1.The Effect of Intra-articular Injection of Steroid on Lysozyme Activity in Patient with Rheumatoid Arthritis
The Journal of the Korean Orthopaedic Association 1976;11(1):110-115
The lysozyme activities of knee joint fluid in normal Korean people, patients with rheumatoid arthritis, and patients with degenerative arthritis have been reported by Lee in 1974. This time I have studied the chronologic changes of lysozyme activity of knee joint fluid in patients with rheumatoid arthritis following intra-articular injection of steroid preparation (6-methylprednisolone acetate). The results obtained were as follows. 1. The synovial concentration of lysozyme in patients with rheumatoid arthritis was found to be 10.88 mcg/ml which is higher than normal value of 8.69 mcg/ml. 2. The lysozyme activity of joint fluid obtained 5 days after intra-articular injection of steroid prepatation was variable ranging from 7.40 mcg/ml to 10.0mcg/ml with the average of 8.97 mcg/ml, which corresponded to the relief of clinical manifestations. 3. The lysozyme activity of joint fluid obtained 10 days after intra-articular injection of steroid preparation decreased to 8.36 mcg/ml on average with the range from 7.60 to 9.30 mcg/ml which was in accordance with much relief of clinical manifestations. 4. The lysozyme activity of joint fluid obtained 20 days after intra-articular steroid injection was 9.55 mcg/ml on average with the range from 8.25 to 11.25 mcg/ml which was in accordance with the aggravations of clinical manifestations.
Arthritis, Rheumatoid
;
Humans
;
Injections, Intra-Articular
;
Joints
;
Knee Joint
;
Muramidase
;
Osteoarthritis
;
Reference Values
2.A case of hereditary non-polyposis colorectal cancer.
Seok Hwan LEE ; Kee Hyung LEE ; Choong YOON
Journal of the Korean Society of Coloproctology 1992;8(3):291-295
No abstract available.
Colorectal Neoplasms*
3.Leiomyosarcoma of the anal canal.
Seok Hwan LEE ; Kee Hyung LEE ; Choong YOON
Journal of the Korean Society of Coloproctology 1991;7(2):149-154
No abstract available.
Anal Canal*
;
Leiomyosarcoma*
4.A clinical study of seasonal affective disorder.
Kyung Kyu LEE ; Do Joon YOON ; Hwan Il CHANG
Journal of Korean Neuropsychiatric Association 1992;31(1):84-92
No abstract available.
Seasonal Affective Disorder*
;
Seasons*
5.A Case Of Cerebellar Hemorrhage Associated with Cavernous Hemangioma and Developmental Venous Anomaly.
Ji Yon LEE ; Sung Hwan KIM ; Soo Han YOON
Journal of the Korean Child Neurology Society 1998;5(2):361-366
Developmental venous anomalies are congenital anomalies of the intracranial venous drainage and clinically asymptomatic. Cavernous hemangiomas are vascular malformations composed of dilated vascular channels lined with a single layer of endothelial cells without any intervening normal neural tissue. Although, cavernous hemangioma may be clinically silent, but frequently cause variable neurologic manifestations; intracranial hemorrhage, seizures, and focal neurologic deficits. Frequent association of these two diseases has already been reported and it has been suggested that cavernous hemangiomas not the developmental venous anomalies that cause the acute clinical symptoms. A 4 year old girl with sudden onset of headache, vomiting, gait disturbance and signs of unilateral cerebellar dysfunction 2 days before admission showed a 2.5x2.5cm sized hematoma with heterogenous signal intensity both in CT and MRI in the left cerebellar hemisphere. Four-vessel cerebral angiography revealed characteristic findings of developmental venous anomalies. Pathologic findings of the surgically removed hematoma disclosed typical feature of cavernous hemangioma. Based on the findings in this case and review of the literatures, we concluded that the possibility of other diseases such as cavernous hemangiomas must be considered in patients who has intracranial hemorrhage due to the developmental venous anomalies.
Cerebellar Diseases
;
Cerebral Angiography
;
Child, Preschool
;
Drainage
;
Endothelial Cells
;
Female
;
Gait
;
Headache
;
Hemangioma, Cavernous*
;
Hematoma
;
Hemorrhage*
;
Humans
;
Intracranial Hemorrhages
;
Magnetic Resonance Imaging
;
Neurologic Manifestations
;
Seizures
;
Vascular Malformations
;
Vomiting
6.Hereditary Nonpolyposis Colorectal Cancer.
Hwan Nam GUNG ; Seok Hwan LEE ; Sung Hwan HONG ; Choong YOON ; Kee Hyung LEE
Journal of the Korean Society of Coloproctology 1997;13(3):363-374
Hereditary nonpolyposis colorectal cancer(HNPCC) is an autosomal dominantly inherited disease associated with a marked increase in cancer susceptibility, especially cancer of the colorectum. The frequency of HNPCC in the general population is yet to be determined, but HNPCC may account for as much as 2% to 5% of colorectal cancer, Colorectal cancer in HNPCC differs from sporadic colorectal cancer by an early age of cancer onset, proximal predominance of colorectal cancer, an excess of synchronous and metachronous colorectal cancer, and excess extra-colonic cancers. We have found 5 HNPCC families since 1992 when we reported first HNPCC family (KHU-Hl) In order to register the patients of HNPCC and to review the clinicopathologic feature and appropriate management, we have analysed 5 HNPCC families. Five HNPCC families included 16 colorectal cancer patients(14 males and 2 females). The average age of first diagnosis was 39. Among 16 patients, 8 patient were operated at the KyungHee University hospital and their operative and pathologic records were available. Two synchronous and seven metachronous cancers were founded, so that eight patients had 15 colorectal cancer lesions. Ten cancers were located proximal to splenic flexure and five were distal. Partial resection of colon was performed in seven cases except one when the first diagnosis was made and recurrence was founded in 5 patients. Recurrence was treated by total colectomy in 3 cases and subtotal colectomy in two. In conclusion, we re-confirmed that HNPCC patient should be treated by no less than a subtotal colectomy because of high multiplicity and high recurrence rate of partial resection.
Colectomy
;
Colon
;
Colon, Transverse
;
Colorectal Neoplasms
;
Colorectal Neoplasms, Hereditary Nonpolyposis*
;
Diagnosis
;
Humans
;
Male
;
Recurrence
7.Clinical anaysis of suction coagulator tonsillectomy.
Byoung Jun BAEK ; Ki Hwan KIM ; Seung Ju LEE ; Yoon Young CHUNG ; Cheon Hwan OH
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(2):193-198
No abstract available.
Suction*
;
Tonsillectomy*
8.A Case of Premature Ovarian Failure Assosiated with Gonadal Dysgenesis.
Sook Hwan LEE ; Tae Ki YOON ; Kwang Yul CHA ; Yoon Sung NAM ; In Pyung KWAK
Korean Journal of Obstetrics and Gynecology 1999;42(1):138-141
Prenature ovarian failure is a condition causing amenarrhea, hypoestrogenism, and elevated genadotropins in women younger than 40 years. A karyotype should be performed as part of basic laboratory evaluation for all patients with premature ovarian failure and prodromal premature ovarian failure. Development of a malignancy in a dysgenetic gonad is of major concern. The presence of a fragment of the Y chromosome is thought to be a key to the oncogenic potential of these gonads. The search for the testicular determining factor(TDF) has engendered much confusion about which part of the Y chromosome plays a role in malignancy. This was initially postulated to be the H- Y antigen. More recent data, however, localize the area near the centromere of the Y Chromosome, on the long arm(Yq). Malignant potential is clearly not linked to the testicular determining factor itself(SRY). This is a critical point in clinical medicine. Feilure to display SRY or a closely related sequence does not rule out the presence of the segment of the Y chromosome postulated to be associated with the development of malignancies. We have experienced a case of premature ovarian failure with chtomosomal abnormality involving Y chromosome fragment. So we report this case with a brief review of literatures.
Centromere
;
Clinical Medicine
;
Female
;
Gonadal Dysgenesis*
;
Gonads*
;
Humans
;
Karyotype
;
Primary Ovarian Insufficiency*
;
Y Chromosome
9.A Case of Microscopic Polyangiitis with Acute Myocardial Infarction.
Kyeong Han YOON ; Dae Hwan KIM ; Kyeong Han YOON ; Eun So LEE ; You Chan KIM
Annals of Dermatology 2002;14(3):181-185
Microscopic polyangiitis is a systemic small-vessel vasculitis, which may involve multiple organs, but cardiac involvement is relatively rare. We report a case of microscopic polyangiitis with multiple organ involvement, in which myocardial infarction was the early manifestation of the disease. A 53-year-old man presented with sudden papulovesicular eruptions and swellings on the face, posterior neck, dorsa of both hands and fingers, and with diffuse erythematous patches on the back. He had suffered from renal dysfunction, arthralgia, and hypertension for more than 8 years. He had been admitted to the department of cardiology for acute myocardial infarction and had suffered from recurrent gastrointestinal bleeding, renal failure, acute pancreatitis and sepsis during the admission. Histopathologically, small-vessel leukocytoclastic vasculitis with out granuloma was seen. Direct immunofluorescence showed no immune deposite. A high serum level of P-ANCA was detected by ELISA.
Acute Kidney Injury
;
Antibodies, Antineutrophil Cytoplasmic
;
Arthralgia
;
Cardiology
;
Enzyme-Linked Immunosorbent Assay
;
Fingers
;
Fluorescent Antibody Technique, Direct
;
Granuloma
;
Hand
;
Hemorrhage
;
Humans
;
Hypertension
;
Microscopic Polyangiitis*
;
Middle Aged
;
Myocardial Infarction*
;
Neck
;
Pancreatitis
;
Sepsis
;
Vasculitis
10.A Case of HAIR - AN Syndrome.
Sook Hwan LEE ; Tae Ki YOON ; Kwang Yul CHA ; In Pyung KWAK ; Yoon Sung NAM
Korean Journal of Obstetrics and Gynecology 1999;42(3):622-624
Polycystic ovary disease is a heterogenous endocrinopathy with many interacting causal factors. One potential such factor is chronic hyperinsulinemia. multiple, independent lines of evidence suppart the contention that chronic hyperinsulinemia causes ovarian hyperandragenism. This evidence includes: (1) mutations in the insulin receptor gene that cause severe hyperinsulinemia appear to be associated with ovarian hyperandrogenism, (2) insulin stimulates ovarian thecal and sttomal androgen seaetion in vitro, and (3) in some experimental models, manipulation of circulating insulin concentrations results in changes in circulating androgens. Although the association between hyperinsulinemia and hyperandrogenism remains to be fully explained at the molecular level, chronic hyperinsulinemia appears to be an important cause of hyperandrogenism. We have experienced a case of HAIR AN syndrome showing hyperandrogenism, insulin resistance and acanthosis nigricans in infertile patient. So we report this case with a brief review of literatures.
Acanthosis Nigricans
;
Androgens
;
Female
;
Fibrinogen
;
Hair*
;
Humans
;
Hyperandrogenism
;
Hyperinsulinism
;
Insulin
;
Insulin Resistance
;
Models, Theoretical
;
Ovary
;
Receptor, Insulin