BACKGROUND: Apoptosis can be induced by various anticancer agents. Resistance to apoptosis may play an important role in tumors refractory to chemotherapy. The authors investigated both the induction of apoptosis by camptothecin, a topoisomerase I inhibitor, in gastric cancer cell lines and the roles of apoptosis-elated gene products. METHODS: Two gastric cancer cell lines, SNU- and SNU-6, were examined for response to chemotherapeutic agents. Cytotoxicity was determined by a MTT assay. Apoptosis was measured by a DNA fragmentation assay using agarose gel electrophoresis and electron microscopy. Apoptosis-elated gene products were determined by western blot analysis. RESULTS: The two gastric cancer cell lines (SNU- and SNU-6) showed different sensitivities to camptothecin. Apoptosis of SNU-6 was easily induced by camptothecin, while SNU- was refractory to apoptosis, which was confirmed by DNA fragment assays and electron microscopy. Western blot analysis revealed that the amount of Bcl- in SNU- was 2.68-imes more than that in SNU-6. There were no differences in the levels of Bax, Bcl-L, Bcl-s, and p53 between the two cell lines. CONCLUSIONS: It is thought that Bcl- may play an important role in blocking cell death due to anticancer drugs in gastric cancer cell lines. Thus, chemosensitivity might be increased if this cell death-locking status were to be modified by new biologic therapies for gastric cancer.
Antineoplastic Agents ; Apoptosis* ; Biological Therapy ; Blotting, Western ; Camptothecin ; Cell Death ; Cell Line* ; DNA ; DNA Fragmentation ; DNA Topoisomerases, Type I ; Drug Therapy ; Electrophoresis, Agar Gel ; Microscopy, Electron ; Stomach Neoplasms*

PURPOSE: The purpose of this study was to evaluate the incidcnce of extrapericardial fat in the left cardiacborder, and with regard to left extrapericardial fat, to correlate chest radiographs with CT scans. MATERIALS AND METHODS: This study involved 132 consecutive patients who underwent chest PA and lateral radiographs, and chestCT scans. According to the results of chest PA radiograph, patients were divided into three groups: those with aclear left cardiac border; those with an indistinct left cardiac border; and those with an indistinct left cardiacborder with increased density; cardiophrenic angle, as seen on lateral radiograph, the presence of increaseddensity in the anterior cardiophrenic angle, as seen on lateral radiograph radiographs was evaluated. On the basisof the results of CT scanning, patients were classified into four groups according to the amount of leftextrapericardial fat: negative, minimum, moderate, and maximum. Left extrapericardial fat, as seen on CT, wascorrelated with the conspicuity of left cardiac border seen on PA radiograph and the presence of increased densityin the anterior cardiophrenic angle, as seen on lateral radiograph. RESULTS: On CT, left extrapericardial fat wasobserved in 51 patients (38.6%). In 38 of these (28.8%), the amount was minimal, in 12 (9.1%), it was moderate,and in one (0.8%), it was maximal. On posteroanterior chest radiograph, clear, indistinct, and indistinct andincreased density of the left cardiac border was seen in 89 (67.4%), 28 (21.2%), and 15 cases (11.4%),respectively. On lateral radiograph, increased density of the anterior cardiophrenic angle was seen in 115 cases(87.1%) but in 17 (12.9%), increase density was not apparent. There was significant correlation between chestradiographs and CT(p<0.001) (sensitivity: 53%; specificity: 100%; positive predictive value: 100%; negativepredictive value: 84%). CONCLUSION: The conspicuousness of the left cardiac border, as seen on PA chestradiograph, correlated with the presence of left extrapericardial fat, as seen on CT, and was related to theamount of left extrapericardial fat. Increased density of the anterior cardiophrenic angle, as seen on lateralradiographs, correlated with the presence of left extrapericardial fat on CT, but the absence of increased densityon lateral radiograph corresponds to the absence or a minimal amount of left extrapericardial fat, as seen on CT.
Humans ; Radiography, Thoracic* ; Sensitivity and Specificity ; Thorax* ; Tomography, X-Ray Computed

Pulmonary siderosis is one kind of pneumoconiosis caused by the long term inhalation of iron dust. Iron is deposited in the lungs, usually in the form of iron oxides. Iron oxides are relatively inert particles with a minimal fibrotic response. It occurs in a number of occupations including welding, steel rolling and grinding, casting, iron ore mining and oxyacetylene cutters. We have experienced the first case of pulmonary siderosis in Korea. A 42-year-old woman who had engaged in a metalware manufacturing factory as a manager for 7 years was admitted because of dyspnea on exertion. A pulmonary function test disclosed a mildly obstructive ventilatory defect. Open lung biosy revealed deposition of iron-laden macrophages in most alveolar spaces by which confirmed the diagnosis of pulmonary siderosis. We report a case of pulmonary siderosis with a review of the literature.
Adult ; Diagnosis ; Dust ; Dyspnea ; Female ; Humans ; Inhalation ; Iron ; Korea ; Lung ; Macrophages ; Mining ; Occupations ; Oxides ; Pneumoconiosis ; Respiratory Function Tests ; Siderosis* ; Steel ; Welding

Asbestosis is the most important change noted in the lung parenchyma after environmental and occupational exposure to asbestos fibers. It is characterized by diffuse interstitial pulmonary fibrosis. In Korea, the incidence of asbestosis will continue to increase for many years to come and the government enacted the Asbestos Damage Relief Law in 2011 to provide compensation to those suffering from asbestos-related diseases. Radiologic evaluation is necessary for diagnosis of asbestosis, and radiologists play a key role in this process. Therefore, it is important for radiologists to be aware of the various imaging features of asbestosis.
Asbestos ; Asbestosis* ; Compensation and Redress ; Diagnosis* ; Incidence ; Jurisprudence ; Korea* ; Lung ; Occupational Diseases ; Occupational Exposure ; Pulmonary Fibrosis ; Radiography

Thoracic foreign bodies (FBs) are serious and relatively frequent in emergency departments. Thoracic FBs may occur in association with aspiration, ingestion, trauma, or iatrogenic causes. Imaging plays an important role in the identification of FBs and their dimensions, structures, and locations, before the initiation of interventional treatment. To guide proper clinical management, radiologists should be aware of the radiologic presentations and the consequences of thoracic FBs. In this pictorial essay, we reviewed the optimal imaging settings to identify FBs in the thorax, classified thoracic FBs into four types according to their etiology, and reviewed the characteristic imaging features and the possible complications.

No abstract available.
Humans*

Lipoma is a common benign neoplasm, but lipoma arising from the pleura is rare; it is composed of mature adipose tissue and occasionally fibrous stroma. The tumor shows characteristic radiographic and CT features of pleural mass, and the lesion is homogeneous and low density, with CT numbers indicating fat. The mass was removed by surgery and confirmed as a lipoma originating from the parietal pleura.
Adipose Tissue ; Lipoma* ; Pleura

PURPOSE: To evaluate the prevalence and degree of tracheal deviation seen on chest PA radiographs of thyroid lesions and to correlate these findings with their size, volume, pattern (localized or diffuse), location, and constitution . MATERIALS AND METHODS: Between May 1995 and July 1998, tracheal deviation seen on chest PA radiographs was retrospectively reviewed in 179 consecutive cases in which a thyroid lesion was seen on ultrasonography and/or CT of the thyroid. The criterion of tracheal deviation was more than 3mm. Thyroid lesions were classified as diffuse or localized according to their pattern; as central, marginal or borderline on the basis of their location, and as cystic, solid or mixed, depending on their constitution. RESULTS: Tracheal deviation was seen in 53 cases (29.6%, n=179); mean deviation was 5.6mm (3 -27 mm). Its incidence increased with lesion size (p<0.05), the mean of which was 5.4 x 2.8 cm in the tracheal deviation group and 1.6 x 1.2 cm in the non-tracheal deviation group. Tracheal deviation was seen in 46 localized-type cases (86.8 %) and 7 diffuse-type cases (13.2 %) (p>0.05). The volume of the former type was measured and the incidence and degree of tracheal deviation was found to increase with lesion volume (p<0.05). For every cubic mm of volume increase, tracheal deviation increased by 0.015 mm (p<0.05). Localized-type lesions were located in the right lobe in 31 cases (67.4 %) and the left lobe in 15 (32.6 %) (p>0.05). The most common location was borderline (n=30, 65.2 %), followed by central (n=12, 26.1%), and marginal (n=4, 8.7%). The most common type by constitution was solid (n=32, 69.6 %), followed by cystic (n=10, 21.7 %), and mixed type (n=4, 8.7 %) (p>0.05). CONCLUSION: Chest PA radiography revealed tracheal deviation of thyroid lesion in 53 cases (29.6 %). The incidence and degree of deviation increased with increasing size and volume of the lesion, but deviation did not correlate with the pattern (localized or diffuse), location or constitution of the lesion.
Constitution and Bylaws ; Incidence ; Prevalence ; Radiography ; Radiography, Thoracic* ; Retrospective Studies ; Thorax* ; Thyroid Gland ; Ultrasonography

PURPOSE: To evaluate the prevalence and degree of tracheal deviation seen on chest PA radiographs of thyroid lesions and to correlate these findings with their size, volume, pattern (localized or diffuse), location, and constitution . MATERIALS AND METHODS: Between May 1995 and July 1998, tracheal deviation seen on chest PA radiographs was retrospectively reviewed in 179 consecutive cases in which a thyroid lesion was seen on ultrasonography and/or CT of the thyroid. The criterion of tracheal deviation was more than 3mm. Thyroid lesions were classified as diffuse or localized according to their pattern; as central, marginal or borderline on the basis of their location, and as cystic, solid or mixed, depending on their constitution. RESULTS: Tracheal deviation was seen in 53 cases (29.6%, n=179); mean deviation was 5.6mm (3 -27 mm). Its incidence increased with lesion size (p<0.05), the mean of which was 5.4 x 2.8 cm in the tracheal deviation group and 1.6 x 1.2 cm in the non-tracheal deviation group. Tracheal deviation was seen in 46 localized-type cases (86.8 %) and 7 diffuse-type cases (13.2 %) (p>0.05). The volume of the former type was measured and the incidence and degree of tracheal deviation was found to increase with lesion volume (p<0.05). For every cubic mm of volume increase, tracheal deviation increased by 0.015 mm (p<0.05). Localized-type lesions were located in the right lobe in 31 cases (67.4 %) and the left lobe in 15 (32.6 %) (p>0.05). The most common location was borderline (n=30, 65.2 %), followed by central (n=12, 26.1%), and marginal (n=4, 8.7%). The most common type by constitution was solid (n=32, 69.6 %), followed by cystic (n=10, 21.7 %), and mixed type (n=4, 8.7 %) (p>0.05). CONCLUSION: Chest PA radiography revealed tracheal deviation of thyroid lesion in 53 cases (29.6 %). The incidence and degree of deviation increased with increasing size and volume of the lesion, but deviation did not correlate with the pattern (localized or diffuse), location or constitution of the lesion.
Constitution and Bylaws ; Incidence ; Prevalence ; Radiography ; Radiography, Thoracic* ; Retrospective Studies ; Thorax* ; Thyroid Gland ; Ultrasonography

Stenotrophomonas maltophilia (S. maltophilia) is a rare, but globally emerging gram-negative multiple-drug-resistant organism usually found in a nosocomial setting in immunocompromised patients. To our best knowledge, computed tomography (CT) features of community-acquired S. maltophilia pneumonia have not been previously reported in an immunocompetent patient. Herein, we presented the CT findings of a previous healthy 56-year-old male with S. maltophilia pneumonia.
Humans ; Immunocompromised Host ; Male ; Middle Aged ; Pneumonia* ; Stenotrophomonas maltophilia* ; Stenotrophomonas*