No abstract available.
Umbilical Cord*

BACKGROUND: Cigarette smoking is a major risk factor for cancer and vascular disease but, a correctable habit. Despite widespread recognition of the hazardous health effects of smoking, Korean men and adolescents' smoking rates are not decreasing and is, emerging as a public health problem. Health care managers in schools and factories are expected to play a critical role in smoking cessation. Health education is one important area that will benefit from using a personal computer (PC). To promote smoking cessation, specified and risk-based approaches are considered to encourage the motivation of smokers. METHODS: This smoking cessation software (CD-Rom) was developed for health care managers in schools and factories using Microsoft Visual Basic and Access. RESULTS: This program divided into two major categories. Part one is a library of various kinds of information about smoking such as articles, lecture notes, pictures, slides, mp3 and motion files. The other part was an autonomous smoking cessation prescription program. This program analyzed smokers' smoking pattern (using WHY test), nicotine addiction level (using Fagerstrom score), stress level (using BEPSI test), and smokers' confidence level. After input of smoker's history by oneself, the program showed smoking cessation prescription automatically in monitor or printer. CONCLUSION: Health care managers in schools and factories can be experts of smoking cessation easily with this program in their work places.
CD-ROM ; Delivery of Health Care* ; Health Education ; Humans ; Male ; Microcomputers* ; Motivation ; Nicotine ; Prescriptions ; Public Health ; Risk Factors ; Smoke* ; Smoking Cessation* ; Smoking* ; Vascular Diseases ; Workplace

BACKGROUND: Renal dysplasia is the abnormal development of the kidney. The condition is usually detected in childhood along with other urinary tract anomalies, but can remain unnoticed until adulthood. It was recently reported that a PAX2 gene mutation plays a major role in the development of renal dysplasia. The aim of this study was to examine the expression of PAX2 in dysplastic kidneys of children and adults. METHODS: A total of 30 cases diagnosed with renal dysplasia after a nephrectomy were examined. PAX2 expression was evaluated using immunohistochemistry. Apoptosis was detected using an Apop Tag detection kit. RESULTS: In the dysplastic kidneys, there was strong PAX2 expression in the epithelia of the primitive ducts in both children and adults, but the degree was significantly lower in adults (p=0.007). However, the mesenchyme surrounding the primitive ducts of children showed stronger staining for the smooth muscle actin antibody and trichrome than the adults. The apoptosis index was significantly higher in the primitive duct epithelia than in the surrounding normal collecting duct epithelia (p=0.000). CONCLUSIONS: PAX2 is overexpressed in the primitive ducts of renal dysplasia, which is sustained until adulthood and is associated with increased apoptosis. However, a decrease in PAX2 expression in the dysplastic epithelia and mesenchymal cuff of adults suggest a gradual regression of the dysplastic elements with time.
Actins ; Adult ; Apoptosis ; Child ; Humans ; Immunohistochemistry ; Kidney ; Mesoderm ; Muscle, Smooth ; Nephrectomy ; Urinary Tract

No abstract available.
Head and Neck Neoplasms* ; Head* ; Incidence* ; Neck* ; Neoplasm Metastasis*

No abstract available.
Burkholderia cepacia* ; Skin*

No abstract available.
Myelography*

The development of transport is being easily shared with people all over the world. It is necessary to appropriately and effectively revise the domestic quarantine law because the fatal infectious diseases are at risk of being easily shared. Today, Korea has an advanced quarantine system approved by World Health Organization, but it maintains partnerships with related ministries (Ministry of Foreign Affairs, Ministry of Justice, local medical institutions) and to introduce new medical technology (electronic quarantine) is important. And since the prevention of quarantine infectious diseases and prevention of the spread, in order to maintain international cooperation with the International Health Regulations, the quarantine law and the system should be amended and improved effectively and it is also a way to prepare for the outbreak of new quarantine infectious diseases. In the past, Korea has experienced great confusion during the past outbreak of swine flu and Middle East respiratory syndrome coronavirus. To prevent similar cases from recurring in the past, the revision of the quarantine law and the improvement of the system should be done to cope with the changing environment (new infections, increased number of overseas travelers, etc.).
Communicable Diseases ; International Cooperation ; Jurisprudence ; Korea ; Middle East Respiratory Syndrome Coronavirus ; Quarantine ; Social Control, Formal ; Social Justice ; Swine ; World Health Organization

The Bcl-2 interacting death suppressor (Bis) protein is known to be involved in a variety of pathophysiological conditions. We recently generated bis-deficient mice, which exhibited early lethality with typical nutritional deprivation status. To further investigate the molecular basis for the malnutrition phenotype of bis deficient mice, we explored Bis expression in the digestive system of normal mice. Western blot analysis and quantitative real time reverse transcription polymerase chain reaction analysis indicated that Bis expression is highest in the esophagus, followed by the stomach, colon, jejunum and ileum. Immunohistochemical data indicated that Bis expression is restricted to the stratified squamous epitheliums in the esophagus and forestomach, and was not notable in the columnar epitheliums in the stomach, small intestine and colon. In addition, strong Bis immunoreactivity was detected in the striated muscles surrounding the esophagus and smooth muscles at a lesser intensity throughout the gastrointestinal (GI) tract. Ganglionated plexuses, located in submucous layers, as well as intermuscular layers, were specifically immunoreactive for Bis. Immunofluorescence studies revealed that Bis is co-localized in glial fibrillary acidic protein-expressing enteric glial cells. Immunostaining with neuron specific esterase antibodies indicate that Bis is also present in the cell bodies of ganglions in the enteric nervous system (ENS). Our findings indicate that Bis plays a role in regulating GI functions, such as motility and absorption, through modulating signal transmission between the ENS and smooth muscles or the intestinal epitheliums.
Absorption ; Animals ; Antibodies ; Blotting, Western ; Colon ; Digestive System ; Enteric Nervous System ; Epithelium ; Esophagus ; Fluorescent Antibody Technique ; Ganglion Cysts ; Ileum ; Immunohistochemistry ; Intestinal Mucosa ; Intestine, Small ; Jejunum ; Malnutrition ; Mice ; Muscle, Smooth ; Muscle, Striated ; Neuroglia ; Neurons ; Phenotype ; Polymerase Chain Reaction ; Reverse Transcription ; Stomach

The pleckstrin homology (PH) domain is a protein module of approximately 100 amino acids, that has been found in signaling molecules, including serinelthreonine kinase, GTPase-activating protein, phospholipase, and some cytoskeletal proteins. Although the specific function of PH domain has not been defined yet, it is believed that this domain is involved in the regulation of signal transduction pathway. The expression plasmids of human PLCg PH domains were constructed to see the roles of them in IL-6 signal transduction. When these expression plasmids are transfected into B9 cells, only N-terminal of PH domain inhibited IL-6-induced B9 cell proliferation. These results suggest that N-terminal of PH domain is critical for IL-6 signal transduction in B9 cells. To search the binding proteins associated PH domains of PLCy1 in B9 cells, Glutathione S-trnaferase (GST) fusion proteins containg PH domains were expressed in E. coli. Then, IL-6-dependent B9 cells were treated with 10 unit/ml IL-6 and the cell lysates were immunoprecipited with GST-PH doman fusion proteins. In vitro kinase assay of immune complex demonstrated that p38 (38 KDa) protein was coprecipitated with NC fusion protein, but IL-6 had no additional effect on it. When S-methaionine labelled cell lysates were used for immunoprecipitation, the same result was observed, conforming the association of p38 with NC motive of PH domain.
Amino Acids ; Antigen-Antibody Complex ; Carrier Proteins ; Cell Proliferation ; Cytoskeletal Proteins ; Glutathione ; GTPase-Activating Proteins ; Humans ; Hydrogen-Ion Concentration ; Immunoprecipitation ; Interleukin-6 ; Phospholipases ; Phosphotransferases ; Plasmids ; Signal Transduction

No abstract available.
Breast* ; Hamartoma*