-time(100pm-6am) periods. Mean ABP and pressure loads(percentage of systolic readings>140mmHg, diastolic readings>90mmHg) were obtained. RESULTS: The mean ABP in 200 subjects was 113+/-8.6/72+/-6.9mmHg over 24 hours, 117+/-9.7/75+/-7.0mmHg during day-time, and 106+/-9.8/67+/-8.3mmHg at night-time, and pressure loadd averaged 5.1+/-7.4/7.9+/-8.9% over 24 hours. The +2 standard deviation(SD) as the upper limit of normal was 130/86mmHg over 24 hours in 200 subjects. The mean ABP and pressure load were 116+/-7.6/74+/-7.6mmHg and 6.4+/-8.3/10.1+/-10.2% in 100 subjects of men, and 110+/-8.3+/-70+/-6.6mmHg, 3.7+/-6.0/5.7+/-6.8% in women. Mean ABP and pressure load showed significant difference in relation to age group and sex, however, no significant difference in relation to a family history of hypertension or smoking. In relation to BMI group, diastolic blood pressure and diastolic pressure load were significantly different.
Adult*
;
Blood Pressure*
;
Female
;
Humans
;
Hypertension
;
Male
;
Reference Values
;
Smoke
;
Smoking
7.Evaluation of the CellaVision Advanced RBC Application for Detecting Red Blood Cell Morphological Abnormalities
Seong Jun PARK ; Jung YOON ; Jung Ah KWON ; Soo-Young YOON
Annals of Laboratory Medicine 2021;41(1):44-50
Background:
The Advanced RBC Application of the CellaVision DM9600 system (CellaVision AB, Lund, Sweden) automatically characterizes and classifies red blood cells (RBCs) into 21 morphological categories based on their size, color, shape, and inclusions. We evaluated the diagnostic performance of the CellaVision Advanced RBC Application with respect to the classification and grading of RBC morphological abnormalities in accordance with the 2015 International Council for Standardization in Haematology (ICSH) guidelines.
Methods:
A total of 223 samples, including 123 with RBC morphological abnormalities and 100 from healthy controls, were included. Seven RBC morphological abnormalities and their grading obtained with CellaVision DM9600 pre- and post-classification were compared with the results obtained using manual microscopic examination. The grading cut-off percentages were determined in accordance with the 2015 ICSH guidelines. The sensitivity and specificity of the CellaVision DM9600 system were evaluated using the manual microscopic examination results as a true positive.
Results:
In pre-classification, > 90% sensitivity was observed for target cells, tear drop cells, and schistocytes, while > 90% specificity was observed for acanthocytes, spherocytes, target cells, and tear drop cells. In post-classification, the detection sensitivity and specificity of most RBC morphological abnormalities increased, except for schistocytes (sensitivity) and acanthocytes (specificity). The grade agreement rates ranged from 35.9% (echinocytes) to 89.7% (spherocytes) in pre-classification and from 46.2% (echinocytes) to 90.1% (spherocytes) in post-classification. The agreement rate of samples with withinone grade difference exceeded 90% in most categories, except for schistocytes and echinocytes.
Conclusions
The Advanced RBC Application of CellaVision DM9600 is a valuable screening tool for detecting RBC morphological abnormalities.
8.The characteristics of blood compinents from 400mL CPDA-1 wholeblood.
Q Eun PARK ; Hyun Ok KIM ; Yoon Jeong DOH ; Oh Hun KWON ; Young Chul OH
Korean Journal of Clinical Pathology 1992;12(1):115-120
No abstract available.
9.A case of advanced abdominal pregnancy.
Yun Jin PARK ; Tae Kyu YOON ; Chang Won KO ; Myung Kwon JEON ; Hong Kyoon LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):1624-1631
No abstract available.
Female
;
Pregnancy
;
Pregnancy, Abdominal*
10.Erythromycin Resistance Phenotype of Streptococcus pyogenes.
Young UH ; Gyu Yel HWANG ; In Ho JANG ; Jong Sun PARK ; Oh Gun KWON ; Kap Jun YOON
Korean Journal of Clinical Microbiology 1999;2(2):131-134
BACKGROUND: The erythromycin-resistance rate and phenotype distribution of Streptococcus propenes are quite different by geographical variation and study period. The aim of the present study was to determine the evolution of resistance to erythromycin and the frequency of erythromycin resistance phenotype of S. pyogenes isolated from Wonju Christian Hospital. METHODS: The minimal inhibitory concentrations (MICs) of erythromycin and clindamycin for 94 S. pyogenes isolated from clinical specimens between 1990 to 1998 were investigated. Double disk test of erythromycin (78microgram) and clindamycin (25microgram) were performed for 15 isolates of erythromycin resistant S. pyogenes to evaluate the erythromycin resistance phenotype. RESULTS: The resistance rates of 94 isolates of S. pyogenes were 16%(15/94) to erythromycin and 4%(4/94) to clindamycin. The frequency of erythromycin resistance phenotype in decreasing order were M phenotype (47%), inducible resistance phenotype (40%), and constitutive resistance phenotype (13%). Erythromycin-resistant S. pyogenes did not exist until 1993, but was isolated since 1994, and ranged from 14.0% to 24.0% during the period of 1994-1998. CONCLUSIONS: Our finding documents the emergence of high resistance rates to erythromycin in S. pyogenes at Wonju area since 1994. The M phenotype (47%) and inducible resistance phenotype (40%) account for the majority of erythromycin-resistant S. pyogenes.
Clindamycin
;
Erythromycin*
;
Gangwon-do
;
Phenotype*
;
Streptococcus pyogenes*
;
Streptococcus*