1.Analysis of genes involved in the pathogenesis of intracellularly survival bacteria.
Tae Il JEON ; Tae Yoon LEE ; Sung Kwang KIM
Yeungnam University Journal of Medicine 1992;9(2):248-255
Eight bacterial strains were examined whether they have phoP/phoQ genes which were known to be involved in the intracellular survival of Salmonella typhimurium. The phoP/phoQ operon were known to sense the stimuli of the genes involved in the adaptation of the environment. Using 514-basepairs EcoRV DNA fragment of phoP region of Salmonella typhimurium as a probe, dot blot hybridization were performed. Chromosomal DNAs of Klebsiella pneumonia, Pseudomonas aeruginosa, Serratia marscescens, Enterobacter cloacae, Salmonella typhimurium, Escherichia coli, Shigella dysenteriae, and Listeria monocytogenes were examined by DNA hybridization assay. Against our expectation, intracellular pathogen, L. monocytogenes, did not have similar DNA sequences to phoP/phoQ of S. typhimurium, while E, coli, S. dysenteriae, and E. cloacae showed the positive signal even though they were not intracellular pathogens. This result suggested that the phoP/phoQ operon was absent in intracellular pathogenic bacterias other than S. typhimurium. Rather it was found in phylogenetically closer bacterias to S. typhimurium, which were not able to survive in intracellular environment. Some different mechanism, which is not dependent on phoP/phoQ operon, could be involved in the intracellular survival of L. monocytogenes.
Bacteria*
;
Base Sequence
;
Cloaca
;
DNA
;
Enterobacter cloacae
;
Escherichia coli
;
Klebsiella
;
Listeria monocytogenes
;
Operon
;
Pneumonia
;
Pseudomonas aeruginosa
;
Salmonella typhimurium
;
Serratia
;
Shigella dysenteriae
2.Significance of Brain MRI in the Diagnosis of Fat Embolism Syndrome
Hyung Ku YOON ; Kwang Pyo JEON ; Dae Eug JUNG ; Ho Seung JEON ; Youn Sang KIM
The Journal of the Korean Orthopaedic Association 1996;31(3):615-622
The fat embolism syndrome is a complication which encounters rarely after fractures of pelvis and long bones of lower extremity of severe injury of soft tissue, and may results in microinfarctions in lungs, brain, heart, kidneys and other important organs when fat globules flow from bone marrow into small vessels. And that is the one of the main cause of death within 72 hours after major trauma of long bones. Diagnosis of fat embolism syndrome was made by clinical criteria by Gurd, but, majority of cases didn't show characteristic clinical symptoms or signs. Recently CT and MRI of the brain are adopted to the diagnosis of FFS as a new method. Authors experiences six cases of fat embolism syndrome from Mar. 1991 to Mar. 1994 and analyzed the brain MRI findings. We concluded that the brain MRI findings such as diffuse brain swelling, petechial hemorrhage and microinfarctions were helpful to diagnose clinically apparent or subclinical fat embolism syndrome.
Bone Marrow
;
Bones of Lower Extremity
;
Brain Edema
;
Brain
;
Cause of Death
;
Diagnosis
;
Embolism, Fat
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Heart
;
Hemorrhage
;
Kidney
;
Lung
;
Magnetic Resonance Imaging
;
Methods
;
Pelvis
3.Comparison between Primary repair and Reconstruction in Acute ACL Injury.
Hyung Ku YOON ; Hoe Seung JEON ; Kwang Pyo JEON ; Dae Eun JUNG ; Yon Sang KIM
The Journal of the Korean Orthopaedic Association 1997;32(7):1536-1542
ACL plays an important role in stability of knee joint and its injury causes instability of joint which is known as the initiation of problem knee. Reconstruction of the anterior cruciate ligament would be preferred to the primary repair in treatment. And recently with the advance of arthroscopic technique and development of bone-patellar tendon-bone (BPB) graft material, the result of reconstruction is somewhat superior to that of primary repair. Authors compared the results of 20 primary repairs (Group I ) and 20 reconstructions (Group II) among 64 acute ACL injury treated Sung-Ae General Hospital from January 1989 to December 1994. The results were as follows: 1. Most common associated injuries were medial collateral ligament rupture and medial meniscal tear. 2. Group I showed postoperatively 13 negative anterior drawer test, 12 negative Lachmann test and 12 negative pivot shift test and group II showed postoperatively 17 negative anterior drawer test, 15 negative Lachmann test and 17 negative pivot shift test. (p<0.05) 3. In postoperative Lysholm knee scoring scale, group I showed 86 points and group II showed 93 points (p<0.05). 4. In postoperative KT-1000 arthrometer, 12 cases in Group I and 16 cases in Group II showed less than 2mm difference with sound side (p<0.05).
Anterior Cruciate Ligament
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Collateral Ligaments
;
Hospitals, General
;
Joints
;
Knee
;
Knee Joint
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Rupture
;
Transplants
4.A Study of the Subjectivity of Quality of Life in Elderly Women.
Boon Han KIM ; Yoon Sook KIM ; Hye Won JEON
Journal of Korean Academy of Adult Nursing 2007;19(5):775-786
PURPOSE: The purpose of the study were to categorize the subjectivity of the quality of life in elderly women and to thereby understand the differences regarding quality of life desires. METHODS: This study used a Q-methodology to measure the quality of life in elderly women. A Q sample was collected from in-depth and objective interviews and WHOQLO. Fourteen participants rated 28 selected Q-statements on a scale of 1-7. The collected data was analyzed using PC Quanl. RESULTS: The principal component analysis identified 4 factors regarding the quality of life of elderly women. These categories were labeled 'hopelessness-oriented', 'relationship/adaptation-oriented', 'physical suffering-oriented', and 'self satisfaction-orientated'. CONCLUSION: Some of the factors regarding the quality of life of elderly women were determined through this research. Further research is necessary to set up and apply different the quality of life between men and women based on this result. The results of this study indicate that different approaches toward quality of life promotion programs are recommended based on the four factors of quality of life among elderly women.
Aged*
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Female
;
Humans
;
Male
;
Principal Component Analysis
;
Quality of Life*
5.A Case of Retroperitoneal Fibrosis Treated with Longitudinal Ureteromyotomy Successfully.
Jun Mo KIM ; Young Ho KIM ; Yoon Soon JEON ; Nam Kyu LEE
Korean Journal of Urology 2000;41(9):1151-1153
No abstract available.
Retroperitoneal Fibrosis*
6.A case of monozygotic twin with Down syndrome.
Seong Heon JEON ; Choong Hyun YOON ; Young Wook KIM ; Ki Bok KIM
Journal of the Korean Pediatric Society 1993;36(3):434-438
No abstract available.
Down Syndrome*
;
Humans
;
Twins, Monozygotic*
7.A Case Report of Takayaeu's Arteritis Associated with, a Retinopathy.
Jin Hwal SUH ; Byung Joo YOON ; Hyung Jeon KIM
Journal of the Korean Ophthalmological Society 1989;30(5):829-833
The authors have experienced a case of Takayasu's arteritis associated with Takayasu's retinopathy which is confirmed by aortography and fluorescent angiography in a 14 year old female.
Adolescent
;
Angiography
;
Aortography
;
Arteritis*
;
Female
;
Humans
;
Takayasu Arteritis
8.A Study on Expression of p53 Protein according to Histologic Types, Degree of Malignancy and Differentiation of the Ovarian Surface Epithelial Tumors.
Young Ju KIM ; Mi Yeong JEON ; Hye Kyoung YOON ; Mi Young SOL
Korean Journal of Pathology 1996;30(12):1099-1105
p53 gene alterations in the ovarian cancers are regarded as early events in the whole process of carcinogenesis. This study is intended to compare p53 protein expression rate in the ovarian surface epithelial tumors according to histologic types, degree of malignancy and differentiation. 134 cases of ovarian epithelial tumors including 26 cases of serous cystadenoma, 7 cases of serous borderline malignancy, 15 cases of serous cystadenocarcinoma, 40 cases of mucinous cystadenoma, 21 cases of mucinous borderline malignancy, 20 cases of mucinous cystadenocarcinoma, 4 cases of endometrioid carcinoma, and 1 case of clear cell carcinoma were studied. Immunohistochemistry using monoclonal p53 antibody(DO-7) was applied to the routine formalin-fixed paraffin embedded tissue. The results were as follows; 1. No immunohistochemical positivity of p53 protein was found in all 66 cases of benign serous and mucinous tumors studied. 2. There was no significant difference of p53 protein expression between serous and mucinous malignant tumors. 3. The expression rate of p53 protein exhibited a statistically significant difference between borderline(42%) and malignant(74%) ovarian surface epithelial tumors (p<0.05). 4. The expression rate of p53 protein of poorly differentiated carcinomas(100%) was higher than those of moderately (88%) and well differentiated carcinomas(60%), but there was no statistical significance. In summary, p53 protein expression might be a good indicator of malignant transformation of the ovarian surface epithelial tumors.
Ovarian Neoplasms
;
Genes, p53
9.Clinical predictive factors of pathologic tumor response after preoperative chemoradiotherapy in rectal cancer.
Chi Hwan CHOI ; Won Dong KIM ; Sang Jeon LEE ; Woo Yoon PARK
Radiation Oncology Journal 2012;30(3):99-107
PURPOSE: The aim of this study was to identify clinical predictive factors for tumor response after preoperative chemoradiotherapy (CRT) in rectal cancer. MATERIALS AND METHODS: The study involved 51 patients who underwent preoperative CRT followed by surgery between January 2005 and February 2012. Radiotherapy was delivered to the whole pelvis at a dose of 45 Gy in 25 fractions, followed by a boost of 5.4 Gy in 3 fractions to the primary tumor with 5 fractions per week. Three different chemotherapy regimens were used (5-fluorouracil and leucovorin, capecitabine, or tegafur/uracil). Tumor responses to preoperative CRT were assessed in terms of tumor downstaging and pathologic complete response (ypCR). Statistical analyses were performed to identify clinical factors associated with pathologic tumor response. RESULTS: Tumor downstaging was observed in 28 patients (54.9%), whereas ypCR was observed in 6 patients (11.8%). Multivariate analysis found that predictors of downstaging was pretreatment relative lymphocyte count (p = 0.023) and that none of clinical factors was significantly associated with ypCR. CONCLUSION: Pretreatment relative lymphocyte count (%) has a significant impact on the pathologic tumor response (tumor downstaging) after preoperative CRT for locally advanced rectal cancer. Enhancement of lymphocyte-mediated immune reactions may improve the effect of preoperative CRT for rectal cancer.
Chemoradiotherapy
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Deoxycytidine
;
Fluorouracil
;
Humans
;
Leucovorin
;
Lymphocyte Count
;
Multivariate Analysis
;
Pelvis
;
Rectal Neoplasms
;
Capecitabine
10.The Actual State of Industrial Accidents in Small-medium Manufacturing Industries.
Seong Ja HONG ; Man Joong JEON ; Chang Yoon KIM
Korean Journal of Occupational Health Nursing 2011;20(1):93-103
PURPOSE: This study was conducted to assess reported industrial accidents and non-reported industrial accidents that took place in 63 small and medium sized manufacturing industries located in Daegu and Gyeongsangbuk-do in the year of 2009. METHODS: During the period from January to December 2009, the number of industrial accidents that happened each month was examined according to the characteristics of industry, industrial accidents, workers with industrial accidents, treatment, as well as causes and treatment of the non-reported. RESULTS: The total incidence rate of industrial accidents was 3.48%, of which only 0.31% reported. The incidence rate in packing and distribution among manufacturing workplace, and in the industry with 50~99 employees, was higher than the other groups. Of the non-reported, over 80% in required under 10 days of medical treatment, and 56% in required cost of less than 100,000 won. Kappa values were 0.771 concurrence in opinions for causes of non-reported, and 0.571 concurrence in opinions for management termination of non-reported between the employees and employer. CONCLUSION: It is suggested that more supportive policy and precise, nationwide survey on the actual state of industrial accidents, including non-reported cases, be implemented to efficiently manage industrial accidents.
Accidents, Occupational
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Hypogonadism
;
Incidence
;
Mitochondrial Diseases
;
Ophthalmoplegia